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WO2010065329A3 - Nanoparticles for cancer treatment - Google Patents

Nanoparticles for cancer treatment Download PDF

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Publication number
WO2010065329A3
WO2010065329A3 PCT/US2009/065172 US2009065172W WO2010065329A3 WO 2010065329 A3 WO2010065329 A3 WO 2010065329A3 US 2009065172 W US2009065172 W US 2009065172W WO 2010065329 A3 WO2010065329 A3 WO 2010065329A3
Authority
WO
WIPO (PCT)
Prior art keywords
nanoparticles
cancer treatment
composition
isothiocyanate
methods
Prior art date
Application number
PCT/US2009/065172
Other languages
French (fr)
Other versions
WO2010065329A2 (en
Inventor
Peng Huang
Gang Chan
Michael J. Keating
Dunyaporn Trachootham
Original Assignee
The Board Of Regents Of The University Of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Regents Of The University Of Texas System filed Critical The Board Of Regents Of The University Of Texas System
Publication of WO2010065329A2 publication Critical patent/WO2010065329A2/en
Publication of WO2010065329A3 publication Critical patent/WO2010065329A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Optics & Photonics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Methods and composition for improving therapeutic potential of isothiocyanate. For example, in certain aspects methods for preparing a composition containing an isothiocyanate nanoparticle formulation and uses thereof are described. Furthermore, the invention provides such a composition.
PCT/US2009/065172 2008-11-25 2009-11-19 Nanoparticles for cancer treatment WO2010065329A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11769608P 2008-11-25 2008-11-25
US61/117,696 2008-11-25

Publications (2)

Publication Number Publication Date
WO2010065329A2 WO2010065329A2 (en) 2010-06-10
WO2010065329A3 true WO2010065329A3 (en) 2010-09-16

Family

ID=42233794

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/065172 WO2010065329A2 (en) 2008-11-25 2009-11-19 Nanoparticles for cancer treatment

Country Status (1)

Country Link
WO (1) WO2010065329A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20121407A1 (en) * 2012-08-07 2014-02-08 Consorzio Interuniversitario Nazion Ale Per La Sci POLYAMIDOAMINE NANOGELES
CN105267967B (en) * 2014-07-18 2021-05-18 无锡杰西医药股份有限公司 Combined application of isothiocyanate compounds and anti-cancer drugs acting on or influencing DNA (deoxyribonucleic acid)
CN104415332B (en) * 2013-08-20 2019-05-17 无锡杰西医药科技有限公司 Isosulfocyanate compound and the use in conjunction of kinase inhibitors drug in cancer treatment
EP3034076B1 (en) * 2013-08-13 2020-09-30 JC (Wuxi) COMPANY, Inc. Combined application of isothiocyanate compound and anti-cancer medicine
WO2016141167A1 (en) 2015-03-03 2016-09-09 Cureport, Inc. Combination liposomal pharmaceutical formulations
JP2018507227A (en) 2015-03-03 2018-03-15 キュアポート インコーポレイテッド Liposome drug formulation with two drugs
CN107007578A (en) * 2017-02-27 2017-08-04 新乡医学院 Application of the sulforaphane in treatment leukemia medicament is prepared
RU2721771C1 (en) * 2019-04-19 2020-05-22 Общество с ограниченной ответственностью "ИННОКОЛЛОИД" Use of composition of copper oxide nanoparticles and n-acetylcysteine for death induction of cells of chronic myeloid leukaemia
CN110538173A (en) * 2019-08-20 2019-12-06 郑州大学第一附属医院 Application of isothiocyanate compounds in the preparation of targeted drugs for esophageal cancer
US20230149420A1 (en) * 2020-03-25 2023-05-18 Scent Science International Inc. Anti-inflammatory immunoenhancer
US20230150932A1 (en) * 2020-04-23 2023-05-18 Vio Chemicals Ag Compositions for stabilizing an isothiocyanate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070292512A1 (en) * 2006-06-09 2007-12-20 Merrion Research Ii Limited Solid Oral Dosage Form Containing an Enhancer
US20080176942A1 (en) * 2007-01-23 2008-07-24 Pharmagra Labs, Inc. Stabilized sulforaphane

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070292512A1 (en) * 2006-06-09 2007-12-20 Merrion Research Ii Limited Solid Oral Dosage Form Containing an Enhancer
US20080176942A1 (en) * 2007-01-23 2008-07-24 Pharmagra Labs, Inc. Stabilized sulforaphane

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KIRAN DHARMALA ET AL.: "Development of Chitosan-SLN Microparticles for chemot herapy: In vitro approach through efflux-transporter modulation.", J.CONTROL. REL., vol. 131, 3 August 2008 (2008-08-03), pages 190 - 197 *

Also Published As

Publication number Publication date
WO2010065329A2 (en) 2010-06-10

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