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WO2011125091A1 - Film comestible - Google Patents

Film comestible Download PDF

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Publication number
WO2011125091A1
WO2011125091A1 PCT/JP2010/002422 JP2010002422W WO2011125091A1 WO 2011125091 A1 WO2011125091 A1 WO 2011125091A1 JP 2010002422 W JP2010002422 W JP 2010002422W WO 2011125091 A1 WO2011125091 A1 WO 2011125091A1
Authority
WO
WIPO (PCT)
Prior art keywords
edible film
weight
parts
water
layer
Prior art date
Application number
PCT/JP2010/002422
Other languages
English (en)
Japanese (ja)
Inventor
月岡忠夫
西村美佐夫
Original Assignee
株式会社 ツキオカ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社 ツキオカ filed Critical 株式会社 ツキオカ
Priority to PCT/JP2010/002422 priority Critical patent/WO2011125091A1/fr
Publication of WO2011125091A1 publication Critical patent/WO2011125091A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Definitions

  • the present invention relates to an edible film, and more particularly to an edible film effective for preventing various infectious diseases.
  • Patent Documents 1 and 2 substances that improve immunity and substances that are effective in preventing infection are well known and are provided as various pharmaceuticals and foods.
  • Patent Documents 1 and 2 conventionally proposed pharmaceuticals and foods containing these substances are in the form of tablets and powders and cannot be continuously ingested without active ingredients without water or liquid food while enjoying them. For this reason, there has been a problem that the intake of medicines and foods is temporary, and sufficient effects cannot be achieved.
  • an object of the present invention is to provide an edible film that is effective in preventing various infectious diseases and that can be continuously ingested with active ingredients without water or liquid food while enjoying it easily.
  • an edible film with high palatability can be obtained by blending appropriate amounts of palatability components (sweetener and fragrance) and the present invention has been completed. That is, the present invention achieves the above object with the following configuration.
  • An edible film containing a water-soluble base and an infection-suppressing component The edible film, wherein the content of the infection-suppressing component is 5 to 40 parts by weight with respect to 100 parts by weight of the water-soluble base. 2.
  • the water-soluble base is composed of a polysaccharide having glucose as a basic structural unit and having no gel point, and a carboxylic acid or sulfur-containing polysaccharide, 2.
  • the edible film according to 2 further comprising 0.1 to 5 parts by weight of a gelling accelerator for sulfur-containing polysaccharides based on 100 parts by weight of the water-soluble base. 4).
  • the edible film contains an immunostimulatory component
  • the edible film according to any one of 1 to 4, wherein the content of the immunostimulatory component is 1 to 10 parts by weight with respect to 100 parts by weight of the water-soluble base. 6).
  • the edible film has a two-layer structure consisting of a first layer and a second layer,
  • the first layer contains the water-soluble base and the immunostimulatory component, and the content of the immunostimulatory component is an amount with respect to 100 parts by weight of the water-soluble base contained in the first layer.
  • the second layer contains the water-soluble base and the infection-suppressing component, and the content of the infection-suppressing component is based on 100 parts by weight of the water-soluble base contained in the second layer.
  • the edible film further has a three-layer structure having a third layer; The third layer contains the water-soluble base and a degranulation phenomenon inhibitor, 6.
  • water-soluble base used in the present invention examples include polyvinylpyrrolidone, polyvinyl alcohol, sodium polyacrylate, carboxymethylcellulose, starch, xanthan gum, karaya gum, sodium alginate, methylcellulose, carboxyvinyl polymer, agar, hydroxypropylcellulose, hydroxypropyl.
  • Methylcellulose phthalate HPMCP
  • cellulose acetate phthalate also known as cellulose acetate phthalate, CAP
  • carboxymethylethylcellulose CMEC
  • ethylcellulose ethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose
  • carboxyvinyl polymer tragacanth, gum arabic, locust bean gum, guar gum
  • Carrageenan (carrageenan) (carrageenan), Kistrin, dextran, amylose, carboxymethylcellulose potassium, carboxymethylcellulose sodium, carboxymethylcellulose calcium, pullulan, chitosan, starch, polyvinyl alcohol, carboxymethylethylcellulose, sodium carboxymethyl starch, plantago seed coat, galactomannan, Eudragit, casein, sodium alginate, alginic acid Alkyl ester, gelatin, shellac resin (shellac, white transparent shellac), starch, cellulose acetate,
  • Ruran can be mixed alone or two or more are in use.
  • Commercial products such as carboxyvinyl polymer (trade name: Carbopol trade name, manufactured by BF Goodrich) can also be used.
  • a water-soluble base comprising a polysaccharide having glucose as a basic structural unit and having no gel point, and a carboxylic acid or sulfur-containing polysaccharide.
  • the polysaccharide having glucose as a basic structural unit include pullulan, alginic acid, and starch.
  • Examples of the carboxylic acid or sulfur-containing polysaccharide include gellan gum and carrageenan.
  • the blending ratio of the two is 1 to 10 parts by weight of carboxylic acid or sulfur-containing polysaccharide with respect to 100 parts by weight of polysaccharide having glucose as a basic structural unit. From the viewpoint of balance, it is more preferably 2 to 5 parts by weight.
  • the infection-suppressing component examples include purified axilla, enzyme-treated axilla, catechin, cacao, mucin, rose juice and the like, and can be used alone or in combination of two or more.
  • the content thereof is 5 to 40 parts by weight with respect to 100 parts by weight of the water-soluble base, and more preferably 10 to 35 parts by weight. When the content is less than 5 parts by weight, the effect of the component cannot be obtained. When the content exceeds 40 parts by weight, the disintegration of the film increases and the composition immediately dissolves when put in the mouth, or an infection-suppressing component The taste of the product becomes too strong, which causes discomfort to the user.
  • purified axilla and enzyme-treated axilla can be particularly preferably used.
  • Axilla is a substance that is said to be effective in preventing influenza virus infection ("Enzyme-treated axilla” inhibits influenza infection "Food ⁇ Style 21, 10 (10), 33-36p, 2006, Yasuo Suzuki And JP-A-2002-68988).
  • additives such as emulsifiers, plasticizers and other medicinal components can be added in addition to the above-mentioned infection-suppressing components.
  • the above emulsifier is a component for improving dispersibility of drugs and the like in the solution, and preventing the repellency from appearing on the substrate film that is the object to be coated when applying the edible film forming solution in the manufacturing process.
  • surfactants such as polyoxyethylene sorbitan oleic acid ester, sucrose fatty acid ester, polyglycerin fatty acid ester, soybean-derived lecithin, and the like can be used alone or in combination of two or more. it can.
  • sucrose fatty acid esters are particularly preferably used in the present invention.
  • the amount of the emulsifier used is preferably 1 to 20 parts by weight, more preferably 3 to 15 parts by weight with respect to 100 parts by weight of the water-soluble base.
  • the plasticizer is a component for imparting flexibility to the edible film, and examples thereof include glycerin, sorbitol, polyglycerin and the like, and each can be used alone or in combination of two or more. Commercial products can also be used. Of these, glycerin is particularly preferably used in the present invention.
  • the amount of the plasticizer used is preferably 5 to 50 parts by weight and more preferably 10 to 30 parts by weight with respect to 100 parts by weight of the water-soluble base.
  • the medicinal ingredients usually used in foods and pharmaceuticals can be mentioned without particular limitation as long as the desired effects of the present invention are not inhibited, and each is used alone or in combination of two or more in use. be able to. Commercial products can also be used.
  • the amount of the other medicinal ingredients used is also arbitrary as long as the desired effects of the present invention are not impaired.
  • an excipient filler can also be used for this invention as needed.
  • the above excipient is a component to improve the solubility and disintegration of the film.
  • Precipitated calcium carbonate, crystalline cellulose, corn starch, partially pregelatinized starch, magnesium stearate, glucomannan, potato starch, low substitution Hydroxypropylcellulose (physically modified hydroxypropylcellulose, L-HPC) and the like can be used, and each can be used alone or in combination of two or more. Commercial products can also be used.
  • stimulating the gelatinization of the said water-soluble base can be added to the edible film of this invention.
  • the gelation accelerator metal salts such as titanium dioxide, sodium phosphate, potassium phosphate, sodium stearate, potassium stearate and the like can be used.
  • the amount of the gelation accelerator used is preferably 0.1 to 5 parts by weight, more preferably 0.5 to 3 parts by weight with respect to 100 parts by weight of the water-soluble base.
  • the edible film of the present invention has other additives such as malt reducing sugar syrup, sucrose, lactose, fructose or saccharin, aspartame, aspartame / L-phenylalanine, as long as the desired effect of the present invention is not inhibited.
  • sweeteners such as sucralose, thaumatin, acesulfame potassium, stevia, peppermint, peppermint oil, cherry flavor, orange oil, fennel oil, ethyl maltol, L-menthol and other flavors, benzoic acid, sodium benzoate, benzyl benzoate, Preservatives such as ethyl paraoxybenzoate, butyl paraoxybenzoate and propyl paraoxybenzoate, opacifying agents such as titanium oxide, and colorants such as iron sesquioxide and yellow iron sesquioxide can also be used.
  • sweeteners such as sucralose, thaumatin, acesulfame potassium, stevia, peppermint, peppermint oil, cherry flavor, orange oil, fennel oil, ethyl maltol, L-menthol and other flavors
  • benzoic acid sodium benzoate
  • benzyl benzoate Preservatives such as ethyl paraoxybenzoate,
  • the immunostimulatory component examples include propolis, peptidoglycan, lipopolysaccharide, peptide, ⁇ -1,3 glucan, chitin, chitosan, lactoferrin, jello juice and the like. Can be used.
  • the content is preferably 1 to 10 parts by weight with respect to 100 parts by weight of the water-soluble base, from the viewpoint of the balance between the ability to gradually dissolve in the mouth and a good feeling in use, and 1 to 5 parts by weight. More preferably, it is part.
  • propolis can be particularly preferably used.
  • the propolis a commercially available propolis can be used without particular limitation.
  • Propolis flavonoids are said to be natural antibiotics.
  • the edible film of the present invention can further contain a degranulation phenomenon inhibitor.
  • the degranulation phenomenon is a phenomenon in which when a foreign substance such as pollen enters the body, a chemical substance such as histamine is released as an immune reaction for removing the foreign substance, and this phenomenon causes allergic symptoms. However, since the degranulation inhibitor suppresses this degranulation phenomenon, allergic symptoms are alleviated.
  • Preferred examples of the degranulation phenomenon inhibitor include jabal juice and the like because they are natural products and have almost no side effects. “Jabara” is a citrus citrus fruit native to Kitayama Village, Wakayama Prefecture.
  • the content of the degranulation phenomenon inhibitor is preferably 1 to 30 parts by weight with respect to 100 parts by weight of the water-soluble base, from the viewpoint of a balance between the ability to gradually dissolve in the mouth and a good feeling of use, More preferably, it is 5 to 20 parts by weight.
  • the edible film of the present invention is effective in preventing various infectious diseases, and can be ingested continuously without water or liquid food while enjoying it easily.
  • FIG. 1 is a perspective view showing one embodiment of the edible film of the present invention.
  • FIG. 2 is a perspective view showing another embodiment of the edible film of the present invention.
  • FIG. 3 is a perspective view showing another embodiment of the edible film of the present invention.
  • the edible film 1 of this embodiment shown in FIG. 1 is a plate-like film, and can be used by dissolving in the user's mouth without water or liquid food.
  • the edible film 1 of the present embodiment has a rectangular shape and a one-layer structure including the first layer 10.
  • the first layer 10 contains the water-soluble base and an axillary purified product as the infection-suppressing component.
  • the edible film 1 of this embodiment can be used by, for example, attaching to the upper jaw and dissolving the film in the oral cavity, and dissolving the film in the mouth for a predetermined time by a combination of the water-soluble base and other additives to be used.
  • the axilla which is an active ingredient can be gradually ingested. This melts the axilla layer and prevents influenza virus infection, making it less likely to suffer from influenza. It is also expected to be effective against hay fever.
  • various sweeteners and fragrances can be added to the edible film as appropriate, so that various tastes and fragrances can be provided according to the user's preference, and the bitterness and smell of the axilla are a concern.
  • the active ingredient can be ingested with ease. This also applies to the case of using propolis as an immunostimulatory component and jabara fruit juice as a degranulation phenomenon inhibitor.
  • the term “one layer” means a layer composed of the same composition component, and the same composition layer is formed by coating the layer forming coating material having the same composition in multiple stages in the production process. This includes the case where the layers are laminated.
  • the edible film 1 of this embodiment is rectangular.
  • the size is 5mm to 50mm on one side.
  • x It is preferable that one side is 5 mm to 50 mm, and the total thickness is within the range of 50 ⁇ to 5,000 ⁇ , even if it adheres to the upper jaw, it does not peel off, and there is not much discomfort in the oral cavity, which is preferable.
  • the edible film of this embodiment is prepared by preparing a first layer forming solution, casting the obtained solution to form a liquid film, and drying the obtained liquid film to obtain a long film.
  • the long film can be obtained by cutting at a predetermined position into a rectangular shape.
  • Solvents that can be used for the first layer forming solution include water, ethanol, acetic acid, acetone, anisole, 1-butanol, 2-butanol, n-butyl acetate, t-butyl methyl ether, cumene, dimethyl Sulfoxide, ethyl acetate, diethyl ether, ethyl formate, formic acid, heptane, isobutyl acetate, isopropyl acetate, methyl acetate, 3-methyl-1-butanol, methyl ethyl ketone, methyl isobutyl ketone, 2-methyl-1-propanol, pentane, 1- Pentanol, 1-
  • the edible film 1 of this embodiment shown in FIG. 2 is rectangular and has a two-layer structure.
  • Such a layer structure is not particularly different from that of a generally known edible film, but specifically includes a first layer 10 and a second layer 20 laminated on the first layer 10.
  • the first layer contains the water-soluble base and propolis as the immunostimulatory component
  • the second layer comprises the water-soluble base and an axillary purification as the infection-suppressing component. It contains thing.
  • the edible film 1 of this embodiment can be used by, for example, attaching the first layer to the upper jaw and dissolving it in the oral cavity in order from the second layer.
  • the second axilla layer is melted first to prevent infection with influenza virus, and then the first propolis layer is melted to enhance the immunity and make it less susceptible to influenza.
  • various sweeteners and fragrances can be appropriately blended in the edible film, so that various tastes and fragrances can be provided according to the user's preference, and the active ingredient can be ingested while enjoying casually. be able to.
  • the edible film 1 of this embodiment is rectangular.
  • the size is 5mm to 50mm on one side.
  • x It is preferable that one side is 5 mm to 50 mm, and the total thickness is within the range of 50 ⁇ to 5,000 ⁇ , even if it adheres to the upper jaw, it does not peel off, and there is not much discomfort in the oral cavity, which is preferable.
  • the thickness of the first layer is preferably 20 ⁇ to 1000 ⁇
  • the thickness of the second layer is preferably 20 ⁇ to 1000 ⁇ .
  • the edible film of the present embodiment is prepared by preparing a first layer forming solution and a second layer forming solution, and sequentially casting each of the obtained solutions to form a liquid film. It can be obtained by drying to obtain a long film, and cutting this long film at a predetermined position into a rectangular shape.
  • the solvent that can be used for the first layer forming solution and the second layer forming solution is the same as the solvent that can be used for the first layer forming solution.
  • the edible film 1 of this embodiment can be used by, for example, attaching the first layer to the upper jaw and dissolving it in the oral cavity in order from the second layer.
  • the second axilla layer is melted first to prevent infection with influenza virus, and then the first propolis layer is melted to enhance the immunity and make it less susceptible to influenza.
  • various sweeteners and fragrances can be appropriately blended in the edible film, so that various tastes and fragrances can be provided according to the user's preference, and the active ingredient can be ingested while enjoying casually. be able to.
  • the edible film 1 of this embodiment shown in FIG. 3 is rectangular and has a three-layer structure. Specifically, it includes a first layer 10, a second layer 20 stacked on the first layer 10, and a third layer 30 stacked on the second layer 20.
  • the third layer 30 contains a water-soluble base and a rose juice as a degranulation phenomenon inhibitor.
  • the thickness of the first layer is 20 ⁇ to 1000 ⁇
  • the thickness of the second layer is 20 ⁇ to 1000 ⁇
  • the thickness of the third layer is 20 ⁇ to 1000 ⁇ . It is preferable to do this.
  • the edible film of the present embodiment has been described by taking a rectangular shape as an example, but the edible film of the present invention is not limited to this example, and may have various shapes such as a circle and an ellipse. it can.
  • Example 1 An edible film having a single-layer structure was prepared with the following composition.
  • a film-forming material having the composition shown in Table 1 is dissolved in ion-exchanged water as a solvent, and a film-forming solution (a solution obtained by mixing 68 parts by weight of the solvent with 32 parts by weight of the film-forming material).
  • the obtained film-forming solution is cast in two stages to form a liquid film, and the obtained liquid film is dried to obtain a long film, which is cut at a predetermined position.
  • An edible film having a rectangular shape as shown in FIG. 1 was obtained.
  • the obtained film had a rectangular shape with a size of 15 ⁇ 20 mm, a weight of 112 g / strip, a film thickness of 130 ⁇ m, and a moisture value of 9.5% by weight.
  • the resulting edible film was highly palatable and could be eaten easily while having fun.
  • Example 2 An edible film having the form shown in FIG. 1 was obtained in the same manner as in Example 1 except that the composition shown in the following table was used.
  • the obtained edible film had high palatability and could be eaten easily while having fun.
  • the obtained film had a rectangular shape with a size of 15 ⁇ 20 mm, a weight of 112 g / strip, a film thickness of 130 ⁇ m, and a moisture value of 9.5% by weight.
  • Example 3 An edible film having a two-layer structure with the following composition was prepared.
  • a film-forming material having the composition shown in the following table was dissolved in ion-exchanged water as a solvent to form a film-forming solution (for the first layer, 63 parts by weight of solvent with respect to 37 parts by weight of film-forming material,
  • 64 parts by weight of a solvent was obtained with respect to 36 parts by weight of the film-forming material.
  • the obtained film-forming solution is cast to form a liquid film, and the obtained liquid film is dried to obtain a long film, which is cut into a rectangular shape at a predetermined position.
  • the edible film of the form shown in FIG. 1 was obtained.
  • the obtained film had a size of 15 ⁇ 20 mm, a weight of 112 g / strip, a film thickness of 260 ⁇ m (each layer 130 ⁇ m), and a moisture value of 9.5% by weight.
  • the obtained edible film had high palatability and could be eaten easily while having fun.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention a trait à un film comestible qui empêche de façon efficace diverses infections et dont la matière active peut être ingérée en continu de manière plaisante et ludique sans eau ni aliment liquide. Le film comestible contient une base hydrosoluble et un composant luttant contre l'infection, le composant luttant contre l'infection constituant de 5 à 40 parties en poids pour 100 parties en poids de la base hydrosoluble. Selon les besoins, le film comestible contient en outre de 1 à 10 parties en poids d'un composant immunostimulant pour 100 parties en poids de la base hydrosoluble.
PCT/JP2010/002422 2010-04-02 2010-04-02 Film comestible WO2011125091A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2010/002422 WO2011125091A1 (fr) 2010-04-02 2010-04-02 Film comestible

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Application Number Priority Date Filing Date Title
PCT/JP2010/002422 WO2011125091A1 (fr) 2010-04-02 2010-04-02 Film comestible

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WO2011125091A1 true WO2011125091A1 (fr) 2011-10-13

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113974156A (zh) * 2021-11-23 2022-01-28 厦门市燕之屋丝浓食品有限公司 燕窝口腔速溶膜及其制备方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002068988A (ja) * 2000-08-23 2002-03-08 Combi Corp ウイルス感染抑制剤及びそれを含有する飲食品
JP2004248665A (ja) * 2002-12-26 2004-09-09 Tsukioka:Kk 可食性フィルム、可食性フィルムの製造方法、および可食性フィルムを含むフィルム
WO2007040021A1 (fr) * 2005-09-30 2007-04-12 Matsutani Chemical Industry Co., Ltd. Pellicule soluble
JP2008072915A (ja) * 2006-09-19 2008-04-03 Dhc Co フィルム状食品
WO2008156027A1 (fr) * 2007-06-20 2008-12-24 Qualicaps Co., Ltd. Composition de revêtement non transparent
JP2009278874A (ja) * 2008-05-19 2009-12-03 Morishita Jintan Co Ltd シームレスカプセル
JP2009284816A (ja) * 2008-05-29 2009-12-10 Uha Mikakuto Co Ltd プロポリス含有キャンディ

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002068988A (ja) * 2000-08-23 2002-03-08 Combi Corp ウイルス感染抑制剤及びそれを含有する飲食品
JP2004248665A (ja) * 2002-12-26 2004-09-09 Tsukioka:Kk 可食性フィルム、可食性フィルムの製造方法、および可食性フィルムを含むフィルム
WO2007040021A1 (fr) * 2005-09-30 2007-04-12 Matsutani Chemical Industry Co., Ltd. Pellicule soluble
JP2008072915A (ja) * 2006-09-19 2008-04-03 Dhc Co フィルム状食品
WO2008156027A1 (fr) * 2007-06-20 2008-12-24 Qualicaps Co., Ltd. Composition de revêtement non transparent
JP2009278874A (ja) * 2008-05-19 2009-12-03 Morishita Jintan Co Ltd シームレスカプセル
JP2009284816A (ja) * 2008-05-29 2009-12-10 Uha Mikakuto Co Ltd プロポリス含有キャンディ

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MIWAKO KIMURA ET AL.: "Kankitsu Kajitsu no Datsu Karyu Yokusei Sayo no Tansaku", INDUSTRIAL TECHNOLOGY CENTER OF WAKAYAMA PREFECTURE KENKYU HOKOKU, 2005, pages 1 - 2 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113974156A (zh) * 2021-11-23 2022-01-28 厦门市燕之屋丝浓食品有限公司 燕窝口腔速溶膜及其制备方法

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