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WO2009038754A3 - Signatures de l'expression génique dans des échantillons de cellules tumorales enrichis - Google Patents

Signatures de l'expression génique dans des échantillons de cellules tumorales enrichis Download PDF

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Publication number
WO2009038754A3
WO2009038754A3 PCT/US2008/010881 US2008010881W WO2009038754A3 WO 2009038754 A3 WO2009038754 A3 WO 2009038754A3 US 2008010881 W US2008010881 W US 2008010881W WO 2009038754 A3 WO2009038754 A3 WO 2009038754A3
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WO
WIPO (PCT)
Prior art keywords
gene expression
circulating
tumor cell
expression signatures
cells
Prior art date
Application number
PCT/US2008/010881
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English (en)
Other versions
WO2009038754A2 (fr
Inventor
Wen-Tien Chen
Original Assignee
The Research Foundation Of State University Of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Research Foundation Of State University Of New York filed Critical The Research Foundation Of State University Of New York
Priority to US12/678,921 priority Critical patent/US8889361B2/en
Priority to EP08831502.3A priority patent/EP2201134B1/fr
Publication of WO2009038754A2 publication Critical patent/WO2009038754A2/fr
Publication of WO2009038754A3 publication Critical patent/WO2009038754A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des procédés de détection de signatures de l'expression génique de cellules de mélanome en circulation, de cellules de cancer ovarien, du sein, colorectal et de cellules progénitrices endothéliales en circulation, lesdites signatures étant efficaces pour distinguer la cellule cancéreuse en circulation des cellules normales en circulation et permettant également de distinguer différents types de cellules cancéreuses en circulation.
PCT/US2008/010881 2007-09-19 2008-09-19 Signatures de l'expression génique dans des échantillons de cellules tumorales enrichis WO2009038754A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/678,921 US8889361B2 (en) 2007-09-19 2008-09-19 Gene expression signatures in enriched tumor cell samples
EP08831502.3A EP2201134B1 (fr) 2007-09-19 2008-09-19 Signatures de l'expression génique dans des échantillons de cellules tumorales enrichis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99459207P 2007-09-19 2007-09-19
US60/994,592 2007-09-19

Publications (2)

Publication Number Publication Date
WO2009038754A2 WO2009038754A2 (fr) 2009-03-26
WO2009038754A3 true WO2009038754A3 (fr) 2014-06-05

Family

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PCT/US2008/010881 WO2009038754A2 (fr) 2007-09-19 2008-09-19 Signatures de l'expression génique dans des échantillons de cellules tumorales enrichis

Country Status (3)

Country Link
US (1) US8889361B2 (fr)
EP (1) EP2201134B1 (fr)
WO (1) WO2009038754A2 (fr)

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EP2524967A1 (fr) * 2011-05-19 2012-11-21 Signature Diagnostics AG Procédés et kits pour diagnostiquer le cancer colorectal
EP2524968A1 (fr) * 2011-05-19 2012-11-21 Signature Diagnostics AG Procédés et kits pour diagnostiquer le cancer colorectal
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US9250242B2 (en) 2012-11-09 2016-02-02 Roche Molecular Systems, Inc. In vitro capture and analysis of circulating tumor cells
CN105408748B (zh) * 2013-02-15 2019-06-04 托马斯杰弗逊大学 生物流体中脱落或循环的肿瘤细胞的检测方法
JP6563379B2 (ja) * 2013-03-15 2019-08-21 ジャンセン ダイアグノスティックス，エルエルシー 白血球の枯渇による循環腫瘍細胞の濃縮
US10053692B2 (en) 2013-10-21 2018-08-21 The General Hospital Corporation Methods relating to circulating tumor cell clusters and the treatment of cancer
EP3100047B1 (fr) 2014-01-27 2021-08-11 Epic Sciences, Inc. Diagnostics de cellules tumorales circulantes pour biomarqueurs du cancer de la prostate
WO2015116780A1 (fr) * 2014-01-31 2015-08-06 Epic Sciences, Inc. Procédés pour la détection et la quantification de mimétiques de cellules tumorales circulantes
US10545151B2 (en) 2014-02-21 2020-01-28 Epic Sciences, Inc. Methods for analyzing rare circulating cells
KR102657306B1 (ko) 2014-12-08 2024-04-12 버그 엘엘씨 전립선암의 진단 및 치료에서 필라민을 포함하는 마커의 용도
AU2016209694B2 (en) 2015-01-21 2020-07-02 Agency For Science, Technology And Research Column-based device and method for retrieval of rare cells based on size, and uses thereof
CN107208154A (zh) 2015-01-21 2017-09-26 新加坡科技研究局 单细胞rna和突变分析pcr(scrm‑pcr)：用于在单细胞水平上同时分析dna和rna的方法
WO2017044885A1 (fr) * 2015-09-09 2017-03-16 uBiome, Inc. Procédé et système pour des diagnostics dérivés du microbiome et agents thérapeutiques pour des affections associées à la santé cérébro-carniofaciale
CN106868103A (zh) * 2015-12-10 2017-06-20 益善生物技术股份有限公司 肝癌循环肿瘤细胞鉴定试剂盒
CN106868098A (zh) * 2015-12-10 2017-06-20 益善生物技术股份有限公司 循环肿瘤细胞分型鉴定试剂盒
CN106868101A (zh) * 2015-12-10 2017-06-20 益善生物技术股份有限公司 循环肿瘤干细胞鉴定试剂盒
CN106868102A (zh) * 2015-12-10 2017-06-20 益善生物技术股份有限公司 胃癌循环肿瘤细胞鉴定试剂盒
CN106868100A (zh) * 2015-12-10 2017-06-20 益善生物技术股份有限公司 结直肠癌循环肿瘤细胞鉴定试剂盒
CN106868099A (zh) * 2015-12-10 2017-06-20 益善生物技术股份有限公司 乳腺癌循环肿瘤细胞鉴定试剂盒
CN106868104A (zh) * 2015-12-10 2017-06-20 益善生物技术股份有限公司 肺癌循环肿瘤细胞分型鉴定试剂盒
WO2019041045A1 (fr) 2017-09-01 2019-03-07 The Hospital For Sick Children Profilage et traitement d'un cancer hypermutant
CN111826351B (zh) * 2020-03-13 2023-10-03 武汉大学深圳研究院 一种基于磁性分离法富集循环肿瘤细胞的磁性红细胞团簇

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Also Published As

Publication number Publication date
WO2009038754A2 (fr) 2009-03-26
EP2201134A4 (fr) 2016-10-19
EP2201134A2 (fr) 2010-06-30
US8889361B2 (en) 2014-11-18
US20100297634A1 (en) 2010-11-25
EP2201134B1 (fr) 2018-11-21

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