+

WO2009036083A3 - Polymer compositions for controllable drug delivery - Google Patents

Polymer compositions for controllable drug delivery Download PDF

Info

Publication number
WO2009036083A3
WO2009036083A3 PCT/US2008/075884 US2008075884W WO2009036083A3 WO 2009036083 A3 WO2009036083 A3 WO 2009036083A3 US 2008075884 W US2008075884 W US 2008075884W WO 2009036083 A3 WO2009036083 A3 WO 2009036083A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymer composition
drug delivery
polymer compositions
controllable drug
aliphatic polyester
Prior art date
Application number
PCT/US2008/075884
Other languages
French (fr)
Other versions
WO2009036083A2 (en
Inventor
Weijian Zhang
Tin Trong Tran
Soonkap Hahn
Jae Young Yang
Younjung Yuk
Kenneth D Brown
Original Assignee
Curexo Usa Inc
Weijian Zhang
Tin Trong Tran
Soonkap Hahn
Jae Young Yang
Younjung Yuk
Kenneth D Brown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curexo Usa Inc, Weijian Zhang, Tin Trong Tran, Soonkap Hahn, Jae Young Yang, Younjung Yuk, Kenneth D Brown filed Critical Curexo Usa Inc
Publication of WO2009036083A2 publication Critical patent/WO2009036083A2/en
Publication of WO2009036083A3 publication Critical patent/WO2009036083A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/65—Low-molecular-weight compounds having active hydrogen with high-molecular-weight compounds having active hydrogen
    • C08G18/66—Compounds of groups C08G18/42, C08G18/48, or C08G18/52
    • C08G18/6666—Compounds of group C08G18/48 or C08G18/52
    • C08G18/667—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38
    • C08G18/6674—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/3203
    • C08G18/6677—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/3203 having at least three hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
    • C08L75/04—Polyurethanes
    • C08L75/08—Polyurethanes from polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2270/00—Compositions for creating interpenetrating networks
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

A polymer composition comprising an IPN polymer network of a branched polyether and a biodegradable aliphatic polyester, or a biodegradable aliphatic polyester exhibits useful physical and drug release characteristics. Accordingly, the polymer composition is useful in drag delivery systems and medical devices, for example, drug eluting stents, and the treatment of mammals therewith. Also provided are methods for synthesizing and characterizing the polymer composition.
PCT/US2008/075884 2007-09-12 2008-09-10 Polymer compositions for controllable drug delivery WO2009036083A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US97182207P 2007-09-12 2007-09-12
US60/971,822 2007-09-12
US99156707P 2007-11-30 2007-11-30
US60/991,567 2007-11-30

Publications (2)

Publication Number Publication Date
WO2009036083A2 WO2009036083A2 (en) 2009-03-19
WO2009036083A3 true WO2009036083A3 (en) 2009-07-02

Family

ID=40342779

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/075884 WO2009036083A2 (en) 2007-09-12 2008-09-10 Polymer compositions for controllable drug delivery

Country Status (1)

Country Link
WO (1) WO2009036083A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090004243A1 (en) 2007-06-29 2009-01-01 Pacetti Stephen D Biodegradable triblock copolymers for implantable devices
US8661630B2 (en) 2008-05-21 2014-03-04 Abbott Cardiovascular Systems Inc. Coating comprising an amorphous primer layer and a semi-crystalline reservoir layer
US8697113B2 (en) * 2008-05-21 2014-04-15 Abbott Cardiovascular Systems Inc. Coating comprising a terpolymer comprising caprolactone and glycolide
DE102009056634A1 (en) * 2009-12-02 2011-06-09 Giesecke & Devrient Gmbh Solid particles with silicon coating
WO2012091680A1 (en) * 2010-12-30 2012-07-05 Nanyang Technological University A device for controlled release of a bioactive agent
WO2016100520A1 (en) * 2014-12-16 2016-06-23 Boston Scientific Scimed, Inc. Bioerodible polymer compositions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984000302A1 (en) * 1982-07-16 1984-02-02 Univ Groningen Biocompatible, antithrombogenic materials suitable for reconstructive surgery
WO1998001493A1 (en) * 1996-07-08 1998-01-15 Jvs-Polymers Oy High impact strength biodegradable material
WO2004021983A2 (en) * 2002-09-03 2004-03-18 Promethean Surgical Devices Llc In situ polymerizing medical compositions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984000302A1 (en) * 1982-07-16 1984-02-02 Univ Groningen Biocompatible, antithrombogenic materials suitable for reconstructive surgery
WO1998001493A1 (en) * 1996-07-08 1998-01-15 Jvs-Polymers Oy High impact strength biodegradable material
WO2004021983A2 (en) * 2002-09-03 2004-03-18 Promethean Surgical Devices Llc In situ polymerizing medical compositions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FURUKAWA ET AL: "Functionally graded polyurethane elastomers prepared with electrophoresis of monomer", CONFERENCE PROCEEDING S KUALA LUMPUR 06-09 OCTOBER 1997, February 1998 (1998-02-01), pages 1015 - 1021, XP000741269 *
YUAN/RUCKENSTEIN: "Polyurethane toughened polylactide", POLYMER BULLETIN, vol. 40, April 1998 (1998-04-01), pages 485 - 490, XP000750414 *

Also Published As

Publication number Publication date
WO2009036083A2 (en) 2009-03-19

Similar Documents

Publication Publication Date Title
WO2008094834A3 (en) Multi-functional drug carriers
WO2009036083A3 (en) Polymer compositions for controllable drug delivery
WO2007103666A3 (en) Implantable medical endoprosthesis delivery systems
WO2012027566A3 (en) Novel medical device coatings
WO2010021757A3 (en) Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
WO2009014827A3 (en) Medical devices comprising polymeric drug delivery systems with drug solubility gradients
WO2007142738A3 (en) Coatings layers for medical devices and methods of making the same
WO2009005909A3 (en) Biodegradable triblock copolymers for implantable devices
MX342897B (en) Devices and methods for delivery of bioactive agents.
WO2008042748A3 (en) Polyelectrolyte media for bioactive agent delivery
WO2009048645A3 (en) Lipid coatings for implantable medical devices
WO2009055306A3 (en) Coating designs for the tailored release of dual drugs from polymeric coatings
ATE526048T1 (en) COATED BIODEGRADABLE METALLIC IMPLANT
WO2007133479A3 (en) Delivery of elastin-stabilizing compound within a body lumen
WO2008137235A3 (en) Implantable medical devices fabricated from polymers with radiopaque groups
WO2007089592A3 (en) Implantable medical device coated with bioactive agent
WO2008151299A3 (en) Implantable medical devices for local and regional treatment
WO2008034123A3 (en) Polymeric conjugates containing positively-charged moieties
WO2007030266A3 (en) Nitric oxide-releasing polymers derived from modified polyimines
WO2012166923A3 (en) Drug loaded polymeric nanoparticles and methods of making and using same
EP4406514A3 (en) Aortic bioprosthesis and systems for delivery thereof
WO2008002632A3 (en) Carbon coating on an implantable device
WO2007139845A3 (en) Systems and methods for introducing and applying a bandage structure within a body lumen or hollow body organ
WO2008002434A3 (en) Medical devices for release of low solubility therapeutic agents
DE602005018178D1 (en) PHOSPHOLIPIDE AND POLLUTION-RESISTANT COATING COMPOSITIONS

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08799419

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08799419

Country of ref document: EP

Kind code of ref document: A2

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载