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WO2011066980A3 - Formes de dose orale avec risque réduit d'abus de médicaments - Google Patents

Formes de dose orale avec risque réduit d'abus de médicaments Download PDF

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Publication number
WO2011066980A3
WO2011066980A3 PCT/EP2010/007340 EP2010007340W WO2011066980A3 WO 2011066980 A3 WO2011066980 A3 WO 2011066980A3 EP 2010007340 W EP2010007340 W EP 2010007340W WO 2011066980 A3 WO2011066980 A3 WO 2011066980A3
Authority
WO
WIPO (PCT)
Prior art keywords
oral dosage
dosage form
drug abuse
reduced potential
dosage forms
Prior art date
Application number
PCT/EP2010/007340
Other languages
English (en)
Other versions
WO2011066980A2 (fr
Inventor
Lars Holger Hermann
Original Assignee
Lars Holger Hermann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lars Holger Hermann filed Critical Lars Holger Hermann
Publication of WO2011066980A2 publication Critical patent/WO2011066980A2/fr
Publication of WO2011066980A3 publication Critical patent/WO2011066980A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une forme de dose orale présentant un risque réduit d'abus de médicament qui comporte (a) au moins un composé actif pharmaceutique contenant une amine ou du sel ou solvate de celui-ci, (b) au moins un acide organique faible ou sel de celui-ci, qui forme un précipité insoluble avec le composant (a) dans un environnement aqueux à un pH d'au moins 5, et (c) au moins un agent basifiant dans une quantité appropriée pour obtenir un pH d'au moins 5 dans l'environnement de la forme de dose orale lorsqu'elle est dissoute. Selon l'invention, ladite au moins une partie de la forme de dose orale est formulée pour être libérée immédiatement et les composants (b) et (c) sont principalement contenus dans cette partie, et une autre partie de la forme de dose orale est formulée pour une libération prolongée et contient au moins la majorité du composant (a).
PCT/EP2010/007340 2009-12-04 2010-12-03 Formes de dose orale avec risque réduit d'abus de médicaments WO2011066980A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09015063.2 2009-12-04
EP09015063 2009-12-04

Publications (2)

Publication Number Publication Date
WO2011066980A2 WO2011066980A2 (fr) 2011-06-09
WO2011066980A3 true WO2011066980A3 (fr) 2011-10-20

Family

ID=42169038

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/007340 WO2011066980A2 (fr) 2009-12-04 2010-12-03 Formes de dose orale avec risque réduit d'abus de médicaments

Country Status (1)

Country Link
WO (1) WO2011066980A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9101636B2 (en) 2012-11-30 2015-08-11 Acura Pharmaceuticals, Inc. Methods and compositions for self-regulated release of active pharmaceutical ingredient

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014024382B1 (pt) 2012-04-18 2022-08-09 SpecGx LLC Composições farmacêuticas de contenção de abuso de liberação imediata e seu processo de preparação
JP6255474B2 (ja) 2013-03-15 2017-12-27 マリンクロッド エルエルシー 機能的割線を有する即時放出用の乱用抑止性固体剤形
ES2764445T3 (es) * 2013-03-15 2020-06-03 Inspirion Delivery Sciences Llc Productos farmacéuticos que comprenden un componente dependiente de pH y un agente de aumento del pH
CA3042642A1 (fr) 2013-08-12 2015-02-19 Pharmaceutical Manufacturing Research Services, Inc. Comprime extrude anti-abus a liberation immediate
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10632113B2 (en) 2014-02-05 2020-04-28 Kashiv Biosciences, Llc Abuse-resistant drug formulations with built-in overdose protection
CA2951563C (fr) 2014-06-09 2019-04-02 Acura Pharmaceuticals, Inc. Procedes et compositions destines a interferer avec l'extraction ou la conversion d'un medicament susceptible d'usage abusif
CA2953396C (fr) 2014-07-03 2022-11-08 Mallinckrodt Llc Formulations a liberation immediate de dissuasion d'abus comprenant des polysaccharides non cellulosiques
CA2910865C (fr) 2014-07-15 2016-11-29 Isa Odidi Compositions et methodes destines a reduire les surdoses
EP3169316A4 (fr) * 2014-07-15 2018-01-24 Isa Odidi Compositions et procédés pour réduire une surdose
AU2015290098B2 (en) 2014-07-17 2018-11-01 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
CA2955477A1 (fr) * 2014-09-27 2016-03-31 Jayendrakumar Dasharathlal PATEL Composition pharmaceutique anti-abus
US20160106737A1 (en) 2014-10-20 2016-04-21 Pharmaceutical Manufacturing Research Services, Inc. Extended Release Abuse Deterrent Liquid Fill Dosage Form
WO2017040607A1 (fr) 2015-08-31 2017-03-09 Acura Pharmaceuticals, Inc. Procédés et compositions pour la libération auto-régulée d'un ingrédient pharmaceutique actif
MX2021002459A (es) 2018-09-25 2021-04-29 SpecGx LLC Formas de dosificacion en capsula disuasorias del abuso de liberacion inmediata.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030170181A1 (en) * 1999-04-06 2003-09-11 Midha Kamal K. Method for preventing abuse of methylphenidate
US20040234608A1 (en) * 2000-06-23 2004-11-25 Moshe Fleshner-Barak Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition
US20050232987A1 (en) * 2004-03-12 2005-10-20 Viswanathan Srinivasan Dosage form containing a morphine derivative and another drug

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030170181A1 (en) * 1999-04-06 2003-09-11 Midha Kamal K. Method for preventing abuse of methylphenidate
US20040234608A1 (en) * 2000-06-23 2004-11-25 Moshe Fleshner-Barak Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition
US20050232987A1 (en) * 2004-03-12 2005-10-20 Viswanathan Srinivasan Dosage form containing a morphine derivative and another drug

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9101636B2 (en) 2012-11-30 2015-08-11 Acura Pharmaceuticals, Inc. Methods and compositions for self-regulated release of active pharmaceutical ingredient

Also Published As

Publication number Publication date
WO2011066980A2 (fr) 2011-06-09

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