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WO2011011847A3 - Composition pharmaceutique de traitement d'états pathologiques et procédé de traitement de troubles alimentaires et de maladies associées - Google Patents

Composition pharmaceutique de traitement d'états pathologiques et procédé de traitement de troubles alimentaires et de maladies associées Download PDF

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Publication number
WO2011011847A3
WO2011011847A3 PCT/BR2010/000253 BR2010000253W WO2011011847A3 WO 2011011847 A3 WO2011011847 A3 WO 2011011847A3 BR 2010000253 W BR2010000253 W BR 2010000253W WO 2011011847 A3 WO2011011847 A3 WO 2011011847A3
Authority
WO
WIPO (PCT)
Prior art keywords
treating
pharmaceutical composition
related diseases
medical conditions
alimentary disorders
Prior art date
Application number
PCT/BR2010/000253
Other languages
English (en)
Other versions
WO2011011847A8 (fr
WO2011011847A2 (fr
Inventor
Andrea Sterman Heimann
Camila Squarzoni Dale
Lakshmi A. Devi
Original Assignee
Sociedade Beneficiente De Senhoras Hospital Sirio Libanes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sociedade Beneficiente De Senhoras Hospital Sirio Libanes filed Critical Sociedade Beneficiente De Senhoras Hospital Sirio Libanes
Priority to ES10742073.9T priority Critical patent/ES2447823T3/es
Priority to US13/388,194 priority patent/US20130196904A1/en
Priority to EP10742073.9A priority patent/EP2459207B1/fr
Publication of WO2011011847A2 publication Critical patent/WO2011011847A2/fr
Publication of WO2011011847A8 publication Critical patent/WO2011011847A8/fr
Publication of WO2011011847A3 publication Critical patent/WO2011011847A3/fr
Priority to US14/703,466 priority patent/US9452196B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne une composition pharmaceutique qui comporte un principe actif, tel qu'un peptide, qui agit comme un antagoniste et/ou agoniste inverse d'un récepteur couplé à la protéine G et un vecteur de qualité pharmaceutique. Ladite composition pharmaceutique peut être utilisée pour traiter l'obésité, ainsi que pour prévenir et traiter le diabète.
PCT/BR2010/000253 2009-07-31 2010-07-30 Composition pharmaceutique de traitement d’états pathologiques et procédé de traitement de troubles alimentaires et de maladies associées WO2011011847A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES10742073.9T ES2447823T3 (es) 2009-07-31 2010-07-30 Composición farmacéutica para su utilización en el tratamiento de la obesidad, diabetes o para aumentar la sensibilidad a la insulina
US13/388,194 US20130196904A1 (en) 2009-07-31 2010-07-30 Pharmaceutical composition for treating medical conditions and a method for treating alimentary disorders and related diseases
EP10742073.9A EP2459207B1 (fr) 2009-07-31 2010-07-30 Composition pharmaceutique pour l'utilisation dans le traitement de l'obesite, diabete ou pour augmenter la sensibilité à l'insuline.
US14/703,466 US9452196B2 (en) 2009-07-31 2015-05-04 Pharmaceutical composition for treating medical conditions and a method for treating alimentary disorders and related diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRPI0902481-6 2009-07-31
BRPI0902481A BRPI0902481B8 (pt) 2009-07-31 2009-07-31 composição farmacêutica compreendendo hemopressina e seu uso.

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/388,194 A-371-Of-International US20130196904A1 (en) 2009-07-31 2010-07-30 Pharmaceutical composition for treating medical conditions and a method for treating alimentary disorders and related diseases
US14/703,466 Continuation US9452196B2 (en) 2009-07-31 2015-05-04 Pharmaceutical composition for treating medical conditions and a method for treating alimentary disorders and related diseases

Publications (3)

Publication Number Publication Date
WO2011011847A2 WO2011011847A2 (fr) 2011-02-03
WO2011011847A8 WO2011011847A8 (fr) 2011-03-31
WO2011011847A3 true WO2011011847A3 (fr) 2011-06-16

Family

ID=43333134

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR2010/000253 WO2011011847A2 (fr) 2009-07-31 2010-07-30 Composition pharmaceutique de traitement d’états pathologiques et procédé de traitement de troubles alimentaires et de maladies associées

Country Status (6)

Country Link
US (2) US20130196904A1 (fr)
EP (1) EP2459207B1 (fr)
BR (1) BRPI0902481B8 (fr)
ES (1) ES2447823T3 (fr)
PT (1) PT2459207E (fr)
WO (1) WO2011011847A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201113596D0 (en) 2011-08-08 2011-09-21 Univ De Coimbra Compounds, compositions and methods to promote oligodendrogenesis and remyelination
BR102012017421A2 (pt) 2012-07-13 2015-04-14 Proteimax Biotecnolgia Ltda Peptídeo, composicão farmacêutica, ligante de receptor cb, metodo para modular a funcao de receptor cb, uso, método para o tratamento de obesidade, e, método para promover a redução de peso estetica em um indivíduo
EP2878306B1 (fr) * 2012-07-13 2018-11-07 Proteimax Biotecnologia Ltda Peptide modifié, ligand de récepeurs cb, trousse, procédé in vitro pour l'évaluation de la liaison aux récepteurs cb, utilisations et composition pharmaceutique pour moduler l'activité de récepteurs cb
RU2537171C2 (ru) * 2013-03-04 2014-12-27 Фармаплант Фабрикацион Хемишер Продукте ГмбХ Биологически активный пептид и способы его применения
BR102017010169A2 (pt) * 2017-05-15 2019-02-26 Remer Consultores Assessoria Empresarial Ltda. composto, intermediário de síntese, uso na preparação de anticonvulsivante, composição farmacêutica anticonvulsivante
WO2018068120A1 (fr) * 2016-10-13 2018-04-19 Proteimax Biotecnologia Ltda Utilisation d'un composé, produit intermédiaire de synthèse, composition pharmaceutique et méthode thérapeutique de neuromodulation
BR102016023848A2 (pt) * 2016-10-13 2018-05-02 Proteimax Biotecnologia Ltda Anticonvulsivante, uso e composição farmacêutica contendo o mesmo

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006119260A2 (fr) * 2005-05-02 2006-11-09 Merck & Co., Inc. Combinaison d'un inhibiteur de la dipeptidyl peptidase-iv et d'un antagoniste du recepteur cb1 cannabinoide dans le traitement du diabete et de l'obesite

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050121762A (ko) * 2000-05-15 2005-12-27 에프. 호프만-라 로슈 아게 신규한 약학 조성물
FR2814678B1 (fr) 2000-10-04 2002-12-20 Aventis Pharma Sa Association d'un antagoniste du recepteur cb1 et de sibutramine, les compositions pharmaceutiques les contenant et leur utilisation pour la traitement de l'obesite
WO2004034968A2 (fr) 2002-08-20 2004-04-29 The Regents Of The University Of California Polythérapie pour contrôler l'appétit
WO2005107806A1 (fr) 2004-04-21 2005-11-17 Orexigen Therapeutics, Inc. Compositions agissant sur une perte de poids
US20060218413A1 (en) 2005-03-22 2006-09-28 International Business Machines Corporation Method of introducing physical device security for digitally encoded data

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006119260A2 (fr) * 2005-05-02 2006-11-09 Merck & Co., Inc. Combinaison d'un inhibiteur de la dipeptidyl peptidase-iv et d'un antagoniste du recepteur cb1 cannabinoide dans le traitement du diabete et de l'obesite

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DODD G T ET AL: "The peptide homopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice", THE JOURNAL OF NEUROSCIENCE, vol. 30, no. 2, 26 May 2010 (2010-05-26), pages 7369 - 7376, XP002614943 *
HEIMANN A S ET AL: "Hemopressin is an inverse agonist of CB1 cannabinoid receptors", PNAS, vol. 104, no. 51, 18 December 2007 (2007-12-18), pages 20588 - 20593, XP002614960 *
OLDFIELD B J ET AL: "The effect of the cannabinoid receptor antagonist, rimonabant (SR 141716) on energy expenditure", APPETITE, ACADEMIC PRESS, NEW YORK, NY, US, vol. 49, no. 1, 17 May 2007 (2007-05-17), pages 337, XP022083436, ISSN: 0195-6663 *
VAN GAAL L F ET AL: "Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients:1-year experience from the RIO-Europe study", LANCET, vol. 365, 16 April 2005 (2005-04-16), pages 1389 - 1397, XP002614949 *
WITKIN ET AL: "A therapeutic role for cannabinoid CB1 receptor antagonists in major depressive disorders", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER, HAYWARTH, GB, vol. 26, no. 12, 1 December 2005 (2005-12-01), pages 609 - 617, XP005168624, ISSN: 0165-6147, DOI: DOI:10.1016/J.TIPS.2005.10.006 *

Also Published As

Publication number Publication date
US20150297669A1 (en) 2015-10-22
WO2011011847A8 (fr) 2011-03-31
EP2459207A2 (fr) 2012-06-06
BRPI0902481A2 (pt) 2011-04-05
BRPI0902481B8 (pt) 2021-05-25
US9452196B2 (en) 2016-09-27
BRPI0902481B1 (pt) 2020-02-04
WO2011011847A2 (fr) 2011-02-03
ES2447823T3 (es) 2014-03-13
US20130196904A1 (en) 2013-08-01
EP2459207B1 (fr) 2013-11-20
PT2459207E (pt) 2014-02-21

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