WO2009138999A3 - Process for the preparation of paroxetine hydrochloride - Google Patents
Process for the preparation of paroxetine hydrochloride Download PDFInfo
- Publication number
- WO2009138999A3 WO2009138999A3 PCT/IN2009/000269 IN2009000269W WO2009138999A3 WO 2009138999 A3 WO2009138999 A3 WO 2009138999A3 IN 2009000269 W IN2009000269 W IN 2009000269W WO 2009138999 A3 WO2009138999 A3 WO 2009138999A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- paroxetine
- paroxetine hydrochloride
- preparation
- hydrolysis
- solvent
- Prior art date
Links
- AHOUBRCZNHFOSL-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine Chemical compound C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 title abstract 7
- 229960005183 paroxetine hydrochloride Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- MOJZPKOBKCXNKG-YJBOKZPZSA-N N-methylparoxetine Chemical compound C1([C@@H]2CCN(C[C@H]2COC=2C=C3OCOC3=CC=2)C)=CC=C(F)C=C1 MOJZPKOBKCXNKG-YJBOKZPZSA-N 0.000 abstract 1
- AHWALFGBDFAJAI-UHFFFAOYSA-N phenyl carbonochloridate Chemical compound ClC(=O)OC1=CC=CC=C1 AHWALFGBDFAJAI-UHFFFAOYSA-N 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The present invention relates to process for the preparation of Paroxetine hydrochloride, wherein Paroxetine-N-phenyl carbamate is isolated as a crystalline solid and further subjected to hydrolysis and converted into Paroxetine hydrochloride. According to our present invention N-methyl paroxetine is reacted with phenylchloroformate in the presence of base, solvent or optionally crystallizing in a solvent to give pure Paroxetine-N-phenyl carbamate. It is subjected to hydrolysis in the presence of base to give pharmaceutically acceptable paroxetine hydrochloride salt.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1113/CHE/2008 | 2008-05-06 | ||
| IN1113CH2008 | 2008-05-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2009138999A2 WO2009138999A2 (en) | 2009-11-19 |
| WO2009138999A3 true WO2009138999A3 (en) | 2011-05-26 |
Family
ID=41319135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IN2009/000269 WO2009138999A2 (en) | 2008-05-06 | 2009-05-05 | Process for the preparation of paroxetine hydrochloride |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2009138999A2 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007015262A2 (en) * | 2005-04-25 | 2007-02-08 | Sun Pharmaceutical Industries Limited | A process for the preparation of (-)-trans-4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl)]piperidine |
-
2009
- 2009-05-05 WO PCT/IN2009/000269 patent/WO2009138999A2/en active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007015262A2 (en) * | 2005-04-25 | 2007-02-08 | Sun Pharmaceutical Industries Limited | A process for the preparation of (-)-trans-4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl)]piperidine |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009138999A2 (en) | 2009-11-19 |
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