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WO2010017264A3 - Hydrogels d’acides nucléiques photoréticulés - Google Patents

Hydrogels d’acides nucléiques photoréticulés Download PDF

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Publication number
WO2010017264A3
WO2010017264A3 PCT/US2009/052795 US2009052795W WO2010017264A3 WO 2010017264 A3 WO2010017264 A3 WO 2010017264A3 US 2009052795 W US2009052795 W US 2009052795W WO 2010017264 A3 WO2010017264 A3 WO 2010017264A3
Authority
WO
WIPO (PCT)
Prior art keywords
photo
nucleic acid
acid hydrogels
crosslinked nucleic
hydrogels
Prior art date
Application number
PCT/US2009/052795
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English (en)
Other versions
WO2010017264A2 (fr
Inventor
Dan Luo
Young Hoon Roh
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Cornell University
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Filing date
Publication date
Application filed by Cornell University filed Critical Cornell University
Priority to US13/057,356 priority Critical patent/US20120040397A1/en
Priority to EP09805484A priority patent/EP2324045A4/fr
Priority to CN2009801391014A priority patent/CN102171234A/zh
Publication of WO2010017264A2 publication Critical patent/WO2010017264A2/fr
Publication of WO2010017264A3 publication Critical patent/WO2010017264A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)

Abstract

L’invention concerne des procédés et des compositions pour la production de structures d’hydrogel d’acides nucléiques à l’aide d’une photoréticulation. L’invention concerne également des procédés d’utilisation des hydrogels photoréticulés pour la production de protéines exemptes de cellules, et pour des composés d’encapsulation et d’administration.
PCT/US2009/052795 2008-08-05 2009-08-05 Hydrogels d’acides nucléiques photoréticulés WO2010017264A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US13/057,356 US20120040397A1 (en) 2008-08-05 2009-08-05 Photo-Crosslinked Nucleic Acid Hydrogels
EP09805484A EP2324045A4 (fr) 2008-08-05 2009-08-05 Hydrogels d'acides nucléiques photoréticulés
CN2009801391014A CN102171234A (zh) 2008-08-05 2009-08-05 光交联核酸水凝胶

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8642308P 2008-08-05 2008-08-05
US61/086,423 2008-08-05

Publications (2)

Publication Number Publication Date
WO2010017264A2 WO2010017264A2 (fr) 2010-02-11
WO2010017264A3 true WO2010017264A3 (fr) 2010-05-14

Family

ID=41664180

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/052795 WO2010017264A2 (fr) 2008-08-05 2009-08-05 Hydrogels d’acides nucléiques photoréticulés

Country Status (4)

Country Link
US (1) US20120040397A1 (fr)
EP (1) EP2324045A4 (fr)
CN (1) CN102171234A (fr)
WO (1) WO2010017264A2 (fr)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8715732B2 (en) 2009-01-05 2014-05-06 Cornell University Nucleic acid hydrogel via rolling circle amplification
US20120029089A1 (en) * 2009-01-14 2012-02-02 Chih-Chang Chu Preparing biodegradable hydrogel for biomedical application
JP2012526130A (ja) * 2009-05-05 2012-10-25 アルテルムネ テクフノロジエス，エルエルシー 化学的にプログラム可能な免疫
EP3604555B1 (fr) 2011-10-14 2024-12-25 President and Fellows of Harvard College Séquençage par assemblage de structure
CN102505339A (zh) * 2011-10-26 2012-06-20 天津大学 包载有活性蛋白的凝胶/pelcl超细纤维膜及制备方法
CN102505350A (zh) * 2011-10-26 2012-06-20 天津大学 原位包载凝胶的聚丙交酯电纺复合膜及其制备方法
EP4491741A3 (fr) 2011-12-22 2025-03-19 President And Fellows Of Harvard College Compositions et procédés de détection d'analyte
ES2991004T3 (es) 2011-12-22 2024-12-02 Harvard College Métodos para la detección de analitos
CN102675562A (zh) * 2012-05-16 2012-09-19 天津大学 一种聚乙二醇大分子单体交联的高强度水凝胶及其光引发自由基聚合法
US9914967B2 (en) 2012-06-05 2018-03-13 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using DNA origami probes
CN102861541B (zh) * 2012-09-25 2014-10-08 陕西师范大学 表面修饰的荧光磁性高分子复合微球的制备方法
US9364543B2 (en) * 2012-10-24 2016-06-14 Indiana University Research And Technology Corporation Visible light curable hydrogels and methods for using
KR20140092430A (ko) * 2012-12-26 2014-07-24 삼성전자주식회사 나노입자 조립체, 이의 제조방법 및 이를 포함하는 활성물질 전달 복합체
WO2014138085A1 (fr) 2013-03-05 2014-09-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Hydrogel thermosensible contenant des microparticules polymères pour l'administration de médicament oculaire non invasive
EP2971184B1 (fr) * 2013-03-12 2019-04-17 President and Fellows of Harvard College Procédé de génération d'une matrice tridimensionnelle contenant des acides nucléiques
CA2908379C (fr) * 2013-03-28 2021-03-30 Japan Advanced Institute Of Science And Technology Analogue de nucleotide photosensible ayant une capacite de photo-reticulation
ES2930537T3 (es) 2013-06-04 2022-12-16 Harvard College Regulación de la transcripción guiada por ARN
GB2516484A (en) * 2013-07-24 2015-01-28 Univ Dublin City Photo-responsive spiropyran-based N-isopropylacrylamide (NIPAM) gels
US20150111764A1 (en) * 2013-10-22 2015-04-23 New York University Polymerized microarrays
US10179932B2 (en) 2014-07-11 2019-01-15 President And Fellows Of Harvard College Methods for high-throughput labelling and detection of biological features in situ using microscopy
EP4328322A3 (fr) 2014-07-30 2024-05-22 President and Fellows of Harvard College Construction de bibliothèque de sondes
CN104264372B (zh) * 2014-08-13 2017-01-25 东华大学 一种静电纺制备聚n‑异丙基丙烯酰胺与乙基纤维素混合纳米纤维膜的方法
CN104275196A (zh) * 2014-10-24 2015-01-14 浙江师范大学 四氧化三铁/碳/硫化镉复合纳米材料及其制备方法
US9937256B2 (en) 2015-01-14 2018-04-10 Board Of Regents, The University Of Texas System Hydrogels for delivery of therapeutic compounds
EP3263624B1 (fr) * 2015-02-25 2022-08-03 FUJIFILM Corporation Dispersion dans l'eau de particules de gel, son procede de production et procede de formation d'images
US10736731B2 (en) 2015-06-12 2020-08-11 The General Hospital Corporation Corneal fillers for correction of ametropia
WO2017015616A1 (fr) * 2015-07-22 2017-01-26 Envisia Therapeutics, Inc. Livraison de protéines dans l'oeil
EP3368020B1 (fr) * 2015-10-26 2021-07-28 University of Wyoming Procédés de production de microparticules et d'hydrogels poreux utilisant la microfluidique
EP3371329A4 (fr) 2015-11-03 2019-06-19 President and Fellows of Harvard College Procédé et appareil pour imagerie volumétrique d'une matrice tridimensionnelle contenant des acides nucléiques
US20170173209A1 (en) * 2015-12-18 2017-06-22 Rousseau Research, Inc. Wound closure compositions and method
WO2017127033A1 (fr) * 2016-01-22 2017-07-27 Yeditepe Universitesi Procédé de préparation d'un système de vecteur à base d'origami d'adn
KR101666792B1 (ko) * 2016-02-05 2016-10-17 주식회사 파마리서치프로덕트 핵산 및 키토산을 포함하는 온도감응성 하이드로겔 조성물
WO2017142879A1 (fr) * 2016-02-16 2017-08-24 The Regents Of The University Of California Procédé de modulation du système immunitaire avec des gels de particules hybridées microporeuses
KR102478639B1 (ko) 2016-02-23 2022-12-19 노을 주식회사 표지 물질을 저장하는 패치, 이를 이용하는 조직 진단 방법 및 장치
US10371610B2 (en) 2016-02-23 2019-08-06 Noul Co., Ltd. Contact-type patch, staining method using the same, and manufacturing method thereof
KR20170099739A (ko) 2016-02-23 2017-09-01 노을 주식회사 접촉식 염색 보조 패치, 그 제조 방법 및 이를 이용하는 염색 방법
CN105622954A (zh) * 2016-03-03 2016-06-01 山东理工大学 一种聚乙烯醇-聚肽-聚三亚甲基碳酸酯-聚乳酸乙醇酸三接枝共聚物的制备方法
EP3231419A1 (fr) * 2016-04-14 2017-10-18 Universität Siegen Génération d'hydrogels d'adn à partir de blocs de construction linéaire
CA3210120C (fr) 2016-04-25 2024-04-09 President And Fellows Of Harvard College Procedes de reaction en chaine d'hybridation pour la detection moleculaire in situ
DE102016110005A1 (de) 2016-05-31 2017-11-30 Universität Zu Lübeck Vorrichtung zur Brechkraftänderung der Cornea
CN106187996B (zh) * 2016-07-07 2018-11-09 华南师范大学 一种新型pH响应的含有稀土配合物的复合水凝胶及其制备方法和应用
GB2569252A (en) 2016-08-31 2019-06-12 Harvard College Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
WO2018045181A1 (fr) 2016-08-31 2018-03-08 President And Fellows Of Harvard College Procédés de génération de bibliothèques de séquences d'acides nucléiques pour la détection par séquençage fluorescent in situ
CN106397795B (zh) * 2016-08-31 2018-12-21 陕西佰傲再生医学有限公司 一种混合透明质酸凝胶及其制备方法
EP3538867B1 (fr) * 2016-11-08 2024-01-03 President and Fellows of Harvard College Imagerie multiplexée utilisant la technique merfish, la microscopie à expansion et les technologies associées
CN106833618B (zh) * 2016-12-19 2019-04-05 中国科学技术大学 双功能化水凝胶聚合物复合材料、其制备方法和用途
US11185568B2 (en) 2017-04-14 2021-11-30 President And Fellows Of Harvard College Methods for generation of cell-derived microfilament network
US20180320173A1 (en) * 2017-05-05 2018-11-08 Scipio Bioscience Methods for trapping and barcoding discrete biological units in hydrogel
CN107141431B (zh) * 2017-05-23 2019-07-02 华东理工大学 一种高力学性能的自修复水凝胶及其合成方法
WO2018218150A1 (fr) 2017-05-26 2018-11-29 President And Fellows Of Harvard College Systèmes et méthodes de criblage à base d'image à haut débit
US20180355121A1 (en) * 2017-06-13 2018-12-13 Uvic Industry Partnerships Inc. Multifunctional microcarriers with thermo-responsive biomaterial coating and use thereof
CN107362130B (zh) * 2017-07-19 2021-03-02 曲阜师范大学 一种铜纳米粒凝胶载药系统及其制备方法和应用
CN107375253A (zh) * 2017-08-16 2017-11-24 海南大学 一种适配体图案化的壳聚糖凝胶膜其制备方法及应用
CN107602891B (zh) * 2017-09-08 2020-11-03 哈尔滨工业大学 复合pnipam基微凝胶pdms膜的制备方法
CN109554331B (zh) * 2017-09-27 2022-09-27 清华大学 L-核酸水凝胶
CN107541510A (zh) * 2017-09-29 2018-01-05 天津大学 枝状基因簇纳米材料及制备方法及应用
US11642642B2 (en) 2017-10-17 2023-05-09 University Of Wyoming Exploiting oxygen inhibited photopolymerization within emulsion droplets for the fabrication of microparticles with customizable properties
CN107753949B (zh) * 2017-11-29 2020-10-16 深圳大学 黑磷纳米片、复合水凝胶及其制备方法与应用
WO2019164450A1 (fr) * 2018-02-22 2019-08-29 Nanyang Technological University Complexe, hydrogel et méthode
CN108525616B (zh) * 2018-03-16 2020-08-18 天津大学 稀土核苷荧光水凝胶及制备方法和在荧光编码中的应用
KR102023839B1 (ko) * 2018-03-28 2019-09-20 포항공과대학교 산학협력단 분지된 dna, 압타머를 포함하는 고효율 압타머 복합체 및 이의 용도
CN108484938A (zh) * 2018-03-30 2018-09-04 东华大学 一种高强度双重响应性纳米复合双网络水凝胶及其制备方法
CN108676769B (zh) * 2018-04-24 2022-09-23 武汉仝干医疗科技股份有限公司 一种促进肝细胞生长的无纺布支架材料及其制备方法
CN110531065B (zh) * 2018-05-25 2022-08-30 清华大学深圳研究生院 一种基于水凝胶的微量全血分离和血浆检测一体化微流控芯片
EP3836967A4 (fr) 2018-07-30 2022-06-15 ReadCoor, LLC Procédés et systèmes de traitement ou d'analyse d'échantillons
WO2020076976A1 (fr) 2018-10-10 2020-04-16 Readcoor, Inc. Indexation moléculaire spatiale tridimensionnelle
CN109821075B (zh) * 2019-01-07 2020-09-08 华中科技大学 一种生物材料及其制备方法与作为骨缺损修复材料的应用
CN109777015B (zh) * 2019-01-22 2021-04-13 青岛大学 一种peg接枝聚合物的发光水凝胶材料的制备方法
CN110006871A (zh) * 2019-02-20 2019-07-12 常州大学 一个基于外源性组胺检测的细胞模型以及应用
CN109796979B (zh) * 2019-03-07 2021-09-24 合肥工业大学 一种超强铁磁性荧光纳米胶束、制备方法及应用
CN109932353A (zh) * 2019-03-29 2019-06-25 辽宁大学 一种特异性检测Cr3+的表面增强拉曼光谱基底及其制备方法和应用
CN111593052A (zh) * 2019-04-28 2020-08-28 华东理工大学 一种rna检测与定量的方法
CN110180026B (zh) * 2019-06-27 2021-02-09 清华-伯克利深圳学院筹备办公室 一种生物支架及其制备方法和应用
US12252582B2 (en) 2019-08-29 2025-03-18 University Of Delaware Biofunctional thiophene monomers and polymers thereof for electronic biomedical devices
CN111040198B (zh) * 2019-12-30 2021-08-17 苏州珀罗汀生物技术有限公司 Dna水凝胶、其制备方法及应用
WO2021138588A1 (fr) * 2020-01-03 2021-07-08 Repertoire Immune Medicines, Inc. Compositions d'hydrogels et leurs procédés d'utilisation
CN111187806B (zh) * 2020-01-09 2021-01-08 中国人民解放军陆军军医大学第一附属医院 一种基于3D DNA纳米网状结构双信号放大技术的microRNA检测方法
GB202001501D0 (en) 2020-02-04 2020-03-18 Fabricnano Ltd Nucleic acid nanostructures
CN113292463A (zh) * 2020-02-21 2021-08-24 京东方科技集团股份有限公司 交联配体、纳米粒子层图案化的方法、量子点发光器件及显示装置
CA3168341A1 (fr) * 2020-02-21 2021-08-26 Zachary BOLDUC Dispositifs et methodes phototherapeutiques
CN111676022B (zh) * 2020-04-24 2021-03-02 浙江海洋大学 修复土壤重金属污染的方法
GB202007428D0 (en) 2020-05-19 2020-07-01 Fabricnano Ltd Polynucleotide synthesis
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants
CN112516323B (zh) * 2020-12-24 2023-05-12 中国药科大学 一种光交联壳聚糖-甲基丙烯酸纳米粒子的制备方法
CN112851842B (zh) * 2021-01-18 2022-11-29 南京邮电大学 一种小尺寸近红外二区荧光成像造影剂及其制备方法和应用
CN112831066B (zh) * 2021-02-18 2021-11-30 四川大学 具有宽阈值和高灵敏的温敏光子晶体凝胶及制备方法
CN113088518B (zh) * 2021-03-29 2024-05-17 中国药科大学 一种功能性树枝状dna、基于该树枝状dna的纳米传感探针及该纳米传感探针的应用
CN115192513A (zh) 2021-04-09 2022-10-18 清华大学 降低细胞剪切损伤的细胞凝胶制剂以及降低细胞剪切损伤的方法
GB2607588A (en) * 2021-06-04 2022-12-14 4D Medicine Ltd Biodegradable polymers
CN114790377B (zh) * 2021-06-08 2023-06-16 天津大学 一种超支化的聚合物压敏胶及其制备方法和应用
GB202110595D0 (en) 2021-07-22 2021-09-08 Fabricnano Ltd Functionalised nucleic acid structure
CN113856573B (zh) * 2021-11-08 2023-09-01 国科温州研究院(温州生物材料与工程研究所) 一种用于dPCR法核酸检测的光响应性凝胶微球及其在奇异变形杆菌检测中的应用
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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5449602A (en) * 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
US5563056A (en) * 1992-02-13 1996-10-08 Bsi Corporation Preparation of crosslinked matrices containing covalently immobilized chemical species and unbound releasable chemical species
US20020086989A1 (en) * 1997-08-15 2002-07-04 Patrick E. Guire Photoactivatable nucleic acid derivatives
US6664061B2 (en) * 1999-06-25 2003-12-16 Amersham Biosciences Ab Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
US6893822B2 (en) * 2001-07-19 2005-05-17 Nanogen Recognomics Gmbh Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
US20070148246A1 (en) * 2005-08-11 2007-06-28 Dan Luo Nucleic Acid-Based Matrixes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE500503C2 (sv) * 1990-12-07 1994-07-04 Inst Polymerutveckling Ab Förfarande och bestrålningsenhet för kontinuerlig tvärbindning av polyeten
US6072044A (en) * 1996-04-26 2000-06-06 New York University Nanoconstructions of geometrical objects and lattices from antiparallel nucleic acid double crossover molecules
US6255469B1 (en) * 1998-05-06 2001-07-03 New York University Periodic two and three dimensional nucleic acid structures
US7223544B2 (en) * 2003-06-27 2007-05-29 Cornell Research Foundation, Inc. Nucleic acid-engineered materials
US7842793B2 (en) * 2005-06-14 2010-11-30 The California Institute Of Technology Methods of making nucleic acid nanostructures
US8486621B2 (en) * 2005-08-11 2013-07-16 Cornell Research Foundation, Inc. Nucleic acid-based matrixes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5449602A (en) * 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
US5563056A (en) * 1992-02-13 1996-10-08 Bsi Corporation Preparation of crosslinked matrices containing covalently immobilized chemical species and unbound releasable chemical species
US20020086989A1 (en) * 1997-08-15 2002-07-04 Patrick E. Guire Photoactivatable nucleic acid derivatives
US6664061B2 (en) * 1999-06-25 2003-12-16 Amersham Biosciences Ab Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
US6893822B2 (en) * 2001-07-19 2005-05-17 Nanogen Recognomics Gmbh Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
US20070148246A1 (en) * 2005-08-11 2007-06-28 Dan Luo Nucleic Acid-Based Matrixes

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JIANQUAN LIU ET AL.: "Template-directed Photoligation of Oligodeoxyribonucleotides via 4-Thiothymidine", NUCLEIC ACIDS RESEARCH, vol. 26, no. 13, 1998, pages 3300 - 3304, XP002988079 *
KENZO FUJIMOTO ET AL.: "Reversible DNA Photocircularization on Triple Helix: Effect of Vinyl Substituent on Base Stacking", TETRAHEDRON LETTERS, vol. 41, 2000, pages 7897 - 7900, XP004235895 *
KENZO FUJIMOTO ET AL.: "Template-Directed Photoreversible Ligation of Deoxyoligonucleotides via 5-Vinyldeoxyuridine", J. AM. CHEM. SOC., vol. 122, 2000, pages 5646 - 5647, XP008142896 *
N. A. LEBEDEVA ET AL.: "Interaction of Replication Protein A with Photoreactive DNA Structures", BIOCHEMISTRY(MOSCOW), vol. 69, no. 2, 2004, pages 1727 - 1736, XP008142892 *
NATALIA DEMESHKIN ET AL.: "Nucleotides of 18S rRNA Surrounding mRNA Codons at the Human Ribosomal A, P, and E Sites: A Crosslinking Study with mRNA Analogs Carrying an Aryl Azide Group at Either the Uracil or the Guanine Residue", RNA, vol. 6, 2000, pages 1727 - 1736, XP008142880 *
See also references of EP2324045A4 *

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US20120040397A1 (en) 2012-02-16
EP2324045A2 (fr) 2011-05-25

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