WO2010130830A3 - Séquences d'acides aminés dirigées contre la sclérostine et polypeptides comprenant ces dernières pour le traitement de maladies et de pathologies des os - Google Patents
Séquences d'acides aminés dirigées contre la sclérostine et polypeptides comprenant ces dernières pour le traitement de maladies et de pathologies des os Download PDFInfo
- Publication number
- WO2010130830A3 WO2010130830A3 PCT/EP2010/056657 EP2010056657W WO2010130830A3 WO 2010130830 A3 WO2010130830 A3 WO 2010130830A3 EP 2010056657 W EP2010056657 W EP 2010056657W WO 2010130830 A3 WO2010130830 A3 WO 2010130830A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sclerostin
- bone diseases
- vhh
- amino acid
- acid sequences
- Prior art date
Links
- 208000020084 Bone disease Diseases 0.000 title abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000019307 Sclerostin Human genes 0.000 abstract 1
- 108050006698 Sclerostin Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne des séquences d'acides aminés qui sont dirigées contre la sclérostine, ainsi que des composés ou des constructions, et en particulier des protéines et des polypeptides, qui comprennent ou qui sont principalement constitués d'une ou plusieurs de ces séquences d'acides aminés. Cette invention porte également sur des compositions pharmaceutiques qui comprennent de telles séquences d'acides aminés et sur les utilisations de ces séquences d'acides aminés ou de ces polypeptides pour prévenir et/ou traiter des maladies ou des pathologies des os.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17867909P | 2009-05-15 | 2009-05-15 | |
US61/178,679 | 2009-05-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010130830A2 WO2010130830A2 (fr) | 2010-11-18 |
WO2010130830A3 true WO2010130830A3 (fr) | 2011-01-27 |
Family
ID=42347538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2010/056657 WO2010130830A2 (fr) | 2009-05-15 | 2010-05-14 | Séquences d'acides aminés dirigées contre la sclérostine et polypeptides comprenant ces dernières pour le traitement de maladies et de pathologies des os |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2010130830A2 (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE481487T1 (de) | 1998-11-27 | 2010-10-15 | Ucb Sa | Zusammensetzungen und verfahren zur erhöhung der knochenmineralisierung |
US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
CL2008002775A1 (es) | 2007-09-17 | 2008-11-07 | Amgen Inc | Uso de un agente de unión a esclerostina para inhibir la resorción ósea. |
ES2894364T3 (es) * | 2009-10-22 | 2022-02-14 | Univ Twente | VHH para su aplicación en la reparación de tejidos, regeneración de órganos, reemplazo de órganos e ingeniería de tejidos |
SMT202000095T1 (it) | 2010-05-14 | 2020-03-13 | Amgen Inc | Formulazioni di anticorpi anti-sclerostina ad alta concentrazione |
MX2013010011A (es) | 2011-03-01 | 2014-10-24 | Amgen Inc | Agentes de unión biespecífica. |
BR112013024493A2 (pt) | 2011-03-25 | 2018-06-26 | Amgen Inc. | cristais de anticorpo antiesclerostina e formulações dos mesmos |
RS60835B1 (sr) | 2011-04-19 | 2020-10-30 | Amgen Inc | Metoda za lečenje osteoporoze |
MX355816B (es) | 2011-08-04 | 2018-05-02 | Amgen Inc | Metodo para tratar los defectos de espacio oseo. |
KR20200056473A (ko) | 2011-12-28 | 2020-05-22 | 암젠 인크 | 항스클레로스틴 항체의 이용을 통한 치조골 소실의 치료 방법 |
JP6770312B2 (ja) * | 2012-07-05 | 2020-10-14 | ユセベ ファルマ ソシエテ アノニム | 骨疾患の治療 |
UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
MA41142A (fr) | 2014-12-12 | 2017-10-17 | Amgen Inc | Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement |
CA2975078A1 (fr) * | 2015-01-27 | 2016-08-04 | Lava Therapeutics B.V. | Anticorps a domaine unique ciblant cd1d |
DK3269735T3 (da) | 2015-03-13 | 2020-12-14 | Jiangsu Hengrui Medicine Co | Antistof mod sclerostin, antigenbindende fragment og medicinsk anvendelse deraf |
GB201604124D0 (en) | 2016-03-10 | 2016-04-27 | Ucb Biopharma Sprl | Pharmaceutical formulation |
US20190185556A1 (en) | 2016-08-08 | 2019-06-20 | Amgen Inc. | Method of improving connective tissue attachment using anti-sclerostin antibodies |
CN112166120B (zh) | 2018-03-30 | 2024-09-10 | 安姆根有限公司 | C末端抗体变体 |
EA202190482A1 (ru) | 2018-08-10 | 2021-05-25 | Эмджен Инк. | Способ получения фармацевтического состава на основе антитела |
AU2019344300A1 (en) | 2018-09-19 | 2021-04-22 | LAVA Therapeutics N.V. | Dual acting CD1D immunoglobulin |
WO2021030179A1 (fr) | 2019-08-12 | 2021-02-18 | Amgen Inc. | Formulations d'anticorps anti-sclérostine |
TW202440614A (zh) | 2022-12-23 | 2024-10-16 | 比利時商艾伯霖克斯公司 | 基於蛋白質的接合載體 |
WO2024170756A1 (fr) | 2023-02-17 | 2024-08-22 | Ablynx N.V. | Polypeptides se liant au récepteur fc néonatal |
WO2025019728A1 (fr) | 2023-07-19 | 2025-01-23 | Amgen Inc. | Procédés de préparation d'une solution tampon pour une formulation protéique thérapeutique |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005003158A2 (fr) * | 2003-06-16 | 2005-01-13 | Celltech R & D, Inc. | Compositions et methodes d'augmentation de la mineralisation osseuse |
WO2005014650A2 (fr) * | 2003-06-16 | 2005-02-17 | Celltech R & D, Inc. | Anticorps specifiques de la sclerostine et methodes permettant d'accroitre la mineralisation osseuse |
WO2007080129A1 (fr) * | 2006-01-13 | 2007-07-19 | A Chan Holding B.V. | Traitement et diagnostic de densité osseuse anormale |
WO2008061013A2 (fr) * | 2006-11-10 | 2008-05-22 | Amgen Inc. | Diagnostic et thérapie basés sur des anticorps |
-
2010
- 2010-05-14 WO PCT/EP2010/056657 patent/WO2010130830A2/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005003158A2 (fr) * | 2003-06-16 | 2005-01-13 | Celltech R & D, Inc. | Compositions et methodes d'augmentation de la mineralisation osseuse |
WO2005014650A2 (fr) * | 2003-06-16 | 2005-02-17 | Celltech R & D, Inc. | Anticorps specifiques de la sclerostine et methodes permettant d'accroitre la mineralisation osseuse |
WO2007080129A1 (fr) * | 2006-01-13 | 2007-07-19 | A Chan Holding B.V. | Traitement et diagnostic de densité osseuse anormale |
WO2008061013A2 (fr) * | 2006-11-10 | 2008-05-22 | Amgen Inc. | Diagnostic et thérapie basés sur des anticorps |
Non-Patent Citations (8)
Title |
---|
DE GENST E ET AL: "Antibody repertoire development in camelids", DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, PERGAMON PRESS, US LNKD- DOI:10.1016/J.DCI.2005.06.010, vol. 30, no. 1-2, 1 January 2006 (2006-01-01), pages 187 - 198, XP025088320, ISSN: 0145-305X, [retrieved on 20060101] * |
EDDLESTON ALISON ET AL: "A short treatment with an antibody to sclerostin can inhibit bone loss in an ongoing model of colitis.", JOURNAL OF BONE AND MINERAL RESEARCH : THE OFFICIAL JOURNAL OF THE AMERICAN SOCIETY FOR BONE AND MINERAL RESEARCH OCT 2009 LNKD- PUBMED:19419292, vol. 24, no. 10, 27 April 2009 (2009-04-27), pages 1662 - 1671, XP002594506, ISSN: 1523-4681 * |
LI XIAODONG ET AL: "Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis.", JOURNAL OF BONE AND MINERAL RESEARCH : THE OFFICIAL JOURNAL OF THE AMERICAN SOCIETY FOR BONE AND MINERAL RESEARCH APR 2009 LNKD- PUBMED:19049336, vol. 24, no. 4, April 2009 (2009-04-01), pages 578 - 588, XP002594505, ISSN: 1523-4681 * |
PADHI-D ET AL.: "Anti-sclerostin antibody increases markers of bne formation in healthy menopausal women", J BONE MINER RES, vol. 21, no. Suppl 1, 1129, 2007, Abstracts ASBMR 29th Annual Meeting, XP002594507 * |
RUDIKOFF S ET AL: "Single amino acid substitution altering antigen-binding specificity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (PNAS), NATIONAL ACADEMY OF SCIENCE, US LNKD- DOI:10.1073/PNAS.79.6.1979, vol. 79, 1 March 1982 (1982-03-01), pages 1979 - 1983, XP007901436, ISSN: 0027-8424 * |
SAERENS D ET AL: "Single-domain antibodies as building blocks for novel therapeutics", CURRENT OPINION IN PHARMACOLOGY, ELSEVIER SCIENCE PUBLISHERS, NL LNKD- DOI:10.1016/J.COPH.2008.07.006, vol. 8, no. 5, 1 October 2008 (2008-10-01), pages 600 - 608, XP025609339, ISSN: 1471-4892, [retrieved on 20080822] * |
VEVERKA VACLAV ET AL: "Characterization of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 17 APR 2009 LNKD- PUBMED:19208630, vol. 284, no. 16, 17 April 2009 (2009-04-17), pages 10890 - 10900, XP002594504, ISSN: 0021-9258 * |
WEIDAUER S E ET AL: "NMR structure of the Wnt modulator protein Sclerostin", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US LNKD- DOI:10.1016/J.BBRC.2009.01.062, vol. 380, no. 1, 27 February 2009 (2009-02-27), pages 160 - 165, XP025937069, ISSN: 0006-291X, [retrieved on 20090121] * |
Also Published As
Publication number | Publication date |
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WO2010130830A2 (fr) | 2010-11-18 |
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