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WO2012168949A3 - A process for preparation of nevirapine - Google Patents

A process for preparation of nevirapine Download PDF

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Publication number
WO2012168949A3
WO2012168949A3 PCT/IN2012/000393 IN2012000393W WO2012168949A3 WO 2012168949 A3 WO2012168949 A3 WO 2012168949A3 IN 2012000393 W IN2012000393 W IN 2012000393W WO 2012168949 A3 WO2012168949 A3 WO 2012168949A3
Authority
WO
WIPO (PCT)
Prior art keywords
nevirapine
preparation
chloro
bicarbonates
cyclization
Prior art date
Application number
PCT/IN2012/000393
Other languages
French (fr)
Other versions
WO2012168949A2 (en
Inventor
Satyanarayana Chava
Seeta Ramanjaneyulu Gorantla
Venkata Sunil Kumar Indukuri
Srinivas Simhadri
Yaseen Mohammed
Original Assignee
Laurus Labs Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laurus Labs Private Limited filed Critical Laurus Labs Private Limited
Publication of WO2012168949A2 publication Critical patent/WO2012168949A2/en
Publication of WO2012168949A3 publication Critical patent/WO2012168949A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention provides a process for the preparation of nevirapine, which comprises reaction of 2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridine carboxamide with cyclopropyl amine in presence of a suitable reagent such as carbonates, bicarbonates, acetates of alkali metals and lanthanum oxide, followed by cyclization of the resultant product.
PCT/IN2012/000393 2011-06-06 2012-06-05 A process for preparation of nevirapine WO2012168949A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1913CH2011 2011-06-06
IN1913/CHE/2011 2011-06-06

Publications (2)

Publication Number Publication Date
WO2012168949A2 WO2012168949A2 (en) 2012-12-13
WO2012168949A3 true WO2012168949A3 (en) 2013-03-28

Family

ID=47296549

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2012/000393 WO2012168949A2 (en) 2011-06-06 2012-06-05 A process for preparation of nevirapine

Country Status (1)

Country Link
WO (1) WO2012168949A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106938981A (en) * 2016-11-10 2017-07-11 浙江华海药业股份有限公司 A kind of preparation method of NVP intermediate sphaerocrystal

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366972A (en) * 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
US5569760A (en) * 1994-02-03 1996-10-29 Boehringer Ingelheim Kg Process for preparing nevirapine
US20040002603A1 (en) * 2002-06-28 2004-01-01 Boehringer Ingelheim Chemicals, Inc. Method for making nevirapine
WO2007010352A1 (en) * 2005-07-19 2007-01-25 Emcure Pharmaceuticals Limited An improved process for industrial manufacture of nevirapine
WO2008142528A2 (en) * 2007-05-22 2008-11-27 Aurobindo Pharma Limited An improved process for preparing nevirapine
CN101585836A (en) * 2008-05-25 2009-11-25 浙江华海药业股份有限公司 Novel method for preparing Nevirapine

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366972A (en) * 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
US5569760A (en) * 1994-02-03 1996-10-29 Boehringer Ingelheim Kg Process for preparing nevirapine
US20040002603A1 (en) * 2002-06-28 2004-01-01 Boehringer Ingelheim Chemicals, Inc. Method for making nevirapine
US6680383B1 (en) * 2002-06-28 2004-01-20 Boehringer Ingelheim Chemicals, Inc. Method for making nevirapine
WO2007010352A1 (en) * 2005-07-19 2007-01-25 Emcure Pharmaceuticals Limited An improved process for industrial manufacture of nevirapine
WO2008142528A2 (en) * 2007-05-22 2008-11-27 Aurobindo Pharma Limited An improved process for preparing nevirapine
CN101585836A (en) * 2008-05-25 2009-11-25 浙江华海药业股份有限公司 Novel method for preparing Nevirapine

Also Published As

Publication number Publication date
WO2012168949A2 (en) 2012-12-13

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