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WO2011077983A1 - Composition de dentifrice - Google Patents

Composition de dentifrice Download PDF

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Publication number
WO2011077983A1
WO2011077983A1 PCT/JP2010/072353 JP2010072353W WO2011077983A1 WO 2011077983 A1 WO2011077983 A1 WO 2011077983A1 JP 2010072353 W JP2010072353 W JP 2010072353W WO 2011077983 A1 WO2011077983 A1 WO 2011077983A1
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WO
WIPO (PCT)
Prior art keywords
extract
component
dentifrice composition
berberine
points
Prior art date
Application number
PCT/JP2010/072353
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English (en)
Japanese (ja)
Inventor
綾香 平澤
将人 荒井
千晴 北川
Original Assignee
ライオン株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ライオン株式会社 filed Critical ライオン株式会社
Priority to CN201080049385.0A priority Critical patent/CN102596163B/zh
Publication of WO2011077983A1 publication Critical patent/WO2011077983A1/fr
Priority to HK12112954.5A priority patent/HK1171963A1/xx

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]

Definitions

  • the present invention is excellent in storage stability of berberine, has improved astringency, and has a salty and irritation-relieved taste with no off-flavor, good foam retention and foaming, and good usability.
  • the present invention also relates to a dentifrice composition containing berberine.
  • Patent Documents 1 to 10 Conventionally, in order to improve the periodontal disease preventive effect, it is known to add a citrus family plant extract such as buckwheat and rosaceae plant extract containing berberine as an active ingredient to the oral composition.
  • Patent Documents 1 to 10 a citrus family plant extract such as buckwheat and rosaceae plant extract containing berberine as an active ingredient.
  • these berberine-containing plant extracts have a bitter taste based on berberine, and there is a problem that the usability and taste of the oral composition are deteriorated.
  • blending of nonionic surfactant (Patent Document 11) and baking soda blending Patent Document 12) reveals that the feeling of use is improved.
  • berberine has a problem that it is inferior in storage stability when blended into a dentifrice composition.
  • a method that does not substantially contain an aldehyde fragrance that inhibits berberine that is blended in the fragrance composition (Patent Document 12), or a modified mint oil is blended.
  • Method (Patent Document 13), Method of blending linear polyphosphate (Patent Document 14), Polyoxyethylene hydrogenated castor oil is effective for stabilizing berberine in a calcium carbonate-containing composition (Patent Document 15) Proposed.
  • amber and auren containing berberine are astringent anti-inflammatory agents, but it is difficult to satisfactorily exert the function of a sufficient astringent effect by itself, and even if the storage stability is improved by the above technique etc. Thus, it was difficult to satisfy the convergence effect satisfactorily.
  • Patent Document 16 a combination of sodium alkyl sulfate and a nonionic surfactant (Patent Document 16), sodium alkyl sulfate and N-acyl glutamate, and a nonionic surfactant having an HLB of 14 or more Combining (Patent Document 17) has been proposed.
  • JP 57-56415 A JP-A-57-85319 Japanese Patent Laid-Open No. 58-39615 JP 58-57320 A JP 61-36215 A JP-A-62-205106 JP-A 63-264529 JP 2001-97835 A JP 2001-97837 A JP 2002-976937 A JP 62-155209 A JP-A-63-63608 JP 2000-72617 A JP 2005-187329 A Japanese Patent Application Laid-Open No. 08-175941 JP-A-57-106606 Japanese Patent Laid-Open No. 10-291921
  • berberine is stably blended over time and exhibits a sufficient convergence effect, and also has a good feeling of use and good usability such as foam retention and foaming during use. New technologies that can do this are desired.
  • the present invention has been made in view of the above circumstances, is excellent in storage stability of berberine, has an astringent effect, has a good feeling without taste, and has excellent foam retention and foaming during use. Another object of the present invention is to provide a dentifrice composition containing berberine.
  • the present inventors have obtained (a) berberine, (b) sodium chloride, (c) rosemary extract, sage extract, orange extract, carrot extract, One or more plant extracts selected from peony extract, honeysuckle extract, birch extract, (d) nonionic surfactant, and (b) component / (d) component mass ratio of 1.5
  • a dentifrice composition containing berberine is combined with sodium chloride and a nonionic surfactant in an appropriate mixing ratio, and a specific plant extract is combined.
  • the astringent effect derived from berberine and sodium chloride is effectively demonstrated, the astringent effect is improved, sufficient astringent effect is exhibited, and the salty taste and off-flavor derived from the ingredients
  • the irritation is alleviated and the usability is good, and the foam retention and foaming at the time of use are good and the usability is excellent.
  • the nonionic surfactant (d) is a polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 5 to 40, an average addition mole number of ethylene oxide of 2 to 20, and an alkyl group. Is preferably selected from polyoxyethylene alkyl ethers having 12 to 22 carbon atoms, which can further improve the foam retention in the oral cavity.
  • (e) lauryl sulfate is further blended, and the mass ratio of the component (d) / (e) is 0.25 to 2. It is desirable to set it to 5, and this can improve foaming more.
  • the present invention provides the following dentifrice composition.
  • Claim 1 One or more plants selected from (a) berberine, (b) sodium chloride, (c) rosemary extract, sage extract, oxon extract, carrot extract, peony extract, honeysuckle extract, birch extract
  • a dentifrice composition comprising an extract, (d) a nonionic surfactant, and a mass ratio of (b) component / (d) component of 1.5 to 20.
  • Claim 2 The dentifrice composition according to claim 1, wherein component (a) is blended as a solvent extract of buckwheat or auren.
  • the nonionic surfactant is at least one selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, decaglyceryl laurate, lauryl glucoside, and sucrose palmitate monoester.
  • Item 3. The dentifrice composition according to Item 1 or 2.
  • the dentifrice composition according to claim 1 or 2 wherein the dentifrice composition is one or more selected from a certain polyoxyethylene alkyl ether.
  • Claim 5 Component (a) is 0.0005 to 0.05% by mass, Component (b) is 2 to 10% by mass, Component (c) is 0.00005 to 0.02% by mass, Component (d) is 0.3 to The dentifrice composition of any one of Claims 1 thru
  • Claim 6 6. The method according to claim 1, further comprising (e) lauryl sulfate and a mass ratio of (d) component / (e) component of 0.25 to 2.5. Dentifrice composition.
  • Claim 7 Furthermore, 2 to 50% by weight of abrasive, 5 to 50% by weight of thickener, 0 to 3% by weight of binder, and 0 to 3% by weight of amphoteric surfactant are prepared as toothpastes.
  • the stability of berberine is excellent and the astringent effect is improved, and there is almost no salty taste or off-flavor, and there is almost no irritation, and the foam retention and foaming usability during use.
  • an excellent dentifrice composition can be obtained, which is effective for the prevention or improvement of periodontal diseases.
  • the dentifrice composition of the present invention is prepared as a dentifrice such as a toothpaste, a liquid dentifrice, a liquid dentifrice, and a moisturized dentifrice, particularly as a dentifrice.
  • a dentifrice such as a toothpaste, a liquid dentifrice, a liquid dentifrice, and a moisturized dentifrice, particularly as a dentifrice.
  • A Berberine
  • Sodium chloride
  • a nonionic surfactant is essential Contained.
  • the berberine as the component (a) can be blended as a solvent extract of a plant containing berberine, in particular, a citrus plant such as duck or a buttercup plant such as auren.
  • a plant containing berberine in particular, a citrus plant such as duck or a buttercup plant such as auren.
  • well-known things can be used as these plant extracts.
  • As the extraction solvent water and / or ethanol are suitable.
  • these plant extracts may be used individually by 1 type, and may use 2 or more types together.
  • a commercial item can be used for the said berberine, for example, a buckwheat extract (powder form) (Oshiro Pharmaceutical Co., Ltd.) and a dried uren extract (powder form) (Oshiro Pharmaceutical Co., Ltd.) can be used.
  • the blending amount of berberine is preferably 0.0005 to 0.05% (mass%, hereinafter the same) in terms of solid content, and more preferably 0.001 to 0 from the viewpoint of anti-inflammatory properties. 0.04%. If it is less than 0.0005%, a sufficient convergence effect may not be exhibited, and if it exceeds 0.05%, an off-taste may appear.
  • a commercial item can be used for sodium chloride, for example, sodium chloride (Nippon Seawater Co., Ltd.) can be used.
  • the blending amount of sodium chloride is preferably 2 to 10% with respect to the whole composition, and is preferably 3 to 7% from the viewpoint of the astringent effect and taste. If it is less than 2%, a sufficient astringent effect may not be exhibited. If it exceeds 10%, a salty taste may be exhibited, or irritation may be caused to the oral mucosa.
  • the component (c) is a plant extract selected from a rosemary extract, a sage extract, an ogon extract, a carrot extract, a peony extract, a honeysuckle extract, and a birch extract. Alternatively, two or more kinds can be used in combination.
  • Rosemary extract is prepared from water, leaves, and flowers of mannen wax, water, ethanol, propylene glycol, 1,3-butylene glycol or a mixture thereof, 1% urea-containing ethanol solution, or 1% urea-containing 1,3-butylene.
  • An extract obtained by extraction with a glycol solution, or an essential oil obtained by steam distillation from fresh leaves, branches, flowers, etc. of Mannerou can be used.
  • As the rosemary extract a commercially available product can be used.
  • rosemary extract Rosemary extract-J, Maruzen Pharmaceutical Co., Ltd.
  • the sage extract can be obtained from sage flowers, leaves or whole plants, water, ethanol, propylene glycol, 1,3-butylene glycol or a mixture thereof, 1% urea-containing ethanol solution or 1% urea-containing 1,3-
  • An extract obtained by extraction with a butylene glycol solution or an essential oil obtained by steam distillation from a sage leaf can be used.
  • Sage is closely related to salvia, and as a sage extract, a sage extract obtained by extracting water from a Labiatae salvia leaf with water, ethanol or hexane can also be used.
  • a commercial item can be used for a sage extract, for example, a sage extract (Salvia extract, Maruzen Pharmaceutical Co., Ltd.) etc. can be used.
  • Ougon extract is extracted with water, ethanol, absolute ethanol, 1,3-butylene glycol, or a mixture of these from the roots of perennial herb periwinkle planted in northern China to East Siberia and the Korean Peninsula. Can be used.
  • a commercially available product can be used as the orgone extract, for example, orgone extract (Ogon extract-J, Maruzen Pharmaceutical Co., Ltd.) and the like.
  • the carrot extract may be obtained by extracting the roots of ginseng root or those obtained by steaming and drying with ethanol, propylene glycol, 1,3-butylene glycol, or a mixture thereof, or absolute ethanol. it can.
  • a commercial item can be used for the carrot extract, for example, a carrot extract (carrot extract, Maruzen Pharmaceutical Co., Ltd.) etc. can be used.
  • peonies extract those obtained by extraction from the roots of peonies or other related plants with water, ethanol, 1,3-butylene glycol, or a mixture thereof can be used.
  • a commercially available product can be used as the peony extract, and for example, a peony extract (Maruzen Pharmaceutical Co., Ltd.) can be used.
  • the honeysuckle extract may be extracted from water, ethanol, propylene glycol, 1,3-butylene glycol, or a mixture thereof from flowers, leaves or stems of honeysuckle or other related plants (Caprifoliaceae). it can.
  • honeysuckle extract a commercially available product can be used.
  • Falco Rex honeysuckle SE Ichimaru Falcos Co., Ltd.
  • Kinginka Extract-J Maruzen Pharmaceutical Co., Ltd.
  • the birch extract used is that extracted from the leaves, bark or xylem of European birch or other related plants (Betulaceae) from water, ethanol, propylene glycol, 1,3-butylene glycol, or a mixture thereof. be able to.
  • a commercially available product can be used as the birch extract, for example, a birch extract (Maruzen Pharmaceutical Co., Ltd.) or the like can be used.
  • the compounding amount of the plant extract as the component (c) is preferably 0.00005 to 0.02%, particularly 0.0001 to 0.01% in terms of the extract content in the composition. If it is less than 0.00005%, the convergence effect may be impaired, and if it exceeds 0.02%, a nasty taste may be expressed, and irritation to the oral mucosa may occur.
  • nonionic surfactant of component (d) examples include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, decaglyceryl laurate, lauryl glucoside, sucrose palmitate monoester, and the like. Two or more types are used, and among them, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, and decaglyceryl laurate are preferable in terms of foam retention.
  • Oxyethylene alkyl ether is most preferred because it can better improve the foam retention in the oral cavity.
  • the average added mole number of ethylene oxide of polyoxyethylene alkyl ether is less than 2, the stimulating and relaxation effect may not be satisfactorily exhibited, and if it exceeds 20, the taste during use may be inferior.
  • the carbon number of the alkyl group of the polyoxyethylene alkyl ether is preferably 12 to 22 from the viewpoint of the stimulating effect and taste.
  • the blending amount of the component (d) is preferably 0.3 to 3%, particularly 0.5 to 2% of the whole composition. If the blending amount is less than 0.3%, the salty taste mitigating effect may not be exhibited, or irritation may occur to the oral mucosa, and if it exceeds 3%, the astringent effect may be impaired.
  • the blending ratio ((b) / (d)) of the sodium chloride as the component (b) and the nonionic surfactant as the component (d) is 1.5 to 20, particularly 2 to 10, especially 2 It is preferably ⁇ 8. If it is less than 1.5, the stability of berberine is inferior and the astringent effect is impaired, and if it exceeds 20, the salty taste mitigating effect is not exhibited and irritation occurs to the oral mucosa.
  • lauryl sulfate is an anionic surfactant having an average alkyl chain length of 12 synthesized from higher fatty acids.
  • alkali metal lauryl sulfates such as sodium lauryl sulfate and potassium lauryl sulfate, and ammonium lauryl sulfate.
  • Sodium lauryl sulfate is particularly preferred because of its ease of incorporation into a dentifrice composition.
  • sodium lauryl sulfate for example, one manufactured by Toho Chemical Industry Co., Ltd. can be used.
  • the blending amount is not particularly limited, but 0.8 to 2%, particularly 1 to 1.5% of the whole composition is preferable, and if it is less than 0.8%, more excellent foam is obtained. In some cases, if it exceeds 2%, irritation to the oral mucosa may occur.
  • the mass ratio of the component (d) / the component (e) is preferably 0.25 to 2.5, particularly 1.0 to 2.0. . If the blending ratio is less than 0.25, the salty taste mitigating effect may not be exhibited, and irritation may occur to the oral mucosa. If it exceeds 2.5, the astringent effect is impaired, or foaming during use is more excellent May not be improved.
  • the dentifrice composition of the present invention can be blended with other known additives in addition to the above essential components in a range not impeding the effects of the present invention, depending on the dosage form and the like.
  • abrasives, thickeners, binders, surfactants other than component (d) and component (e), and further sweeteners, preservatives as necessary (a), (b) and (c)
  • An active ingredient other than the ingredients, a colorant (pigment), a fragrance and the like can be blended, and these ingredients and water can be mixed and produced by an ordinary method.
  • the thickening agent one or more of glycerin, sorbit, propylene glycol, polyethylene glycol having an average molecular weight of 200 to 6000, ethylene glycol, sugar alcohol such as reduced starch saccharified product, polyhydric alcohol and the like can be used (usually) (Mixing amount 5-50%).
  • organic binders such as sodium polyacrylate, xanthan gum, sodium alginate, propylene glycol ester alginate, sodium carboxymethyl cellulose, hydroxyethyl cellulose, carbopol, guar gum, gelatin, Avicel, montmorillonite, kaolin, bentonite, etc.
  • inorganic binders normally 0 to 5%, particularly 0.1 to 3%.
  • surfactant in addition to the nonionic surfactant of component (d) above, and in addition to the lauryl sulfate salt of component (e), other surfactants may be blended. Specifically, amphoteric surfactants may be added. Examples of the agent include N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine and the like (when blended, the usual blending amount is 0.1 to 3%, especially 0.5 to 2%).
  • Sweeteners include saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartin, etc., and preservatives include parabens (paraoxybenzoate) such as butylparaben and ethylparaben. And sodium benzoate.
  • Various active ingredients include: fluorides such as sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, sodium monofluorophosphate, and water-soluble phosphate compounds such as orthophosphoric acid potassium salt and sodium salt. , Tranexamic acid, epsilon-aminocaproic acid, allantochlorohydroxyaluminum, ascorbic acid, dl-tocopherol acetate, dihydrocholesterol, ⁇ -bisabolol, chlorhexidine salts, azulene, glycyrrhetin, glycyrrhetinic acid, copper chlorophyllin sodium, chlorophyll, glycerophosphate, etc.
  • fluorides such as sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, sodium monofluorophosphate, and water-soluble phosphate compounds such as orthophosphoric acid potassium salt and sodium salt.
  • fluorides such
  • Phosphate compounds copper compounds such as copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite , Methoxy ethylene, epi-dihydro cholesterol, benzethonium chloride, dihydrocholesterol, trichlorocarbanilide, zinc citrate, camomile, clove, like extracts of safflower like.
  • the compounding quantity of these active ingredients can be made into an effective quantity in the range which does not prevent the effect of this invention.
  • Perfumes are peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime oil, lavender Oil, laurel oil, camomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint, absolute rose, orange flower, etc.
  • Natural fragrances, and fragrances processed by these natural fragrances front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder fragrance, etc.
  • menthol carvone, anethole, cineole
  • Methyl salicylate synthetic aldehyde Eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramentane-3-carboxamide, pinene, octylaldehyde, citral, pregon , Beer acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexan
  • the blending amount of the fragrance is not particularly limited, but the above-mentioned fragrance material is preferably used at 0.000001 to 1% in the preparation composition.
  • the flavoring fragrance using the fragrance material is preferably used in an amount of 0.1 to 2.0% in the preparation composition.
  • colorants examples include Blue No. 1, Yellow No. 4, Green No. 3, and the like.
  • the material of the container for storing the dentifrice composition of the present invention is not particularly limited, and a container usually used for a dentifrice composition can be used. Specifically, plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon can be used.
  • the present invention will be specifically described with reference to examples and comparative examples, but the present invention is not limited to the following examples.
  • the blending amount is mass%.
  • test dentifrice composition having the compositions shown in Tables 1 to 7 were prepared by the following method, and the innermost layer was a linear low density polyethylene laminate tube having a diameter of 26 mm and a diameter of 8 mm (low 50 g in density polyethylene 72 ⁇ m / ethylene / acrylic acid copolymer resin 90 ⁇ m / aluminum 10 ⁇ m / ethylene / acrylic acid copolymer resin 35 ⁇ m / linear low density polyethylene 50 ⁇ m, thickness 257 ⁇ m (manufactured by Dai Nippon Printing Co., Ltd.) Filled.
  • a phase was prepared by mixing and dissolving water-soluble components (excluding binder and propylene glycol) in purified water at room temperature.
  • a phase B in which a binder was dispersed at room temperature in propylene glycol was prepared.
  • B phase was added and mixed in A phase under stirring, and C phase was prepared.
  • ingredients other than water-soluble ingredients such as fragrances and abrasives are mixed at room temperature using a 1.5 L kneader (manufactured by Ishiyama Kogakusho) and degassed under reduced pressure (5.3 kPa).
  • the dentifrice composition 1.2kg was obtained.
  • the preparation of the dentifrice composition was prepared by using the Abou extract (trade name: Abou extract (berberine content 5%), a water-made dry extract, Ogi Seiyaku Co., Ltd.), an aurene extract (trade name: Aureen dry extract (berberine). 5%), 30% ethanol dry extract, Oshiro Pharmaceutical Co., Ltd., sodium chloride (Nihonkaisui Co., Ltd.), rosemary extract (trade name: rosemary extract-J (rosemary leaf extract 0) 96%, ethanol 49.52%, water 49.52%), Maruzen Pharmaceutical Co., Ltd.), sage extract (trade name: salvia extract (sage leaf extract 1%, ethanol 49.5%, water 49.52%).
  • Abou extract trade name: Abou extract (berberine content 5%
  • a water-made dry extract Ogi Seiyaku Co., Ltd.
  • an aurene extract trade name: Aureen dry extract (berberine). 5%
  • 30% ethanol dry extract Oshir
  • Berberine content (ppm) WS ⁇ (100 ⁇ D) ⁇ (353.37 / 371.81) ⁇ (QT / QS) ⁇ (K / WT) WS: Standard amount of berberine chloride (g) WT: Sample amount (g) D: Moisture content of standard berberine chloride (%) K: Constant (set by dilution concentration, etc.) 353.37: Molecular weight of berberine 371.81: Molecular weight of berberine chloride
  • Berberine residual rate was evaluated according to the following criteria. Evaluation criteria ⁇ : 95% or more ⁇ : 90% or more and less than 95% ⁇ : 85% or more and less than 90% ⁇ : Less than 85%
  • the numerical value in () is the amount of each extract (the same applies hereinafter). Moreover, in the compounding quantity of (A) component, the numerical value in () is a solid content conversion value (hereinafter the same).

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Abstract

La présente invention concerne une composition de dentifrice à base de berbérine. La berbérine contenue est hautement stable et la composition de dentifrice est non irritante, elle présente une amélioration de l'astringence et aucun goût déplaisant. Lors de son utilisation, ladite composition de dentifrice est agréable, mousse bien et présente des caractéristiques excellentes de rétention de mousse. Ladite composition contient : (a) de la berbérine ; (b) du chlorure de sodium ; (c) au moins un extrait de plante choisi parmi un extrait de romarin, un extrait de Salvia, un extrait de Scutellaria baicalensis, un extrait de carotte, un extrait de Paeonia lactiflora, un extrait de Lonicera japonica et un extrait de Betula platyphylla variété japonica ; (d) et un agent tensioactif non ionique. Le rapport massique du composant (b) sur le composant (d) se situe entre 1,5 et 20. La composition de dentifrice contient également (e) du laurylsulfate et le rapport massique du composant (d) sur le composant (e) se situe entre 0,25 et 2,5.
PCT/JP2010/072353 2009-12-22 2010-12-13 Composition de dentifrice WO2011077983A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201080049385.0A CN102596163B (zh) 2009-12-22 2010-12-13 洁齿剂组合物
HK12112954.5A HK1171963A1 (en) 2009-12-22 2012-12-14 Dentrifice composition

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JP2009-290751 2009-12-22
JP2009290751A JP5381685B2 (ja) 2009-12-22 2009-12-22 歯磨剤組成物

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WO (1) WO2011077983A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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CN107095805A (zh) * 2017-06-23 2017-08-29 上海利康消毒高科技有限公司 一种洗必泰混合精油口腔护理牙膏
EP3459555A4 (fr) * 2016-05-18 2019-03-27 Nippon Zettoc Co., Ltd. Composition à usage buccal
CN111084741A (zh) * 2019-12-30 2020-05-01 柳州两面针股份有限公司 赤芍提取物在制备口腔护理用品中的应用

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JP5742261B2 (ja) * 2011-02-01 2015-07-01 ライオン株式会社 ベルベリン含有歯磨剤組成物及びその安定化方法
JP6348267B2 (ja) * 2013-09-30 2018-06-27 小林製薬株式会社 収斂用組成物
JP7409775B2 (ja) * 2013-09-30 2024-01-09 小林製薬株式会社 低収斂性組成物
CN106924106B (zh) * 2015-12-28 2020-11-13 天津金士力佳友日化用品有限公司 一种用于抑制牙菌斑和减轻牙龈炎症的牙膏
JP7124403B2 (ja) * 2018-04-11 2022-08-24 ライオン株式会社 歯磨剤組成物
WO2021177065A1 (fr) * 2020-03-02 2021-09-10 ライオン株式会社 Composition pour cavité buccale

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EP2727627A3 (fr) * 2012-11-06 2016-06-15 Henkel AG & Co. KGaA Produit de nettoyage et d'entretien de la bouche et des dents contenant de la vitamine E
EP3459555A4 (fr) * 2016-05-18 2019-03-27 Nippon Zettoc Co., Ltd. Composition à usage buccal
US10603271B2 (en) 2016-05-18 2020-03-31 Nippon Zettoc Co., Ltd. Oral composition
CN107095805A (zh) * 2017-06-23 2017-08-29 上海利康消毒高科技有限公司 一种洗必泰混合精油口腔护理牙膏
CN111084741A (zh) * 2019-12-30 2020-05-01 柳州两面针股份有限公司 赤芍提取物在制备口腔护理用品中的应用

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JP2011132137A (ja) 2011-07-07
JP5381685B2 (ja) 2014-01-08

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