WO2009039361A3 - Process for the preparation of (s)-2-(3-tert-butylureido)-3,3-dimethylbutanoic acid - Google Patents
Process for the preparation of (s)-2-(3-tert-butylureido)-3,3-dimethylbutanoic acid Download PDFInfo
- Publication number
- WO2009039361A3 WO2009039361A3 PCT/US2008/077001 US2008077001W WO2009039361A3 WO 2009039361 A3 WO2009039361 A3 WO 2009039361A3 US 2008077001 W US2008077001 W US 2008077001W WO 2009039361 A3 WO2009039361 A3 WO 2009039361A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- butylureido
- tert
- preparation
- dimethylbutanoic acid
- dimethylbutanoic
- Prior art date
Links
- RAAPXVRHYBAJQU-SSDOTTSWSA-N (2s)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoic acid Chemical compound CC(C)(C)NC(=O)N[C@H](C(O)=O)C(C)(C)C RAAPXVRHYBAJQU-SSDOTTSWSA-N 0.000 title abstract 2
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
(S)-2-(3-tert-Butylureido)-3,3-dimethylbutanoic acid is conveniently prepared in a single reaction vessel from commercially available starting materials in a process that can be run on a kilogram or larger scale.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97401207P | 2007-09-20 | 2007-09-20 | |
US60/974,012 | 2007-09-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009039361A2 WO2009039361A2 (en) | 2009-03-26 |
WO2009039361A3 true WO2009039361A3 (en) | 2009-05-14 |
Family
ID=40468782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/077001 WO2009039361A2 (en) | 2007-09-20 | 2008-09-19 | Process for the preparation of (s)-2-(3-tert-butylureido)-3,3-dimethylbutanoic acid |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009039361A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013190509A2 (en) * | 2012-06-22 | 2013-12-27 | Dr.Reddys Laboratories Limited | Preparation of intermediates of boceprevir |
CN103396344B (en) * | 2013-08-08 | 2014-10-29 | 苏州永健生物医药有限公司 | One-pot synthetic method for N-t-butyl-aminocarbonyl-3-methyl-L-valine |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60155967A (en) * | 1984-01-25 | 1985-08-16 | Sumitomo Chem Co Ltd | Gas chromatography stationary phase and analysis method for enantiomeric mixtures using the same |
JPH11349552A (en) * | 1998-06-08 | 1999-12-21 | Ricoh Co Ltd | New ester compound with urea bond |
WO2004113294A1 (en) * | 2003-06-17 | 2004-12-29 | Schering Corporation | Process and intermediates for the preparation of (1r, 2s, 5s)-3-azabicyclo[3, 1, 0]hexane-2-carboxamide, n-[3-amino-1-(cyclobutylmethyl)-2, 3-dioxopropyl] ]-3-[(2s)-2-[[[1, 1-dimethylethyl]amino]carbonylamino]-3, 3-dimethyl-1-oxobutyl]-6, 6-dimethyl |
-
2008
- 2008-09-19 WO PCT/US2008/077001 patent/WO2009039361A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60155967A (en) * | 1984-01-25 | 1985-08-16 | Sumitomo Chem Co Ltd | Gas chromatography stationary phase and analysis method for enantiomeric mixtures using the same |
JPH11349552A (en) * | 1998-06-08 | 1999-12-21 | Ricoh Co Ltd | New ester compound with urea bond |
WO2004113294A1 (en) * | 2003-06-17 | 2004-12-29 | Schering Corporation | Process and intermediates for the preparation of (1r, 2s, 5s)-3-azabicyclo[3, 1, 0]hexane-2-carboxamide, n-[3-amino-1-(cyclobutylmethyl)-2, 3-dioxopropyl] ]-3-[(2s)-2-[[[1, 1-dimethylethyl]amino]carbonylamino]-3, 3-dimethyl-1-oxobutyl]-6, 6-dimethyl |
Also Published As
Publication number | Publication date |
---|---|
WO2009039361A2 (en) | 2009-03-26 |
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