WO2010088667A1 - Crèmes topiques améliorées - Google Patents
Crèmes topiques améliorées Download PDFInfo
- Publication number
- WO2010088667A1 WO2010088667A1 PCT/US2010/022884 US2010022884W WO2010088667A1 WO 2010088667 A1 WO2010088667 A1 WO 2010088667A1 US 2010022884 W US2010022884 W US 2010022884W WO 2010088667 A1 WO2010088667 A1 WO 2010088667A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- weight
- camphor
- phenol
- menthol
- acne
- Prior art date
Links
- 230000000699 topical effect Effects 0.000 title claims abstract description 24
- 239000006071 cream Substances 0.000 title abstract description 12
- 206010000496 acne Diseases 0.000 claims abstract description 41
- 208000002874 Acne Vulgaris Diseases 0.000 claims abstract description 34
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims abstract description 26
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims abstract description 23
- 241000723346 Cinnamomum camphora Species 0.000 claims abstract description 23
- 229960000846 camphor Drugs 0.000 claims abstract description 23
- 229930008380 camphor Natural products 0.000 claims abstract description 23
- 238000002360 preparation method Methods 0.000 claims abstract description 23
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 20
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229940041616 menthol Drugs 0.000 claims abstract description 20
- 239000003974 emollient agent Substances 0.000 claims abstract description 15
- 230000003750 conditioning effect Effects 0.000 claims description 6
- 206010013786 Dry skin Diseases 0.000 claims description 3
- 206010040849 Skin fissures Diseases 0.000 claims description 2
- 229960003742 phenol Drugs 0.000 abstract description 4
- 210000003491 skin Anatomy 0.000 description 20
- 210000002374 sebum Anatomy 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 7
- 238000011282 treatment Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 6
- 210000001732 sebaceous gland Anatomy 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 208000035475 disorder Diseases 0.000 description 5
- 241001635598 Enicostema Species 0.000 description 4
- 206010027626 Milia Diseases 0.000 description 4
- 239000003205 fragrance Substances 0.000 description 4
- 230000003902 lesion Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 210000004927 skin cell Anatomy 0.000 description 4
- 208000017520 skin disease Diseases 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 239000004264 Petrolatum Substances 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 229940066842 petrolatum Drugs 0.000 description 3
- 235000019271 petrolatum Nutrition 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 239000002884 skin cream Substances 0.000 description 3
- 208000020154 Acnes Diseases 0.000 description 2
- 102000011782 Keratins Human genes 0.000 description 2
- 108010076876 Keratins Proteins 0.000 description 2
- 230000003255 anti-acne Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000037336 dry skin Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- -1 oetyiadodeeanol Chemical compound 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- LQIAZOCLNBBZQK-UHFFFAOYSA-N 1-(1,2-Diphosphanylethyl)pyrrolidin-2-one Chemical compound PCC(P)N1CCCC1=O LQIAZOCLNBBZQK-UHFFFAOYSA-N 0.000 description 1
- JNTZUDRDSUSKQT-UHFFFAOYSA-N C1(=CC=CC=C1)O.C1(CC(C(CC1)C(C)C)O)C.C12(C(=O)CC(CC1)C2(C)C)C Chemical compound C1(=CC=CC=C1)O.C1(CC(C(CC1)C(C)C)O)C.C12(C(=O)CC(CC1)C2(C)C)C JNTZUDRDSUSKQT-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 206010040954 Skin wrinkling Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 241000221484 Tilletiaceae Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 229940082483 carnauba wax Drugs 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 231100000547 follicle rupture Toxicity 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 229940059904 light mineral oil Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 229940105132 myristate Drugs 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 229940056211 paraffin Drugs 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229940057874 phenyl trimethicone Drugs 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000003860 topical agent Substances 0.000 description 1
- 229940100611 topical cream Drugs 0.000 description 1
- LINXHFKHZLOLEI-UHFFFAOYSA-N trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1 LINXHFKHZLOLEI-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 229940045860 white wax Drugs 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Definitions
- the present invention relates to improved topical creams, Preferably, these creams are anti-acne creams * face creams and body skin creams.
- these creams are anti-acne creams * face creams and body skin creams.
- acne is a dermatologicat disorder that affects 20 to 25 million
- acne produces a hypersecretion of the sebaceous glands
- substances having a seboreguialing. or seboinhibiting activity fOOO ⁇
- a ⁇ ti-microbial agents are often used. These compounds have been useful since all are active against the principle germs associated with acne, such as staphylococcus aureas, staphylococcus albus and especially eorynebaeterium acnes and Propionbacterium granules um.
- the lesions associated with acne are the result of the rupture of a sebaceous follicle.
- the lesions When the rapture is followed by inflammation and pus, the lesions is known as a whitehead.
- the rupture is followed by the accumulation of clogged material in the sebaceous follicle and the lesion is then known as a blackhead.
- This is caused by (he plugging of the upper portion of tire follicle, i.e., the pore, into which ⁇ sebum is secreted.
- the pore is in direct communication with the skin surface and may be clogged by cells, sebum, bacteria and other debris.
- the plugged sebaceous gland continues to produce sebum, stretching the mfundibulurn until the pore or a lower portion of the follicle ruptures.
- the present invention provides other benefits for the skin, such as improving texture and feei.
- the present invention relates to cosmetic and/or derraatologieal medicated compositions and methods for treatment of acne and its improvement and maintenance, together with conditioning of human skin, by improving texture and feel, which include those for regulating sebum on facial and the body skin of a human subject prowling cosmetic and or therapeutic benefits.
- the topical agents work by normalizing the skin's production of keratin and the sebaceous gland's production of sebum, thereby preventing obstruction of the follicle while at the .same time attacking the mature pimples, blackheads- whiteheads, redness and dead skin cells to be exfoliated, and cleansing while nourishing and moisturizing the skin.
- the skin becomes supple, soft, smooth and fcels good.
- the present, invention through a blend of oils and compounds and extracts advantageously treats acne without any adverse effect, and conditions skin cells io reduce the likelihood of further acne.
- Hie present invention provides such a topical treatment and in addition contains a skin cell conditioning and repairing component in an amount sufficient to properly regulate the sebum in the sebaceous glands and keratin production of the skm ceils as long as this topical invention is massaged well onto the skin and is consistently applied as directed,
- lite present invention envisions three products:
- Product I anti-acne cream composition for the healing, reduction and prevention of acne and for conditioning the skin cells that are inflicted with disorders, for men, women and teenagers;
- Product II - lace cream for the purpose of conditioning skin, and preventing acne and other disorders while toning, moisturizing and softening skin, for men, women and teenagers;
- Product 111 body skin cream, for prevention, maintenance, conditioning and moisturizing of chapped, dry skin, for men. women and teenagers.
- Products comprise a base of an oleaginous base and emollient.
- the concentration of camphor is greater than the concentration of phenol by weight, with the concentration of menthol by weight being about not less than the concentration of phenol and about no greater than die concentration of camphor. More preferably, the concentration of camphor is about twice the concentration of phenol by weight, and the concentration of menthol is about 60% the concentration of camphor by weight.
- the above Products are topical cosmetic and/or dermatologies! medicated skin treatments. They include an acne healing and reducing component in an amount sufficient to reduce the swelling, redness and blemishes associated with acne as well as unplugging whiteheads and blackheads on the skin. They also control, exfoliate, clean, moisturize, tone and improve the condition and appearance of human skin, In addition to the acne healing and reducing component, the above products or formulations also include oleaginous base. They can be used to treat, heal and reduce acne as well as improve she condition and appearance of skin.
- a 4 gram preparation contains about 1 % camphor by weight ⁇ eg., about ,04g) about i),6% menthol by weight (e.g., about .024g) and about 0.5% phenol by weight (e.g., aboui .02g).
- the remainder comprises an oleaginous base such as petrolatum and emollients.
- the emollients can be selected from the group consisting of cocoa butter, lanolin, light mineral oil, white wax, carnauba wax. araehidyl propionate, atyl alcohol, tsopt'ophyl myristate.
- isopropyl ianolate methylparaben, oetyiadodeeanol, oleyl alcohol, paraffin, phenyl trimethicone or propyl paraben, or mixtures thereof. Fragrance can also be added.
- the concentration of emollient is preferably greater than the concentration of oleaginous base. More preferably, the base of Product I contains about 40% by weight of oleaginous base and about 60% by weight emollient, More preferably, Product I contains about 45% oleaginous base with the remainder comprising emollient, camphor, menthol, phenol and other optional ingredients.
- Product 1 can be massaged onto the skin, optionally with additional amounts added to acne infection, like cysts and mature pimples, 3 to 5 times a day until the face is cleared.
- Product t can also be used to heal cuts, soothe rwuor bunts and stop minor burns from graduating into blisters when applied soon after the bum.
- Product II discussed more MIy below, can be used as a preventative.
- Product U of the instant invention is a face cream.
- ft contains the .same active ingredients (about Mg camphor, about ,024g menthol and about ,02g phenol) as Product I, except they are in a total weight of 28 grams of Product and thus are more diluted.
- Ilie remaining weight is oleaginous base such as petrolatum and emollients, with fragrance optional.
- Product 31 will contain about .(M)14% by weight camphor, about .0009% by weight menthol and about .0007% by weight phenol.
- Product Il preferably contains more oleaginous base than Product I. More preferably.
- Product H contains about 55% by weight oleaginous base, with the remainder comprising the rest of the ingredients.
- Product J Us a normal face cream and is used for normal or troubled skin to exfoliate, cleanse, moisturize, (one, maintain, condition, prevent and reduce acne, dry skin, wrinkles and other skin disorders. It can also be used to prevent water loss, heal cuts and keep dry shaved skin supple, moisturized and toned. It can be applied when needed, typically 1-2 times a day.
- Product III also contains about .04g camphor, about ,024g menthol and about ,02g phenol, these ingredients would be contained in about 36 grams of product. Again, as was the ease with Product U, the remaining weight comprises oleaginous base such as petrolatum, emollients and optionally fragrance. Thus, Product HI will contain about ,0013% by weight camphor, about .00007% by weight menthol and about .00006% by weight phenol.
- Product Ul preferably contains more oleaginous base than Product I or Product IL
- Product 111 contains about 65-70% by weight oleaginous base, with the remainder comprising the rest of the ingredients.
- Product IH is used for the maintenance of body skin, leaving a moist and healthy feei. It also helps prevent chapped skin. Product IH can also be used as a make-up remover. Product JII can be applied when needed, for example multiple times a day, daily or weekly, [00023]
- the above Products can be compounded via any traditional technique.
- the camphor, menthol and phenol are mixed together first, '(-hey can then be added to the oleaginous base with emollients and other ingredients (e.g., fragrance) added later or the oleaginous base and emollients can be mixed together first and men camphor-menthol-phenol mixture added to that.
- the other ingredient can be added at any time.
- the other ingredient can be added at any time.
- some lightening of the skin might occur, although this is not a frequent or severe event.
- the above topical preparations can contain other ingredients.
- the preparation also contaias sun screen.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
La présente invention concerne des crèmes topiques améliorées. Ces crèmes comprennent une base oléagineuse et un émollient et contiennent également du camphre, du menthol et du phénol. Ces préparations sont utiles par exemple pour traiter l'acné.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14903609P | 2009-02-02 | 2009-02-02 | |
US61/149,036 | 2009-02-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2010088667A1 true WO2010088667A1 (fr) | 2010-08-05 |
Family
ID=42396081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/022884 WO2010088667A1 (fr) | 2009-02-02 | 2010-02-02 | Crèmes topiques améliorées |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2010088667A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9623062B2 (en) * | 2014-06-27 | 2017-04-18 | Jeju National University Industryacademic Cooperation Foundation | Anti-ageing activity of camphor in fibroblast cell line |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4970216A (en) * | 1986-03-17 | 1990-11-13 | Richardson Vicks, Inc. | Skin treatment composition and method |
US5961997A (en) * | 1997-03-25 | 1999-10-05 | Swinehart; James M. | Antipruritic composition |
US20050042196A1 (en) * | 2003-06-03 | 2005-02-24 | Ian Askill | Antimicrobial phenol containing cyanoacrylate compositions |
US20070142317A1 (en) * | 2003-12-29 | 2007-06-21 | Qlt Usa, Inc. | Topical composition for treatment of skin disorders |
-
2010
- 2010-02-02 WO PCT/US2010/022884 patent/WO2010088667A1/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4970216A (en) * | 1986-03-17 | 1990-11-13 | Richardson Vicks, Inc. | Skin treatment composition and method |
US5961997A (en) * | 1997-03-25 | 1999-10-05 | Swinehart; James M. | Antipruritic composition |
US20050042196A1 (en) * | 2003-06-03 | 2005-02-24 | Ian Askill | Antimicrobial phenol containing cyanoacrylate compositions |
US20070142317A1 (en) * | 2003-12-29 | 2007-06-21 | Qlt Usa, Inc. | Topical composition for treatment of skin disorders |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9623062B2 (en) * | 2014-06-27 | 2017-04-18 | Jeju National University Industryacademic Cooperation Foundation | Anti-ageing activity of camphor in fibroblast cell line |
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