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WO2011138265A3 - Indole and indazole derivatives as orexin receptor antagonists - Google Patents

Indole and indazole derivatives as orexin receptor antagonists Download PDF

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Publication number
WO2011138265A3
WO2011138265A3 PCT/EP2011/056938 EP2011056938W WO2011138265A3 WO 2011138265 A3 WO2011138265 A3 WO 2011138265A3 EP 2011056938 W EP2011056938 W EP 2011056938W WO 2011138265 A3 WO2011138265 A3 WO 2011138265A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor antagonists
indole
orexin receptor
indazole derivatives
compounds
Prior art date
Application number
PCT/EP2011/056938
Other languages
French (fr)
Other versions
WO2011138265A2 (en
Inventor
Jonathan Mark Bentley
Tara Davenport
Mark Slack
Original Assignee
Evotec Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evotec Ag filed Critical Evotec Ag
Publication of WO2011138265A2 publication Critical patent/WO2011138265A2/en
Publication of WO2011138265A3 publication Critical patent/WO2011138265A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

The invention relates to compounds of formula (I) wherein A, R1 to R8 have the meaning as cited in the description and the claims. Said compounds are useful as Orexin Receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.
PCT/EP2011/056938 2010-05-03 2011-05-02 Indole and indazole derivatives as orexin receptor antagonists WO2011138265A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10161735.5 2010-05-03
EP10161735 2010-05-03

Publications (2)

Publication Number Publication Date
WO2011138265A2 WO2011138265A2 (en) 2011-11-10
WO2011138265A3 true WO2011138265A3 (en) 2015-06-25

Family

ID=42732252

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/056938 WO2011138265A2 (en) 2010-05-03 2011-05-02 Indole and indazole derivatives as orexin receptor antagonists

Country Status (1)

Country Link
WO (1) WO2011138265A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
CA2863413A1 (en) 2012-02-07 2013-08-15 Eolas Therapeutics, Inc. Substituted prolines / piperidines as orexin receptor antagonists
ITMI20130830A1 (en) 2013-05-22 2014-11-23 Laboratorio Chimico Int Spa PROCEDURE FOR THE PREPARATION OF IVABRADINA
JP6663909B2 (en) 2014-08-13 2020-03-13 エオラス セラピューティクス， インコーポレイテッド Difluoropyrrolidine as an orexin receptor modulator
JO3719B1 (en) 2014-11-20 2021-01-31 Takeda Pharmaceuticals Co 4- Oxo-4,3-dihydro-3,2,1-benzotriazines as controls for GPR139
HRP20220906T1 (en) 2016-02-12 2022-10-14 Astrazeneca Ab Halo-substituted piperidines as orexin receptor modulators
WO2022119864A1 (en) * 2020-12-01 2022-06-09 Purdue Research Foundation Compounds for the treatment of sars
WO2024209363A1 (en) 2023-04-06 2024-10-10 Pfizer Inc. Substituted indazole propionic acid derivative compounds and uses thereof as ampk activators

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000046199A2 (en) * 1999-02-05 2000-08-10 Astrazeneca Ab Indole derivatives as anti-inflammation agents
WO2000047576A1 (en) * 1999-02-12 2000-08-17 Smithkline Beecham Plc Cinnamide derivatives as orexin-1 receptors antagonists
WO2000047577A1 (en) * 1999-02-12 2000-08-17 Smithkline Beecham Plc Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists
WO2005040114A1 (en) * 2003-10-14 2005-05-06 Oxagen Limited Compounds having crth2 antagonist activity
WO2009105722A1 (en) * 2008-02-22 2009-08-27 Irm Llc Compounds and compositions as modulators of gpr119 activity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1274687E (en) 2000-03-14 2005-04-29 Actelion Pharmaceuticals Ltd 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES
JP4611608B2 (en) 2000-06-16 2011-01-12 スミスクライン ビーチャム ピー エル シー Piperidine for use as an orexin receptor antagonist
EP1435955A2 (en) 2001-05-05 2004-07-14 SmithKline Beecham P.L.C. N-aroyl cyclic amine derivatives as orexin receptor antagonists
PL373223A1 (en) 2002-07-09 2005-08-22 Actelion Pharmaceuticals Ltd. 7,8,9,10-tetrahydro-6h-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2h-pyrrolo[2,1-b]-quinazolinone derivatives
KR101113626B1 (en) 2006-08-15 2012-02-17 액테리온 파마슈티칼 리미티드 Azetidine compounds as orexin receptor antagonists
EP2161266A1 (en) 2008-08-22 2010-03-10 EVOTEC Neurosciences GmbH Benzofuran derivatives as orexin receptor antagonists

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000046199A2 (en) * 1999-02-05 2000-08-10 Astrazeneca Ab Indole derivatives as anti-inflammation agents
WO2000047576A1 (en) * 1999-02-12 2000-08-17 Smithkline Beecham Plc Cinnamide derivatives as orexin-1 receptors antagonists
WO2000047577A1 (en) * 1999-02-12 2000-08-17 Smithkline Beecham Plc Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists
WO2005040114A1 (en) * 2003-10-14 2005-05-06 Oxagen Limited Compounds having crth2 antagonist activity
WO2009105722A1 (en) * 2008-02-22 2009-08-27 Irm Llc Compounds and compositions as modulators of gpr119 activity

Also Published As

Publication number Publication date
WO2011138265A2 (en) 2011-11-10

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