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WO2012060365A1 - Clapet de non-retour ayant un écoulement limité, unité de tube comportant ledit clapet de non-retour, système de perfusion de solution médicale - Google Patents

Clapet de non-retour ayant un écoulement limité, unité de tube comportant ledit clapet de non-retour, système de perfusion de solution médicale Download PDF

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Publication number
WO2012060365A1
WO2012060365A1 PCT/JP2011/075161 JP2011075161W WO2012060365A1 WO 2012060365 A1 WO2012060365 A1 WO 2012060365A1 JP 2011075161 W JP2011075161 W JP 2011075161W WO 2012060365 A1 WO2012060365 A1 WO 2012060365A1
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WO
WIPO (PCT)
Prior art keywords
valve
way valve
branch tube
valve body
chemical
Prior art date
Application number
PCT/JP2011/075161
Other languages
English (en)
Japanese (ja)
Inventor
由美子 吹越
Original Assignee
株式会社根本杏林堂
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社根本杏林堂 filed Critical 株式会社根本杏林堂
Priority to JP2012541871A priority Critical patent/JP6393452B2/ja
Publication of WO2012060365A1 publication Critical patent/WO2012060365A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/24—Check- or non-return valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14546—Front-loading type injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/24—Check- or non-return valves
    • A61M2039/2406—Check- or non-return valves designed to quickly shut upon the presence of back-pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/24—Check- or non-return valves
    • A61M2039/2433—Valve comprising a resilient or deformable element, e.g. flap valve, deformable disc
    • A61M2039/2446—Flexible disc

Definitions

  • the present invention relates to a one-valve structure with a limited inflow operation, which is preferably used in a chemical solution injection system for injecting a chemical solution filled in a chemical solution container through a tube.
  • Medical diagnostic imaging apparatuses include a CT (Computed Tomography) scanner, an MRI (Magnetic Resonance Imaging) apparatus, a PET (Positron Emission Tomography) apparatus, an angiographic apparatus, and an MRA (MR Angio) apparatus.
  • CT Computer Tomography
  • MRI Magnetic Resonance Imaging
  • PET PET
  • angiographic apparatus an angiographic apparatus
  • MRA MR Angio
  • the chemical solution injector includes an injection head to which a syringe filled with a chemical solution is detachably mounted, and an injection control unit that controls the operation of the injection head.
  • the syringe has a cylinder and a piston inserted in the cylinder so as to be movable in the axial direction, and the liquid medicine is filled in the cylinder.
  • the injection head has a piston drive mechanism that operates to advance at least the piston of the attached syringe relative to the cylinder.
  • an injection head having two piston drive mechanisms is often used so that two syringes can be attached and each syringe can be operated individually.
  • Each of the two syringes is filled with a contrast medium and physiological saline, and each syringe is connected to a branch tube branched into two at the end side.
  • An injection tube or a catheter to which an injection needle is connected is connected to the tip of the branch tube, and a contrast medium and physiological saline can be injected through the branch tube.
  • Saline is mainly used to boost the injected contrast agent after injecting the contrast agent, flush the tube to prevent blood clotting in the tube, and inject at the same time as the contrast agent. Used to dilute contrast agent.
  • Patent Document 1 discloses that when one piston drive mechanism is in the forward state and the other piston drive mechanism is in the stopped state, the other piston drive is performed. There has been disclosed a chemical injection device having a reverse prohibiting means for prohibiting the reverse of the mechanism. As an example of the reverse prohibition means, Patent Document 1 discloses an electromagnetic brake.
  • Patent Document 1 Japanese Patent Application Laid-Open No. 2002-102343
  • the piston of one syringe is retracted to reverse the chemical solution in the branch tube. There is. If blood flows into the tube by this operation, the catheter is inserted into the blood vessel. However, if a one-way valve is attached to each end of the branch tube, the piston cannot be retracted to reverse the chemical solution in the branch tube.
  • a conventional small tube syringe that is connected to a normal tube without a one-way valve and filled with, for example, physiological saline. was prepared separately from the injection of the chemical solution, and the insertion position was confirmed by connecting the tube connected to the small volume syringe to the injection tube or catheter connected to the subject. Then, after confirming the insertion position, the branch tube is removed from the normal tube having a small capacity, and then the two syringes are connected and the air is removed from the branch tube. Then, the tube for removing the insertion position confirmation syringe is connected. . Thereafter, the chemical solution can be injected from each syringe in the same manner as a normal procedure.
  • An object of the present invention is to use a one-way valve that can be suitably used even when confirming the insertion position of a catheter or the like in a chemical injection system that injects a chemical from a plurality of chemical containers through a branch tube and the same Is to provide a system.
  • the one-way valve of the present invention is deformed by the action of a valve chamber in which the liquid inlet and outlet are opened and a pressure difference in which the pressure on the inlet is larger than the pressure on the outlet.
  • the valve body is disposed in the valve chamber so as to open the inlet, and the valve body is deformed so that the inlet opens when the pressure difference becomes a specific pressure difference. It is limited.
  • the branch tube unit of the present invention includes a branch tube having a plurality of branched ends, and at least one of the above-described present invention connected to at least one of the ends other than one of the plurality of ends of the branch tube. And a valve.
  • the chemical solution injection system of the present invention is a chemical solution injection system that injects a chemical solution from a plurality of chemical solution containers through a branch tube, and is connected to a branch tube having a plurality of ends branched to a plurality of terminal sides of the branch tube.
  • at least one one-way valve of the present invention connected to at least one of the ends.
  • the one-way valve has a pressure difference that does not intend the flow of liquid between the inlet side and the outlet side by limiting the deformation of the valve body for opening the flow path. In this case, it is possible to prevent an unnecessary flow of the liquid from occurring. Therefore, in the case where the one-way valve of the present invention is configured to be able to inject a chemical solution from a plurality of chemical solution containers via the branch tube, normally, the liquid flow from the chemical solution container toward the branch tube side is allowed. It can be particularly preferably used in a chemical solution injection system that may prevent the flow of a chemical solution from the chemical solution container to the branch tube side.
  • the insertion position can be easily confirmed.
  • the one-way valve can be configured without using electromagnetically operated parts, all the parts and units used in the chemical liquid injection system can be made of non-magnetic material, whereby the chemical liquid injection system of the present invention can be configured. It can also be used in combination with an MRI apparatus that generates a strong magnetic field.
  • FIG. 1 is a perspective view of a fluoroscopic imaging system according to an embodiment of the present invention. It is a perspective view of the chemical injection device shown in FIG. It is a perspective view which shows the injection
  • FIG. 4 is a perspective view of the one-way valve shown in FIG. 3 with limited inflow operation.
  • FIG. 4B is an exploded perspective view of the one-way valve shown in FIG. 4A.
  • FIG. 4B is a top view showing the one-way valve shown in FIG. 4A in a state where the casing and the lid member are separated.
  • FIG. 6 is a cross-sectional view taken along line AA in FIG.
  • FIG. 4B It is the figure which looked at the casing from the lid member side in Drawing 4B. It is the perspective view which looked at the cover member from the casing side in FIG. 4B. It is sectional drawing similar to FIG. 6 of the one-way valve shown to FIG. 4A which shows the state by which the inflow port was obstruct
  • FIG. 15 is a cross-sectional view similar to FIG. 14 when liquid is introduced from the inflow pipe side in the one-way valve shown in FIG. 13.
  • FIG. 15 is a cross-sectional view similar to FIG. 14 in a state where the release button is pressed in the one-way valve shown in FIG. 13. It is a perspective view of the other example of the one-way valve with an open function.
  • a fluoroscopic imaging system 1000 which includes a chemical solution injection device 100 and a fluoroscopic imaging device 300.
  • the fluoroscopic imaging device 300 and the chemical liquid injector 100 are connected to each other so that their operations can be synchronized.
  • the fluoroscopic imaging apparatus 300 may be any imaging apparatus such as an X-ray CT apparatus, an MRI apparatus, a PET apparatus, an angio apparatus, or an MRA apparatus.
  • the fluoroscopic imaging apparatus 300 includes a scanner 301 that executes an imaging operation, and an imaging control unit 302 that controls the operation of the scanner 301.
  • the imaging control unit 302 includes a scanner 301 and a chemical solution. It is arranged in a separate chamber from the injection device 100.
  • the chemical injection device 100 includes an injection head 110 that is mounted on an upper portion of a stand 111 via an arm 112, and an injection control unit 101 that is connected to the injection head 110 with a cable 102.
  • the injection control unit 101 includes a main operation panel 103, a touch panel 104 serving as a display unit and an input unit, a hand unit 107 serving as an auxiliary input unit connected to the main body of the injection control unit 101 with a cable 108, and the like. ing.
  • the injection head 110 has two concave portions 114 formed as syringe holding portions on the upper surface of the head main body 113, and the syringes 200 ⁇ / b> C and 200 ⁇ / b> P, which are drug solution containers, are removable in the concave portions 114, respectively. It is attached to.
  • the syringes 200 ⁇ / b> C and 200 ⁇ / b> P have a cylinder 210 and a piston 220.
  • Each of the syringes 200C and 200P is filled with a chemical solution.
  • one syringe 200C can be filled with a contrast medium, and the other syringe 200P can be filled with physiological saline.
  • the injection head 110 is provided with two piston drive mechanisms 130 that are driven independently of each other to operate the pistons 220 of the syringes 200 ⁇ / b> C and 200 ⁇ / b> P attached to the recesses 114, corresponding to the recesses 114. .
  • These piston driving mechanisms 130 operate the pistons 220 of the syringes 200C and 200P respectively attached to the recesses 114, thereby separately or simultaneously applying the contrast medium and the physiological saline filled in the syringes 200C and 200P to the subject. Can be injected.
  • the branch tube unit is connected to the syringes 200C and 200P so that the contrast medium and physiological saline filled in the syringes 200C and 200P can be injected into the subject.
  • a catheter (not shown) is connected to the distal end of the branch tube unit, and a distal side of the branch tube unit is branched into two for connection to each syringe 200C, 200P, and one end of the branch tube 230 And a one-way valve 250 connected in such a direction that the chemical solution flows only from the syringe side to the catheter side.
  • one syringe for example, a contrast medium syringe 200C
  • the other syringe for example, a saline syringe 200P
  • the medicinal solution injection system of the present invention is a system for injecting medicinal solutions in a plurality of medicinal solution containers from the end side of the branch tube through a branch tube whose end is branched to a number equal to the number of the drug solution containers.
  • the chemical solution injection system includes a chemical solution injection device 100, a plurality of syringes 200C and 200P, and a branch tube unit.
  • the syringes 200 ⁇ / b> C and 200 ⁇ / b> P may be syringes of a type that are filled with a chemical solution at a medical site, or prefilled type syringes that are provided to a medical site in a state of being filled with a chemical solution by a manufacturer. Further, the syringes 200C and 200P, the branch tube 230 and the one-way valve 250 are provided separately, or a combination of the branch tube 230 and the one-way valve 250 is provided as a branch tube unit, or the prefilled type syringes 200C and 200P and the branch are provided.
  • the combination of the tube 230 and the one-way valve 250 can be provided as a syringe kit, or can be provided in any combination.
  • the branch tube 230 and the one-way valve 250 may be connected in advance or may not be connected.
  • the syringes 200C and 200P, the branch tube 230, and the one-way valve 250 may be connected in advance or may not be connected.
  • the one-way valve 250 that constitutes the branch tube unit together with the branch tube 230 has a casing 260 and a lid member 270, which are combined to form a valve chamber.
  • the casing 260 has a substantially cylindrical casing main body 261 having one end opened, and an inflow pipe 262 that communicates with the valve chamber and extends from the other end of the casing main body 261.
  • a body 255 is accommodated.
  • the lid member 270 is liquid-tightly joined to the casing body 261 so as to close the open end of the casing body 261 in order to form a valve chamber together with the casing body 261.
  • the lid member 270 is formed with a valve body presser 271 for holding the valve body 255 at a predetermined position in the valve chamber, and an outflow pipe 272 communicating with the valve chamber.
  • the valve body presser 271 is located in a portion located in the liquid chamber in a state where the lid member 270 is joined to the casing body 261, and the outflow pipe 272 is formed to extend to the opposite side of the casing 260.
  • the inflow pipe 262 is connected to the tip of a syringe (in this embodiment, the contrast medium injection syringe 200 ⁇ / b> C), and the outflow pipe 272 is connected to one end of the branch tube 230. . Therefore, the inflow pipe 262 and the outflow pipe 272 are formed with an appropriate connection structure such as a luer lock for connecting the syringe and the branch tube 230 so as not to cause liquid leakage.
  • one or a plurality of blade portions 272 a extending radially outward from the outer peripheral surface of the outflow pipe 272 are integrally formed with the outflow pipe 272.
  • the one-way valve 250 and the syringe can be easily connected by placing a finger on the blade 272a and rotating the one-way valve 250 with respect to the syringe.
  • this embodiment shows an example in which the blade portion 272a is formed in the outflow pipe 272, the blade portion (not shown) may be formed in the inflow tube 262.
  • the piston 220 of the syringe 200P for injecting physiological saline is advanced in the cylinder 210, since the syringe 200P is directly connected to the branch tube 230, the physiological saline in the syringe 200P is used as the branch tube 230. And can be injected into the subject from there.
  • the internal pressure of the branch tube 230 is increased, and the increased internal pressure is also transmitted to the end side connected to the other syringe 200C.
  • the pressure on the outflow pipe 272 side of the one-way valve 250 becomes higher than the pressure on the inflow pipe 262 side, and the valve body 255 closes the flow path from the inflow pipe 262 to the outflow pipe 272 due to the pressure difference. Operates as follows. Therefore, when the physiological saline is to be injected into the subject, the one-way valve 250 prevents the physiological saline from flowing into the contrast agent injection syringe 200 ⁇ / b> C via the branch tube 230.
  • the one-way valve 250 is operated by a pressure difference between the upstream side and the downstream side thereof. Therefore, the one-way valve 250 is not only negatively applied to the outflow pipe 272 side when the chemical liquid is sucked in from the outflow pipe 272 side as well as the pressure in the inflow pipe 262 side is increased by the inflow of the chemical liquid from the inflow pipe 262 side. Even when pressure is generated and the pressure on the inflow pipe 262 side becomes relatively higher than the pressure on the outflow pipe 272 side, the flow path opens, and the flow of the chemical solution from the inflow pipe 262 side to the outflow pipe 272 side occurs. Occurs.
  • the insertion position is confirmed by retracting the piston 220 of the physiological saline injection syringe 200P, which is a syringe directly connected to the branch tube 230, so that a part of the chemical solution in the branch tube 230 is moved into the syringe 200P. And confirming the inflow of blood into the tube by this suction.
  • the suction force from the outflow pipe 272 side acts on the one-way valve 250. If the contrast medium in the contrast medium injection syringe 200C is sucked into the branch tube 230 and further into the physiological saline injection syringe 200P by this suction force, the contrast medium is wasted or a chemical solution is used. Various inconveniences such as a change in the concentration of the chemical solution occur during injection.
  • the one-way valve 250 is designed as a one-way valve 250 in which the inflow operation is limited so that the flow path is opened only when the pressure difference between the upstream side and the downstream side becomes large to some extent. More specifically, in the one-way valve 250, the flow path is caused by a pressure difference generated between the upstream side and the downstream side of the one-way valve 250 by advancing the piston 220 of the syringe 200C in the cylinder 210 for injection of contrast medium. It opens, but the flow path is not opened by the pressure difference generated between the upstream side and the downstream side of the one-way valve 250 by retreating the piston 220 of the syringe 200P for injecting physiological saline to confirm the insertion position. Designed.
  • FIG. 6 a cross-sectional view taken along the line AA of FIG. 5 which is a plan view of the one-way valve 250 (FIG. 6).
  • a view seen from the downstream side in the direction (FIG. 7), a perspective view of the lid member 270 seen from the upstream side in the flow direction of the chemical in the one-way valve (FIG. 8), and the like will be described.
  • the casing body 261 has a recess 263 that forms a liquid chamber by joining a lid member 270.
  • An inflow port 264 that communicates the inside of the inflow pipe 272 with the liquid chamber is opened on the bottom surface of the recess 263, and a plurality of ribs 265 are arranged radially around the inflow port 264.
  • the valve body 255 is a flexible sheet-like member, and is arranged by closing the inflow port 264 in a region surrounded by a plurality of ribs 265 with the bottom surface of the recess 263 as a valve seat. Since the valve body 255 is surrounded by the ribs 265, the valve body 255 is substantially immovable in the radial direction. As will be described in detail later, the opening and closing of the flow path in the one-way valve 250 is achieved by deformation of the valve body 255. Therefore, in order to minimize the unnecessary flow of the chemical solution, the valve body 255 is formed of an elastic material such as rubber so that the flow path is closed immediately when the pressure difference between the upstream side and the downstream side of the one-way valve 250 is reduced.
  • valve body 255 is formed of a material that does not deteriorate due to the chemical liquid flowing through the one-way valve 255. From this point of view, as a material for the valve body 255 in the application of chemical liquid injection as in this embodiment, Silicone rubber or the like can be preferably used.
  • the lid member 270 has an outlet 273 that connects the inside of the outflow pipe 272 and the liquid chamber at a portion constituting the liquid chamber by joining with the casing 260.
  • the valve body presser 271 of the lid member 270 is located between the outlet 273 and the valve body 255, and is arranged in a cross shape inside the annular portion 274 fitted into the concave portion 263 of the casing body 261 and the annular portion 274.
  • the four presser protrusions 275 are provided.
  • valve body presser 271 contacts the valve body 255, so that the valve body 255 closes the inflow port 264, as shown in FIG. 9.
  • the valve body 255 is held so as not to move substantially in the flow direction of the chemical liquid.
  • the position where each presser protrusion 275 holds the valve body 255 is a position between the center of the valve body 255 and the outer peripheral edge in the radial direction of the valve body 255 and inside the region where the inflow port 264 is open. It is.
  • the pressure in the valve chamber becomes higher than the pressure on the inflow pipe 262 side, as shown in FIG.
  • the valve body 255 is pressed against the inlet 264 side.
  • the inlet 264 is blocked by the valve body 255 and the flow path of the valve 255 is closed, so that the flow of the chemical solution from the outflow pipe 272 side to the inflow pipe 262 side is prevented.
  • the pressure of the flowing chemical solution acts on the valve body 255.
  • the valve body 255 is held at the position inside the region where the inlet 264 is opened by the presser protrusion 275, the outer periphery of the valve body 255 is the pressure of the chemical liquid as shown in FIG. And the inlet 264 opens. That is, the flow path of the one-way valve 250 is opened. By opening the flow path, the chemical liquid can flow into the liquid chamber and flow through the outflow port 273 to the outflow pipe 272 side.
  • the valve body 255 In the valve chamber, the valve body 255 is held by the four pressing protrusions 275, so that the region in which the valve body 255 can be deformed is limited so that only the outer peripheral portion can move.
  • the deformation of the valve body 255 itself is limited, and as a result, the pressure difference such that the pressure on the inflow pipe 262 side is larger than the pressure on the outflow pipe 272 side. Only when a certain pressure difference is reached, the valve body 255 is deformed and the inlet 264 is opened.
  • the pressure difference at which the valve body 255 begins to deform is the holding area 255b (see FIG. 11) held by the presser protrusion 275 with respect to the holding area ratio of the valve body 255, that is, the area of the main surface 255a (see FIG. 11) of the valve body 255. 11 depends on the area ratio).
  • the valve body 255 is less likely to be deformed as the holding area ratio is larger, and conversely, the valve body 255 is more likely to be deformed as the holding area ratio is smaller.
  • the larger the holding area ratio the larger the pressure difference required to open the inlet 264, and the smaller the holding area ratio, the smaller the pressure difference opens the inlet 264.
  • the holding region 255b of the valve body 255 can be substantially deformed not only by the portion where the presser protrusion 275 is actually in contact with the valve body but also by the presser protrusion 275 being in contact. It means the area of the valve body 255 that cannot be used.
  • the pressure difference that can be caused by the negative pressure on the outflow pipe 272 side of the one-way valve 250 is the inflow port.
  • H.264 does not open, but the holding area ratio is set so that the inflow port 264 is opened due to a specific pressure difference larger than that, and the valve body 255 is held at that holding area ratio.
  • a presser protrusion 275 is disposed. More specifically, the specific pressure difference is larger than the pressure difference generated in the one valve 250 when the liquid medicine is sucked from the syringe 200P side connected without the one-way valve 250, and is connected through the one-way valve 250. The pressure difference generated in the one-way valve 250 when the chemical solution in the syringe 200C is injected is smaller.
  • the syringes 200C and 200P are mounted on the injection head 110, the syringes 200C and 200P are connected to the branch tube unit as described above. After the syringes 200 ⁇ / b> C and 200 ⁇ / b> P are connected to the injection head 110, the operator appropriately drives each piston drive mechanism 130 to fill the branch tube 230 with the contrast medium and physiological saline, and bleed the branch tube 230. .
  • the operator After releasing the air from the branch tube 230, the operator inserts, for example, a catheter connected to the tip of the branch tube 230 into the blood vessel of the subject.
  • the operator confirms the insertion position, which is confirmation of whether or not the catheter is inserted into the blood vessel in the subject.
  • the insertion position is confirmed by operating the piston drive mechanism 130 that operates the syringe 200P for injecting physiological saline to retract the piston 220, thereby using the negative pressure generated in the syringe 200P via the branch tube 230.
  • a liquid including at least one of a contrast medium and a physiological saline filled in the branch tube 230
  • a liquid including at least one of a contrast medium and a physiological saline filled in the branch tube 230
  • the negative pressure generated in the syringe 200P acts not only on the catheter side but also on the other end side of the branch tube 230 to which the contrast agent injection syringe 200C is connected.
  • the syringe 200 ⁇ / b> C is connected via a one-way valve 250. If the conventional one-way valve is connected, the liquid flow from the syringe 200C side to the branch tube 230 side is allowed.
  • the one-way valve 250 used in the present embodiment has the valve body 255 and the valve so that the valve body 255 is not deformed and the inlet 264 is not opened by the negative pressure generated when the insertion position is confirmed. Since the mutual relationship between the body pressers 271 is set, the inflow port 264 is not opened in the insertion position confirmation. Therefore, the contrast agent in the syringe 200 ⁇ / b> C does not flow out to the branch tube 230 through the one-way valve 250. Therefore, when confirming the insertion position, the liquid flowing from the catheter side connected to the distal end of the branch tube 230 is only the body fluid of the subject.
  • the catheter is normally inserted into the blood vessel of the subject. In other cases, it means that the catheter is not normally inserted into the blood vessel of the subject, so that the operator stops the piston drive mechanism 130 and then inserts the catheter again, and the catheter is inserted into the blood vessel of the subject. Repeat the above confirmation procedure until inserted.
  • the operator stops the operation of the piston drive mechanism 130, thereby completing the insertion position confirmation process.
  • the operator sets injection conditions for the chemical solution according to the test purpose of the subject.
  • the injection conditions can be set using the main operation panel 103, the touch panel 104, or the like.
  • the injection control unit 101 controls the operation of the piston drive mechanism 130 in accordance with the set injection conditions, whereby the drug solution is injected into the subject. Is done.
  • the contrast medium is injected first.
  • physiological saline is injected and the contrast agent is boosted by the physiological saline so that the contrast agent reaches a desired site with a small injection amount of the contrast agent.
  • physiological saline may be used for flushing the branch tube 230.
  • the contrast medium and the physiological saline are injected by advancing the pistons 220 of the syringes 200C and 200P in the cylinder 210 by the piston drive mechanism 130, respectively.
  • the pressure on the inflow pipe 262 side increases in the one-way valve 250, and the inflow occurs between the inflow pipe 262 side and the outflow pipe 272 side.
  • a pressure difference is generated such that the tube 262 side is higher.
  • the contrast agent is usually injected at a relatively high pressure.
  • the pressure difference generated in the one-way valve 250 is much larger than the pressure difference generated when the insertion position is confirmed.
  • the valve body 255 is deformed and the inflow port 264 is opened, and the contrast medium flows from the syringe 200C through the one-way valve 250 to the branch tube 230 and is finally injected into the subject.
  • the piston 220 of the syringe 200P advances in the cylinder 210 for injection of physiological saline
  • the internal pressure of the branch tube 230 is thereby increased, and the increased internal pressure is connected to the syringe 200C for contrast medium injection. It also acts on the other end side.
  • the injection pressure of physiological saline acts on the other end side of the branch tube 230
  • the pressure on the outlet 272 side of the one-way valve 250 becomes higher than the pressure on the inlet 262 side, and the valve body 255 becomes the inlet 264. Deforms to block.
  • the flow of the chemical solution from the branch tube 230 to the syringe 200C is blocked, and the chemical solution in the branch tube 230 can be prevented from flowing into the syringe 200C.
  • the pressure difference between the pressure on the inlet 264 side and the pressure on the outlet 273 side is greater than the pressure on the inlet 264 side.
  • a branch tube unit having a one-way valve 250 at one end of the branch tube 230 is used so that the deformation of the valve body 255 is limited so that the inlet 264 is opened by such a specific pressure difference.
  • the one-way valve 250 operates without electromagnetic control, all components and units used in the chemical solution injection system can be made of a non-magnetic material.
  • a chemical injection system in which all parts and units are made of a non-magnetic material does not cause any problems when used with an MRI apparatus that generates a strong magnetic field.
  • the one-way valve 250 of this embodiment is configured such that liquid flows from the inlet pipe 262 side to the outlet pipe 272 side by deformation of the outer periphery of the valve body 255, and in this state, the inlet 264 is only partially opened. Absent. However, in a chemical solution injection system, injecting a large amount of chemical solution into a subject in a short time increases the physical burden on the subject, and thus the chemical solution is generally injected at a relatively low injection rate. Therefore, a relatively small amount of the chemical liquid flowing through the one-way valve 250 is sufficient, and it can be said that the one-way valve 250 of this embodiment is suitable for use in a chemical liquid injection system.
  • the valve body presser 271 has four presser protrusions 275, and by arranging these presser protrusions 275 at appropriate positions, the pressure difference generated inside the one-way valve is confirmed as the insertion position check.
  • the valve body 255 is set to operate when a pressure difference that sometimes occurs is exceeded.
  • the number and position of the presser protrusions 275 are arbitrary as long as the valve body 255 can achieve the desired operation described above.
  • the overall structure of the valve body presser 271 is not a structure having a plurality of presser protrusions 275 that receive the valve body 255 by points, for example, a structure that receives the valve body 255 by a line, a frustum shape, a columnar shape, etc.
  • An arbitrary structure such as a structure for receiving the valve body 255 by a surface may be used.
  • the pressure difference at which the valve body 255 is deformed depends not only on the structure of the valve body presser 271 with respect to the diameter of the valve body 255 but also on the mechanical properties of the material of the valve body 255. Of the mechanical properties, one of the parameters that greatly affects the deformation of the valve body 255 is the elastic modulus of the material constituting the valve body 255. If the elastic modulus of the material constituting the valve body 255 is made higher, the valve body 255 becomes more difficult to deform, so that the pressure difference when the inflow port 264 is opened can be set larger. In addition, the pressure difference at which the valve body 255 operates also depends on the thickness of the valve body 255. If the valve body 255 is made thicker, the valve body 255 becomes more difficult to deform, and the inlet 264 opens. The pressure difference can be set larger.
  • valve body presser 271 is not received in a region where the valve body 255 has a predetermined holding area ratio, but is simply received at one point, for example, by a protrusion that contacts the center of the valve body 255.
  • the deformation of the valve body 255 can be limited by changing the material and / or the thickness of the valve body 255 as appropriate according to the above structure.
  • FIG. 12 the same parts and units as those in the above-described embodiment are denoted by the same reference numerals as those in FIG. 12, and detailed description thereof will be omitted.
  • the 12 has another one-side valve 350 in addition to the one-way valve 250 described above.
  • the one valve 350 is connected to the end of the branch tube 230 on the side where the one valve 250 used in the above-described form is not connected, and the branch tube unit is constituted by the two one valves 250 and 350 and the branch tube 230. Is configured. Therefore, in this embodiment, the syringe 200P for injecting physiological saline is connected to the branch tube 230 via the one-side valve 240, and the one-side valve 350 is directed to allow the flow of the drug solution from the syringe 200P side to the catheter side. It is said that.
  • the one-way valve 350 connected to the physiological saline syringe 200P is in a state in which a fluid flows only in one direction and a state in which the fluid can flow in both directions by a predetermined operation. It is a one-way valve with an opening function that can be switched. Hereinafter, the one-way valve 350 with the opening function will be described in detail.
  • the one-way valve 350 includes a substantially cylindrical casing 351 constituting a valve chamber, an inflow pipe 353 extending from one end of the casing 351, an outflow pipe 359 extending from the other end of the casing 351, And an open button 365 provided on the casing 351.
  • the inflow pipe 353 is connected to the tip of the syringe 200P (see FIG. 12), and the outflow pipe 359 is connected to the end of the branch tube 230 (see FIG. 12).
  • These connections are preferably luer lock type connection structures. Further, as shown in FIG.
  • FIG. 19 shows an example in which the blade portion 359a is formed in the outflow pipe 359, the blade portion (not shown) may be formed in the inflow tube 353.
  • the casing 351 includes a casing main body 352 in which an inflow pipe 353 is formed, and a lid member 358 in which an outflow pipe 359 is formed and is liquid-tightly joined to the casing main body 352.
  • the casing main body 352 and the lid member 358 are joined in a liquid-tight manner, whereby the inlet 355 communicating with the inlet pipe 353 and the outlet 361 communicating with the outlet pipe 359 are opposed to each other inside the casing 351.
  • a valve chamber that opens to a position is formed.
  • annular rib 354 is formed in the casing main body 352 so as to surround the periphery of the inflow port 355, and a plurality of outer ribs 356 are formed on the outer side in the radial direction.
  • the outer ribs 356 are higher than the annular ribs 354, and are arranged radially around the annular ribs 354 as shown in FIG.
  • a flexible sheet-like valve body 370 is disposed in the valve chamber.
  • the diameter of the valve body 370 is larger than the outer diameter of the annular rib 354, and one main surface of the valve body 370 is supported on the tip surface of the annular rib 354. That is, the annular rib 354 plays a role as a valve seat. Further, the diameter of the valve body 370 is smaller than the diameter of the space formed inside the plurality of outer ribs 356, and the valve body 370 is configured to be substantially immovable in the radial direction by the plurality of outer ribs 356. ing.
  • a valve body presser 360 is formed on the lid member 358 so as to face the valve body 370 in the valve chamber.
  • the valve body presser 360 has a structure in which two ribs having an isosceles triangle cross section whose bottom side crosses the outflow port 361 are crossed at the center in the length direction of the bottom side. have.
  • the apex of the valve body presser 360 is located substantially in the center in the radial direction of the valve body 370 and substantially contacts the valve body 370.
  • the valve body presser 360 holds the valve body 370 supported on the annular rib 354 at the center so that the valve body 370 cannot substantially move in the flow direction of the chemical solution between the inflow port 355 and the outflow port 361. Has been.
  • valve body 370 Due to the structure of the valve chamber as described above, when the chemical solution flows into the one valve 350 from the inflow pipe 353 side, the pressure of the flowing chemical solution acts on the valve body 370. At this time, since the central portion of the valve body 370 is held by the valve body presser 360 as described above, the outer periphery of the valve body 370 is deformed to the outflow pipe 359 side by the pressure of the chemical solution as shown in FIG. To do. Thereby, the inflow port 355 is opened, and the chemical liquid can flow to the outflow pipe 359 side through the valve chamber.
  • the one-way valve 350 with an opening function of this embodiment includes an opening button 365 that is manually operated for confirming the insertion position.
  • the release button 365 is attached to the peripheral surface of the casing 351 as shown in FIG. 13, and is manually operated from the outside of the casing 351 by the operator.
  • the release button 365 is attached to the casing main body 352 so as to be movable in the radial direction of the valve body 370, and is radially outward of the casing main body 352 (in a direction away from the valve body 370) by the coil spring 368. ).
  • the release button 365 is integrally formed with an action portion 366 that acts on the valve body 370 in the valve chamber when the release button 365 is pushed inward in the radial direction of the casing body 352.
  • the action portion 366 is a rod-shaped portion extending in the moving direction of the release button 365 toward the valve chamber, and the tip portion enters the valve chamber via a through hole 357 formed in the peripheral surface of the casing body 352. is doing.
  • An O-ring 367 is attached to the outer peripheral surface of the action part 366 in order to ensure the liquid tightness of the gap between the through hole 357 and the action part 366.
  • the release button 365 and the casing body 352 have an appropriate stopper structure that limits the movement range of the release button 365 to a predetermined range, and the stopper structure moves the opening button 365 in the radial direction of the casing body 352.
  • the range is limited.
  • the movement range of the release button 365 is such that the action portion 366 is separated from the outer peripheral end of the valve body 370 (see FIG. 14) and the outer periphery of the valve body 370 is lifted from the annular rib 354. This is a range between the second position (see FIG. 18) where the action portion 366 contacts the outer peripheral portion of the valve body 370 so that the outer peripheral portion is deformed in the thickness direction of the valve body 370.
  • the release button 365 When the release button 365 is pushed against the biasing force of the coil spring 368, the release button 365 is positioned at the second position, but when the release button 365 is released, the release button 365 is moved by the biasing force of the coil spring 368. Return to the first position. That is, the release button 365 is positioned at the second position only while being pressed.
  • the action portion 366 is placed on the outer peripheral portion of the valve body 370.
  • the valve body 370 is deformed in the thickness direction so that the valve body 370 is in contact with the part and part of the annular rib 354. This opens the inlet 355.
  • the pressure of the flowing chemical liquid acts to press the valve body 370 against the annular rib 354, but the valve body 370 has an annular rib on the outer periphery by the action portion 366.
  • the state of lifting from 354 is maintained.
  • the chemical liquid that has flowed into the valve chamber can flow to the inflow pipe 353 through the inflow port 355.
  • the release button 365 is released, the release button 365 is returned to the first position by the biasing force of the coil spring 368, the action portion 366 is separated from the valve body 370, and the valve body 370 corresponds to the direction in which the pressure of the chemical liquid acts. Since the behavior described above is shown, the chemical liquid does not flow from the outflow pipe 359 side to the inflow pipe 253 side.
  • the one-way valve 350 of the present embodiment normally, it functions as a general one-way valve that enables the flow of the chemical liquid from the inflow pipe 353 side only to the outflow pipe 359 side.
  • the flow path between the inflow pipe 353 and the outflow pipe 359 can be opened by an extremely simple operation by simply pressing the release button 365.
  • the valve body 370 since the central portion of the valve body 370 is held by the valve body presser 360, the valve body 370 can be stably and reliably deformed by the operation of the release button 365.
  • the one-way valve 350 is opened only while the release button 365 is being pressed, it is possible to prevent the one-way valve 350 from being opened when it is not necessary due to an operation error or the like. it can.
  • the tip part of the action part 366 is downstream in the flow direction of the chemical in the valve chamber from the inflow pipe 353 side to the outflow pipe 359 side.
  • the side part is cut diagonally to form a wedge shape.
  • valve body 370 can be smoothly deformed as the release button 365 moves. Further, in a state where the release button 365 is located at the second position, the deformed portion of the valve body 370 is supported by the inclined surface of the action portion 366, so that the open state of the one-way valve 350 can be reliably maintained. .
  • the apex of the action portion 366 formed by making the cross section a wedge shape is located in the vicinity of the contact surface of the annular rib 354 with the valve body 370.
  • tip part of the action part 366 becomes easy to approach between the valve body 370 and the annular rib 354, a deformation
  • the shape is not restricted to a wedge shape, For example, it can be set as arbitrary shapes, such as column shape.
  • the chemical solution injection system of this embodiment can be performed from the setting of the syringes 200C and 200P to the injection head 110 to the injection of the chemical solution in the same procedure as described above, except for the operation at the time of confirming the insertion position.
  • the procedure of the insertion position confirmation work in this embodiment will be described.
  • the insertion position is confirmed by retreating the piston 220 of the syringe 200P for injecting physiological saline.
  • the operator presses the open button 365 of the one-way valve 350 with an open function. Since the liquid can be moved from the branch tube 230 side to the syringe 200P side while the release button 365 is being pressed, the operator operates the piston drive mechanism 130 while pressing the release button 365.
  • the piston 220 of the syringe 200P is retracted.
  • the liquid flows into the branch tube 230 from the catheter side by the retraction of the piston 220 of the syringe 200P.
  • the operator determines whether or not the catheter has been normally inserted into the blood vessel of the subject based on the liquid that has flown in the same manner as described above. When it is confirmed that the catheter is normally inserted into the blood vessel of the subject, the operator stops the piston drive mechanism 130 and releases the release button 265 of the one-way valve 250.
  • a contrast medium and physiological saline are injected in a predetermined procedure, and further, physiological saline is pushed out from the syringe 200P for flushing the branch tube 230 as necessary.
  • the contrast medium injection syringe 200C and the physiological saline injection syringe 200P each have a specific and different function, that is, the one valve 250 with an inflow operation restricted and the opening function. It is connected to the branch tube 230 via the attached one-way valve 350.
  • the function of the one valve 250, 350 on the side of the drug solution that is not injected is basically the function of the one of the other drugs. Inflow to the syringe side can be prevented.
  • the one-way valve 250 whose inflow operation is limited is connected to the contrast agent injection syringe 200C, but the one-way valve 250 is connected to the physiological saline injection syringe 200P.
  • the insertion position can also be confirmed by retreating the piston 220 of the contrast agent injection syringe 200C.
  • the one-way valve 250 whose inflow operation is restricted is connected to the syringe 200P for injecting physiological saline
  • the one-way valve 350 with an opening function is further used, the one valve 350 is connected to the syringe 200C for injecting the contrast medium. To do.
  • the piston drive mechanism for operating the syringe 200C for contrast medium injection cannot be moved backward only by moving the piston forward.
  • the one-way valve 250 whose inflow operation is restricted is connected to the contrast agent injection syringe 200C, and the insertion position is confirmed by connecting the piston 220 of the syringe 200P for physiological saline injection. This is done by retreating.
  • the number of syringes that can be equipped with an injection head may be three or more.
  • the branch tube is branched at the end by the number of syringes that can be attached to the injection head, and at least one one-way valve 250 is provided on the outlet side. Connected to at least one of the ends of the branch tube except for one of the ends.
  • Each syringe is connected to the inlet side of the one-way valve 250 or the end of the branch tube to which the one-way valve 250 is not connected.
  • the insertion position can be confirmed by retracting the piston of the syringe to which the one-way valve 250 is not connected, whereby the one-way valve 250 is connected when confirming the insertion position of the catheter or the like.
  • the inflow of the chemical solution from the syringe to the branch tube is prevented.
  • the one-way valve 250 may be connected to all ends except one of the plurality of ends of the branch tube. desirable.
  • each syringe is connected to the inlet side of the one valve 250 or the inlet side of the one valve 350 with an opening function.
  • the contrast medium and the physiological saline are exemplified as the chemical solution, but the present invention can be applied to a system for injecting various chemical solutions such as nutrients and antibiotics in addition to these liquids.
  • the chemical solution injection device in the above-described embodiment, the chemical solution injection device that injects the chemical solution in the syringe by advancing the piston of the syringe filled with the chemical solution is shown.
  • any chemical solution injection device can be used. It is.
  • a chemical solution injection device including a plurality of tube pumps that convey a chemical solution by sequentially crushing a built-in tube from the upstream side to the downstream side in the chemical solution conveyance direction.
  • a bag or the like is used as a chemical solution container instead of a syringe, and the end of the branch tube unit and the chemical solution container are connected via a tube pump.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Selon la présente invention, un clapet de non-retour a un boîtier (260) et un élément de couvercle (270) et la combinaison de ceux-ci forme une chambre de clapet. Le boîtier (260) a un orifice de débit entrant s'ouvrant dans la chambre de clapet, et l'élément de couvercle (270) a un orifice de débit sortant s'ouvrant dans la chambre de clapet. Dans la chambre de clapet, un élément de clapet (255) est disposé bloquant l'orifice de débit entrant de sorte que, lorsque la pression sur le côté orifice de débit entrant est supérieure à celle sur le côté orifice de débit sortant, la différence de pression amène l'élément de clapet (255) à se déformer, permettant ainsi d'ouvrir l'orifice de débit entrant. La déformation de l'élément de clapet (255) est limitée de telle sorte que l'orifice de débit entrant s'ouvre seulement à une différence de pression spécifique.
PCT/JP2011/075161 2010-11-02 2011-11-01 Clapet de non-retour ayant un écoulement limité, unité de tube comportant ledit clapet de non-retour, système de perfusion de solution médicale WO2012060365A1 (fr)

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JP2012541871A JP6393452B2 (ja) 2010-11-02 2011-11-01 流入動作が制限された一方弁を備えた分岐チューブユニットおよび薬液注入システム

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JP2015526195A (ja) * 2012-08-20 2015-09-10 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 血液逆流を防止するための装置および使用の方法
CN105498025A (zh) * 2016-02-22 2016-04-20 上海康德莱医疗器械股份有限公司 一种带单向功能的无针加药接头

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CN113350613B (zh) * 2021-06-04 2022-03-11 北京泰杰伟业科技有限公司 药液控制装置及药液供给系统
KR102530087B1 (ko) 2022-11-25 2023-05-04 김정선 워터제트직기용 체크밸브

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JP2015526195A (ja) * 2012-08-20 2015-09-10 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 血液逆流を防止するための装置および使用の方法
JP2018075475A (ja) * 2012-08-20 2018-05-17 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 血液逆流を防止するための装置および使用の方法
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CN109364325A (zh) * 2012-08-20 2019-02-22 贝克顿·迪金森公司 用于血液回流阻止的医疗设备及其使用方法
CN109364325B (zh) * 2012-08-20 2021-04-27 贝克顿·迪金森公司 用于血液回流阻止的医疗设备及其使用方法
US11517675B2 (en) 2012-08-20 2022-12-06 Becton, Dickinson And Company Medical devices for blood reflux prevention and methods of use
US12138431B2 (en) 2012-08-20 2024-11-12 Becton, Dickinson And Company Medical devices for blood reflux prevention and methods of use
CN105498025A (zh) * 2016-02-22 2016-04-20 上海康德莱医疗器械股份有限公司 一种带单向功能的无针加药接头

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