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WO2009116069A3 - Process for preparation of 1-(9h-carbazol-4-yloxy)-3-[[2-(2- methoxyphenoxy) ethyl] amino]-2-propanol - Google Patents

Process for preparation of 1-(9h-carbazol-4-yloxy)-3-[[2-(2- methoxyphenoxy) ethyl] amino]-2-propanol Download PDF

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Publication number
WO2009116069A3
WO2009116069A3 PCT/IN2009/000073 IN2009000073W WO2009116069A3 WO 2009116069 A3 WO2009116069 A3 WO 2009116069A3 IN 2009000073 W IN2009000073 W IN 2009000073W WO 2009116069 A3 WO2009116069 A3 WO 2009116069A3
Authority
WO
WIPO (PCT)
Prior art keywords
carbazol
methoxyphenoxy
yloxy
propanol
ethyl
Prior art date
Application number
PCT/IN2009/000073
Other languages
French (fr)
Other versions
WO2009116069A2 (en
Inventor
Ashok Kumar
Satish Rajanikant Soudagar
Rajendra Raghunath Patil
Prashant Dayakrishana Gautam
Original Assignee
Ipca Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipca Laboratories Limited filed Critical Ipca Laboratories Limited
Publication of WO2009116069A2 publication Critical patent/WO2009116069A2/en
Publication of WO2009116069A3 publication Critical patent/WO2009116069A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to a process for preparation of l-(9H-carbazol-4-yloxy)-3- [[2-(2-methoxyphenoxy) ethyl] amino]-2-propanol and its salts comprising; a)reacting 1- (9H-carbazol-4-yloxy)-3-arylmethylamino-2-propanol or its 9-substituted derivatives with 2-(2-methoxyphenoxy)-haloethane; and b) deprotecting the resulting intermediate to obtain l-(9H-carbazol— 4— yloxy)-3-[[2-(2-methoxyphenoxy)ethyl] amino]-2-propanol in free form or its acid addition salt, which are pharmaceutically valuable compounds.
PCT/IN2009/000073 2008-02-04 2009-02-03 Process for preparation of 1-(9h-carbazol-4-yloxy)-3-[[2-(2- methoxyphenoxy) ethyl] amino]-2-propanol WO2009116069A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN242/MUM/2008 2008-02-04
IN242MU2008 2008-02-04

Publications (2)

Publication Number Publication Date
WO2009116069A2 WO2009116069A2 (en) 2009-09-24
WO2009116069A3 true WO2009116069A3 (en) 2011-01-27

Family

ID=41091330

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000073 WO2009116069A2 (en) 2008-02-04 2009-02-03 Process for preparation of 1-(9h-carbazol-4-yloxy)-3-[[2-(2- methoxyphenoxy) ethyl] amino]-2-propanol

Country Status (1)

Country Link
WO (1) WO2009116069A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102190613B (en) * 2010-03-14 2014-06-25 浙江华海药业股份有限公司 Method for preparing carvedilol
AU2016369528B2 (en) * 2015-12-16 2021-04-22 Genentech, Inc. Process for the preparation of tricyclic PI3K inhibitor compounds and methods for using the same for the treatment of cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0918055A1 (en) * 1997-11-24 1999-05-26 Egis Gyogyszergyar Rt. Process and intermediates for preparing 1-[9'H-carbazol-4'-yloxy]-3-[ 2''-(2'''- methoxy -phenoxy)-ethyl)-amino]-propan-2-ol[carvedilol]
WO2004113296A1 (en) * 2003-06-20 2004-12-29 Sun Pharmaceutical Industries Limited A process for preparation of 1-[9h-carbazol-4-yloxy]- 3-[{2-(2-(-(methoxy)phenoxy)-ethyl}-amino]-propan-2-ol
WO2005113502A1 (en) * 2004-05-20 2005-12-01 Cipla Limited Process for the preparation of carvedilol

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0918055A1 (en) * 1997-11-24 1999-05-26 Egis Gyogyszergyar Rt. Process and intermediates for preparing 1-[9'H-carbazol-4'-yloxy]-3-[ 2''-(2'''- methoxy -phenoxy)-ethyl)-amino]-propan-2-ol[carvedilol]
WO2004113296A1 (en) * 2003-06-20 2004-12-29 Sun Pharmaceutical Industries Limited A process for preparation of 1-[9h-carbazol-4-yloxy]- 3-[{2-(2-(-(methoxy)phenoxy)-ethyl}-amino]-propan-2-ol
WO2005113502A1 (en) * 2004-05-20 2005-12-01 Cipla Limited Process for the preparation of carvedilol

Also Published As

Publication number Publication date
WO2009116069A2 (en) 2009-09-24

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