WO2009036599A1

WO2009036599A1 - Irradiation device and system

Info

Publication number: WO2009036599A1
Application number: PCT/CN2007/002772
Authority: WO
Inventors: Kai-Shu Song; Chin-Tien Huang
Original assignee: Kai-Shu Song
Priority date: 2007-09-20
Filing date: 2007-09-20
Publication date: 2009-03-26

Abstract

An irradiation device comprises at least one LED (11). The LED (11) can generate more than one narrow bandwidth centered at a wavelength as low-energy non-parallel concentrated light. The wavelength of the concentrated light is between 600 to 850nm, the energy density of the light is between 2 to 16J/cm2, and the divergence angle of the light is within 16 degree. An irradiation system using the irradiation device comprises a driver (12) to drive the LED (11) to generate the concentrated light, and a power supply (13) to provide power to the system.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medical device, and more particularly to an illumination device, and a system including the same, which can be used as a photobiostimulation illumination device for cell therapy. BACKGROUND OF THE INVENTION In conventional medicine, a certain fixed frequency and a fixed energy of concentrated light are generally used as a light source for medical irradiation, and the effect on biological stimulation is limited, so that only a fixed light and a fixed energy concentrated light are used. It is impossible to fully function. In addition, this existing light source adopts a large divergence angle, and the energy density of the light source is weak, which has a poor effect on biological stimulation. SUMMARY OF THE INVENTION It is an object of the present invention to provide an illumination device that can be used for biocellular therapy that produces different frequencies and different energy bundles of light.

To achieve the above object, the illumination device of the present invention comprises: at least one light emitting diode capable of generating a low-energy non-parallel beam that is concentrated in a narrow band of a pulse width and suitable as a biological stimulus for biological cell therapy, The beam light has a wavelength between 600 and 850 nm, and the light energy density is between ² and 16 joules/cm ² , preferably between 2. 5 and 5 joules/cm ² , and the light divergence angle is within 16 degrees. 4 to 10 degrees.

Another object of the present invention is to provide an illumination system that can be used for biological cell therapy.

The illumination system comprises: at least one set of light emitting diode devices having at least one light emitting diode, the light emitting diodes being capable of generating more than one narrow bandwidth centered at a wavelength, suitable for biological cell therapy 5〜5焦耳/厘米² 2。 The bio-stimulated low-energy non-parallel concentrating light, the wavelength of the beam is between 600 and 850 nm, the light energy density is between 2 and; 16 joules / cm ² , preferably between 2. 5 ~ 5 joules / cm ² And the divergence angle is within 16 degrees, preferably 4 to 10 degrees; a driver includes a voltage control circuit and a microprocessor, the voltage control circuit mainly receives signals transmitted by the central processing unit, providing different The output voltage is applied to the light emitting diodes to generate bundled light of different energies; the calculation of the microprocessor is used to regulate different frequencies, and the signals are output to the voltage control circuit; a power supply device is provided to provide power to the device.

In addition, the system further includes a button device coupled to the central processing unit to enable the operator to To enter the desired light energy and frequency data.

The system includes an overcurrent protection circuit to protect the unit.

The voltage control circuit of the system uses a pulse wave adjustment circuit to receive the pulse signal of the central processing unit and provide different output voltages to the diode.

It is still another object of the present invention to provide a method of generating light irradiation energy comprising the following steps -

(a) at least one light-emitting diode capable of emitting a narrow pulse width and concentrated in the therapeutic band of the infrared or near-infrared spectral region, the wavelength of the band being between 600 and 850 nm _;

(b) driving at least one of the diodes to emit a non-continuous non-parallel bundle of light having a divergence angle within 16 degrees;

(c) emitting at least one band of non-parallel bundled light and controlling the optical energy density at ^{2 to} 16 Joules/cm ² .

Furthermore, the method includes the following six modes:

The first mode is that the method comprises a light irradiation step of three different numerical energies, and the light energy density is controlled to be in the range of ^{2 to} 16 joules/cm ² , and 0. 5X joules, IX joules, 1. The light energy of 5X joules is increased, and X is a variable. The light of each step illuminates the energy, the slope of the Θ angle increases, the angle of Θ, and the steps of the method can be repeated multiple times. 5秒,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, The wave pattern is a sudden rise and fall.

The second mode is that the method comprises a light irradiation step of three different numerical energies, wherein the three steps are to control the light energy density in the range of ^{2 to} 16 joules/cm ² , to 1.5 X joules, IX joules, 0. 5X Joule's light energy is decremented, and X is a variable. The light of each step illuminates the energy, and the slope of the Θ angle increases. The 9 angle is ≥ 45 degrees, and this step can be repeated several times. The volatility is 0. 5~1. The fluctuation frequency is between 0 and 5 times. The fluctuation frequency is between 0. 5~1. 5 seconds, the fluctuation mode is a slow rise and a sudden drop.

The third mode is that the method comprises a light irradiation step of two different numerical energies, wherein the two steps are to control the light energy density in the range of ^{2 to} 16 joules/cm ² , to 0. 5X joules, IX joules The light energy is increased, and the X is a variable. The light illuminating energy of the first step is increased by the 角度 angle slope, the Θ angle is 60 degrees, and the step can be repeated several times. The second step of the number of fluctuations is 0. 5~1. 5 seconds, the number of fluctuations in the first step is 0. 5~1. 5 seconds, the number of fluctuations in the first step is further increased by a slight fluctuation in the light of each step. For 9 or 27 times, the fluctuation mode is a sudden rise and fall, and the second fluctuation is 6 times or 18 times. The fluctuation mode is a slow rise and a sudden drop.

The fourth mode is that the method includes two different numerical energy light illumination steps, the two steps The light energy density is controlled in the range of ^{2 to} 16 joules/cm ² , and the light energy of IX joules and 0.5X joules is decreased. The X is a variable, and the light irradiation energy of the first step is increased by the slope of the angle ,. The angle ^ is 60 degrees, and this step can be repeated several times. The second step of the number of fluctuations is 0. 5~ 1. 5 seconds, the fluctuation frequency of the first step is 0. 5~ 1. 5 seconds, the number of fluctuations of the first step is further increased by a slight fluctuation in the light irradiation of each step. For 6 or 18 times, the fluctuation mode is a slow rise and a sudden drop, and the second fluctuation is 9 times or 27 times. The fluctuation mode is a sudden rise and fall.

The fifth mode is that the method comprises a light irradiation step of numerical energy, wherein the light energy density is controlled within a range of 2 to 16 joules/cm ² , the irradiation energy is X joules, and X is a variable, and The illuminating energy is increased by the slope of the Θ angle, the Θ angle is about 45 degrees, and the step can be repeated several times. 5秒。 The number of fluctuations is 9 times, the amplitude of the fluctuation is 0. 5~1. 5 seconds, and the number of fluctuations is 9 times. Or 27 times, the fluctuation mode is a sudden rise and fall.

The sixth mode is that the method comprises a light irradiation step of numerical energy, wherein the light energy density is controlled within a range of ^{2 to} 16 joules/cm ² , the irradiation energy is X joules, and X is a variable, and the method The illuminating energy is increased by the slope of the Θ angle, the Θ angle is about 45 degrees, and this step can be repeated several times. And the fluctuation frequency is 0. 25~1. 0 seconds, and the number of fluctuations is 6 times. The method further applies a slight fluctuation in the light irradiation of each step, the fluctuation amplitude is within 20% of the light energy of the stage, and the fluctuation frequency is 0. 25~1. Or 18 times, the fluctuation mode is a slow rise and a sudden drop.

The apparatus and method provided by the present invention have the following advantages:

Since the LED device provided by the invention can generate different frequency and different energy bundle light, the applicability is wide; the invention selects the bundle light with a divergence angle of less than 16 degrees, and the optical energy density is ² ~16 joules/cm ² , It has good penetrability and promotes the differentiation and growth of cells. For example, the system of the present invention has excellent differentiation and production ability for inflamed or wound tissue cells during use, and can increase immunoglobulin and enhance resistance. The tissue fluid can be quickly taken away, and the healing time of the wound is accelerated. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a block diagram of a preferred embodiment of an illumination device of the present invention.

Figure 2: is a circuit diagram compared to Figure 1.

Fig. 3 is a graph showing the energy fluctuation of the first mode method in the light irradiation method of the present invention. Fig. 4 is a graph showing the energy fluctuation of the second mode method in the light irradiation method of the present invention. Fig. 5 is a graph showing the energy fluctuation of the third mode method in the light irradiation method of the present invention. Fig. 6 is a graph showing the energy fluctuation of the fourth mode method in the light irradiation method of the present invention. Fig. 7 is a graph showing the energy fluctuation of the fifth mode method in the light irradiation method of the present invention. Fig. 8 is a graph showing the energy fluctuation of the sixth mode method in the light irradiation method of the present invention. 1 to 2, and particularly to FIG. 1, the present invention provides an illumination system usable as a cell therapy, comprising at least one set of light emitting diode devices 1 1, at least one driver 1 2. A power supply unit 13.

The light emitting diode device 11 of the present invention has at least one light emitting diode, such as an LD, an LED or the like, which can generate more than one narrow band concentrated in a pulse width, for example: infrared light or near infrared light spectral region, Suitable for low-energy non-parallel bundled light for biological stimulation of biological cell therapy, the wavelength of the bundled light is preferably between 600 and 850 nm, and the optical energy density is between ² and 16 Joules/cm ² , and preferably at 2. 5 to 5 joules/cm ² , the divergence angle of the bundled light is within 16 degrees, and preferably between 4 and 10 degrees. The LED device 11 can select a plurality of diodes of different wavelengths to form diode devices 1 1 of different wavelength bands, which can provide different applications.

In the embodiment of Fig. 2, the diode device 1 1 has two groups, and in actual use, one or more sets of designs can be used.

Referring to Figures 1 and 2, the driver 12 of the present invention is mainly used to drive the LED device 1 1 to generate concentrated light, which comprises a voltage control circuit 1 2 1, a central processing unit (CPU frequency control) 1 2 2, and the voltage control circuit 1 2 1 mainly receives the modulated pulse wave transmitted by the central processing unit 1 2 2, and provides different output voltages to the LED device 1 1 to generate bundled light of different intensity; The voltage control circuit 1 2 1 adopts a pulse wave adjusting circuit as shown in the embodiment of FIG. 2, and the central processing unit 12 2 can control different frequencies by calculation and output a signal to the voltage control circuit 1 21 .

Referring to FIG. 2, the power supply device 13 of the present invention can use a power supply, a battery, and an application, which can utilize the power management to supply the power supply of the present invention, and can obtain a better power supply.

Referring to Figures 1 and 2, the present invention has a memory 1 2 6 (memory) connected to the central processing unit 1 2 2, which can provide an operator to store information, such as storing a desired illumination mode.

Referring to Figures 1 and 2, the present invention further includes an overcurrent protection circuit 1 2 3 for protecting the voltage control circuit 112. And the present invention has a button device 1 2 4 coupled to the central processing unit 1 2 2 for inputting required voltage values and frequency data for operating the irradiated light energy and frequency, and from a display unit 1 2 5 All the information is displayed on it. The method for generating light irradiation energy by using the foregoing illumination system comprises the following steps:

(a) providing at least one of the foregoing light-emitting diodes capable of emitting a narrow pulse width and focusing on a therapeutic band of a red or near-infrared light spectral region having a wavelength between 600 and 850 nm _;

(b) driving at least one of the diodes to emit a discontinuous non-parallel bundle of light having a divergence angle of within 16 degrees, and preferably between 4 and 10 degrees.

(b) The non-parallel bundle of light having at least one wavelength band illuminates the affected area, and the light energy density is controlled to be between ² and 16 joules/cm ² , and preferably between 2. 5 and 5 joules/cm ² .

To generate light illumination energy, there are six modes:

Referring to FIG. 3, the method of the first mode of the present invention comprises three light irradiation steps of different numerical energies, wherein the three steps control the optical energy density in the range of ^{2 to} 16 joules/cm ² to 0. 5X Joules, IX Joules, 1. 5X Joules of energy increase, and X is a variable, the light of each step illuminates the energy, the slope of the Θ angle increases, the angle of Θ, and this step can be repeated multiple times. The oscillating frequency is 0. 5~ The frequency of the fluctuation is between 0. 5~ 1. 5 seconds, the fluctuation mode is a sudden rise and fall.

Referring to FIG. 4, the method of the second mode of the present invention includes three different numerical energy light irradiation steps, wherein the three steps are to control the optical energy density within a range of ^{2 to} 16 Joules/cm ² to 1. 5X joules, IX joules, 0. 5X joules of energy decrement, and X is a variable, the first step of the light illuminates the energy, increasing the slope of the Θ angle, the angle ^ 45 degrees, and can repeat this multiple times step. 5〜 The fluctuation frequency is between 0. 5~. The fluctuation frequency is between 0. 5~ 1. 5 seconds, the fluctuation mode is a slow rise and a sudden drop.

Referring to FIG. 5, the method of the third mode of the present invention comprises two light irradiation steps of different numerical energies, wherein the two steps are to control the optical energy density within a range of 2 to 16 Joules/cm ² to 0. 5X joules, IX joules of energy increase, and X is a variable, the light irradiation energy of each step increases with the 角度 angle slope, the Θ angle ≤ 60 degrees, and the steps of the method can be repeated multiple times. The pulsation frequency is 0. 5~1. 5 seconds, the first wave of fluctuations is 9 Second or 27 times, the fluctuation mode is a sudden rise and fall, and the second fluctuation is 6 times or 18 times. The fluctuation mode is a slow rise and a sudden drop.

Referring to FIG. 6, the method of the fourth mode of the present invention comprises two light irradiation steps of different numerical energies, wherein the two steps are to control the optical energy density within a range of ^{2 to} 16 Joules/cm ² to IX Joules, 0. 5X Joules have a decreasing energy, and X is a variable. The first step of the light illuminates the energy. The slope of the angle is increased, the angle of the ^ is ^60 degrees, and the steps of the method can be repeated a plurality of times. Moreover, the method can apply a slight fluctuation in the light irradiation at each step, the fluctuation amplitude is within 20% of the energy of the stage, the fluctuation frequency is 0.5 to 1.5 seconds, and the fluctuation frequency of the first step is 6 times or 18 times. The fluctuation mode is a slow rise and a sudden drop. The second fluctuation is 9 times or 27 times, and the fluctuation mode is a sudden rise and fall.

Referring to FIG. 7, the method of the fifth mode of the present invention comprises a light irradiation step of numerical energy, wherein the light energy density is controlled within a range of ^{2 to} 16 Joules/cm ² and the irradiation energy is X Joules. And X is a variable, and the irradiation energy is increased by the slope of the Θ angle, the Θ angle is about 45 degrees, and the step can be repeated a plurality of times. Moreover, this method further applies a slight fluctuation in the light irradiation at each step, the fluctuation amplitude is within 20% of the light energy of the stage, the fluctuation frequency is 0.5 to 1.5 seconds, and the number of fluctuations is 9 times or 27 times. The wave pattern is a sudden rise and fall.

Referring to FIG. 8 , it is a method of the sixth mode of the present invention. The method comprises a light irradiation step of numerical energy, wherein the light energy density is controlled within a range of ^{2 to} 16 Joules/cm ² , and the irradiation energy is X, X is a variable, and the irradiation energy is increased by the slope of the Θ angle, the Θ angle is about 45 degrees, and the step can be repeated a plurality of times. Moreover, the method can apply a slight fluctuation in the light irradiation at each step, the fluctuation amplitude is within 20% of the light energy of the stage, the fluctuation frequency is 0.25 to 1.0 second, and the fluctuation frequency is 6 times or 18 times, and the fluctuation The way is to slow down and drop.

The following is a description of X in the above-mentioned one to six modes. For example, in the first mode, when X = 4, the light energy of the prescription provided by the three steps is:

0.5X4 joules = 2 joules

1X4 joules = 4 joules

1.5X4 joules = 6 joules

When X = 5, the light energy of the prescription provided in the 3 steps is:

0.5X5 joules two 2.5 joules

1X5 joules = 5 joules

1.5X5 joules = 7.5 joules

When X=10.66, the light energy of the prescription provided in the three steps is:

0.5X10.66 joules = 5.33 joules

1X10.66 joules = 10.66 joules

1.5X10.66 joules = 15.99 joules

Therefore, X is between 4 and 10.66, and the light energy does not exceed ^{2 to} 16 joules/cm ² . The second to six modes are the same.

In operation, the value and time of X are set according to the professional and experience of the system operator, and Record these parameters in memory.

However, since the photo-energy passivation effect is inactivated when the light energy density exceeds about 16 joules/cm ² , the photo-stimulating effect is inversely affected. If the optical energy density is too small to be less than about 2 joules/cm ² , the biostimulating effect of the cells is poor or The effect of the invention is preferably between ² and 16 joules/cm ² , especially 2. 5 to 5 joules/cm ² .

In addition, when the light divergence angle is too large, the light energy is weak, and the biological excitation effect is poor, and the light divergence angle of the present invention is within 16 degrees, especially at 4 to 10 degrees, the light energy is the strongest, and the light stimulation effect is good. . Industrial applicability

In the device and system provided by the invention, the light-emitting diode selects the concentrated light with a divergence angle of less than 16 degrees, and the light energy density is 2 to 16 J/cm, and the penetration is good, and the tissue cells of the inflamed or wound have Excellent differentiation and ability to produce, at the same time increase the immunoglobulin, enhance the resistance, and quickly take away the tissue fluid, so that the wound healing time is accelerated. Therefore, the present invention can be widely applied to medical fields and is suitable for industrial applications.

Claims

Rights request

What is claimed is: 1. An illumination device comprising at least one light emitting diode, the light emitting diode capable of generating more than one narrow band of one pulse width as low energy non-parallel bundled light, wherein the wavelength of the bundled light is between 600 ~850nm, the light energy density is between ² ~16 J/cm ² , and the light divergence angle is within 16 degrees.

2. The illumination device of claim 1 wherein the light divergence angle is between 4 and 10 degrees.

5〜 5 J/厘米^{2 2} The light energy density is 2. 5~ 5 J/cm ²

4. An illumination system, characterized in that it comprises:

At least one set of the light emitting diode device of any one of claims 1 to 3;

a driver for driving the LED device to generate concentrated light;

A power supply unit that provides system power.

5. The illumination system of claim 4, wherein the driver comprises: a voltage control circuit that receives the modulated pulse wave transmitted by a central processing unit to provide a different output voltage to Light emitting diode device to generate concentrated light of different intensity;

The central processing unit uses the calculation of the central processing unit to regulate different frequencies and outputs a signal to a voltage control circuit.

6. The illumination system of claim 5, further comprising a button device coupled to the central processing unit.

7. The illumination system of claim 5 wherein the voltage control circuit has an overcurrent protection circuit.

8. The illumination system of claim 5 wherein the voltage control circuit comprises a pulse wave conditioning circuit.

9. The illumination system of claim 4, further comprising a memory coupled to the central processing unit.

10. A method of producing light illumination energy, comprising the steps of:

(1) Providing at least one of the light-emitting diodes according to any one of claims 1 to 3, capable of emitting a narrow pulse width and focusing on a wavelength band of a red or near-infrared light spectrum region, the wavelength of the wavelength band being between 600 and 850 nm ;

(2) driving at least one of the diodes to emit a discontinuous non-parallel bundle of light having a divergence angle within 16 degrees; (3) emitting at least one band of non-parallel bundled light and controlling the optical energy density at ^{2 to} 16 J/cm ² .

11. The method of producing light irradiation energy according to claim 10, characterized in that the method comprises three steps of irradiating light energy of different values, the three steps controlling the light energy density at 2 to 16 J/cm. ^{In the} range of ² , 0.5X, IX, 1. 5X Joules of energy increase, and X is a variable, the light irradiation energy of each step increases with the 角度 angle slope, which is ^60 degrees.

The method for generating light irradiation energy according to claim 11, wherein the method further applies a slight fluctuation in the light irradiation of each step, the fluctuation amplitude being 20 of the light energy of the stage. Within 5 %, the frequency of fluctuations is 6 or 9 times, and the fluctuation frequency is 0. 5~1. 5 seconds, and the fluctuation mode is a sudden rise and fall.

13. The method of producing light irradiation energy according to claim 10, wherein the method comprises three different numerical energy light irradiation steps, wherein the three steps control the light energy density to 2 to 16 J/cm. ^{In the} range of ² , the energy of 1. 5X, IX, 0. 5X Joule is decremented, and X is a variable. The light of the first step illuminates the energy, and the slope of the Θ angle increases. The angle ^ is 45 degrees and can be repeated. This step is repeated many times.

The method for generating light irradiation energy according to claim 13, wherein the method further applies a slight fluctuation in the light irradiation of each step, the fluctuation amplitude being 20 of the light energy of the stage. Within 5 %, the fluctuation frequency is between 0. 5 and 1. 5 seconds, and the fluctuation mode is a slow rise and a sudden drop.

15. A method of producing light illumination energy according to claim 10, wherein the method comprises two different numerical energy light illumination steps, the two steps controlling the light energy density at 2 to 16 J/cm. ^{In the} range of ² , the energy of 0. 5X, IX joules is increased, and X is a variable. The light irradiation energy of each step is increased by the slope of the angle ^, the angle ^ is ₆₀ degrees, and the steps of the method can be repeated multiple times. .

The method for generating light irradiation energy according to claim 15, wherein the method further applies a slight fluctuation in the light irradiation of each step, and the fluctuation amplitude is 20% of the light energy at the stage. The fluctuation frequency is 0. 5~1. 5 seconds, the first wave of fluctuations is 9 or 27 times, the fluctuation mode is the sudden rise and fall, and the second fluctuation is 6 or 18 times. Slow rise and fall.

17. A method of producing light illumination energy according to claim 10, wherein the method comprises two different numerical energy light illumination steps, the two steps controlling the light energy density at 2 to 16 J/cm. ^{In the} range of ² , the energy of IX, 0.5X Joule is decremented, and X is a variable. The illuminating energy of the first step is increased by the slope of the Θ angle, which is 60 degrees, and can be repeated many times. Steps.

The method for generating light irradiation energy according to claim 17, wherein in the method, the light irradiation at each step is further subjected to a slight fluctuation, and the fluctuation amplitude is within 20% of the energy of the stage. The fluctuation frequency is 0. 5~1. 5 seconds, the first step of the fluctuations is 6 or 18 times, the fluctuation mode is a slow rise and a sudden drop, the second fluctuation is 9 times or 27 times, and the fluctuation mode is a sharp rise. Slow down.

The method for generating light irradiation energy according to claim 10, characterized in that the method comprises a light irradiation step of numerical energy, which is controlled in the range of ^{2 to} 16 J/cm ² with a light energy density, The irradiation energy is X Joules, and X is a variable, and the irradiation energy is increased by the slope of the Θ angle, the Θ angle is 45 degrees, and the step can be repeated a plurality of times.

The method for generating light irradiation energy according to claim 19, wherein the method further applies a slight fluctuation in the light irradiation of each step, and the fluctuation amplitude is within 20% of the light energy of the stage. The fluctuation frequency is 0. 5~1. 5 seconds, and the number of fluctuations is 9 or 27 times, and the fluctuation mode is a sudden rise and fall.

The method for generating light irradiation energy according to claim 10, characterized in that the method comprises a light irradiation step of numerical energy, wherein the light energy density is controlled within a range of ^{2 to} 16 J/cm ² , and the irradiation The energy is X joules, and X is a variable, and the irradiation energy is increased by the slope of the Θ angle, the Θ angle is 45 degrees, and the step can be repeated a plurality of times.

The method for generating light irradiation energy according to claim 21, wherein the method further applies a slight fluctuation in the light irradiation of each step, and the fluctuation amplitude is within 20% of the light energy of the stage. The fluctuation frequency is 0. 25~1. 0 seconds, and the number of fluctuations is 6 or 18 times, and the fluctuation mode is a slow rise and a sudden drop.