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WO2012169819A3 - Procédé de préparation de polyhydroxyalcanoate contenant du 2-hydroxybutyrate en tant que monomère - Google Patents

Procédé de préparation de polyhydroxyalcanoate contenant du 2-hydroxybutyrate en tant que monomère Download PDF

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Publication number
WO2012169819A3
WO2012169819A3 PCT/KR2012/004523 KR2012004523W WO2012169819A3 WO 2012169819 A3 WO2012169819 A3 WO 2012169819A3 KR 2012004523 W KR2012004523 W KR 2012004523W WO 2012169819 A3 WO2012169819 A3 WO 2012169819A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxybutyrate
monomer
polyhydroxyalkanoate containing
producing
producing polyhydroxyalkanoate
Prior art date
Application number
PCT/KR2012/004523
Other languages
English (en)
Korean (ko)
Other versions
WO2012169819A2 (fr
Inventor
이상엽
박시재
이승환
송봉근
이태우
Original Assignee
한국과학기술원
한국화학연구원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한국과학기술원, 한국화학연구원 filed Critical 한국과학기술원
Publication of WO2012169819A2 publication Critical patent/WO2012169819A2/fr
Publication of WO2012169819A3 publication Critical patent/WO2012169819A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

La présente invention concerne un procédé de préparation de polyhydroxyalcanoate contenant du 2-hydroxybutyrate en tant que monomère et, plus précisément, un procédé de préparation, à partir de souches recombinantes et par génie métabolique, de polyhydroxyalcanoate contenant du 2-hydroxybutyrate. La présente invention concerne un microorganisme recombinant capable de générer du polyhydroxyalcanoate contenant du 2-hydroxybutyrate, un polymère biodégradable inédit, en tant que monomère, ainsi qu'un procédé de préparation de polyhydroxyalcanoate contenant du 2-hydroxybutyrate en tant que monomère, impliquant la culture dudit microorganisme recombinant.
PCT/KR2012/004523 2011-06-08 2012-06-08 Procédé de préparation de polyhydroxyalcanoate contenant du 2-hydroxybutyrate en tant que monomère WO2012169819A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110055113A KR101273599B1 (ko) 2011-06-08 2011-06-08 2-하이드록시부티레이트를 모노머로 함유하고 있는 폴리하이드록시알카노에이트의 제조방법
KR10-2011-0055113 2011-06-08

Publications (2)

Publication Number Publication Date
WO2012169819A2 WO2012169819A2 (fr) 2012-12-13
WO2012169819A3 true WO2012169819A3 (fr) 2013-03-07

Family

ID=47296616

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/004523 WO2012169819A2 (fr) 2011-06-08 2012-06-08 Procédé de préparation de polyhydroxyalcanoate contenant du 2-hydroxybutyrate en tant que monomère

Country Status (2)

Country Link
KR (1) KR101273599B1 (fr)
WO (1) WO2012169819A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017171260A1 (fr) * 2016-03-28 2017-10-05 주식회사 엘지화학 Biopolymère liquide, son utilisation et procédé de préparation
WO2018159965A1 (fr) * 2017-02-28 2018-09-07 한국과학기술원 Procédé de production de polyhydroxyalcanoate à l'aide de 2-hydroxyisocaproate-coa transférase
KR102036828B1 (ko) 2017-02-28 2019-10-25 한국과학기술원 2-하이드록시이소카프로에이트-CoA 전이효소를 이용한 폴리하이드록시알카노에이트의 제조방법
KR102497785B1 (ko) * 2018-01-08 2023-02-07 주식회사 엘지화학 2-하이드록시부티레이트 및 락테이트의 공중합체 제조를 위한 재조합 균주 및 방법
KR102361618B1 (ko) * 2018-01-08 2022-02-09 주식회사 엘지화학 2-하이드록시부티레이트 및 3-하이드록시부티레이트의 공중합체 및 이의 제조방법
KR20190090602A (ko) * 2018-01-25 2019-08-02 주식회사 엘지화학 2-하이드록시부티레이트, 2-하이드록시이소발레레이트 및 락테이트의 삼중합체 제조를 위한 재조합 균주 및 방법
CN114561333B (zh) * 2022-02-23 2023-08-25 山东第一医科大学(山东省医学科学院) 一种转化支链氨基酸的工程菌及在制备治疗枫糖尿症产品中的应用
CN115851510B (zh) * 2022-10-13 2023-09-12 深圳中科翎碳生物科技有限公司 盐单胞菌及其在联产四氢嘧啶和聚羟基脂肪酸酯的应用

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HOZUI, F. ET AL., APPL. MICROBIOL. BIOTECHNOL., vol. 85, 2010, pages 949 - 954 *
MATSUMOTO, K. ET AL., BIOMACROMOLECULES, vol. 6, 2005, pages 99 - 104 *
MATSUMOTO, K. ET AL., BIOMACROMOLECULES, vol. 7, 2006, pages 2436 - 2442 *
SHOZUI, F. ET AL., APPL. MICROBIOL. BIOTECHNOL., vol. 84, 2009, pages 1117 - 1124 *
TAKASE, K. ET AL., J. BIOCHEM., vol. 133, 2003, pages 139 - 145 *

Also Published As

Publication number Publication date
KR101273599B1 (ko) 2013-06-11
KR20120136099A (ko) 2012-12-18
WO2012169819A2 (fr) 2012-12-13

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