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WO2009118002A2 - Destruction de germes au moyen de dioxyde de carbone et traitement par cavitation d'adjuvants - Google Patents

Destruction de germes au moyen de dioxyde de carbone et traitement par cavitation d'adjuvants Download PDF

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Publication number
WO2009118002A2
WO2009118002A2 PCT/DE2009/000444 DE2009000444W WO2009118002A2 WO 2009118002 A2 WO2009118002 A2 WO 2009118002A2 DE 2009000444 W DE2009000444 W DE 2009000444W WO 2009118002 A2 WO2009118002 A2 WO 2009118002A2
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WO
WIPO (PCT)
Prior art keywords
cavitation
carbon dioxide
germs
treatment
germicidal
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PCT/DE2009/000444
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German (de)
English (en)
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WO2009118002A3 (fr
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Hans-Werner Bender
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Hans-Werner Bender
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Publication of WO2009118002A2 publication Critical patent/WO2009118002A2/fr
Publication of WO2009118002A3 publication Critical patent/WO2009118002A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/025—Ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H33/00—Bathing devices for special therapeutic or hygienic purposes
    • A61H33/60—Components specifically designed for the therapeutic baths of groups A61H33/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H35/00—Baths for specific parts of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B2017/22005—Effects, e.g. on tissue
    • A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
    • A61B2017/22008—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing used or promoted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H33/00—Bathing devices for special therapeutic or hygienic purposes
    • A61H33/02—Bathing devices for use with gas-containing liquid, or liquid in which gas is led or generated, e.g. carbon dioxide baths

Definitions

  • at least one potentially germicidal substance and at least one complementary treatment with adjuvant effect Using the example of carbon dioxide as a potential germicidal substance and a complementary sound treatment with sound-induced supporting (adjuvant) cavitation.
  • Germs and infections caused by germs, especially problematic germs and infections due to problematic germs, are not only common problems in medicine, but also in other areas of life science as well as in the technical / industrial field. Methicillin infections can often not be solved Resistant Staphylococcus aureus (MRSA) and / or vancomycin-resistant enterococci (VRE) are a serious challenge in treating infections. Also, seed colonies protected by "protective coatings" such as biofilms, small colony variants (SCV) and / or other protective coatings are often difficult to treat.
  • MRSA Resistant Staphylococcus aureus
  • VRE vancomycin-resistant enterococci
  • seed colonies protected by "protective coatings" such as biofilms, small colony variants (SCV) and / or other protective coatings are often difficult to treat.
  • Germ treatment especially if problematic germs / problem infections are to be treated, other forms of treatment / methods for killing germs and / or treatment of infections fail and / or are not applicable for different reasons and / or should not be used.
  • the offered treatment is simple and safe to perform, for example, in the medical treatment of infected wounds, skin infections, bone infections and more.
  • a treatment with at least one suitable non-germicidal substance which, in combination with at least one other appropriate complementary treatment (a treatment with mechanical and / or other physical and / or chemical and / or bioactive / biological / Physiological adjuvant effect) can be germicidal effect.
  • a treatment with mechanical and / or other physical and / or chemical and / or bioactive / biological / Physiological adjuvant effect can be germicidal effect.
  • the interaction of the appropriate substance and the complementary treatment leads to a synergistic effect, which makes the germ-killing substance per se a germicidal substance.
  • the germicidal effect of the substance is based on properties of the substance itself, for example on its chemical properties, but not on the direct / immediate effect of the complementary treatment and / or its adjuvant effect.
  • the potentially germicidal substance can be germicidal under certain conditions, the prerequisites for this are created by the complementary treatment and / or by one of its adjuvant effects.
  • This complementary treatment and / or its effect (at least one of its effects) has an auxiliary function, a supporting function, a preparatory function, a promoting function, an activating function (ie an adjuvant function / effect) without itself - under the given treatment conditions - in sufficient amount / in sufficient numbers germicidal to act.
  • Carbon dioxide is normally per se a little or no germicidal gas acting on germs / microorganisms, especially by protective layers protected germs, no / hardly germicidal activity to it as suitable for killing germs, in particular problematic germs and / or for the treatment of infections / Problem infections appear to be particularly suitable.
  • a Kavitationsmediums with germicidal effect by a Kavitationsrial for example in a cavitation treatment with high sound energy (power sound). But that is not meant here. What is meant is the effect of carbon dioxide as a germicidal substance in the interaction of carbon dioxide with adjuvant cavitation treatment as described later.
  • the suitable, potentially germicidal substance is usually referred to in the description below as “substance.”
  • Carbon dioxide is always “substance”.
  • “Substance” may be replaced by carbon dioxide in the description, but “Substance” may be another suitable substance.
  • Another suitable treatment with at least one mechanical and / or other physical and / or chemical and / or bioactive effect is hereinafter also referred to in the description as “complementary treatment", the effect also being "adjuvant”.
  • Sound complementary treatment
  • sound-induced cavitation adjuvant effect / cavitation.
  • Carbon dioxide as a relatively small molecule, can easily penetrate tissue (eg, skin), biological structures of germs / microorganisms (eg, through normal diffusion), which is normally harmless to germs.
  • tissue eg, skin
  • biological structures of germs / microorganisms eg, through normal diffusion
  • carbon dioxide can become germicidal and therefore "potentially"
  • a medium eg water
  • cavitation effect creates conditions that make carbon dioxide germicidal, namely as a substance with its properties and not (causally, directly) through the cavitation effect itself is only indirectly supportive involved.
  • the cavitation is induced by sound with low to medium
  • Cavitation has the task / function of biological structures of germs change, for example, that carbon dioxide is enriched in the cell interior of germs / and can cause in the cytoplasm / cytosol by a dissociation reaction (according to DE 102 33 293, Figure Figure 1) no longer regulated by the germ lowering of the pH
  • the "change" of biological structures of the germs by an adjuvant cavitation effect and the penetration of carbon dioxide into these structures, the penetration of carbon dioxide into the cell interior of the germs is an example of the interaction of cavitation and carbon dioxide.
  • Cavitation creates the conditions for carbon dioxide to penetrate these structures into the cell interior of the germs.
  • Another example of the interaction is that carbon dioxide, as a cavitation-effective component of the cavitation medium, participates in the cavitation and at the same time (at the same time) can act as a potentially germicidal substance.
  • the cavitation-based potential germicidal effect of carbon dioxide in the treatment of problematic germs and / or problematic infections with a carbon dioxide strongly enriched medium is characterized in that as a result, in a Kavitationsmedium (z B. the said medium), complementarily successful sound treatment of the germs with Kavitationsrial on the germs, the carbon dioxide can accumulate in a sufficient for a germicidal effect high concentration in the cell interior of the germs to trigger a reaction in the aqueous environment of the cytoplasm (cytosol) , which leads to a strong, no longer controllable by the germ hyperacidity of the cytosol and thus to cell death.
  • a carbon dioxide strongly enriched medium which may preferably serve as a cavitation medium, not must
  • a cavitation medium is used as described in detail in the documents DE 10 233 293, DE 10 2004 004 415 ("Carbonic acid water", then carbon dioxide is a cavitation-effective component of the cavitation medium and cavitation (as "oscillating / oscillating gas bubbles") At the same time, carbon dioxide is a potentially germicidal gas as a constituent of the cavitation medium, which results in new features, properties and applications for the cavitation medium.
  • Carbon dioxide as a potentially germicidal gas and carbon dioxide as a cavitation effective component of the cavitation medium in a sound-induced cavitation by the interaction of Kavitationsrial and the effect of potentially germicidal acting gas synergy effect, which can not be achieved with carbon dioxide alone and / or by cavitation alone would.
  • the cavitation treatment can be carried out simultaneously with the use of carbon dioxide, as shown schematically in Figure 1.
  • the cavitation treatment can be carried out promptly with the use of carbon dioxide, as shown schematically in Figure 2.
  • Adjuvant in the sense of aids auxiliary ...
  • a complementary treatment of the description is for example a sound treatment. This induces / produces an adjuvant / supportive cavitation / cavitation effect.
  • a cavitation treatment / cavitation / cavitation effect of the description has an adjuvant / supporting effect, for example for carbon dioxide, for example in such a way that cavitation creates conditions for carbon dioxide to be germicidal, and not due to cavitation.
  • Physiology Physiological reactions, for example, are all life-regulating processes.
  • An active substance is a substance that triggers a certain effect in a small dose in an organism of humans and / or animals, eg. B. a physiological reaction.
  • a pharmaceutical (pharmacologically active) active ingredient such as a drug, a drug (in the broader sense
  • Drugs drugs, medicines
  • other substances such as disinfectants, some anti-infective agents, etc.
  • active substances are also such substances that serve for example for cleaning / hygiene, certain ingredients in cosmetics and others. Also in the field of crop protection.
  • Pharmaceutical agent drug, drug, drug, e.g. As antibiotics, anti-infective agents,
  • cavitation preferably means a cavitation induced by a complementary sound treatment, an effect of the sound is thus that of a cavitation effect.
  • Problem germs are, for example, germs which have formed a resistance to pharmaceutical active substances and / or to another germicidal substance / active substance, for example MRSA, VRE and / or by a protective layer (eg biofilm, SCV, pus, fibrin, etc.). But also when other conventional treatments / methods for germ treatment fail / are ineffective and / or difficult to perform and / or can not be used / performed. Other equally important examples of application and / or problem infections by problem germs are listed later. Problem infections are infections (for example of wounds) by problem germs.
  • Problem infections are those infections that are not and / or not sufficient and / or very difficult to treat with conventional, conventional methods and / or devices and / or devices, for example, not by an ultrasound application at high sound energy (power sound) such as ultrasonic debridement.
  • power sound high sound energy
  • Sound in the description initially means sound of any sound frequency, preferably sound in the specification means ultrasound with at least one sound frequency between 20 kHz and 20 MHz, more preferably sound in the specification means low frequency ultrasound with at least one sound frequency between 20 kHz and 800 kHz More preferably, sound in the specification means low frequency ultrasound with at least one sound frequency between 20 kHz and 150 kHz.
  • Germs represent a biological system. Germs can all germs, preferably pathogen / facultative pathogens acting germs / microorganisms (eg anaerobic / aerobic bacteria, gram-negative / gram-positive bacteria, dermatophytes, yeasts, molds, dimorphic fungi and other microorganisms , possibly also viruses). Common infections / problem infections for example by Pseudomonas aeruginosa, Staphylococcus. aureus, Staphylococcus epidermidis, Escheria coli, Candida albicans and the like. a ..
  • Structures of biological systems can be, for example, cell walls / membranes and other components of germs. Structures of biological systems (biologic structures) may be biofilm, other protective layers, etc. Biological structures as protective layer / biological, mechanical barrier can be for example Biofiime. Biofilms (covering, mucous layer) can Germs in multiple layers contained as a solid phase, embedded in a slimy matrix of extracellular polymeric substances / EPS / exopolysaccharides and water as hydrogel, containing besides polysaccharides also polypeptides, proteins, lipids and other substances.
  • coatings may also consist of mixed forms of different organic and / or inorganic substances / materials / materials, for example fibrin coatings, pus, mucus, necrotic material, bacteria, germs, cell debris, liquids, blood, other biological material and / or other compounds / materials , mostly of organic material. Also difficult to treat are small colony variants (CSV) of germs.
  • CSV colony variants
  • Germicidal is a (generic) term that includes, for example, terms such as biocidal, antibacterial, disinfecting, antiseptic, bactericidal / bacteriostatic, fungicidal / fungistatic, virucidal / virustatic, toxic, antiseptic, cytotoxic / cytostatic, denaturing, etc.
  • Cavitation of which preference is the milder form of cavitation
  • the gas cavitation which at lower to medium sound intensity / sound energy to stimulate and with a suitable Kavitationsmedium (for example, "carbonic acid”) is better controlled and shows a better biocompatibility compared to the transient cavitation.
  • the milder gas bubble cavitation gas cavitation, pseudo cavitation, stable cavitation
  • the strength of this cavitation should not be sufficient to kill germs in sufficient numbers (sufficient number means medically sufficient, therapeutically effective / necessary, hygienically necessary, etc.).
  • the sound-induced cavitation of which in particular by low-frequency ultrasound in the lower frequency range (20 kHz - 150 kHz) induced cavitation.
  • a cavitation-effective [cavitation-active, cavitation-involved, cavitation-capable, cavitation-effecting] component of a cavitation medium is, for example, a gas which contains cavitation medium (eg a liquid such as water, etc.) in the form of gas bubbles and / or cavitation medium molecular form (molecular) and / or dissolved in another form.
  • cavitation medium eg. a liquid such as water, etc.
  • Sound effects on the cavitation medium eg, as in FIG. 1 stimulate gas bubbles to oscillate (oscillating gas bubbles) and / or gas bubbles are newly formed, which are then excited to cavitation oscillations. Excitation of gas bubbles to a sound-induced cavitation.
  • Potentially germicidal substances are those that are normally not germicidal and not originally intended for germ killing, and are generally not used for this purpose.
  • Carbon dioxide per se is a non-germicidal gas.
  • carbon dioxide is a potentially germicidal gas because, under certain conditions, it can have a germicidal effect on germs.
  • germ killing as a direct effect of a cavitation effect on germs at, for example, high sound energy / high-energy cavitation, z. B. by power sound (sound of very high intensity to over 300 W / cm 2 ) induced high-energy cavitation.
  • other effects of cavitation and / or other sound effects that are germicidal.
  • germicidal effects of pharmaceutical agents and / or other active substances that are germicidal per se, eg.
  • anti-infective agents As antibiotics, anti-infective agents, antiseptics, disinfectants (including ethanol, methanol and other, higher-value alcohols, formaldehyde / formalin and other aldehydes, phenols, other disinfectants, denaturants / denaturing methods) etc .
  • Potentially germicidal in the sense of the description also means not in that at least one per se acting germicidal substance (eg an antibiotic) is contained in the cavitation medium and / or this substance is subsequently applied to a cavitation treatment and the germicidal effect is completely and / or predominantly due to this substance.
  • wounds / infected wounds for example diabetic foot, leg ulcers, bedsores, burn wounds, traumatic wounds, surgical wounds, osteomyelitis (wound including bone infection, also referred to as osteitis), stoma wounds and other wounds. Also for infection prophylaxis.
  • Medical treatment of germs eg. Treatment of germs, for example for disinfecting, hygiene, cleaning, etc .. Treatment of germs in the technical / industrial area.
  • polar liquids eg, alcohol, alcoholic solutions, acetone, serum, etc.
  • water as a cavitation medium in which carbon dioxide in high to very high concentration (up to 1500 mg CO 2 /! Even to over 1500 mg CO 2 / I at about 40 ° C and atmospheric pressure, and is partially supersaturated) is enriched and because of the dissociation of carbon dioxide in water (corresponding to DE 102 33 293, Fig. 1) may also be called “carbonic acid water.”
  • the carbon dioxide is partly contained therein as gas bubbles, but predominantly dissolved therein in molecular form (molecular) and / or in in another form, for example in (fine) disperse form, in the form of associated molecules (cluster, aggregation, micelle form, others associated Shapes, etc.).
  • the cavitation medium is stable to handle.
  • Said medium is a gas bubble source, in which potentially viable (namely, when they are formed by the sound effect in Kavitationsmedium) vibrating gas bubbles are available in large numbers. Potentially because gas bubbles in the medium, for example under sound effect, can only arise. Due to the high concentration of carbon dioxide in the medium, new gas bubbles can always arise.
  • cavitation medium is also that the carbon dioxide through the molecular and / or finely dispersed distribution in the cavitation medium in small hairline cracks, crevices, pores, caverns, courses of mechanical / biological structures (eg skin, biofilms and other protective layers of Germs, etc.) can penetrate, which gas bubbles can not to this extent in order to be effective (wherever the water comes also carbon dioxide and everywhere there is a cavitation possible).
  • Such a cavitation medium (“carbonic acid water”) is described in detail in the documents DE 102 33 293, DE 10 2004 004 415. The production and / or production of such a cavitation medium are mentioned in the cited documents, where further applications, uses, treatment of called biological systems
  • Carbon dioxide concentration in “carbon dioxide” is equivalent to “high density”?
  • Ultrasound in particular with low frequency ultrasound, preferably as cavitation treatment in one
  • Cavitation medium such as subaqual and contactless in a water bath, has been publicly publicized at international congresses since about 1990. These treatments were performed at low sound intensity up to 100mW / cm 2 . Schematic representation of a subaqual treatment in FIG.
  • the low-frequency ultrasound device used for the abovementioned treatments corresponded in technically essential points to the description in EP 0335851, EP 0595783.
  • Ultrasonic debridement takes place at high to very high sound intensity (power sound) and at the same time has a germicidal effect.
  • a special cavitation medium is not necessary. This particular treatment of wound debridement is in the hands of trained professionals and, unlike low frequency / midrange low intensity ultrasound, is not available to anyone, nor anywhere, and involves some risks.
  • the germ killing with carbon dioxide is used industrially, for example in the food industry.
  • an accumulation of carbon dioxide in the germs can be achieved, which then - allegedly by a no longer regulated by the microorganism pH change - lowering the pH - leads to the death of germs.
  • Selection of Literature "Killing Microorganisms by Compressed Carbon Dioxide” Dissertation (2005) to obtain a Doctor of Engineering degree from the Faculty of Mechanical Engineering of the Ruhr University Bochum presented by Reiner Daiminger from Burghausen.
  • the treatment of germs / problem germs preferably the medical treatment of infections / problem infections, for the purpose of killing germs by a carbon dioxide application in conjunction with an adjuvant sound-induced cavitation treatment of the germs, has not been described, the effect of cavitation being insufficient to prevent germs from cavitation kill in sufficient numbers.
  • the germicidal effect is mainly based on the effect of carbon dioxide as a potentially germicidal gas.
  • Protective layers for example biofilms, which shield the germs from external influences and therefore, for example, render topically and / or systemically applied / administered active substances ineffective.
  • Undesirable side effects for example of active substances, for example allergy formation, intolerance, stress on the organs, interaction with other drugs, cell damage, disruption of cell growth (eg of granulation tissue) etc.
  • Certain treatments can not be used and / or should not be used. For example, because of the location / location of the infection, because of adverse reactions in / by the treatment and / or for other reasons.
  • Treatment should only be performed by trained personnel, but not at home by the patient, etc ...
  • the treatment is linked to certain (expensive) treatment devices / treatment methods that are not available everywhere, can not be used by anyone, etc.
  • the germ killing by treatment of the germs with a potentially germicidal substance and a complementary treatment with a supporting effect is based on carbon dioxide as a potentially germicidal substance and a complementary sound treatment with sound-induced cavitation (adjuvant) as a "cavitation-based, potentially germicidal effect of carbon dioxide" described.
  • the cavitation-based potential germicidal effect of carbon dioxide that is the germicidal effect of carbon dioxide on germs, preferably by a (mostly in the cell interior (cytoplasm) of the germs) caused by carbon dioxide effect / reaction of physical and / or chemical and / or bioactive / physiological nature / Way that leads to cell death.
  • a sound-induced cavitation (adjuvant) contributes / creates the conditions for the carbon dioxide to penetrate, pass through, and penetrate biological structures of germs into the cell interior of the germs.
  • the cavitation-based potential germicidal effect of carbon dioxide treats / affects the killing effect of carbon dioxide on germs and further when, how and under what circumstances (prerequisites, conditions) carbon dioxide can be germicidal on germs.
  • the medium can also serve as a cavitation medium.
  • One for carbon dioxide treatment Completely complementary sonic treatment with cavitation effect on the germs and / or on their biological structures lead to changes (for example increased permeability to external substances) of the biological structures (for example cell walls, biofilms, other protective layers) such that carbon dioxide is in for a germicidal effect sufficiently high concentration in the cell interior of the germs can accumulate in order to trigger a reaction in the aqueous environment of the cytoplasm (cytosol), which leads to a strong, no longer controllable by the germ hyperacidity of the cytosol and thus to cell death.
  • cytoplasm cytoplasm
  • Carbon dioxide can under certain conditions have a germicidal effect, namely, for example, if it is possible to bring carbon dioxide to the surface of the germs and especially in the germs / in the cell interior of the germs in a sufficiently large amount / in a sufficiently high concentration.
  • the carbon dioxide then dissolves in the aqueous environment of the cytoplasm (in the cytosol), dissociates (corresponding to the Figure 1 Fig. Document DE 102 33 293) and thereby causes hyperacidity of the cytosol by lowering the pH. Due to the sufficiently high concentration of carbon dioxide (sufficiently high concentration to achieve this effect) in the cell interior of the germs / cytoplasm, the germ can no longer regulate the hyperacidity and dies off.
  • Accompanying adjuvant sound-induced cavitation treatment creates the prerequisites for carbon dioxide to be enriched in the germs and / or to be introduced in a sufficiently high concentration into the cell interior of the germs.
  • biological structures in the simplest case, the cell walls, otherwise biofilms and other protective layers
  • carbon dioxide can penetrate these structures, pass through these structures, if these structures can penetrate
  • cell walls / membranes are to enter from outside (from the surface of the germs) into the cell interior of the germs.
  • carbon dioxide can penetrate from the surrounding medium into these protective layers, penetrate them and initially accumulate / concentrate in the environment / surface of the germs, in order then to reach the cell interior of the germs / to be introduced. Additional effects / effects of sound and / or cavitation may promote / accelerate these processes (eg microflow, including micromassage, compression / traction, mass transfer, flow phenomena, injection of matter into matter, etc., also effects biological / physiological, mechanical / physical, chemical type. Accumulation of carbon dioxide on and / or in the germs can be due to high Carbon dioxide concentration in the medium, by high partial pressure, by diffusion, etc. take place.
  • carbon dioxide is a cavitation-active constituent of a cavitation medium, preferably the carbon dioxide called “carbonic acid.”
  • carbonic acid carbon dioxide is also present in high concentration in molecularly dissolved form.
  • the sound-induced cavitation (preferably a gas cavitation) should be excited by sound of low to medium energy / intensity. Sufficient to produce useful cavitation, but not sufficient to kill germs in sufficient numbers by the effect of cavitation. Sufficient to produce a usable cavitation means that the effect of cavitation on the biological structures of the germs, for example, causes a mechanical change of the structures. That is, the structures (eg, protective layers) become more permeable to at least one externally supplied substance, such as carbon dioxide.
  • a cavitation medium used in the treatment, as described above, for example, as "carbonic acid water"
  • the carbon dioxide can penetrate further and further into the biological structures during the treatment, and by cavitation loosen up the structures and modify them so that more carbon dioxide enters these structures penetrate, penetrate and possibly destroy, with the aim that carbon dioxide can reach the germs, is enriched to the germs to penetrate into the germs (inside the cell) / to be introduced.
  • the effect of cavitation and the effect of carbon dioxide as a potentially germicidal substance have a synergistic effect.
  • the cavitation medium with carbon dioxide as a cavitation-active ingredient itself, by the carbon dioxide has a potential germicidal effect and is synergistically effective.
  • a cavitation medium is used in the treatment, as described above, for example, as "carbonic acid water”, then carbon dioxide is a cavitation-effective component of the cavitation medium (eg involved as "oscillating gas bubbles" in the cavitation processes) and at the same time a potentially germicidal substance.
  • Carbon dioxide acts as a cavitation-effective component of the cavitation medium as Kavitationsrial and carbon dioxide is also effective as a germicidal substance and has the interaction of these effects a synergy effect (by the same gas.)
  • Carbon dioxide cavitation effective component of Kavitationsmediums has by cavitation effect on the germs and / or on their biological structures, which cause changes in the germs and / or biological structures of the germs, which are prerequisites for carbon dioxide to have a germicidal effect
  • the effect of carbon dioxide as a cavitation-effective component with a cavitation effect and as a potentially germicidal substance is an effect that would not be possible without the interaction. This is not to be confused with a cavitation treatment, at the cavitation itself germicides.
  • FIG. 1 shows one of the possible arrangements of a treatment with a potentially germicidal substance and at least a complementary treatment (in the example carbon dioxide and sound / cavitation).
  • Arrangement of object in the example a leg / foot immersed in a cavitation medium for a subaquale ("underwater") treatment and a (in this example) also immersed in the Kavitationsmedium sound applicator by sound / sound on / generates cavitation in the cavitation medium, for example by the sound effect in the cavitation medium gas bubbles are excited to cavitation oscillations (oscillating gas bubbles) and / or gas bubbles are formed by the sound effect, which are then excited to vibrate, in this example, the cavitation predominantly ( Preferably, in the layer between the object / the object surface and the sound-emitting surface of the sound applicator.To allow the cavitation to take place close to and / or on the object surface, the layer (distance sound-emitting surface to the object surface) should be as small as possible.
  • the cavitation itself should not / only slightly germicidal effect / can be, for. B. because of too low a sound intensity and thus insufficient energy-rich cavitation. That is, the germicidal effect of such a treatment should not be based / only to a small extent on mechanical forces that lead to the destruction of the germs, but completely / predominantly on the potential germicidal effect of carbon dioxide.
  • carbon dioxide is a cavitation-effective component of the cavitation medium and at the same time a potentially germ-destroying gas.
  • the cavitation medium (containing carbon dioxide) is a potentially germicidal cavitation medium.
  • these protective layers Due to the cavitation effect on the protective layers (biological structures) and / or on the germs, these protective layers are initially mechanically modified superficially in their structure (eg by crack formation, hair / capillary cracks, etc.), biofilms already show a corresponding topography with aisles , Pores, caverns, etc. into which carbon dioxide can penetrate), so that the cavitation medium can penetrate into these protective layers. Since the cavitation medium contains molecularly and / or finely dispersed carbon dioxide in a high concentration, cavitation can also be produced in the hair / capillary cracks, and the destruction of the hair Protective layer can be continued (gas bubbles could penetrate because of their size, or only in small numbers in the fine cracks, capillary cracks).
  • the structure of the protective layer is further loosened, more cavitation medium, more carbon dioxide penetrates into the protective layer, this loosens further by cavitation and reaches the germs around them in a similar manner (eg, their protective covers, membranes, cell walls) attack.
  • Carbon dioxide can accumulate on and / or in the germs and unfold with this / by the enrichment a germicidal effect.
  • the penetration of the protective layers with the cavitation medium / carbon dioxide and / or the accumulation of carbon dioxide in the germs is promoted by further effects / effects by / of low-frequency ultrasound and / or cavitation, eg. B. by microflows.
  • FIG. 2 schematically shows the timely, non-simultaneous application of a cavitation treatment and a carbon dioxide treatment.
  • the use of carbon dioxide as a germicidal active ingredient is not carried out simultaneously with the cavitation treatment, but the application of (highly concentrated) carbon dioxide (as gas, gas mixture, water / gas mixture / mist, aerosol, etc.) takes place, for example, promptly following a cavitation treatment.
  • a cavitation treatment eg subaqual with a cavitation medium containing no or insufficient carbon dioxide
  • carbon dioxide for example in a pressure chamber containing carbon dioxide.
  • the cavitation-based, potentially germicidal effect of carbon dioxide is:
  • the treatment of germs and / or their biological structures with at least one potentially germicidal substance - is not germicidal - in interaction with at least one complementary treatment - a treatment with mechanical and / or other physical and / or chemical and / or other action (adjuvant effect) - can be germicidal effect, the complementary treatment and / or at least one of its effects creates conditions that the substance can be germicidal effect, without the complementary treatment and / or at least one of its effects is itself sufficiently germicidal.
  • the substance is preferably carbon dioxide, the complementary treatment preferably a sonication, at least one effect of the sonication is that of a sound-induced cavitation.
  • the cavitation-based potential germicidal effect of carbon dioxide in the treatment of problematic germs and / or problematic infections with a medium strongly enriched with carbon dioxide is characterized in that due to a complementary in a cavitation medium sound treatment of the germs with Kavitationsrial on the germs, the carbon dioxide in a concentration sufficient for a germicidal effect in the cell interior of the germs can accumulate to trigger a reaction in the aqueous environment of the cytoplasm (cytosol), which leads to a strong, no longer regulated by the germ hyperacidity of the cytoplasm / cytosol and thus cell death.
  • the cavitation medium is preferably identical to the carbon dioxide-rich medium which is used to treat the germs / infections.
  • ⁇ characterized by a complementary to the application of carbon dioxide treatment with at least one mechanical and / or other physical and / or chemical and / or bioactive effect.
  • a complementary sound treatment with a cavitation effect for example, a complementary sound treatment with a cavitation effect.
  • the cavitation-based potential germicidal effect of carbon dioxide in the treatment of germs and / or infections is characterized by the fact that carbon dioxide, which is used in the treatment in a carbon dioxide-containing medium, then germicidal effect, if by means of a supporting acting cavitation effect on the Germs and / or on their biological structures such as cell walls, biofilms, other protective layers carbon dioxide in the cytoplasm / in the aqueous cytosol of germs accumulate in sufficient for a germicidal effect amount and the enriched carbon dioxide in the physiology of the germs can intervene such that this by a Acidification of the cytosol leads to cell death, but the cavitation is not directly involved in cell death, the germ killing is thus not by a Kavitations Koch but by an effect of carbon dioxide.
  • the cavitation-based potential germicidal effect of carbon dioxide in the treatment of germs and / or infections is characterized by the fact that carbon dioxide, if a supportive, adjuvant Kavitations Koch on the germs and / or their biological structures such as cell walls, biofilms, other protective layers for the conditions that carbon dioxide accumulates in the cytoplasm of the germs and the enriched carbon dioxide in the physiology of the germs [the life processes concerning the functional level of, for example, cells, cell assemblies, such as regulating mechanisms that regulate and / or control the metabolic processes, cell division, etc.) can intervene that this leads to cell death, but the cavitation is not directly involved in cell death, the germ killing is thus not done by a Kavitations Koch but by an effect of carbon dioxide.
  • carbon dioxide can have a germicidal effect if carbon dioxide in sufficiently large amount / in sufficiently high concentration at / in germs / in the cell interior of germs is introduced.
  • the substance is carbon dioxide .
  • carbon dioxide which creates as a cavitation effective component of a cavitation by cavitation the conditions for it in that the carbon dioxide, as a constituent of the cavitation medium, can become germicidal by being able to penetrate into the germs in order to unfold its germicidal effect there.
  • a substance preferably carbon dioxide
  • the substance, preferably carbon dioxide is synergistically effective, especially if the substance, preferably carbon dioxide, is a cavitation-effective and potentially germicidal component of a cavitation medium. This is especially true in a cavitation treatment in the presence of this substance, preferably carbon dioxide.
  • ⁇ Characterized by a Kavitationsmedium that by the same substance (preferably this carbon dioxide) as part of the Kavitationsmediums at least two different functions and / or effects, which are due to different effects of this one substance and these modes of action complement each other and together to a synergistic effect through the same substance.
  • carbon dioxide as the cavitation-effective component of a cavitation medium cavitation can be induced by sound in the cavitation medium (this is a mode of action of carbon dioxide), this cavitation has involved carbon dioxide in the treatment of germs and / or their biological structures and the like. a. a mechanical effect on the structures and leads to changes in the structures through which the carbon dioxide can get into and into the germs to be enriched there.
  • the treatment may be subaqual, as shown in FIG. 1 and / or in the description associated with FIG. 1 and / or relating thereto. And / or in a based on the subaqualen treatment and the arrangement described thereby underlying, but modified form, can be done.
  • the cavitation medium is characterized by further possible therapeutic effects, for example physiological effects of the gas dissolved therein (eg carbon dioxide).
  • the carbon dioxide strongly enriched medium for the treatment of problematic germs and problematic infections is preferably identical to the Kavitationsmedium and preferably consists of water and / or an aqueous solution in which carbon dioxide is dissolved in high to very high concentration, preferably in one Concentration 1500mg / l, even over 1500mg / l.
  • the cavitation medium is a medium in which the dissolved carbon dioxide in cavitation, as a cavitation effective component, is involved and at the same time contained as a germicidal substance in cavitation medium, the carbon dioxide in the cavitation medium has at least two different effects, the cavitation effect and that of the germicidal substance and both effects complement each other synergistically.
  • the cavitation medium has at least two different effects due to the carbon dioxide dissolved therein, which together have a synergistic effect.
  • the sonication from the cavitation medium induces a supporting cavitation in such a way that the cavitation / cavitation effect acts on the biological structures of the germs, preferably on cell walls, biofilms and other protective layers, preferably mechanically, to make them externally supplied substances How to make the carbon dioxide permeable with the aim of enriching carbon dioxide inside the cell, thereby causing cell death.
  • the treatment can be combined with other treatments.
  • a gentle / tissue-sparing treatment for example in contrast to a risky ultrasound debridement.
  • Carbon dioxide can have multiple effects that can be used therapeutically at the same time. Carbon dioxide can penetrate into the smallest cracks, pores, etc., in order to be effective there.
  • the treatment is easy to perform, inexpensive, safe to handle, without side effects.
  • Fig. 2. Represents a possible arrangement in which the cavitation treatment and the application of carbon dioxide take place in a timely manner.
  • the cavitation treatment of the biological system can also take place in the chamber and / or outside the chamber. Subsequently, the thus treated biological system is subjected to an application with carbon dioxide. In the example, inside the chamber under pressure in a concentrated carbon dioxide atmosphere.
  • the sound characteristic has an effect on the cavitation and / or on depth / surface effect, including the transport of substances, the absorption of substances / of biological systems, etc.
  • further sound characteristics also play a role. For example, whether the sound is emitted in continuous or in pulsed form.
  • the burst of sound eg, sinusoidal, triangular, rectangular, or other shape
  • the signal / waveform eg, symmetric, asymmetrical
  • A continuous sound.
  • B delivery in rectangular shaped sound packets (sound bursts) with temporal
  • cavitation medium with carbon dioxide as a cavitation-active ingredient and as a potentially germicidal substance in the treatment of germs, preferably in the treatment of problematic germs, more preferably in the medical treatment of infections, even more preferably in the medical treatment of Problem infections in humans and / or animals.
  • the described "carbonic acid water” is preferred as the cavitation medium.
  • carbon dioxide and / or a carbon dioxide-containing medium preferably a cavitation medium, for example the "carbonic acid water”
  • a cavitation medium for example the "carbonic acid water”
  • Method / method for killing germs / microorganisms with a potentially germicidal cavitation medium and / or a potentially germicidal substance ⁇ Method / method for killing germs / microorganisms with carbon dioxide and a complementary sound treatment, preferably with Kavitations Basil.
  • Method and / or method for killing germs with a potentially germicidal substance preferably of carbon dioxide, in the case of by (with the help of) physical and / or chemical forces / energy / effect, preferably by sound-induced cavitation at low to Moderate sound intensity, by the action of these forces / effects / energies on germs and / or on their biological structures (for example protective layers)
  • Prerequisites for example and / or preferably by structural alteration of biological structures of the germs, eg loosening, destruction, increase of Permeability, etc.
  • the germicidal effect of the method and / or the method is not / not predominantly based on the Kavitationsrial, so not / mostly not by mechanical destruction of the germs as would be the case for example in
  • Requirements for example and / or preferably by structural alteration of biological structures of the germs, eg loosening, destruction, increase in permeability etc.
  • the germicidal effect of the method and / or the method is not / not predominantly based on the cavitation effect, ie not / predominantly not by mechanical destruction of the germs as would be the case for example in transient cavitation (eg ultrasonic debridement).
  • a cavitation medium preferably the "carbonic acid” water to kill germs in conjunction with a complementary sound treatment with Kavitationsrial ⁇
  • a suitable material preferably carbon dioxide for the production of a potentially germicidal cavitation medium (as described above ), preferably with carbon dioxide as the cavitation-active ingredient and / or as a germicidal substance.
  • a suitable substance preferably of carbon dioxide
  • at least one further complementary treatment preferably sound
  • physical and / or chemical and / or bioactive action preferably with cavitation effect
  • a cavitation medium preferably a cavitation medium / cavitation medium with potentially germicidal action (as described above) for enrichment of at least one potentially germicidal substance, preferably of carbon dioxide, in the cell interior of germs / microorganisms.
  • ⁇ Cavitation medium and / or use / application of a cavitation medium, preferably a cavitation medium with potentially germicidal effect (as described above) for acting on germs and / or their biological structures, for example by cavitation, to their permeability / permeability for externally supplied substances / substances increase.
  • Use / application / use of the cavitation effect and / or its (mechanical) effect in order to make a germ-killing substance from a per se not or only slightly toxic substance (preferably carbon dioxide) by the cavitation and / or their effect of Substance can accumulate on / in the germ and cause an effect that has a germicidal effect, not germicidal / only slightly effective by the Kavitations Basil.
  • Cavitation medium and / or use / application / use thereof which in addition to its action / function / use as Kavitationsmedium simultaneously (by at least one suitable and / or cavitation effective gas / suitable material, preferably carbon dioxide) at least one bioactive, for example, a physiological and / or has a germicidal effect, especially when this cavitation medium is used in combination with sound for a cavitation treatment and / or the sound is coupled to the biological system by means of the cavitation medium.
  • the combination of at least two potentially germicidal substances may be possible, for example carbon dioxide with oligodynamically active substances / compounds, eg. Metals / metal ions / alloys / metal compounds.
  • oligodynamically active substances / compounds eg. Metals / metal ions / alloys / metal compounds.
  • other substances / active ingredients / pharmaceutical agents can be added to the Kavitationsmittel and / or applied before, after a Kavitations opposition.
  • substances other than carbon dioxide can penetrate into the protective layers made permeable by the cavitation effect, for example substances added to the cavitation medium.
  • the treatment of germs, cells, cell aggregates, etc. with potentially germicidal substances, such as carbon dioxide, can in principle also in not openly accessible places (eg. As organs) may be possible, for example, if they can be enriched / filled with a potentially germicidal substance, for example, in a cavity.
  • the formation of the gas bubbles and the cavitation preferably take place on and / or near the object surface (eg of the biological system).
  • the cavitation medium is used for coupling the sound to the biological system, wherein the germs / microorganisms, for example as a germ / bacteria suspension, can be located directly in the cavitation medium. More commonly, the cavitation medium will contact the germs / microorganisms and / or their biological structures at an interface, for example, in subaqually treating a skin infection similar to that shown in FIG. 1.
  • Sound in the description may mean monofrequent sound (one frequency) and / or duo-frequency (two different frequencies) and / or multifrequency sound (with at least two different sound frequencies).
  • duo and / or multifrequent sound the different frequencies simultaneously and / or not simultaneously (for example, temporally intermittent and / or in another form) to the medium, for. B. to the Kavitationsmedium, by at least one sound source (for example, at least one sound applicator) are delivered.
  • the sound characteristics can have a special influence on the cavitation as well as on the effect (depth / surface effect) of the sound / cavitation. / Waveform, etc.). Sound emission according to the technical state and according to the optimization of a certain effect, for example optimization with regard to cavitation.
  • Sound in the description initially means sound of any sound intensity [in accordance with conventional terms such as SATA, etc.] (eg, from 0.001 watts / cm 2 to 500 watts / cm 2 , 0.001 watts / cm 2 to 20 watts / cm 2 , preferably 0.001 watt / cm 2 to 10 watt / cm 2, more preferably 0.001 watt / cm 2 to 5 watt / cm 2 , more preferably 0.001 watt / cm 2 to 2 watt / cm 2 ), any sound pressure (eg from 0, 05 Pa to over 500000 kPa range, preferably 0.5 Pa to 500 kPa, further preferred sound pressure ranges 0, 5 Pa to 50 kPa, 50 kPa to 2100 kPa, 100 kPa to 300 kPa, 300 kPa to 500 kPa), any sound amplitude.
  • any sound intensity eg, from 0.001 watts / cm 2 to 500 / cm 2
  • the distance of the sound-emitting surface to the object may initially be arbitrary (0.0001 mm - 100 m) Preferably below 1mm to 100cm, more preferably below 1mm to 20cm, even more preferably from below 1mm to 5cm, most preferably from less than 1 mm (for example) 0.01 mm to 2 cm.
  • the coupling of the sound to the biological system should preferably take place through the cavitation medium, preferably subaqual as in FIG. 1 and / or in that the cavitation medium contacts the biological system and / or the object surface.
  • the cavitation medium preferably subaqual as in FIG. 1 and / or in that the cavitation medium contacts the biological system and / or the object surface.
  • at least one further sound-conducting layer can be located and / or attached, wherein for example the sound is transmitted from the sound applicator to the further sound-conducting layer and from there to the cavitation medium.
  • any suitable gas that can potentially kill germs under the conditions described.
  • the gas dissolves in water, in aqueous solutions and / or in another suitable liquid, other suitable medium in a sufficiently high concentration, for example, polar gases in polar liquids.
  • gases are mentioned in DE 102004004415, which, however, need not be suitable gases.
  • the cavitation is preferably carried out in a liquid cavitation medium, but other conventional well-known cavitation media (for example, steam, fog, aerosol, etc.) are possible.
  • cavitation cavitation occurs by excitation of, for. B. located in Kavitationsmedium, gas bubbles to (oscillating) gas bubble oscillations up to resonant vibrations of the gas bubbles.
  • the formation of gas bubbles from the cavitation medium may be possible by a sound effect on the cavitation medium during the treatment (by the passage of dissolved, eg molecularly dissolved gas into the gas bubble state), and these gas bubbles are excited to vibrate.
  • the cavitation medium serves as a gas bubble source.
  • Gas dissolved in the cavitation medium is converted to the bubbling state (gas bubble formation) by the sound pressure when sound is applied to the cavitation medium.
  • Cavitation has almost only an effect on a biological system and / or its surface, if the cavitation occurs near the surface and / or on the surface. This can be achieved, for example, if the distance of the sound-emitting surface to the object surface can be kept low.
  • the gas concentration in the medium should be high and it should be possible to repeatedly form new gas bubbles (in situ) during the treatment.
  • Cavitation preferably sound-induced cavitation, more preferably ultrasound-induced cavitation, even more preferably cavitation induced by low-frequency ultrasound.
  • a cavitation / cavitation reaction can also take place without an actual cavitation medium, for example if an object surface (eg skin as the surface of a biological system) is enriched with gas bubbles which adhere to the surface / in pores etc.
  • an object surface eg skin as the surface of a biological system
  • gas bubbles which adhere to the surface / in pores etc.
  • Cavitation can also take place without actual cavitation medium. For example, if sufficient gas bubbles are available for cavitation in the boundary layer between the coupling medium and the object surface and these can also be excited to oscillate.
  • an object surface surface of a biological system, eg skin, wound, etc.
  • at least one gas e.g. With carbon dioxide.
  • One possibility for enriching the surface of the object (eg skin) with gas / gas bubbles may be that the retention / adhesion (eg by adhesion) of the gas at the surface is improved, for example by using the polarity in the case of polar Gases like carbon dioxide.
  • Another possibility may be that the object surface is first wetted with a polar liquid layer and then exposed to a gas atmosphere (eg carbon dioxide), preferably under pressure (analogous to FIG.
  • Another possibility may be that, for example by using at least one further substance / active substance (eg urea, containing urea as an example), which is applied to the surface, moisture (eg water) is supplied to the surface and this leads to a chemical reaction / decomposition in which at least one gas is released, for example the hydrolysis of urea.
  • moisture eg water
  • urea decomposes by hydrolysis into carbon dioxide and ammonia. Gases that are cavitation-active and potentially capable of destroying germs.
  • Cavitation such as sonication have on the object to be treated / biological system depth as well as surface effect (DE 10 2004 004 415).
  • Area of application / field of application / field of application of the potentially germ-killing action of carbon dioxide supported by cavitation can be any areas in which germs are to be killed, in particular also where problem germs occur and / or other methods / methods for germ treatment fail and / or are not used can. This also applies in areas with biofilm problems.
  • Field of application / field of application / field of application of a cavitation medium which contains carbon dioxide as a cavitation-effective constituent and / or as a potentially germicidal gas as constituent can be any areas in which germs are to be killed, this also applies where problem germs occur and / or other processes / Methods for germ treatment fail and / or can not be applied. This also applies in areas with biofilm problems.
  • Sound energy / sound intensity is to be preferred.
  • Therapeutic / medical treatment of infections that can not be treated externally, for example, organs, for example, organs that form a cavity and could be filled with a cavitation medium and / or a suitable gas. Ultrasonic application from the outside and / or from the inside possible.

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Abstract

L'invention concerne une destruction de germes à l'aide d'au moins une substance fiable, potentiellement germicide en association avec au moins un traitement complémentaire à effet physique et/ou chimique dans le traitement de germes et/ou de leurs structures biologiques. A cause du développement des résistances des germes, des couches protectrices des germes (par exemple des biofilms, etc...) et/ou pour d'autres raisons, il est difficile ou parfois même impossible de traiter des germes/ des germes problématiques et/ou de traiter médicalement des infections/ des infections problématiques, par exemple des blessures. Afin de résoudre ce problème, l'invention concerne un traitement à l'aide de dioxyde de carbone concentré en association avec un traitement par sonication complémentaire à effet de cavitation à une énergie acoustique faible à moyenne, la cavitation présentant un effet de renforcement mais un caractère germicide insuffisant, et l'effet germicide étant créé par réaction chimique du dioxyde de carbone. Le procédé de l'invention est utilisé dans le traitement médical d'infections, en particulier d'infections provoquées par des germes problématiques. Il peut être également utilisé dans le traitement non médical de germes/ de germes problématiques pour le nettoyage, l'hygiène, etc... mais également dans le domaine technique.
PCT/DE2009/000444 2008-03-27 2009-03-27 Destruction de germes au moyen de dioxyde de carbone et traitement par cavitation d'adjuvants WO2009118002A2 (fr)

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Cited By (1)

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WO2019078806A1 (fr) 2017-10-17 2019-04-25 Osypenko Serhii Procédé permettant d'obtenir un biofertilisant organique liquide pour sol et/ou végétaux, biofertilisant et procédés d'utilisation associés

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US4888834A (en) 1988-02-23 1989-12-26 Malmros Holding, Inc. Bathing system
US4942868A (en) 1988-03-30 1990-07-24 Malmros Holding, Inc. Ultrasonic treatment of animals
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EP0442278B1 (fr) 1990-02-02 1995-04-12 PETER KRAUTH GmbH Dispositif pour thérapie par voie humide à ultrason
DE4306645A1 (de) * 1993-03-03 1994-09-08 David Jackson Verfahren zum Reinigen, Sterilisieren und Implantieren von Substraten mittels eines Hochenergetischen verdichteten Fluids
GB9617749D0 (en) 1996-08-23 1996-10-02 Young Michael J R Improved apparatus for ultrasonic therapeutic trteatment
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AU2003257394A1 (en) * 2002-07-22 2004-03-03 Hans-Werner Bender Ultrasonic applicator device with a flat, flexible ultrasonic applicator and cavitation medium
DE10233293A1 (de) 2002-07-22 2004-02-19 Bender, Hans-Werner, Dr. Anordnung zur Verbesserung der Kavitations- und Wirkeigenschaften bei der Behandlung von Oberflächen biologischer Systeme
DE102004060071A1 (de) 2003-12-11 2005-08-25 Bender, Hans-Werner, Dr. Trägerelement für eine Vorrichtung mit einem Schallapplikator
EP1933943A1 (fr) 2005-06-09 2008-06-25 Hans-Werner Bender Element support comme module pour un dispositif de traitement

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019078806A1 (fr) 2017-10-17 2019-04-25 Osypenko Serhii Procédé permettant d'obtenir un biofertilisant organique liquide pour sol et/ou végétaux, biofertilisant et procédés d'utilisation associés

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