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WO2009137538A3 - Azoles substitués fongicides - Google Patents

Azoles substitués fongicides Download PDF

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Publication number
WO2009137538A3
WO2009137538A3 PCT/US2009/042922 US2009042922W WO2009137538A3 WO 2009137538 A3 WO2009137538 A3 WO 2009137538A3 US 2009042922 W US2009042922 W US 2009042922W WO 2009137538 A3 WO2009137538 A3 WO 2009137538A3
Authority
WO
WIPO (PCT)
Prior art keywords
substituted azoles
compounds
formula
disclosed
fungicidal substituted
Prior art date
Application number
PCT/US2009/042922
Other languages
English (en)
Other versions
WO2009137538A2 (fr
Inventor
Thomas Paul Selby
James Francis Bereznak
John Joseph Bisaha
Amy X. Ding
Vijayagopal Gopalsamuthiram
Mary Ann Hanagan
Jeffrey Keith Long
Andrew Edmund Taggi
Original Assignee
E. I. Du Pont De Nemours And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E. I. Du Pont De Nemours And Company filed Critical E. I. Du Pont De Nemours And Company
Priority to US12/988,888 priority Critical patent/US20110045101A1/en
Priority to EP09743637A priority patent/EP2274284A2/fr
Priority to PCT/US2009/043096 priority patent/WO2009137651A2/fr
Publication of WO2009137538A2 publication Critical patent/WO2009137538A2/fr
Publication of WO2009137538A3 publication Critical patent/WO2009137538A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention porte sur des composés représentés par la formule (I), y compris tous les isomères géométriques et stéréoisomères, N-oxydes et sels de ceux-ci, dans laquelle formule J représente Q2 ou R1; X représente N, CR2 ou CQ3; Y représente N ou CR3; Z représente N ou CR4; et Q1, Q2, Q3, R1, R2 et R3 sont tels que définis dans la description. L'invention porte également sur des compositions contenant les composés représentés par la formule (1) et sur des procédés, pour lutter contre une maladie de plante provoquée par un pathogène fongique, qui comportent l'application d'une quantité efficace d'un composé ou d'une composition de l'invention.
PCT/US2009/042922 2008-05-08 2009-05-06 Azoles substitués fongicides WO2009137538A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/988,888 US20110045101A1 (en) 2009-05-06 2009-05-07 Fungicidal substituted azoles
EP09743637A EP2274284A2 (fr) 2008-05-08 2009-05-07 Azoles substitués fongicides
PCT/US2009/043096 WO2009137651A2 (fr) 2008-05-08 2009-05-07 Azoles substitués fongicides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12699008P 2008-05-08 2008-05-08
US61/126,990 2008-05-08

Publications (2)

Publication Number Publication Date
WO2009137538A2 WO2009137538A2 (fr) 2009-11-12
WO2009137538A3 true WO2009137538A3 (fr) 2012-04-19

Family

ID=41119404

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2009/042922 WO2009137538A2 (fr) 2008-05-08 2009-05-06 Azoles substitués fongicides
PCT/US2009/043096 WO2009137651A2 (fr) 2008-05-08 2009-05-07 Azoles substitués fongicides

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2009/043096 WO2009137651A2 (fr) 2008-05-08 2009-05-07 Azoles substitués fongicides

Country Status (7)

Country Link
EP (1) EP2274284A2 (fr)
AR (1) AR071769A1 (fr)
CL (1) CL2009001094A1 (fr)
PE (1) PE20091953A1 (fr)
TW (1) TW200950698A (fr)
UY (1) UY31811A (fr)
WO (2) WO2009137538A2 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR075713A1 (es) 2009-03-03 2011-04-20 Du Pont Pirazoles fungicidas
US20120149661A1 (en) * 2009-08-26 2012-06-14 Novartis Ag Tetra-substituted heteroaryl compounds and their use as mdm2 and/or mdm4 modulators
TW201117722A (en) * 2009-11-04 2011-06-01 Du Pont Fungicidal mixtures
BR112012018358A2 (pt) * 2009-12-21 2016-08-09 Bayer Cropscience Ag tienilpiri(mi)dinilazol e seu uso para controlar fungos fitopatogênicos
WO2012023143A1 (fr) * 2010-08-19 2012-02-23 E. I. Du Pont De Nemours And Company Pyrazoles fongicides
TWI504350B (zh) 2010-09-01 2015-10-21 Du Pont 殺真菌吡唑及其混合物
TW201245155A (en) * 2010-09-01 2012-11-16 Du Pont Fungicidal pyrazoles
BR112013007635A2 (pt) * 2010-09-29 2016-07-26 Du Pont ''composto selecionados da fórmula 1, composição fungicida e método para controlar doenças de planta''
TWI568721B (zh) 2012-02-01 2017-02-01 杜邦股份有限公司 殺真菌之吡唑混合物
EP2872509B1 (fr) 2012-07-12 2016-09-14 Chiesi Farmaceutici S.p.A. Inhibition d'enzymes
WO2014130241A1 (fr) 2013-02-20 2014-08-28 E. I. Du Pont De Nemours And Company Pyrazoles fongicides
WO2015026646A1 (fr) 2013-08-20 2015-02-26 E. I. Du Pont De Nemours And Company Pyrazoles fongicides
WO2015171392A1 (fr) 2014-05-06 2015-11-12 E. I. Du Pont De Nemours And Company Pyrazoles fongicides
EP3172190A1 (fr) 2014-07-24 2017-05-31 Bayer CropScience Aktiengesellschaft Dérivés de pyrazole fongicide
WO2016149311A1 (fr) 2015-03-19 2016-09-22 E I Du Pont De Nemours And Company Pyrazoles fongicides
WO2018052838A1 (fr) 2016-09-16 2018-03-22 E. I. Du Pont De Nemours And Company Pyrazoles fongicides
JP7037507B2 (ja) 2017-01-26 2022-03-16 三井化学アグロ株式会社 ピリドン化合物およびそれを有効成分とする農園芸用殺菌剤
EP3611166B1 (fr) 2017-04-10 2022-09-21 Mitsui Chemicals Agro, Inc. Composé pyridone, et bactéricide à usage agricole et horticole ayant ce composé pour principe actif
CA3059675A1 (fr) 2017-04-10 2018-10-18 Mitsui Chemicals Agro, Inc. Composes pyridone, et fongicide agricole et horticole en renfermant comme ingredients actifs
CN110234627B (zh) 2017-04-11 2023-09-01 三井化学植保株式会社 吡啶酮化合物及以吡啶酮化合物作为有效成分的农园艺用杀菌剂
WO2018213377A1 (fr) 2017-05-17 2018-11-22 Arcus Biosciences, Inc. Dérivés quinazoline-pyrazole pour le traitement de troubles liés au cancer
WO2018225829A1 (fr) 2017-06-08 2018-12-13 三井化学アグロ株式会社 Composé de pyridone et fongicide agricole et horticole
WO2019189731A1 (fr) * 2018-03-30 2019-10-03 住友化学株式会社 Composé hétérocyclique et agent de lutte contre les arthropodes nuisibles le contenant
WO2020022360A1 (fr) * 2018-07-24 2020-01-30 三井化学アグロ株式会社 Composé de pyridone et fongicide agricole et horticole le comprenant en tant que composant actif
JP7291143B2 (ja) 2018-07-25 2023-06-14 三井化学クロップ＆ライフソリューション株式会社 ピリドン化合物およびそれを有効成分とする農園芸用殺菌剤
EP3886854A4 (fr) 2018-11-30 2022-07-06 Nuvation Bio Inc. Composés pyrrole et pyrazole et leurs procédés d'utilisation
CN111819947B (zh) * 2020-07-17 2022-03-04 新疆农业大学 一种利于天山花楸种子破除休眠的催芽方法
CA3194198A1 (fr) * 2020-09-14 2022-03-17 Genzyme Corporation Composes utilises en tant que modulateurs de la bisphosphoglycerate mutase pour le traitement de la drepanocytose

Citations (7)

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Publication number Priority date Publication date Assignee Title
WO1994029300A1 (fr) * 1993-06-07 1994-12-22 Rhone Poulenc Agrochimie Fongicides pyrazoles substitues en position 3 par un heterocycle
WO1998051673A1 (fr) * 1997-05-09 1998-11-19 Agrevo Uk Limited Nouveaux derives de l'imidazole et du pyrrole utiles comme fongicides
US5869509A (en) * 1996-07-31 1999-02-09 Bristol-Myers Squibb Company Diphenyl oxadiazolones as potassium channel modulators
WO2007077490A2 (fr) * 2006-01-05 2007-07-12 Pfizer Products Inc. Composés d'hétéroaryles bicycliques comme inhibiteurs de la pde10
EP2053046A1 (fr) * 2007-10-26 2009-04-29 Syngeta Participations AG Nouveaux dérivés d'imidazole
EP2053045A1 (fr) * 2007-10-26 2009-04-29 Syngenta Participations AG Nouveaux dérivés d'imidazole
EP2053044A1 (fr) * 2007-10-26 2009-04-29 Syngenta Participations AG Nouveaux dérivés d'imidazole

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Publication number Priority date Publication date Assignee Title
WO1994029300A1 (fr) * 1993-06-07 1994-12-22 Rhone Poulenc Agrochimie Fongicides pyrazoles substitues en position 3 par un heterocycle
US5869509A (en) * 1996-07-31 1999-02-09 Bristol-Myers Squibb Company Diphenyl oxadiazolones as potassium channel modulators
WO1998051673A1 (fr) * 1997-05-09 1998-11-19 Agrevo Uk Limited Nouveaux derives de l'imidazole et du pyrrole utiles comme fongicides
WO2007077490A2 (fr) * 2006-01-05 2007-07-12 Pfizer Products Inc. Composés d'hétéroaryles bicycliques comme inhibiteurs de la pde10
EP2053046A1 (fr) * 2007-10-26 2009-04-29 Syngeta Participations AG Nouveaux dérivés d'imidazole
EP2053045A1 (fr) * 2007-10-26 2009-04-29 Syngenta Participations AG Nouveaux dérivés d'imidazole
EP2053044A1 (fr) * 2007-10-26 2009-04-29 Syngenta Participations AG Nouveaux dérivés d'imidazole

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BELLINA ET AL.: "Regioselective Synthesis of 1,5-Diaryl-1H-imidazoles by Palladium-Catalyzed Direct Arylation of 1-Aryl-1H-imidazoles", J. ORG. CHEM., vol. 70, 2005, pages 3997 - 4005, XP002669349 *
BELLINA F ET AL: "Novel imidazole-based combretastatin A-4 analogues: Evaluation of their in vitro antitumor activity and molecular modeling study of their binding to the colchicine site of tubulin", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 16, no. 22, 15 November 2006 (2006-11-15), pages 5757 - 5762, XP025106709, ISSN: 0960-894X, [retrieved on 20061115], DOI: 10.1016/J.BMCL.2006.08.087 *
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Also Published As

Publication number Publication date
UY31811A (es) 2010-01-05
WO2009137651A2 (fr) 2009-11-12
AR071769A1 (es) 2010-07-14
WO2009137651A8 (fr) 2010-03-18
TW200950698A (en) 2009-12-16
EP2274284A2 (fr) 2011-01-19
WO2009137538A2 (fr) 2009-11-12
CL2009001094A1 (es) 2010-10-08
WO2009137651A3 (fr) 2012-04-26
PE20091953A1 (es) 2010-01-09

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