WO2009108364A3 - Antagonistic analogues of ghrh - Google Patents
Antagonistic analogues of ghrh Download PDFInfo
- Publication number
- WO2009108364A3 WO2009108364A3 PCT/US2009/001279 US2009001279W WO2009108364A3 WO 2009108364 A3 WO2009108364 A3 WO 2009108364A3 US 2009001279 W US2009001279 W US 2009001279W WO 2009108364 A3 WO2009108364 A3 WO 2009108364A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- analogues
- hghrh
- inhibit
- ghrh
- antagonistic
- Prior art date
Links
- 230000003042 antagnostic effect Effects 0.000 title abstract 2
- 101150102363 Ghrh gene Proteins 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 101710198286 Growth hormone-releasing hormone receptor Proteins 0.000 abstract 1
- 102100033365 Growth hormone-releasing hormone receptor Human genes 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001817 pituitary effect Effects 0.000 abstract 1
- 230000036515 potency Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
There is provided a novel series of synthetic antagonistic analogues of hGHRH(l- 29)NH2 (SEQ E) NO: 1). These analogues inhibit the activity of endogenous hGHRH on the pituitary GHRH receptors, and therefore prevent the release of growth hormone. The analogues also inhibit the proliferation of human cancers through a direct effect on the cancer cells. The inhibitory potencies of the new analogues result from replacement of various amino acids.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6731808P | 2008-02-27 | 2008-02-27 | |
| US61/067,318 | 2008-02-27 | ||
| US20736609P | 2009-02-11 | 2009-02-11 | |
| US61/207,366 | 2009-02-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2009108364A2 WO2009108364A2 (en) | 2009-09-03 |
| WO2009108364A3 true WO2009108364A3 (en) | 2010-01-07 |
Family
ID=41016657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2009/001279 WO2009108364A2 (en) | 2008-02-27 | 2009-02-27 | Antagonistic analogues of ghrh |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2009108364A2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113929761B (en) * | 2020-03-18 | 2024-02-20 | 深圳纳福生物医药有限公司 | Modification and dimerization preparation of new growth hormone-releasing hormone-like peptides and their applications |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4689318A (en) * | 1985-08-29 | 1987-08-25 | The Salk Institute For Biological Studies | GRF analogs |
| US20050148515A1 (en) * | 2002-08-09 | 2005-07-07 | Dong Zheng X. | Growth hormone releasing peptides |
| US20070042950A1 (en) * | 2003-08-05 | 2007-02-22 | Administrators Of The Tulane Educational Fund, The | Antagonistic analogs of gh rh (2003) |
-
2009
- 2009-02-27 WO PCT/US2009/001279 patent/WO2009108364A2/en active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4689318A (en) * | 1985-08-29 | 1987-08-25 | The Salk Institute For Biological Studies | GRF analogs |
| US20050148515A1 (en) * | 2002-08-09 | 2005-07-07 | Dong Zheng X. | Growth hormone releasing peptides |
| US20070042950A1 (en) * | 2003-08-05 | 2007-02-22 | Administrators Of The Tulane Educational Fund, The | Antagonistic analogs of gh rh (2003) |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009108364A2 (en) | 2009-09-03 |
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