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WO2011108009A3 - Process for the preparation of fampridine - Google Patents

Process for the preparation of fampridine Download PDF

Info

Publication number
WO2011108009A3
WO2011108009A3 PCT/IN2011/000134 IN2011000134W WO2011108009A3 WO 2011108009 A3 WO2011108009 A3 WO 2011108009A3 IN 2011000134 W IN2011000134 W IN 2011000134W WO 2011108009 A3 WO2011108009 A3 WO 2011108009A3
Authority
WO
WIPO (PCT)
Prior art keywords
fampridine
preparation
reducing
agent
nitrifying
Prior art date
Application number
PCT/IN2011/000134
Other languages
French (fr)
Other versions
WO2011108009A2 (en
Inventor
Siva Kumar Venkata Bobba
Alok Pramod Tripathi
Eswara Rao Kodali
Girish Bansilal Patel
Sanjay Dashrath Vaidya
Original Assignee
Enaltec Labs Pvt. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enaltec Labs Pvt. Ltd. filed Critical Enaltec Labs Pvt. Ltd.
Publication of WO2011108009A2 publication Critical patent/WO2011108009A2/en
Publication of WO2011108009A3 publication Critical patent/WO2011108009A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a process for the preparation of substantially pure fampridine compound of structural formula (I), (II), (III) comprising nitrifying pyridine-N-oxide hydrochloride with suitable nitrating agent; reducing with suitable reducing agent and purifying by recrystallizing in water followed by treating with an alkyl acetate solvent.
PCT/IN2011/000134 2010-03-05 2011-03-03 Process for the preparation of fampridine WO2011108009A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN585/MUM/2010 2010-03-05
IN585MU2010 2010-03-05

Publications (2)

Publication Number Publication Date
WO2011108009A2 WO2011108009A2 (en) 2011-09-09
WO2011108009A3 true WO2011108009A3 (en) 2012-03-29

Family

ID=44259681

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000134 WO2011108009A2 (en) 2010-03-05 2011-03-03 Process for the preparation of fampridine

Country Status (1)

Country Link
WO (1) WO2011108009A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022124946A1 (en) * 2020-12-10 2022-06-16 Общество С Ограниченной Ответственностью "Валента-Интеллект" New polymorphic forms of 4-aminopyridine and pharmaceutical application of same
CN114751855B (en) * 2022-05-23 2024-05-07 上海皓鸿生物医药科技有限公司 Preparation method of 2-bromo-4-amino-5-methylpyridine
CN115184486B (en) * 2022-06-27 2023-07-18 河北一品生物医药有限公司 Method for detecting diaminopyridine phosphate related substances by high performance liquid chromatography
CN116162055B (en) * 2023-03-10 2023-09-12 山东汇智药物研究有限公司 Method for preparing piperidine derivative from pyridine N-oxide derivative

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1879324A (en) 1929-07-23 1932-09-27 Winthrop Chem Co Inc Pyridine derivatives and the process of producing them
US3812137A (en) 1971-11-29 1974-05-21 American Cyanamid Co Catalytic production of aniline and other amines from carboxylic acids and ammonia
US4140853A (en) 1975-04-18 1979-02-20 Schering Aktiengesellschaft Process for the preparation of aminopyridines
CN1311185A (en) 2000-03-03 2001-09-05 山东新华制药股份有限公司 Method for preparing 4-amino pyridine and its derivatives
JP4475368B2 (en) 2000-03-10 2010-06-09 富士電機システムズ株式会社 Speed sensorless vector controller
CN1319947C (en) 2005-01-21 2007-06-06 北京化工大学 4-aminopyridine preparation method

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; WANG, ZHIXIANG ET AL: "Improved preparation of 4-aminopyridine", XP002652907, retrieved from STN Database accession no. 2001:292472 *
MOSHER H.S. ET AL: "Pyridine-N-oxide", ORGANIC SYNTHESES, vol. 4, no. 33, 1 January 1953 (1953-01-01) - 1 January 1953 (1953-01-01), pages 828 - 830, XP009150355 *
ZHONGGUO YIYAO GONGYE ZAZHI , 32(2), 83-84 CODEN: ZYGZEA; ISSN: 1001-8255, 2001 *

Also Published As

Publication number Publication date
WO2011108009A2 (en) 2011-09-09

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