+

WO2011090947A3 - Methods for the diagnosis and treatment of parkinson's disease - Google Patents

Methods for the diagnosis and treatment of parkinson's disease Download PDF

Info

Publication number
WO2011090947A3
WO2011090947A3 PCT/US2011/021581 US2011021581W WO2011090947A3 WO 2011090947 A3 WO2011090947 A3 WO 2011090947A3 US 2011021581 W US2011021581 W US 2011021581W WO 2011090947 A3 WO2011090947 A3 WO 2011090947A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
diagnosis
treatment
disease
parkinson
Prior art date
Application number
PCT/US2011/021581
Other languages
French (fr)
Other versions
WO2011090947A2 (en
Inventor
Chee Yeun Chung
Ole Isacson
Original Assignee
The Mclean Hospital Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Mclean Hospital Corporation filed Critical The Mclean Hospital Corporation
Publication of WO2011090947A2 publication Critical patent/WO2011090947A2/en
Publication of WO2011090947A3 publication Critical patent/WO2011090947A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to methods for treatment or prevention of Parkinsons disease and associated conditions by increasing the expression Otx2 in the midbrain dopaminergic neurons of the patient. The present invention further relates to methods for the diagnosis and evaluation of Parkinsons disease. For instance, patient test samples are analyzed for the presence of one or more specific variant sequences associated with Parkinsons disease. In some embodiments, the variant is a promoter mutation in the Otx2 gene.
PCT/US2011/021581 2010-01-19 2011-01-18 Methods for the diagnosis and treatment of parkinson's disease WO2011090947A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29642410P 2010-01-19 2010-01-19
US61/296,424 2010-01-19

Publications (2)

Publication Number Publication Date
WO2011090947A2 WO2011090947A2 (en) 2011-07-28
WO2011090947A3 true WO2011090947A3 (en) 2011-12-29

Family

ID=44307536

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/021581 WO2011090947A2 (en) 2010-01-19 2011-01-18 Methods for the diagnosis and treatment of parkinson's disease

Country Status (1)

Country Link
WO (1) WO2011090947A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101567921B1 (en) * 2013-10-11 2015-11-10 한국과학기술원 The composition for preventing and treating retinal degenerative diseases containing Otx2 protein

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080038234A1 (en) * 2004-03-23 2008-02-14 Shuji Hayashi Bone Marrow-Related Cells Associated With Tissue Maintenance And/Or Repair
US20090191171A1 (en) * 2008-01-18 2009-07-30 Yupo Ma Reprogramming of Differentiated Progenitor or Somatic Cells Using Homologous Recombination
US20090274667A1 (en) * 2008-04-22 2009-11-05 Regenerative Research Foundation Retinal pigment epithelial stem cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080038234A1 (en) * 2004-03-23 2008-02-14 Shuji Hayashi Bone Marrow-Related Cells Associated With Tissue Maintenance And/Or Repair
US20090191171A1 (en) * 2008-01-18 2009-07-30 Yupo Ma Reprogramming of Differentiated Progenitor or Somatic Cells Using Homologous Recombination
US20090274667A1 (en) * 2008-04-22 2009-11-05 Regenerative Research Foundation Retinal pigment epithelial stem cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EDUARDO PUELLES ET AL.: "Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain", DEVELOPMENT., vol. 131, no. 9, May 2004 (2004-05-01), pages 2037 - 2048, XP055101628, DOI: doi:10.1242/dev.01107 *

Also Published As

Publication number Publication date
WO2011090947A2 (en) 2011-07-28

Similar Documents

Publication Publication Date Title
BR112013010023A2 (en) improved algorithm for diabetes detection
EP4219760A3 (en) Methods, compositions, and devices utilizing microrna to determine physiological conditions
NZ588638A (en) Screening method for identifying a subject for treatment with a modified hyaluronidase polypeptides
MX2009013649A (en) Genetic variants on chr 15q24 as markers for use in diagnosis, prognosis and treatment of exfoliation syndrome and glaucoma.
EP3683320A3 (en) Mirna fingerprint in the diagnosis of lung cancer
WO2010101628A3 (en) Methods and products for in vivo enzyme profiling
WO2011141823A3 (en) Methods of treating and/or preventing cell proliferation disorders with il-17 antagonists
WO2012142301A3 (en) Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
WO2010117829A8 (en) Differentially expressed micrornas as biomarkers for the diagnosis and treatment of sjögren's syndrome
WO2011144718A3 (en) Methods and kits for diagnosing colorectal cancer
WO2011064225A8 (en) Novel diagnostic method for the diagnosis of alzheimer's disease or mild cognitive impairment
WO2012017430A3 (en) Microrna patterns for the diagnosis, prognosis and treatment of melanoma
WO2007098070A3 (en) Non-invasive methods for evaluating retinal affecting neurodegenerative diseases
WO2010007031A3 (en) Methods for improving cardiac differentiation of human embryonic stem cells
WO2010037859A3 (en) Methods for predicting or monitoring whether a patient affected by a cancer is responsive to a treatment with a molecule of the taxoid family
MX2013015409A (en) Diagnosis of alzheimer's disease.
WO2008009751A3 (en) Transcription infidelity, detection and uses thereof
WO2011027310A8 (en) Novel tumor markers
WO2009120712A3 (en) Compositions and methods for diagnosing and treating melanoma
MX2012009908A (en) Assays and kits for serotyping pseudomonas aeruginosa and oligonucleotide sequences useful in such methods and kits.
CY1120057T1 (en) MOLECULAR GENETIC APPROACH TO TREATMENT AND DIAGNOSIS OF ALCOHOL AND DRUG ADDICTION
WO2010047938A3 (en) Mmp activation peptide detection in biological samples
WO2014177867A3 (en) Differentially expressed biomarkers for alzheimer's disease
WO2009087689A3 (en) Novel primers for identification of astrocytoma, it's grades and glioblastoma prognosis
WO2011090947A3 (en) Methods for the diagnosis and treatment of parkinson's disease

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11735051

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 11735051

Country of ref document: EP

Kind code of ref document: A2

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载