WO2009120049A2 - Bande multicanal pour biocapteur - Google Patents
Bande multicanal pour biocapteur Download PDFInfo
- Publication number
- WO2009120049A2 WO2009120049A2 PCT/KR2009/001612 KR2009001612W WO2009120049A2 WO 2009120049 A2 WO2009120049 A2 WO 2009120049A2 KR 2009001612 W KR2009001612 W KR 2009001612W WO 2009120049 A2 WO2009120049 A2 WO 2009120049A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- biosensor
- strip
- biosensor according
- channel strip
- sample introduction
- Prior art date
Links
- 239000000758 substrate Substances 0.000 claims abstract description 34
- 238000006243 chemical reaction Methods 0.000 claims abstract description 32
- 239000000463 material Substances 0.000 claims abstract description 9
- 108090000790 Enzymes Proteins 0.000 claims description 8
- 102000004190 Enzymes Human genes 0.000 claims description 8
- 238000001727 in vivo Methods 0.000 claims description 7
- 239000002313 adhesive film Substances 0.000 claims description 5
- 230000002209 hydrophobic effect Effects 0.000 claims description 5
- 229920000515 polycarbonate Polymers 0.000 claims description 5
- 239000004417 polycarbonate Substances 0.000 claims description 5
- 229920000728 polyester Polymers 0.000 claims description 5
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 4
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000002207 metabolite Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000004800 polyvinyl chloride Substances 0.000 claims description 4
- 239000012491 analyte Substances 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 102000004157 Hydrolases Human genes 0.000 claims description 2
- 108090000604 Hydrolases Proteins 0.000 claims description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 2
- 108090000854 Oxidoreductases Proteins 0.000 claims description 2
- 102000004316 Oxidoreductases Human genes 0.000 claims description 2
- 102000004357 Transferases Human genes 0.000 claims description 2
- 108090000992 Transferases Proteins 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 235000012000 cholesterol Nutrition 0.000 claims description 2
- 229940109239 creatinine Drugs 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 abstract description 3
- 201000010099 disease Diseases 0.000 abstract description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 2
- 238000003556 assay Methods 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 description 6
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 230000027756 respiratory electron transport chain Effects 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 229910052697 platinum Inorganic materials 0.000 description 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229930195712 glutamate Natural products 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 229910052763 palladium Inorganic materials 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 108010025188 Alcohol oxidase Proteins 0.000 description 1
- 108010089254 Cholesterol oxidase Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 description 1
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- 239000004366 Glucose oxidase Substances 0.000 description 1
- 108010073450 Lactate 2-monooxygenase Proteins 0.000 description 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940116332 glucose oxidase Drugs 0.000 description 1
- 235000019420 glucose oxidase Nutrition 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000007734 materials engineering Methods 0.000 description 1
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000001771 vacuum deposition Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/525—Multi-layer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00158—Elements containing microarrays, i.e. "biochip"
Definitions
- the present invention relates to a multi-channel strip for a biosensor, and more particularly, to analyze a plurality of in vivo materials at once, including a plurality of reaction sections and a plurality of sample introduction sections in one strip.
- the present invention relates to a multichannel strip for a biosensor.
- Biosensors can be described as "a system that uses biological elements or mimics biological elements when obtaining information from an object to be converted into useful signals that can be recognized, such as color, fluorescence, and electrical signals.” Therefore, biosensor is a future fusion technology that requires science-wide technologies such as electronics, chemistry, biology, materials engineering, and enzyme engineering.
- biosensors The main fields of use for biosensors are medical, environmental, food, industrial, military, and experimental research. Among them, medical is the most widely used field, and most of the market size is mainly biosensor for glucose measurement.
- Biosensors have a small amount of required sample, high accuracy of measurement, low influence of surrounding environment, easy measurement and real time measurement. In addition, it is a product that is in the early stage of market entry in terms of market, and has a variety of fields of use and is expected to have high growth potential.
- examples of the sample introduction portion of the conventional biosensor can be largely classified into
- the sample introduction of the shaped structure has a structure in which a hole is formed at the end of the straight sample introduction passage to form a capillary tube.
- -shaped structure has a disadvantage in that the amount of the injected sample may change due to the phenomenon that the end portion of the passage is not completely filled or overflows depending on the viscosity of the sample injected through the sample introduction passage.
- it can be used only to analyze a single feature, and when a single biosensor strip is provided with multiple channels, the samples are mixed, which makes it difficult to measure each channel.
- the sample introduction portion of the? -Shaped structure has a structure that forms a straight passage from the side of the sensor to the opposite side.
- Such ⁇ shaped sample introduction part has the inconvenience of introducing the sample from the side, and it is difficult to use in strips for biosensors having multiple channels like the ⁇ shaped sample introduction part.
- the present inventors have studied in view of the above point, and the lower substrate having a plurality of reaction portions separated from each other and the upper substrate abuts with a portion of the upper portion of each of the plurality of reaction portions, the upper substrate having a sample introduction portion It is possible to simultaneously analyze a plurality of materials through a plurality of reaction units, the structure is simple, easy to manufacture, it is possible to manufacture a multi-channel strip for biosensors that can introduce a small amount of sample without pretreatment process. It was confirmed that the present invention was completed.
- the multi-channel strip for the biosensor of the present invention can analyze a plurality of materials at the same time in a plurality of reaction units, the structure is simple, easy to manufacture, and a small amount of samples can be introduced without pretreatment, and various samples It can be used efficiently for the analysis and diagnosis of various diseases.
- 1 is a three-dimensional view of a multichannel strip for a biosensor.
- FIG. 2 is a diagram of a multichannel strip for a biosensor.
- FIG 3 is a diagram of a multi-channel strip for a biosensor, characterized in that the tip of the sample introduction section extends orthogonally so as to open toward the lower substrate.
- the sample inlet 24 refers to the upper end of the sample introduction section.
- It provides a multi-channel strip for a biosensor comprising a.
- the lower substrate 1 having a plurality of reaction parts in which the regions of (a) of the present invention are separated from each other includes at least one, preferably 2 to 100, more preferably 2 to 10 electrodes. And reacting with the analyte to form on the electrode.
- the substrate may include a working electrode, a reference electrode, and / or a counter electrode, similarly to a biosensor for measuring analytes in a sample.
- the working electrode can be fabricated using carbon, graphite, platinum treated carbon, silver, gold, palladium or platinum components.
- the working electrode can be printed on the lower substrate using an ink consisting of carbon or platinum treated carbon, or an ink comprising palladium.
- the working electrode may be formed on the lower substrate by vacuum deposition using gold.
- the lower substrate of (a) may include a hydrophobic adhesive film 4 on the top in addition to the plurality of reaction parts. It is necessary to impart insulation to the lower substrate, and preferably can be prepared by selecting from the group consisting of polyester, poly vinyl chloride, polycarbonate, and mixtures thereof.
- the reaction unit may generate a reaction such as the following reaction formula.
- the reduced electron transfer mediator generated by the reaction between the substrate and the enzyme oxidizes the electron transfer mediator in the reduced state by applying a constant voltage to the working electrode based on the reference electrode or the auxiliary electrode.
- the analyte in the sample can be quantified by measuring.
- various in vivo materials may be used as analytes, and examples thereof include enzymes and metabolites in vivo.
- the enzymes include oxidoreductases such as glucose oxidase, lactate oxidase, cholesterol oxidase and alcohol oxidase; Glucose dehydrogenase, GOT (glutamate oxaloacetate transmianse) and GPT (glutamate pyruvate transmianse), such as transferases and hydrolases, and the like, the metabolites include cholesterol, lactate, creatinine, alcohol, blood sugar and the like.
- GOT glycoxaloacetate transmianse
- GPT glutmate pyruvate transmianse
- the amount of sample that can be used in the strip according to the invention is small, preferably 1 to 10 ⁇ l may be used.
- each of the plurality of reaction portions of the above (b) of the present invention provided with a plurality, preferably 2 to 100, more preferably 2 to 10 sample introduction portions (22, 23)
- the upper substrate 2 protects the electrode and the reaction section is divided 21.
- a plurality of samples may be introduced through the plurality of sample introduction parts, and the reaction parts may be completely separated by the upper substrate 2, and thus, the plurality of samples may not be mixed, thereby enabling accurate analysis.
- the air outlets 22 and 23 are provided so that when the sample is introduced into the reaction unit, the air filled in the reaction unit through the air discharge unit is introduced into the reaction unit while the sample introduced through the sample inlet enters the reaction unit. As it is discharged to the sample suction speed to the reaction unit can be further improved. That is, the strip of the present invention has the advantage of applying a rapid suction speed and a constant amount of sample by sample injection using a simple capillary phenomenon without using an absorbent pad.
- the sample introduction part may be located in both the transverse direction 22 and the longitudinal direction 23, and when manufactured thinner and longer, the injection efficiency is better. If one direction is used as the sample introduction part, the other direction is used as the air outlet part. Therefore, the sample introduction portion and the air discharge portion of the present invention "b" or "a" shape, or the bent portion in the shape is 90 ° or less, preferably 30 ° to 90 °, more preferably 60 ° to 90 It has a shape consisting of an angle of °.
- sample introduction portion of the present invention can be orthogonally extended such that its tip is open toward the lower substrate 10, as shown in FIG.
- the upper substrate may preferably be prepared from the group consisting of polyesters, polyvinylchlorides, polycarbonates and mixtures thereof.
- the present invention in addition to the above (a) and (b) it may include a cover (3).
- the cover protects the sample inlet from the outside to prevent evaporation or loss of each substrate fixed to the reaction unit and the introduced sample, thereby preventing their concentration change. This makes it possible to further improve the accuracy of the analysis.
- the cover can be made of any material commonly used, and preferably made of polyester, polyvinylchloride, polycarbonate.
- the multi-channel strip for biosensor of the present invention is capable of analyzing a plurality of materials at the same time, has a simple structure, is easy to manufacture, and a small amount of samples can be introduced without pretreatment. It can be used efficiently for the diagnosis of
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
L'invention concerne une bande multicanal pour biocapteur, qui comprend; substrat inférieur à plusieurs parties de réaction, chacune avec une zone préétablie; et substrat supérieur en contact avec le sommet de chaque partie de réaction et possédant plusieurs entrées d'échantillons et de sorties d'air. Ladite bande peut être utilisée efficacement pour l'analyse de divers échantillons et le diagnostic de toutes natures car on peut analyser un certain nombre de matériaux de façon simultanée, car il s'agit d'une configuration simple; en outre la bande en question est facile à produire et peut recevoir une petite quantité d'échantillons sans prétraitement.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20-2008-0004083 | 2008-03-28 | ||
| KR2020080004083U KR200448186Y1 (ko) | 2008-03-28 | 2008-03-28 | 바이오센서용 다채널 스트립 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2009120049A2 true WO2009120049A2 (fr) | 2009-10-01 |
| WO2009120049A3 WO2009120049A3 (fr) | 2009-12-17 |
Family
ID=41114480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2009/001612 WO2009120049A2 (fr) | 2008-03-28 | 2009-03-30 | Bande multicanal pour biocapteur |
Country Status (2)
| Country | Link |
|---|---|
| KR (1) | KR200448186Y1 (fr) |
| WO (1) | WO2009120049A2 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101517593B1 (ko) | 2013-08-20 | 2015-05-06 | (주)타스컴 | 바이오센서용 스트립 |
| KR101568362B1 (ko) | 2013-10-31 | 2015-11-12 | (주)타스컴 | 바이오 측정 시스템 |
| KR20220116633A (ko) | 2021-02-15 | 2022-08-23 | 주식회사 더도니 | 바이오 센서용 스트립과 그 제작방법 및 이를 이용한 채혈 측정 장치 |
| WO2023003070A1 (fr) * | 2021-07-21 | 2023-01-26 | 주식회사 에이아이더뉴트리진 | Puce sur support papier capable de réaliser un diagnostic en une étape de multiples acides nucléiques |
| KR102370580B1 (ko) * | 2021-07-21 | 2022-03-07 | 주식회사 에이아이더뉴트리진 | 원스텝 다중 핵산 진단이 가능한 유체흐름조절 오프너 기반 페이퍼 칩 구조물 |
| KR102370572B1 (ko) * | 2021-07-21 | 2022-03-07 | 주식회사 에이아이더뉴트리진 | 원스텝 다중 핵산 진단이 가능한 유체흐름조절 오프너 기반 페이퍼 칩 비색진단법 |
| KR102370561B1 (ko) * | 2021-07-21 | 2022-03-07 | 주식회사 에이아이더뉴트리진 | 원스텝 다중 핵산 비색 검출이 가능한 페이퍼 칩 검출방법 |
| KR102370553B1 (ko) * | 2021-07-21 | 2022-03-07 | 주식회사 에이아이더뉴트리진 | 원스텝 다중 핵산 비색 검출이 가능한 측면유동 페이퍼 칩 검출방법 |
| KR102370566B1 (ko) * | 2021-07-21 | 2022-03-07 | 주식회사 에이아이더뉴트리진 | 원스텝 형광 다중 핵산진단 방법 |
| KR102437064B1 (ko) * | 2022-02-28 | 2022-08-26 | 주식회사 에이아이더뉴트리진 | 측방 유동성의 일체형 시스템에 기반으로 정제 및 검출이 동시에 이루어지는핵산 검출용 랩-온-페이퍼 플랫폼 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100475634B1 (ko) * | 2001-12-24 | 2005-03-15 | 주식회사 아이센스 | 일정 소량의 시료를 빠르게 도입할 수 있는 시료도입부를구비한 바이오 센서 |
| KR100554649B1 (ko) * | 2003-06-09 | 2006-02-24 | 주식회사 아이센스 | 전기화학적 바이오센서 |
| KR100698961B1 (ko) * | 2005-02-04 | 2007-03-26 | 주식회사 아이센스 | 전기화학적 바이오센서 |
| KR100841355B1 (ko) * | 2006-04-04 | 2008-07-01 | 주식회사 올메디쿠스 | 무동력 혈액분리수단을 구비한 바이오센서 칩 |
-
2008
- 2008-03-28 KR KR2020080004083U patent/KR200448186Y1/ko not_active Expired - Lifetime
-
2009
- 2009-03-30 WO PCT/KR2009/001612 patent/WO2009120049A2/fr active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009120049A3 (fr) | 2009-12-17 |
| KR200448186Y1 (ko) | 2010-03-24 |
| KR20090009947U (ko) | 2009-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2009120049A2 (fr) | Bande multicanal pour biocapteur | |
| CN1230679C (zh) | 具有改善加样性能的生物传感器 | |
| CN103814122B (zh) | 多分析物化验装置和系统 | |
| US6923894B2 (en) | Biosensor with multiple sampling ways | |
| US7138041B2 (en) | Electrochemical biosensor by screen printing and method of fabricating same | |
| US5916156A (en) | Electrochemical sensors having improved selectivity and enhanced sensitivity | |
| CN104487834B (zh) | 用于快速检测传染性微生物的方法和设备 | |
| Ruan et al. | Sensitive, rapid, and automated detection of DNA methylation based on digital microfluidics | |
| US20040118705A1 (en) | Electrochemical test strip having a plurality of reaction chambers and methods for using the same | |
| WO2005119238A1 (fr) | Biocapteurs avec application d’echantillonnage amelioree et utilisateurs de ceux-ci | |
| CN101014851A (zh) | 电化学电池和生产电化学电池的方法 | |
| US20140021046A1 (en) | Electrode strip and sensor strip and manufacture method thereof and system thereof | |
| CN103616427A (zh) | 一种针对前列腺癌不同类型血清标志物进行同时检测的微流控电化学生物传感系统 | |
| US20190178807A1 (en) | Closed bipolar electrode-enabled electrochromic detector for chemical sensing | |
| CN106996951A (zh) | 一种进样缺口隔绝电流干扰的同步多分析物传感试纸及其应用 | |
| WO2024181853A1 (fr) | Procédé de dépistage électrochimique d'acides nucléiques utilisant un transmetteur de signaux dans une technique d'amplification d'acide nucléique | |
| Fattahi et al. | MicroRNA biosensors for the detection of liver cancer | |
| WO2024051595A1 (fr) | Biocapteur implantable et son procédé de préparation | |
| Kimura et al. | Open-type capillary-assembled microchip for rapid, single-step, simultaneous multi-component analysis of serum sample | |
| WO2014007557A1 (fr) | Dispositif de pcr en temps réel pour détecter des signaux électrochimiques, et procédé de pcr en temps réel l'utilisant | |
| WO2010140773A2 (fr) | Biocapteur destiné à mesure un biomatériau | |
| KR100776393B1 (ko) | 바이오센서 및 그 제조방법 | |
| KR102083979B1 (ko) | 센서 스트립 및 이를 이용한 생체 물질 측정 장치 | |
| EP1225449B1 (fr) | Electrode non-enzymatique et disposable contenant un tensioactif pour la détection d'acide urique ou d'hémoglobine; méthode pour le produire et son utilisation | |
| US20060269915A1 (en) | Pyrophosphate acid detection sensor, method of detection of nucleic acid, and method of discrimination of base type |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 09725042 Country of ref document: EP Kind code of ref document: A2 |
|
| NENP | Non-entry into the national phase |
Ref country code: DE |
|
| 122 | Ep: pct application non-entry in european phase |
Ref document number: 09725042 Country of ref document: EP Kind code of ref document: A2 |