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WO2012168680A8 - Pharmaceutical preparation comprising recombinant fsh - Google Patents

Pharmaceutical preparation comprising recombinant fsh Download PDF

Info

Publication number
WO2012168680A8
WO2012168680A8 PCT/GB2012/000491 GB2012000491W WO2012168680A8 WO 2012168680 A8 WO2012168680 A8 WO 2012168680A8 GB 2012000491 W GB2012000491 W GB 2012000491W WO 2012168680 A8 WO2012168680 A8 WO 2012168680A8
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical preparation
recombinant fsh
fsh
glycan structures
recombinant
Prior art date
Application number
PCT/GB2012/000491
Other languages
French (fr)
Other versions
WO2012168680A1 (en
Inventor
Ian Cottingham
Daniel Plaksin
Bjorn Rikard Lorentz SANDSTROM
Original Assignee
Ferring B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring B.V. filed Critical Ferring B.V.
Priority to EP12730594.4A priority Critical patent/EP2717904A1/en
Publication of WO2012168680A1 publication Critical patent/WO2012168680A1/en
Publication of WO2012168680A8 publication Critical patent/WO2012168680A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Preparations including FSH, for example recombinant FSH, wherein 17% to 23% of the sialyated glycan structures are tetra-sialylated glycan structures.
PCT/GB2012/000491 2011-06-06 2012-06-06 Pharmaceutical preparation comprising recombinant fsh WO2012168680A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP12730594.4A EP2717904A1 (en) 2011-06-06 2012-06-06 Pharmaceutical preparation comprising recombinant fsh

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11168816 2011-06-06
EP11168816.4 2011-06-06

Publications (2)

Publication Number Publication Date
WO2012168680A1 WO2012168680A1 (en) 2012-12-13
WO2012168680A8 true WO2012168680A8 (en) 2014-01-03

Family

ID=46397316

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2012/000491 WO2012168680A1 (en) 2011-06-06 2012-06-06 Pharmaceutical preparation comprising recombinant fsh

Country Status (3)

Country Link
EP (1) EP2717904A1 (en)
AR (1) AR090095A1 (en)
WO (1) WO2012168680A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108348465B (en) * 2015-09-17 2020-11-10 葛莱高托普有限公司 Mammalian follicle stimulating hormone composition with improved stability

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI488640B (en) 2008-04-16 2015-06-21 Ferring Int Ct Sa Pharmaceutical preparation
HUE056726T2 (en) 2017-09-01 2022-03-28 Ferring Bv Controlled ovarian stimulation preparation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1438336T3 (en) * 2001-10-22 2006-10-02 Applied Research Systems Gonadotropins for follicle formation
WO2005080585A1 (en) * 2004-02-13 2005-09-01 Glycotope Gmbh Highly active glycoproteins-process conditions and an efficient method for their production
TWI488640B (en) 2008-04-16 2015-06-21 Ferring Int Ct Sa Pharmaceutical preparation
TWI532495B (en) * 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 Pharmaceutical preparation
WO2012016576A1 (en) 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108348465B (en) * 2015-09-17 2020-11-10 葛莱高托普有限公司 Mammalian follicle stimulating hormone composition with improved stability

Also Published As

Publication number Publication date
WO2012168680A1 (en) 2012-12-13
AR090095A1 (en) 2014-10-22
EP2717904A1 (en) 2014-04-16

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