WO2009123206A1 - Composition pharmaceutique à administration per os - Google Patents
Composition pharmaceutique à administration per os Download PDFInfo
- Publication number
- WO2009123206A1 WO2009123206A1 PCT/JP2009/056701 JP2009056701W WO2009123206A1 WO 2009123206 A1 WO2009123206 A1 WO 2009123206A1 JP 2009056701 W JP2009056701 W JP 2009056701W WO 2009123206 A1 WO2009123206 A1 WO 2009123206A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pharmaceutical composition
- inflammatory
- oral pharmaceutical
- acid
- analgesic
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the present invention relates to an oral pharmaceutical composition. More specifically, the present invention relates to an oral pharmaceutical composition comprising a phenylpropionic acid-based anti-inflammatory analgesic as an active ingredient, wherein the gastric mucosal damage caused by the anti-inflammatory analgesic is reduced and the sustainability is improved. Furthermore, the present invention relates to a method for reducing gastric mucosal damage caused by phenylpropionic acid anti-inflammatory analgesics.
- the oral pharmaceutical composition of the present invention can be preferably used for the purpose of suppressing inflammation.
- the active ingredient phenylpropionic anti-inflammatory analgesic preferably ibuprofen
- the detoxification, analgesic and anti-inflammatory action of the component (a) is adversely affected by using three components together.
- the proportion of the component (c) to 100 parts by weight of the component (a) can be appropriately selected from the range of usually 5 to 1200 parts by weight. The range is preferably 10 to 1000 parts by weight, more preferably 16 to 667 parts by weight.
- ibuprofen which is a phenylpropionic acid anti-inflammatory analgesic
- tranexamic acid and dry aluminum hydroxide gel can prevent side effects such as gastric mucosal damage possessed by ibuprofen.
- Example 2 a graph comparing the edema rate (%) over time after carrageenin inoculation for the test substance administration group (Example 1, Comparative Examples 1, 3, 9 to 10) and the non-treatment group is shown.
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Composition pharmaceutique à administration per os contenant un agent anti-inflammatoire analgésique de type acide phényl-propionique, dans laquelle l'attaque de la muqueuse gastrique par l'agent analgésique est réduite. L'invention concerne également un composition pharmaceutique à administration per os contenant un agent anti-inflammatoire analgésique de type acide phénilproprionique dans laquelle ledit agent inflammatoire agit pendant un laps de temps prolongé. Plus précisément, l'invention concerne une préparation pharmaceutique à administration per os comprenant (a) un agent anti-inflammatoire analgésique de type acide phénilproprionique, (b) un acide tranexamique et (c) un gel d'hydroxyde d'aluminium séché.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008-094331 | 2008-03-31 | ||
| JP2008094331A JP5542309B2 (ja) | 2008-03-31 | 2008-03-31 | 経口医薬組成物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2009123206A1 true WO2009123206A1 (fr) | 2009-10-08 |
Family
ID=41135574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2009/056701 WO2009123206A1 (fr) | 2008-03-31 | 2009-03-31 | Composition pharmaceutique à administration per os |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP5542309B2 (fr) |
| WO (1) | WO2009123206A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020100611A (ja) * | 2018-12-25 | 2020-07-02 | 小林製薬株式会社 | 内服用医薬組成物 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5828609B2 (ja) * | 2008-03-31 | 2015-12-09 | 小林製薬株式会社 | 持続性解熱鎮痛消炎剤 |
| JP5835865B2 (ja) * | 2008-09-04 | 2015-12-24 | 興和株式会社 | ロキソプロフェン含有医薬組成物 |
| JP5740896B2 (ja) * | 2009-10-27 | 2015-07-01 | ライオン株式会社 | 解熱鎮痛組成物 |
| JP5844976B2 (ja) * | 2010-01-29 | 2016-01-20 | 興和株式会社 | ロキソプロフェン又はその塩を含有する医薬組成物 |
| JP2011246441A (ja) * | 2010-03-31 | 2011-12-08 | Kowa Co | ロキソプロフェン又はその塩を含有する医薬組成物 |
| JP6206069B2 (ja) * | 2012-10-19 | 2017-10-04 | 大正製薬株式会社 | 固形製剤 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0841076A (ja) * | 1993-07-26 | 1996-02-13 | Fuji Chem Ind Co Ltd | 乾燥水酸化アルミニウムゲル及びその製法並びに制酸剤 |
| JPH0948728A (ja) * | 1995-03-27 | 1997-02-18 | Shiseido Co Ltd | 解熱鎮痛剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2704721B2 (ja) * | 1987-02-12 | 1998-01-26 | ライオン株式会社 | イブプロフエン製剤 |
| JP3170855B2 (ja) * | 1992-03-03 | 2001-05-28 | ライオン株式会社 | イブプロフェン含有解熱鎮痛剤 |
| JP2894955B2 (ja) * | 1994-07-25 | 1999-05-24 | ロート製薬株式会社 | イブプロフェン製剤 |
| JPH09124493A (ja) * | 1995-11-02 | 1997-05-13 | Fuji Chem Ind Co Ltd | 制酸剤及びその製法 |
| JP4947609B2 (ja) * | 2003-01-29 | 2012-06-06 | 大正製薬株式会社 | 解熱鎮痛用組成物 |
-
2008
- 2008-03-31 JP JP2008094331A patent/JP5542309B2/ja active Active
-
2009
- 2009-03-31 WO PCT/JP2009/056701 patent/WO2009123206A1/fr active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0841076A (ja) * | 1993-07-26 | 1996-02-13 | Fuji Chem Ind Co Ltd | 乾燥水酸化アルミニウムゲル及びその製法並びに制酸剤 |
| JPH0948728A (ja) * | 1995-03-27 | 1997-02-18 | Shiseido Co Ltd | 解熱鎮痛剤 |
Non-Patent Citations (1)
| Title |
|---|
| PAROJCIC J. ET AL.: "Rationale for ibuprofen co-administration with antacids: Potential interaction mechanisms affecting drug absorption", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 69, no. 2, 10 January 2008 (2008-01-10), pages 640 - 647 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020100611A (ja) * | 2018-12-25 | 2020-07-02 | 小林製薬株式会社 | 内服用医薬組成物 |
| JP7229013B2 (ja) | 2018-12-25 | 2023-02-27 | 小林製薬株式会社 | 内服用医薬組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009242365A (ja) | 2009-10-22 |
| JP5542309B2 (ja) | 2014-07-09 |
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