+

WO2012006038A3 - Agents and compounds for imaging and other applications, and methods of use and synthesis thereof - Google Patents

Agents and compounds for imaging and other applications, and methods of use and synthesis thereof Download PDF

Info

Publication number
WO2012006038A3
WO2012006038A3 PCT/US2011/042061 US2011042061W WO2012006038A3 WO 2012006038 A3 WO2012006038 A3 WO 2012006038A3 US 2011042061 W US2011042061 W US 2011042061W WO 2012006038 A3 WO2012006038 A3 WO 2012006038A3
Authority
WO
WIPO (PCT)
Prior art keywords
agents
compounds
synthesis
applications
methods
Prior art date
Application number
PCT/US2011/042061
Other languages
French (fr)
Other versions
WO2012006038A2 (en
Inventor
Dean A. Sherry
Yunkou Wu
Garry E. Kiefer
Original Assignee
The Board Of Regents, The University Of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Regents, The University Of Texas System filed Critical The Board Of Regents, The University Of Texas System
Publication of WO2012006038A2 publication Critical patent/WO2012006038A2/en
Publication of WO2012006038A3 publication Critical patent/WO2012006038A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

According to an illustrative embodiment, provided herein are paramagnetic chemical exchange saturation transfer MRI contrast agents having a tetraazacyclododecane ligand and a paramagnetic ion that provides a ratiometric imaging measurement that can be used to measure biological parameters including pH, temperature, reactive oxygen species, and specific enzymes, among others. The agents and compounds may also be usable in other applications. Methods of use and synthesis of the agents and compounds herein are also provided.
PCT/US2011/042061 2010-06-28 2011-06-27 Agents and compounds for imaging and other applications, and methods of use and synthesis thereof WO2012006038A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35933310P 2010-06-28 2010-06-28
US61/359,333 2010-06-28

Publications (2)

Publication Number Publication Date
WO2012006038A2 WO2012006038A2 (en) 2012-01-12
WO2012006038A3 true WO2012006038A3 (en) 2012-03-29

Family

ID=45441721

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/042061 WO2012006038A2 (en) 2010-06-28 2011-06-27 Agents and compounds for imaging and other applications, and methods of use and synthesis thereof

Country Status (1)

Country Link
WO (1) WO2012006038A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106908170B (en) * 2017-03-14 2019-04-19 吉首大学 A Raman frequency shift temperature measurement method and system

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6746662B1 (en) * 1999-02-09 2004-06-08 Board Of Regents The University Of Texas System pH sensitive MRI contrast agents
US20040146463A1 (en) * 2000-05-04 2004-07-29 Meade Thomas J. Functional MRI agents for cancer imaging
US20050191243A1 (en) * 2002-01-29 2005-09-01 Silvio Aime Responsive paramagnetic mri contrast agents
US7012140B1 (en) * 2003-07-14 2006-03-14 Board Of Regents, The University Of Texas System Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents
US20060057071A1 (en) * 2004-09-14 2006-03-16 Wing-Tak Wong Paramagnetic complexes with pendant crown compounds showing improved targeting-specificity as MRI contrast agents
US20060140869A1 (en) * 2004-12-23 2006-06-29 Egidijus Uzgiris Polymeric contrast agents for use in medical imaging
US20070218010A1 (en) * 2004-03-31 2007-09-20 Jens Hasserodt Contrast Agents for Magnetic Resonance Imaging

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6746662B1 (en) * 1999-02-09 2004-06-08 Board Of Regents The University Of Texas System pH sensitive MRI contrast agents
US20040146463A1 (en) * 2000-05-04 2004-07-29 Meade Thomas J. Functional MRI agents for cancer imaging
US20050191243A1 (en) * 2002-01-29 2005-09-01 Silvio Aime Responsive paramagnetic mri contrast agents
US7012140B1 (en) * 2003-07-14 2006-03-14 Board Of Regents, The University Of Texas System Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents
US20070218010A1 (en) * 2004-03-31 2007-09-20 Jens Hasserodt Contrast Agents for Magnetic Resonance Imaging
US20060057071A1 (en) * 2004-09-14 2006-03-16 Wing-Tak Wong Paramagnetic complexes with pendant crown compounds showing improved targeting-specificity as MRI contrast agents
US20060140869A1 (en) * 2004-12-23 2006-06-29 Egidijus Uzgiris Polymeric contrast agents for use in medical imaging

Also Published As

Publication number Publication date
WO2012006038A2 (en) 2012-01-12

Similar Documents

Publication Publication Date Title
IL275598A (en) System for conducting the identification of bacteria in biological samples
GB2440628B (en) Nuclear magnetic resonance measurement techinques in non-uniform fields
IL261338A (en) Compositions and methods for treatment in broad-spectrum, undifferentiated or mixed clinical applications
WO2011100708A3 (en) Assay card for sample acquisition, treatment and reaction
GB2433602B (en) Combined titration and pH electrode for the preparation of liquid samples in particular for NMR spectroscopy
EP1972269B8 (en) System for in vivo measurement of an analyte concentration
EP2545373A4 (en) Measurement devices and methods for measuring analyte concentration incorporating temperature and ph correction
WO2006114739A3 (en) Method for using cest contrast agents in mri
IL201420A0 (en) Nucleic acid enzymes and complexes and methods for their use
WO2007129275A3 (en) Rapid magnetic biosensor
EP2545367A4 (en) Magnetic sensor based quantitative binding kinetics analysis
WO2011116006A3 (en) A rapid method to measure cyanide in biological samples
EP2382462A4 (en) Membrane layer for electrochemical biosensor and method of accommodating electromagnetic and radiofrequency fields
WO2010141719A3 (en) Materials and methods for measuring nitric oxide levels in a biological fluid
EP2463660A4 (en) Nucleic acid element for use in analysis, and analytical method, analytical reagent and analytical instrument using same
EP2179278A4 (en) Electrochemical biosensor measuring system
EP2116837A4 (en) Instrument for measuring concentration of particulates in fluid, measuring method, and measuring program
KR101099029B9 (en) An agitator for chemical fermentation using magnetic coupler
EP1911398A3 (en) Device for measuring biomagnetic fields
WO2006113477A3 (en) Use of phosphonazo iii for the measurement of calcium, magnesium and sodium in analytical samples
EP2732288A4 (en) Biological microchip for the estimation of immunoglobulin e and g levels in human blood, method of assay thereof, and reagent kit comprising same
HK1175384A1 (en) Method for the electrochemical measurement of an analyte concentration in vivo, and fuel cell for this purpose
EP2062178A4 (en) A non-destructive on-line method for measuring predetermined physical, electrochemical, chemical or biological state transformation of a substance and a system thereof
EP2755029A4 (en) Method for inhibiting non-specific binding in step of detecting substance in biological sample, and agent for use in the method
EP2615178A4 (en) Method for preparation of algal cells, and kit for evaluation of toxicity of chemical substance

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11804100

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 11804100

Country of ref document: EP

Kind code of ref document: A2

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载