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WO2010065079A3 - Antibodies to il-6 and use thereof - Google Patents

Antibodies to il-6 and use thereof Download PDF

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Publication number
WO2010065079A3
WO2010065079A3 PCT/US2009/006274 US2009006274W WO2010065079A3 WO 2010065079 A3 WO2010065079 A3 WO 2010065079A3 US 2009006274 W US2009006274 W US 2009006274W WO 2010065079 A3 WO2010065079 A3 WO 2010065079A3
Authority
WO
WIPO (PCT)
Prior art keywords
elevated
antibody
proteιn
πsk
coagulants
Prior art date
Application number
PCT/US2009/006274
Other languages
French (fr)
Other versions
WO2010065079A2 (en
Inventor
Leon Garcia - Martinez
Anne Elisabeth Carvalho Jensen
Katie Olson
Ben Dutzar
John Latham
Brian Kovacevich
Jeffrey T.L. Smith
Mark Litton
Randall Schatzman
Original Assignee
Alder Biopharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/366,567 external-priority patent/US8062864B2/en
Priority claimed from US12/391,717 external-priority patent/US8178101B2/en
Priority claimed from US12/399,156 external-priority patent/US20090238825A1/en
Priority claimed from US12/502,581 external-priority patent/US8323649B2/en
Priority to EA201100641A priority Critical patent/EA201100641A1/en
Priority to NZ592516A priority patent/NZ592516A/en
Priority to AU2009323009A priority patent/AU2009323009B2/en
Priority to MX2014008792A priority patent/MX364874B/en
Priority to EP09830697.0A priority patent/EP2367570B1/en
Priority to MX2011005411A priority patent/MX2011005411A/en
Application filed by Alder Biopharmaceuticals, Inc. filed Critical Alder Biopharmaceuticals, Inc.
Priority to CN200980155120.6A priority patent/CN102292106B/en
Priority to EP17194768.2A priority patent/EP3338799B1/en
Priority to SG2011037496A priority patent/SG171804A1/en
Priority to BRPI0921569A priority patent/BRPI0921569A2/en
Priority to NO09830697A priority patent/NO2367570T3/no
Priority to CA2744400A priority patent/CA2744400C/en
Priority to JP2011537437A priority patent/JP5898496B2/en
Publication of WO2010065079A2 publication Critical patent/WO2010065079A2/en
Publication of WO2010065079A3 publication Critical patent/WO2010065079A3/en
Priority to IL212728A priority patent/IL212728B/en
Priority to ZA2011/03803A priority patent/ZA201103803B/en
Priority to IL257290A priority patent/IL257290A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Abstract

Disclosed are therapeutic methods using IL-6 antagonists such as an Ab 1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof Patients will preferably comprise those exhibiting (or at πsk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related proteιn(s), cachexia, fever, weakness and/or fatigue prior to treatment The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others
PCT/US2009/006274 2008-11-25 2009-11-24 Antibodies to il-6 and use thereof WO2010065079A2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
BRPI0921569A BRPI0921569A2 (en) 2008-11-25 2009-11-24 antibodies to il-6 and their use
NO09830697A NO2367570T3 (en) 2008-11-25 2009-11-24
CA2744400A CA2744400C (en) 2008-11-25 2009-11-24 Antibodies to il-6 and use thereof
JP2011537437A JP5898496B2 (en) 2008-11-25 2009-11-24 Antibodies against IL-6 and uses thereof
SG2011037496A SG171804A1 (en) 2008-11-25 2009-11-24 Antibodies to il-6 and use thereof
AU2009323009A AU2009323009B2 (en) 2008-11-25 2009-11-24 Antibodies to IL-6 and use thereof
MX2014008792A MX364874B (en) 2008-11-25 2009-11-24 Antibodies to il-6 and use thereof.
EP09830697.0A EP2367570B1 (en) 2008-11-25 2009-11-24 Antibodies to il-6 and use thereof
MX2011005411A MX2011005411A (en) 2008-11-25 2009-11-24 Antibodies to il-6 and use thereof.
EA201100641A EA201100641A1 (en) 2008-11-25 2009-11-24 ANTIBODIES TO IL-6 AND THEIR APPLICATION
CN200980155120.6A CN102292106B (en) 2008-11-25 2009-11-24 IL-6 antibody and uses thereof
EP17194768.2A EP3338799B1 (en) 2008-11-25 2009-11-24 Antibodies to il-6 and use thereof
NZ592516A NZ592516A (en) 2008-11-25 2009-11-24 Antibodies to il-6 and use thereof
IL212728A IL212728B (en) 2008-11-25 2011-05-05 Antibodies to il-6 and use thereof
ZA2011/03803A ZA201103803B (en) 2008-11-25 2011-05-24 Antibodies to il-6 and use thereof
IL257290A IL257290A (en) 2008-11-25 2018-02-01 Antibodies to il-6 and use thereof

Applications Claiming Priority (16)

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US11783908P 2008-11-25 2008-11-25
US11786108P 2008-11-25 2008-11-25
US11781108P 2008-11-25 2008-11-25
US61/117,839 2008-11-25
US61/117,861 2008-11-25
US61/117,811 2008-11-25
US12/366,567 US8062864B2 (en) 2007-05-21 2009-02-05 Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US12/366,567 2009-02-05
US39161509A 2009-02-24 2009-02-24
US12/391,717 US8178101B2 (en) 2007-05-21 2009-02-24 Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
US12/391,717 2009-02-24
US12/391,615 2009-02-24
US12/399,156 2009-03-06
US12/399,156 US20090238825A1 (en) 2007-05-21 2009-03-06 Novel rabbit antibody humanization methods and humanized rabbit antibodies
US12/502,581 2009-07-14
US12/502,581 US8323649B2 (en) 2008-11-25 2009-07-14 Antibodies to IL-6 and use thereof

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WO2010065079A3 true WO2010065079A3 (en) 2010-07-29

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PCT/US2009/006266 WO2010065077A2 (en) 2008-11-25 2009-11-24 Antagonists of il-6 to prevent or treat thrombosis
PCT/US2009/006274 WO2010065079A2 (en) 2008-11-25 2009-11-24 Antibodies to il-6 and use thereof
PCT/US2009/006257 WO2010065072A1 (en) 2008-11-25 2009-11-24 Antagonists of il-6 to raise albumin and/or lower crp
PCT/US2009/006273 WO2010065078A1 (en) 2008-11-25 2009-11-24 Antagonists of il-6 to prevent or treat cachexia, weakness, fatigue and/or fever

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PCT/US2009/006266 WO2010065077A2 (en) 2008-11-25 2009-11-24 Antagonists of il-6 to prevent or treat thrombosis

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PCT/US2009/006257 WO2010065072A1 (en) 2008-11-25 2009-11-24 Antagonists of il-6 to raise albumin and/or lower crp
PCT/US2009/006273 WO2010065078A1 (en) 2008-11-25 2009-11-24 Antagonists of il-6 to prevent or treat cachexia, weakness, fatigue and/or fever

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JP (9) JP5832291B2 (en)
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CN (5) CN102292106B (en)
AR (1) AR074227A1 (en)
AU (5) AU2009323002B2 (en)
BR (1) BRPI0921569A2 (en)
CA (1) CA2744400C (en)
DK (1) DK3338799T3 (en)
EA (1) EA201100641A1 (en)
HK (1) HK1256622A1 (en)
IL (2) IL212728B (en)
MX (7) MX2011005411A (en)
NO (1) NO2367570T3 (en)
NZ (2) NZ592516A (en)
SG (1) SG171804A1 (en)
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9187560B2 (en) 2008-11-25 2015-11-17 Alderbio Holdings Llc Antagonists of IL-6 to treat cachexia, weakness, fatigue, and/or fever
US9241990B2 (en) 2007-05-21 2016-01-26 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRIP
US9265825B2 (en) 2008-11-25 2016-02-23 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US9304134B2 (en) 2010-11-23 2016-04-05 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of anemia
US9546213B2 (en) 2007-05-21 2017-01-17 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2892925T3 (en) 2006-03-31 2022-02-07 Chugai Pharmaceutical Co Ltd Methods for monitoring the blood pharmacokinetics of antibodies
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
LT3187506T (en) 2007-05-21 2019-04-25 Alderbio Holdings Llc Antibodies to il-6 and use thereof
US8252286B2 (en) 2007-05-21 2012-08-28 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US8178101B2 (en) 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
TWI563002B (en) 2007-09-26 2016-12-21 Chugai Pharmaceutical Co Ltd Antibody constant region mutant
ES2595638T3 (en) 2007-09-26 2017-01-02 Chugai Seiyaku Kabushiki Kaisha Method to modify the isoelectric point of an antibody by replacing amino acids in a CDR
NZ602884A (en) 2008-04-11 2014-08-29 Chugai Pharmaceutical Co Ltd Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
TWI440469B (en) 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
US8323649B2 (en) 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
US8992920B2 (en) 2008-11-25 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of arthritis
US9212223B2 (en) 2008-11-25 2015-12-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
MX2011005411A (en) * 2008-11-25 2011-06-16 Alder Biopharmaceuticals Inc Antibodies to il-6 and use thereof.
US9452227B2 (en) 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
US8323883B1 (en) 2009-10-09 2012-12-04 Cold Spring Harbor Laboratory Methods of assessing therapeutic benefits of patients having cancers resistant to epidermal growth factor receptor kinase inhibitors
US7947653B1 (en) 2009-10-09 2011-05-24 Cold Spring Harbor Laboratory Methods for treating epidermal growth factor receptor tyrosine kinase inhibitor-resistant cancers
AU2010324739B2 (en) 2009-11-24 2016-05-05 H. Lundbeck A/S. Antibodies to IL-6 and use thereof
US9775921B2 (en) 2009-11-24 2017-10-03 Alderbio Holdings Llc Subcutaneously administrable composition containing anti-IL-6 antibody
JP2012041271A (en) * 2010-08-12 2012-03-01 Univ Of Tokyo Composition having effect of inhibiting thrombogenesis
JP2013541594A (en) 2010-11-08 2013-11-14 ジェネンテック， インコーポレイテッド Anti-IL-6 receptor antibody administered subcutaneously
TWI654203B (en) 2010-11-30 2019-03-21 中外製藥股份有限公司 Antibodies with calcium-dependent antigen binding ability
ES2704848T3 (en) * 2011-10-12 2019-03-20 Sbi Pharmaceuticals Co Ltd Treatment agent and / or prophylactic agent for side effects of cancer drugs
JO3370B1 (en) * 2011-11-10 2019-03-13 Regeneron Pharma Methods of inhibiting tumor growth by antagonizing il-6 receptor
WO2013165791A1 (en) * 2012-05-03 2013-11-07 Boehringer Ingelheim International Gmbh Anti-il-23p19 antibodies
EP3338794B1 (en) * 2012-07-13 2020-02-26 The Trustees of the University of Pennsylvania Toxicity management for anti-tumor activity of cars
EP2875360B1 (en) * 2012-07-20 2018-08-08 Agency For Science, Technology And Research In vitro assay for predicting renal proximal tubular cell toxicity
US10822420B2 (en) * 2012-09-13 2020-11-03 Chugai Seiyaku Kabushiki Kaisha Gene knock-in non-human animal
PT2722341T (en) * 2012-10-22 2018-03-12 Fountain Biopharma Inc Antibodies to interleukin-6 and uses thereof
JP6408492B2 (en) * 2013-02-18 2018-10-17 ヴェジェニクス プロプライエタリー リミテッドＶｅｇｅｎｉｃｓ Ｐｔｙ Ｌｉｍｉｔｅｄ Ligand binding molecules and uses thereof
KR101332836B1 (en) * 2013-05-15 2013-11-27 재단법인 통합의료진흥원 Composition comprising jaeumkanghwa-tang for treatment of breast cancer
JP6442404B2 (en) 2013-06-11 2018-12-19 国立研究開発法人国立精神・神経医療研究センター Method for predicting treatment prognosis in patients with relapsing-remitting multiple sclerosis (RRMS), and method for determining new treatment indication
WO2015054293A1 (en) * 2013-10-07 2015-04-16 Alder Biopharmaceuticals, Inc. Anti-il-6 antibodies for the treatment of psoriatic arthritis
CN103739672B (en) * 2013-12-31 2015-06-10 威特曼生物科技（南京）有限公司 Polyethylene glycol modified polypeptide inhibiting VEGFR2 (vascular endothelial growth factor receptor2) tyrosine kinase and application thereof
EP2926815A1 (en) 2014-04-03 2015-10-07 Institut Curie New derivatives of cephalosporin for treating cancer
JO3663B1 (en) * 2014-08-19 2020-08-27 Merck Sharp & Dohme Anti-lag3 antibodies and antigen-binding fragments
CN104147120A (en) * 2014-09-04 2014-11-19 成都市飞龙水处理技术研究所 Orally-taken traditional Chinese liquid medicine for treating multiple neurofibromatosis and preparation method thereof
CN107074976B (en) * 2014-11-04 2020-10-09 北京韩美药品有限公司 Recombinant fusion protein capable of blocking B7/CD28 and IL6/IL6R/GP130 signal channel simultaneously
EP3263132B1 (en) 2015-02-27 2023-12-06 Chugai Seiyaku Kabushiki Kaisha Composition for treating il-6-related diseases
WO2016186154A1 (en) 2015-05-19 2016-11-24 国立研究開発法人国立精神・神経医療研究センター Method for determining application of novel therapy to multiple sclerosis (ms) patient
JP7128460B2 (en) 2015-06-04 2022-08-31 国立研究開発法人国立精神・神経医療研究センター Psychiatric disorder therapeutic agent containing IL-6 inhibitor as an active ingredient
CN108026582A (en) * 2015-07-31 2018-05-11 米迪缪尼有限公司 Methods for treating hepcidine-mediated disorders
CN105586426B (en) * 2016-03-01 2019-02-26 浙江大学 IL-6 gene rs2069852 locus marker associated with chronic hepatitis B virus infection and its application
KR102055390B1 (en) * 2017-01-06 2019-12-12 경북대학교 산학협력단 Fusion peptide comprising clot-targeting peptide, ferritin fragment and thrombolytic peptide and its uses
CA3051865C (en) 2017-02-01 2023-01-17 Yale University Treatment of diuretic resistance
EP3620531A4 (en) 2017-05-02 2021-03-17 National Center of Neurology and Psychiatry Method for predicting and evaluating therapeutic effect in diseases related to il-6 and neutrophils
US11452707B2 (en) * 2017-08-31 2022-09-27 Hanyi Bio-Technology (Beijing) Co., Ltd. Use of cannabidiol in preparation of drugs for resisting against influenza
US11692037B2 (en) 2017-10-20 2023-07-04 Hyogo College Of Medicine Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion
JP7355319B2 (en) * 2017-11-24 2023-10-03 国立研究開発法人理化学研究所 Anti-fatigue composition containing an IL-1β and/or IL-6 expression inhibitor for preventing and/or improving fatigue caused by intracerebral inflammation and its use
CA3088845A1 (en) * 2018-01-04 2019-07-11 Vitaeris, Inc. Use of anti-il-6 antibody, e.g., clazakizumab for desensitization of solid organ transplant recipients and/or for preventing, stabilizing or reducing antibody mediated rejection (abmr)
MA51584A (en) 2018-01-05 2020-11-11 Corvidia Therapeutics Inc METHODS OF TREATING IL-6 MEDIA INFLAMMATION WITHOUT IMMUNOSUPPRESSION
US20190263931A1 (en) * 2018-01-05 2019-08-29 Immunext Inc. Anti-mct1 antibodies and uses thereof
WO2019164628A1 (en) * 2018-02-26 2019-08-29 The Trustees Of Columbia University In The City Of New York Zinc associated treatment for and diagnosis of cachexia
JP7336717B2 (en) 2018-09-26 2023-09-01 パナソニックＩｐマネジメント株式会社 Opening/closing unit, outlet with opening/closing function, and production method thereof
US11633399B2 (en) 2018-12-25 2023-04-25 Sol-Gel Technologies Ltd. Treatment of skin disorders with compositions comprising an EGFR inhibitor
CN110297093B (en) * 2019-03-18 2022-04-22 山西瑞豪生物科技有限公司 Method and kit for detecting human immunoglobulin G4
BR112022008683A2 (en) 2019-11-05 2022-07-19 Abbvie Inc DOSAGE SCHEMES FOR USE IN THE TREATMENT OF MYELOFIBROSIS AND MPN-RELATED DISORDERS WITH NAVITOCLAX
CN111053909A (en) * 2020-02-27 2020-04-24 南通大学 Application of 2019-nCoV3CL hydrolase inhibitor and IL-6 monoclonal antibody in the preparation of drugs for the treatment of new coronary pneumonia
AU2021236655A1 (en) * 2020-03-18 2022-10-06 Vitaeris Inc. Use of anti-IL-6 antibody, e.g., clazakizumab for treatment/prevention of ARDS associated with coronavirus (COVID-19) infection
CN112098549B (en) * 2020-09-03 2022-11-15 长沙创新药物工业技术研究院有限公司 Method for determining impurity content in arbidol hydrochloride solution
CN112175080B (en) * 2020-10-22 2021-05-25 优睿赛思(武汉)生物科技有限公司 Human interleukin-6 resistant high affinity rabbit monoclonal antibody and application
US20230382990A1 (en) 2020-10-30 2023-11-30 National Cerebral And Cardiovascular Center Therapeutic agent for peripartum cardiomyopathy
WO2022188013A1 (en) * 2021-03-08 2022-09-15 苏州大学 Chemiluminescence-mediated nanoparticle, self-assembled aggregate, preparation method therefor and use thereof
KR20230140518A (en) * 2022-03-24 2023-10-06 (주) 테라베스트 Pharmaceutical composition comprising natural killer cells for treating or preventing degenerative brain disease

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030219839A1 (en) * 2001-09-20 2003-11-27 Katherine Bowdish Anti-PDGF antibodies and methods for producing engineered antibodies
US20040014658A1 (en) * 2000-10-31 2004-01-22 Oren Bogin Active variants of FGF with improved specificity
US6709660B1 (en) * 1998-01-14 2004-03-23 Chrion S.R.L. Meningococcal antigens
WO2004078938A2 (en) * 2003-03-04 2004-09-16 Alexion Pharmaceuticals, Inc. Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof
US20070280941A1 (en) * 2006-05-31 2007-12-06 Junho Chung Vcam-1 specific monoclonal antibody
US7345217B2 (en) * 1998-09-22 2008-03-18 Mendel Biotechnology, Inc. Polynucleotides and polypeptides in plants
US20080075726A1 (en) * 2006-08-03 2008-03-27 Vaccinex, Inc. Anti-IL-6 monoclonal antibodies and uses thereof
US7431927B2 (en) * 2005-03-24 2008-10-07 Epitomics, Inc. TNFα-neutralizing antibodies

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5202422A (en) 1989-10-27 1993-04-13 The Scripps Research Institute Compositions containing plant-produced glycopolypeptide multimers, multimeric proteins and method of their use
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5210075A (en) 1990-02-16 1993-05-11 Tanabe Seiyaku Co., Ltd. Interleukin 6 antagonist peptides
CA2090126C (en) 1990-08-02 2002-10-22 John W. Schrader Methods for the production of proteins with a desired function
WO1992022653A1 (en) 1991-06-14 1992-12-23 Genentech, Inc. Method for making humanized antibodies
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
WO1994021293A1 (en) 1993-03-19 1994-09-29 Duke University Method of treatment of tumors with an antibody binding to tenascin
WO1994028159A1 (en) 1993-05-31 1994-12-08 Chugai Seiyaku Kabushiki Kaisha Reconstructed human antibody against human interleukin-6
EP1624068A1 (en) 1993-06-01 2006-02-08 Life Technologies Inc. Genetic immunization with cationic lipids
WO1996004925A1 (en) 1994-08-12 1996-02-22 Immunomedics, Inc. Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells
US6172042B1 (en) 1995-09-28 2001-01-09 Yeda Research And Development Co. Ltd Synthetic peptides that inhibit IL-6 activity
US6841533B1 (en) 1995-12-07 2005-01-11 Peptor Limited Conformationally constrained backbone cyclized interleukin-6 antagonists
US6653104B2 (en) 1996-10-17 2003-11-25 Immunomedics, Inc. Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells
EP0972780A1 (en) 1998-05-18 2000-01-19 Applied Research Systems ARS Holding N.V. Il-6 antagonist peptides
US7169573B2 (en) * 2001-02-20 2007-01-30 Oklahoma Medical Research Foundation Method for monitoring coagulability and hypercoagulable states
JP2003066047A (en) * 2001-06-14 2003-03-05 Matsushita Electric Ind Co Ltd Immune reaction measuring method and immune reaction measuring reagent used therefor
ES2624547T3 (en) 2001-11-14 2017-07-14 Janssen Biotech, Inc. Anti il 6 antibodies, compositions, methods and uses
KR100468316B1 (en) 2002-01-29 2005-01-27 주식회사 웰진 Peptides increasing the transfer efficiency of DNA into cell or tissue
AU2003264009A1 (en) * 2002-08-15 2004-03-03 Epitomics, Inc. Humanized rabbit antibodies
KR20050058486A (en) 2002-08-30 2005-06-16 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 Human antihuman interleukin-6 antibody and fragment of the antibody
US20050090453A1 (en) 2003-01-15 2005-04-28 Solbec Pharmaceuticals Co., Ltd. Methods of modulating IL-6
JPWO2004101529A1 (en) 2003-05-19 2006-07-13 小野薬品工業株式会社 Nitrogen-containing heterocyclic compound and pharmaceutical use thereof
NZ546557A (en) * 2003-10-17 2010-01-29 Chugai Pharmaceutical Co Ltd Therapeutic agent for mesothelioma comprising interleukin-6
ES2393555T3 (en) 2003-10-22 2012-12-26 Keck Graduate Institute Methods for the synthesis of hetero-multimeric polypeptides in yeasts using a haploid mating strategy.
JP2008504363A (en) * 2004-06-29 2008-02-14 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー Combination therapy using benzamide inhibitor of P2X7 receptor
GB0419424D0 (en) 2004-09-02 2004-10-06 Viragen Scotland Ltd Transgene optimisation
WO2006047639A2 (en) * 2004-10-27 2006-05-04 Medimmune, Inc. Modulation of antibody specificity by tailoring the affinity to cognate antigens
US20080033027A1 (en) * 2005-03-21 2008-02-07 Vicus Therapeutics Spe 1, Llc Drug combination pharmaceutical compositions and methods for using them
JO3058B1 (en) 2005-04-29 2017-03-15 Applied Molecular Evolution Inc Anti-IL-6 Antibodies,Compositions,Methods and uses
PL1960430T3 (en) 2005-12-09 2015-03-31 Ucb Pharma Sa Antibody molecules having specificity for human il-6
WO2008093148A2 (en) * 2005-12-22 2008-08-07 Anaborex, Inc. Compositions and methods for prevention and treatment of cachexia
CA2635615A1 (en) * 2005-12-30 2007-07-12 Merck Patent Gesellschaft Mit Beschraenkter Haftung Anti-il-6 antibodies preventing the binding of il-6 complexed with il-6ralpha to gp130
WO2007120656A2 (en) * 2006-04-10 2007-10-25 Abbott Biotechnology Ltd. Uses and compositions for treatment of rheumatoid arthritis
JP5607357B2 (en) * 2006-05-19 2014-10-15 アルダー・バイオファーマシューティカルズ・インコーポレーテッド Culture method for obtaining a clonal population of antigen-specific B cells
WO2008042611A2 (en) 2006-09-29 2008-04-10 Centocor, Inc. Method of using il6 antagonists with mitoxantrone for prostate cancer
TW200831528A (en) * 2006-11-30 2008-08-01 Astrazeneca Ab Compounds
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
NZ601583A (en) * 2007-05-21 2013-08-30 Bristol Myers Squibb Co Novel rabbit antibody humanization methods and humanized rabbit antibodies
US8178101B2 (en) 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
LT3187506T (en) * 2007-05-21 2019-04-25 Alderbio Holdings Llc Antibodies to il-6 and use thereof
MX2011005411A (en) * 2008-11-25 2011-06-16 Alder Biopharmaceuticals Inc Antibodies to il-6 and use thereof.
US11783908B2 (en) 2019-10-11 2023-10-10 SK Hynix Inc. Stacked semiconductor device and semiconductor system including the same

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6709660B1 (en) * 1998-01-14 2004-03-23 Chrion S.R.L. Meningococcal antigens
US7345217B2 (en) * 1998-09-22 2008-03-18 Mendel Biotechnology, Inc. Polynucleotides and polypeptides in plants
US20040014658A1 (en) * 2000-10-31 2004-01-22 Oren Bogin Active variants of FGF with improved specificity
US20030219839A1 (en) * 2001-09-20 2003-11-27 Katherine Bowdish Anti-PDGF antibodies and methods for producing engineered antibodies
WO2004078938A2 (en) * 2003-03-04 2004-09-16 Alexion Pharmaceuticals, Inc. Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof
US7431927B2 (en) * 2005-03-24 2008-10-07 Epitomics, Inc. TNFα-neutralizing antibodies
US20070280941A1 (en) * 2006-05-31 2007-12-06 Junho Chung Vcam-1 specific monoclonal antibody
US20080075726A1 (en) * 2006-08-03 2008-03-27 Vaccinex, Inc. Anti-IL-6 monoclonal antibodies and uses thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9241990B2 (en) 2007-05-21 2016-01-26 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRIP
US9546213B2 (en) 2007-05-21 2017-01-17 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
US9187560B2 (en) 2008-11-25 2015-11-17 Alderbio Holdings Llc Antagonists of IL-6 to treat cachexia, weakness, fatigue, and/or fever
US9265825B2 (en) 2008-11-25 2016-02-23 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US9304134B2 (en) 2010-11-23 2016-04-05 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of anemia

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