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WO2009033661A3 - Use of rgdspasskp and optionally angiotensin ii as therapeutic agents in the treatment of eg s. pneumoniae infections - Google Patents

Use of rgdspasskp and optionally angiotensin ii as therapeutic agents in the treatment of eg s. pneumoniae infections Download PDF

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Publication number
WO2009033661A3
WO2009033661A3 PCT/EP2008/007436 EP2008007436W WO2009033661A3 WO 2009033661 A3 WO2009033661 A3 WO 2009033661A3 EP 2008007436 W EP2008007436 W EP 2008007436W WO 2009033661 A3 WO2009033661 A3 WO 2009033661A3
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WIPO (PCT)
Prior art keywords
diseases
ser
pro
treatment
optionally
Prior art date
Application number
PCT/EP2008/007436
Other languages
French (fr)
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WO2009033661A2 (en
Inventor
Dorian Bevec
Fabio Cavalli
Vera Cavalli
Gerald Bacher
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Mondobiotech Laboratories Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Mondobiotech Laboratories Ag filed Critical Mondobiotech Laboratories Ag
Priority to US12/676,927 priority Critical patent/US20100197603A1/en
Priority to CA2698748A priority patent/CA2698748A1/en
Priority to AU2008297931A priority patent/AU2008297931A1/en
Priority to JP2010523350A priority patent/JP2010538979A/en
Priority to EP08801999A priority patent/EP2197463A2/en
Publication of WO2009033661A2 publication Critical patent/WO2009033661A2/en
Publication of WO2009033661A3 publication Critical patent/WO2009033661A3/en

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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
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Abstract

The present invention is directed to the use of the peptide compound Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquide buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro-OH optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.
PCT/EP2008/007436 2007-09-11 2008-09-09 Use of a peptide as a therapeutic agent WO2009033661A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US12/676,927 US20100197603A1 (en) 2007-09-11 2008-09-09 Use of rgdspasskp and optionally angiotensin ii as therapeutic agents in the treatment of eg s. pneumoniae infections
CA2698748A CA2698748A1 (en) 2007-09-11 2008-09-09 Use of a peptide as a therapeutic agent
AU2008297931A AU2008297931A1 (en) 2007-09-11 2008-09-09 Use of RGDSPASSKP and optionally angiotensin II as therapeutic agents in the treatment of Eg S. pneumoniae infections
JP2010523350A JP2010538979A (en) 2007-09-11 2008-09-09 S. Use of RGDSPASSKP and optional angiotensin II as therapeutic agents to treat Pneumoniae infections, etc.
EP08801999A EP2197463A2 (en) 2007-09-11 2008-09-09 Use of rgdspasskp and optionally angiotensin ii as therapeutic agents in the treatment of eg s. pneumoniae infections

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07017745.6 2007-09-11
EP07017745 2007-09-11

Publications (2)

Publication Number Publication Date
WO2009033661A2 WO2009033661A2 (en) 2009-03-19
WO2009033661A3 true WO2009033661A3 (en) 2009-12-17

Family

ID=40228066

Family Applications (17)

Application Number Title Priority Date Filing Date
PCT/EP2008/007882 WO2009033768A2 (en) 2007-09-11 2008-09-09 Use of a peptide as a therapeutic agent
PCT/EP2008/007967 WO2009033783A2 (en) 2007-09-11 2008-09-09 Use of a peptide as a therapeutic agent
PCT/EP2008/007622 WO2009043451A2 (en) 2007-09-11 2008-09-09 Use of chorionic gonadotropin-beta (109-145) as a therapeutic agent
PCT/EP2008/007815 WO2009046825A1 (en) 2007-09-11 2008-09-09 Use of a peptide acetyl-calpastatin as a therapeutic agent
PCT/EP2008/007436 WO2009033661A2 (en) 2007-09-11 2008-09-09 Use of a peptide as a therapeutic agent
PCT/EP2008/007642 WO2009043462A1 (en) 2007-09-11 2008-09-09 Use of neuropeptide af as a therapeutic agent
PCT/EP2008/007600 WO2009040004A2 (en) 2007-09-11 2008-09-09 Use of a peptide as a therapeutic agent
PCT/EP2008/007595 WO2009033720A1 (en) 2007-09-11 2008-09-09 Mastoparan for the treatment of diseases
PCT/EP2008/007873 WO2009033764A2 (en) 2007-09-11 2008-09-09 Use of a peptide as a therapeutic agent
PCT/EP2008/007603 WO2009043436A2 (en) 2007-09-11 2008-09-09 Use of af12198 as a therapeutic agent
PCT/EP2008/007499 WO2009033696A1 (en) 2007-09-11 2008-09-09 Use of a peptide pyx-1 as a therapeutic agent
PCT/EP2008/007669 WO2009033732A2 (en) 2007-09-11 2008-09-09 Use of the peptide phpfhlfvy (renin inhibitor) as a therapeutic agent
PCT/EP2008/007668 WO2009033731A2 (en) 2007-09-11 2008-09-09 Use of a laminin peptide as a therapeutic agent
PCT/EP2008/007454 WO2009033667A2 (en) 2007-09-11 2008-09-09 Use of a peptide as a therapeutic agent
PCT/EP2008/007718 WO2009040024A2 (en) 2007-09-11 2008-09-09 Use of a peptide as a therapeutic agent
PCT/EP2008/007541 WO2009039993A2 (en) 2007-09-11 2008-09-09 Use of melanocyte-stimulating hormone release-inhibiting factor as a therapeutic agent in the treatment of pseudomonas aeruginosa infection
PCT/EP2008/007800 WO2009040045A2 (en) 2007-09-11 2008-09-09 Use of a peptide as a therapeutic agent

Family Applications Before (4)

Application Number Title Priority Date Filing Date
PCT/EP2008/007882 WO2009033768A2 (en) 2007-09-11 2008-09-09 Use of a peptide as a therapeutic agent
PCT/EP2008/007967 WO2009033783A2 (en) 2007-09-11 2008-09-09 Use of a peptide as a therapeutic agent
PCT/EP2008/007622 WO2009043451A2 (en) 2007-09-11 2008-09-09 Use of chorionic gonadotropin-beta (109-145) as a therapeutic agent
PCT/EP2008/007815 WO2009046825A1 (en) 2007-09-11 2008-09-09 Use of a peptide acetyl-calpastatin as a therapeutic agent

Family Applications After (12)

Application Number Title Priority Date Filing Date
PCT/EP2008/007642 WO2009043462A1 (en) 2007-09-11 2008-09-09 Use of neuropeptide af as a therapeutic agent
PCT/EP2008/007600 WO2009040004A2 (en) 2007-09-11 2008-09-09 Use of a peptide as a therapeutic agent
PCT/EP2008/007595 WO2009033720A1 (en) 2007-09-11 2008-09-09 Mastoparan for the treatment of diseases
PCT/EP2008/007873 WO2009033764A2 (en) 2007-09-11 2008-09-09 Use of a peptide as a therapeutic agent
PCT/EP2008/007603 WO2009043436A2 (en) 2007-09-11 2008-09-09 Use of af12198 as a therapeutic agent
PCT/EP2008/007499 WO2009033696A1 (en) 2007-09-11 2008-09-09 Use of a peptide pyx-1 as a therapeutic agent
PCT/EP2008/007669 WO2009033732A2 (en) 2007-09-11 2008-09-09 Use of the peptide phpfhlfvy (renin inhibitor) as a therapeutic agent
PCT/EP2008/007668 WO2009033731A2 (en) 2007-09-11 2008-09-09 Use of a laminin peptide as a therapeutic agent
PCT/EP2008/007454 WO2009033667A2 (en) 2007-09-11 2008-09-09 Use of a peptide as a therapeutic agent
PCT/EP2008/007718 WO2009040024A2 (en) 2007-09-11 2008-09-09 Use of a peptide as a therapeutic agent
PCT/EP2008/007541 WO2009039993A2 (en) 2007-09-11 2008-09-09 Use of melanocyte-stimulating hormone release-inhibiting factor as a therapeutic agent in the treatment of pseudomonas aeruginosa infection
PCT/EP2008/007800 WO2009040045A2 (en) 2007-09-11 2008-09-09 Use of a peptide as a therapeutic agent

Country Status (10)

Country Link
US (6) US20100210555A1 (en)
EP (6) EP2187907A2 (en)
JP (6) JP2010538979A (en)
KR (6) KR20100057046A (en)
AT (1) ATE522225T1 (en)
AU (6) AU2008297931A1 (en)
CA (6) CA2698981A1 (en)
ES (1) ES2371521T3 (en)
RU (6) RU2010114009A (en)
WO (17) WO2009033768A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5631201B2 (en) 2007-03-28 2014-11-26 プレジデント アンド フェローズ オブ ハーバード カレッジ Stitched polypeptide
CN108570097A (en) 2010-08-13 2018-09-25 爱勒让治疗公司 Peptidomimetic macrocyclic compound
EP2678002A2 (en) 2011-02-25 2014-01-01 Medtronic, Inc. Therapy for kidney disease and/or heart failure
US20130244937A1 (en) 2011-09-02 2013-09-19 Nile Therapeutics, Inc. Chimeric natriuretic peptide compositions and methods of preparation
EP2768518A4 (en) 2011-10-18 2015-05-27 Aileron Therapeutics Inc PEPTIDOMIMETIC MACROCYCLES
CN104144695A (en) 2012-02-15 2014-11-12 爱勒让治疗公司 Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
NZ627528A (en) 2012-02-15 2016-05-27 Aileron Therapeutics Inc Peptidomimetic macrocycles
JP6526563B2 (en) 2012-11-01 2019-06-05 エイルロン セラピューティクス，インコーポレイテッド Disubstituted amino acids and methods for their preparation and use
KR20150067517A (en) * 2013-12-10 2015-06-18 인제대학교 산학협력단 Pharmaceutical composition for preventing or treating of scarring after glaucoma filteration surgery
HUE065829T2 (en) 2014-09-19 2024-06-28 Ferring Bv Method of treating prader-willi syndrome
US10471120B2 (en) 2014-09-24 2019-11-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
JP2018516844A (en) 2015-03-20 2018-06-28 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Peptidomimetic macrocycles and uses thereof
KR102436084B1 (en) * 2017-11-24 2022-08-25 주식회사 젬백스앤카엘 Novel peptides and compositions comprising them
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
TW202031283A (en) 2018-09-20 2020-09-01 馬克 Ｃ 曼寧 Stable intranasal formulations of carbetocin
AU2019345313A1 (en) 2018-09-20 2021-03-18 Levo Therapeutics, Inc. Carbetocin drug product and process for preparing same
RU2679120C1 (en) * 2018-10-29 2019-02-06 Федеральное государственное бюджетное образовательное учреждение высшего образования "Алтайский государственный медицинский университет" Министерства здравоохранения Российской Федерации Pharmacological agent for urinary stone disease treatment
KR102022118B1 (en) * 2019-01-07 2019-09-18 주식회사 아스트로젠 Serine derivative compound for the prevention or treatment of centralnervous system diseases
US20220211771A1 (en) * 2019-04-19 2022-07-07 Pitt Hopkins Research Foundation Microbiota transfer therapy for pitt hopkins syndrome
CA3144963A1 (en) * 2019-07-02 2021-02-25 Trustees Of Tufts College Novel peptide, compositions and method for delivery of agents into cells and tissues
WO2022047730A1 (en) * 2020-09-04 2022-03-10 Shanghai Pharmaceuticals Holding Co., Ltd. Methods to treat inflammatory bowel disease
WO2022073008A1 (en) * 2020-09-30 2022-04-07 Baylor College Of Medicine Oxytocin treatment for hypermobile ehlers-danlos syndrome
KR20220061018A (en) * 2020-11-05 2022-05-12 한국생명공학연구원 A novel peptide having anti-inflammatory and regenerative effect
AU2022383744A1 (en) * 2021-11-02 2024-05-02 Enumita As Tri-, tetra and pentapeptides, compositions thereof and their use in the therapy of psoriasis

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19529909A1 (en) * 1995-08-15 1997-02-20 Fresenius Ag Aqueous rinse solution
US5629292A (en) * 1993-09-24 1997-05-13 The University Of Southern California Use of angiotensin III and analogs thereof in tissue repair
US5629294A (en) * 1991-11-07 1997-05-13 University Of Southern California Compositions and methods for preventing adhesion formation
US6239109B1 (en) * 1998-02-09 2001-05-29 University Of Southern California Method of promoting erythropoiesis
US6492332B1 (en) * 1995-12-12 2002-12-10 Omeros Corporation Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
US20050187146A1 (en) * 2004-02-20 2005-08-25 Helmus Michael N. Biomaterials for enhanced healing
WO2008130082A1 (en) * 2007-04-19 2008-10-30 Caregen Co., Ltd Tgfp-cap peptide and its uses

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3708593A (en) * 1971-08-24 1973-01-02 Abbott Lab Use of l-prolyl l-leucyl glycine amide as an anti-depressant
US3795738A (en) * 1972-12-26 1974-03-05 Abbott Lab Use of l-propyl l-leucyl glycine amide to treat parkinson's disease
US4100271A (en) 1976-02-26 1978-07-11 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4188373A (en) 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4235988A (en) 1976-12-13 1980-11-25 Imperial Chemical Industries Limited Delivery means for biologically active agents
US4269827A (en) * 1980-06-23 1981-05-26 The Massachusetts General Hospital Process and composition for reducing blood pressure
US4478827A (en) * 1983-05-09 1984-10-23 The General Hospital Corporation Renin inhibitors
US4478822A (en) 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4474752A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US4474753A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Topical drug delivery system utilizing thermosetting gels
US5432176A (en) * 1988-11-29 1995-07-11 The John Hopkins University Method of retarding the progression of chronic renal failure
US5256396A (en) 1990-01-24 1993-10-26 Colgate-Palmolive Company Topical composition
JP3523252B2 (en) * 1990-11-21 2004-04-26 ホウテン ファーマシューティカルズ インコーポレイテッド Synthesis of equimolar multi-oligomer mixtures, especially oligopeptide mixtures
WO1992011866A1 (en) * 1991-01-14 1992-07-23 Duke University LAMININ SEQUENCE AS tPA ACTIVATOR
DE69128283T2 (en) 1991-08-12 1998-03-19 Nestle Sa Food composition
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
WO1993017701A1 (en) * 1992-03-12 1993-09-16 The Administrators Of The Tulane Educational Fund Endothelin receptor-binding peptides
US5569741A (en) * 1992-07-27 1996-10-29 Biomeasure, Inc. Cyclic octapeptide neuromedin B receptor antagonists
EP0696208B1 (en) * 1993-04-22 2001-08-22 Emisphere Technologies, Inc. Oral drug delivery compositions
US5726155A (en) * 1993-08-02 1998-03-10 The Scripps Research Institute Regulation of oxidative burst using LMWG-derived peptides and analogs
NZ283160A (en) 1994-05-06 1998-07-28 Pfizer Azithromycin in a controlled release dosage form for treating microbiol infections
WO1995030418A1 (en) * 1994-05-09 1995-11-16 The Johns Hopkins University Method of slowing the progression of hiv infection
US5888980A (en) * 1994-06-30 1999-03-30 Bio-Logic Research And Development Corporation Compositions for enhancing immune function
US5677275A (en) * 1994-08-05 1997-10-14 The United States Of America As Represented By The Department Of Health And Human Services Treatment of cancer with human chorionic gonadotropin
US6075009A (en) * 1995-04-17 2000-06-13 East Carolina University Neuropeptide Y analogues, compositions and methods of lowering blood pressure
CZ262698A3 (en) 1996-02-19 1999-03-17 Nycomed Imaging A/S Contrast preparation for ultrasound representation and process for preparing thereof
AU3587797A (en) * 1996-06-24 1998-01-14 University Of Maryland Biotechnology Institute Methods of treatment of wasting syndrome based on administration of derivatives of human chorionic gonadotropin
TW360501B (en) 1996-06-27 1999-06-11 Nestle Sa Dietetically balanced milk product
US6500934B1 (en) * 1996-07-24 2002-12-31 Michael Rush Lerner Bivalent agonists for G-protein coupled receptors
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
ES2148670T3 (en) 1996-09-24 2000-10-16 Nestle Sa SUBSTITUTE FOR MILK AND MANUFACTURING PROCEDURE.
SE9701162D0 (en) * 1997-03-27 1997-03-27 Karolinska Innovations Ab New use II
US6583109B1 (en) * 1997-06-24 2003-06-24 Robert C. Gallo Therapeutic polypeptides from β-hCG and derivatives
AU1918299A (en) * 1998-02-23 1999-09-06 Warner-Lambert Company Substituted quinoxaline derivatives as interleukin-8 receptor antagonists
IL138214A0 (en) * 1998-03-09 2001-10-31 Zealand Pharmaceuticals As Pharmacolgically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
US7175679B2 (en) * 2001-03-29 2007-02-13 Biotempt B.V. Oligopeptide treatment of NF-κB mediated inflammation
US6333313B1 (en) * 1998-10-29 2001-12-25 Board Of Regents, The University Of Texas System Clinical use of oxytocin alone or in combination to treat bone disorders
DE69919019T2 (en) 1998-11-24 2004-11-25 Société des Produits Nestlé S.A. Process for the preparation of a protein composition and a baby food containing the same
WO2000041717A2 (en) * 1998-12-18 2000-07-20 Avi Biopharma, Inc. Chorionic gonadotropin dna vaccines and methods
WO2001017958A2 (en) * 1999-09-10 2001-03-15 Merck & Co., Inc. Neuropeptide sf receptor assays, compounds and therapeutic methods
US6894026B1 (en) * 2000-01-11 2005-05-17 Atossa Healthcare, Inc. Long-acting oxytocin analogues for the treatment and prevention of breast cancer and psychiatric disorders
SE0001440D0 (en) * 2000-04-18 2000-04-18 Entretech Medical Ab A drug against climacteric disorders
WO2001087328A2 (en) * 2000-05-12 2001-11-22 Immunex Corporation Interleukin-1 inhibitors in the treatment of diseases
AU2001278084A1 (en) * 2000-07-31 2002-02-13 The Regents Of The University Of California Model for alzheimer's disease and other neurodegenerative diseases
US20020082409A1 (en) * 2000-10-26 2002-06-27 Hsu Sheau Yu Stresscopins and their uses
SE0100684D0 (en) * 2001-02-28 2001-02-28 Kerstin Uvnaes Moberg New subject matter
GB0115515D0 (en) * 2001-06-25 2001-08-15 Ferring Bv Oxytocin agonisys
SE0102910D0 (en) * 2001-08-31 2001-08-31 Moberg Kerstin Uvnaes New use
ATE362707T1 (en) 2001-11-23 2007-06-15 Nestle Sa METHOD FOR PRODUCING MILK POWDER AND CONCENTRATED MILK PRODUCTS
CA2391118A1 (en) * 2002-06-21 2003-12-21 Universite Du Quebec A Montreal Oxytocin as cardiomyogenesis inducer and uses thereof
BR0312276A (en) * 2002-06-28 2005-04-26 Centocor Inc Mammalian epo ch1-removed mimetibodies, compositions, methods and uses
EP1578381A2 (en) * 2002-12-24 2005-09-28 The Board of Regents of The University of Texas System Chemokine antagonists and uses thereof
EP1594544B1 (en) * 2003-01-31 2016-04-06 Childrens Hospital Los Angeles Oral compositions of fenretinide having increased bioavailability and methods of using the same
WO2004085505A2 (en) * 2003-03-24 2004-10-07 Sequoia Pharmaceuticals, Inc. Long acting biologically active conjugates
US20060270592A1 (en) * 2004-03-19 2006-11-30 Ophthalmic Research Associates, Inc. Use of neurotransmitters and neuropeptides for the treatment of dry eye diseases and related conditions
BRPI0518622A2 (en) * 2004-12-02 2008-12-02 Domantis Ltd uses of interleukin-1 (il-1r1) type 1 receptor antagonists for the manufacture of a medicament for the treatment of a respiratory disease; A pharmaceutical composition comprising an IL-1R1 antagonist and a physiologically acceptable carrier and drug delivery device.
US7507581B2 (en) * 2005-04-05 2009-03-24 Synthecon, Inc. Inhibition of pancreatic islet aggregation
US20090035287A1 (en) * 2005-09-26 2009-02-05 Zurit Levine Atrial natriuretic peptide (anp) splice variants and methods of using same
AU2007209725A1 (en) * 2006-01-24 2007-08-02 Sirius Genomics Inc. Vasopressin pathway polymorphisms as indicators of subject outcome in critically ill subjects
BRPI0708773B1 (en) 2006-03-10 2021-10-19 Laboswiss Ag METHOD FOR SOLUBILIZATION, DISPERSION AND STABILIZATION OF SUBSTANCES, MANUFACTURED PRODUCTS ACCORDING TO THE METHOD, AS WELL AS THE USE OF THE SAME
GB0702972D0 (en) * 2007-02-15 2007-03-28 Cambridge Entpr Ltd Induction of autography

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629294A (en) * 1991-11-07 1997-05-13 University Of Southern California Compositions and methods for preventing adhesion formation
US5629292A (en) * 1993-09-24 1997-05-13 The University Of Southern California Use of angiotensin III and analogs thereof in tissue repair
DE19529909A1 (en) * 1995-08-15 1997-02-20 Fresenius Ag Aqueous rinse solution
US6492332B1 (en) * 1995-12-12 2002-12-10 Omeros Corporation Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
US6239109B1 (en) * 1998-02-09 2001-05-29 University Of Southern California Method of promoting erythropoiesis
US20050187146A1 (en) * 2004-02-20 2005-08-25 Helmus Michael N. Biomaterials for enhanced healing
WO2008130082A1 (en) * 2007-04-19 2008-10-30 Caregen Co., Ltd Tgfp-cap peptide and its uses

Non-Patent Citations (29)

* Cited by examiner, † Cited by third party
Title
AGER ELEANOR I ET AL: "The renin-angiotensin system and malignancy", CARCINOGENESIS (OXFORD), vol. 29, no. 9, 16 July 2008 (2008-07-16), pages 1675 - 1684, XP002541994, ISSN: 0143-3334 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1991, LIU Z ET AL: "THE RELATIONSHIP BETWEEN HEPATITIS B AND RENIN ANGIOTENSIN ALDOSTERONE SYSTEM", XP002542010, Database accession no. PREV199293069186 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; June 1998 (1998-06-01), TAKEMOTO YUJI ET AL: "Association between angiotensin II receptor gene polymorphism and serum angiotensin converting enzyme (SACE) activity in patients with sarcoidosis", XP002542007, Database accession no. PREV199800357237 *
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; November 2003 (2003-11-01), WOO D S ET AL: "The Therapeutic Effect of Angiotensin II Receptor Antagonist in Idiopathic Pulmonary Fibrosis", XP002542009, Database accession no. EMB-2004055454 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 1 September 2001 (2001-09-01), OUALI N: "[Complications in kidney transplantation]", XP002542011, Database accession no. NLM11577577 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 2002, DITIATKOV A E ET AL: "[Respiratory and renal functions and blood electrolytic composition in patients with pulmonary tuberculosis in the treatment of heart failure]", XP002542008, Database accession no. NLM12125252 *
HAULICA I ET AL: "New bioactive angiotensins formation pathways and functional involvements.", ROMANIAN JOURNAL OF INTERNAL MEDICINE = REVUE ROUMAINE DE MÉDECINE INTERNE 2004, vol. 42, no. 1, 2004, pages 27 - 40, XP009121336, ISSN: 1220-4749 *
HEFFELFINGER S C: "The renin angiotensin system in the regulation of angiogenesis", CURRENT PHARMACEUTICAL DESIGN, vol. 13, no. 12, April 2007 (2007-04-01), pages 1215 - 1229, XP002541993, ISSN: 1381-6128 *
HIRAMATSU NORIYUKI ET AL: "Angiotensin II type 1 receptor blockade inhibits the development and progression of HIV-associated nephropathy in a mouse model", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 18, no. 2, February 2007 (2007-02-01), pages 515 - 527, XP002541999, ISSN: 1046-6673 *
HYLAND L J ET AL: "Adaptation of the plasma renin radioimmunoassay for use with HIV-1 protease", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS INC, NEW YORK, vol. 197, no. 1, 15 August 1991 (1991-08-15), pages 225 - 230, XP024823696, ISSN: 0003-2697, [retrieved on 19910815] *
IDEURA HIROSHI ET AL: "Angiotensin II provokes podocyte injury in murine model of HIV-associated nephropathy", AMERICAN JOURNAL OF PHYSIOLOGY - RENAL PHYSIOLOGY, vol. 293, no. 4, 25 July 2007 (2007-07-25), pages F1214 - F1221, XP002542000, ISSN: 0363-6127 *
IGIC RAJKO ET AL: "Properties and distribution of angiotensin I converting enzyme.", CURRENT PHARMACEUTICAL DESIGN, vol. 9, no. 9, 2003, pages 697 - 706, XP009121266, ISSN: 1381-6128 *
JOURNAL OF WEST CHINA UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 3, 1991, pages 303 - 306, ISSN: 0257-7712 *
KLOTZ STEPHEN A ET AL: "Inhibition of adherence and killing of Candida albicans with a 23-mer peptide (Fn/23) with dual antifungal properties", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 48, no. 11, November 2004 (2004-11-01), pages 4337 - 4341, XP002542304, ISSN: 0066-4804 *
LI XIAOPENG ET AL: "Angiotensin converting enzyme-2 is protective but downregulated in human and experimental lung fibrosis", AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, vol. 295, no. 1, 25 April 2008 (2008-04-25), pages L178 - L185, XP002541995, ISSN: 1040-0605 *
MIECZYSLAW LITWIN ET AL: "Add-on therapy with angiotensin II receptor 1 blocker in children with chronic kidney disease already treated with angiotensin-converting enzyme inhibitors", PEDIATRIC NEPHROLOGY ; JOURNAL OF THE INTERNATIONAL PEDIATRIC NEPHROLOGY ASSOCIATION, SPRINGER, BERLIN, DE, vol. 21, no. 11, 15 August 2006 (2006-08-15), pages 1716 - 1722, XP019428889, ISSN: 1432-198X *
MOLTENI AGOSTINO ET AL: "Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-beta (TGF-beta) and alpha-actomyosin (alpha SMA), important mediators of radiation-induced pneumopathy and lung fibrosis", CURRENT PHARMACEUTICAL DESIGN, vol. 13, no. 13, May 2007 (2007-05-01), pages 1307 - 1316, XP002541996, ISSN: 1381-6128 *
PENN H ET AL: "Scleroderma renal crisis: patient characteristics and long-term outcomes", QJM, vol. 100, no. 8, August 2007 (2007-08-01), pages 485 - 494, XP002541998, ISSN: 1460-2725 *
PINKSE GABRIELLE G M ET AL: "Hepatocyte survival depends on beta1-integrin-mediated attachment of hepatocytes to hepatic extracellular matrix", LIVER INTERNATIONAL, vol. 24, no. 3, June 2004 (2004-06-01), pages 218 - 226, XP002542305, ISSN: 1478-3223 *
PRESSE MÉDICALE (PARIS, FRANCE : 1983) 1 SEP 2001, vol. 30, no. 24 Pt 2, 1 September 2001 (2001-09-01), pages 13 - 15, ISSN: 0755-4982 *
PROBLEMY TUBERKULEZA 2002, no. 4, 2002, pages 39 - 41, ISSN: 0032-9533 *
ROCKEY ET AL: "Antifibrotic therapy in chronic liver disease", CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, AMERICAN GASTROENTEROLOGICAL ASSOCIATION, US, vol. 3, no. 2, 1 February 2005 (2005-02-01), pages 95 - 107, XP005120678, ISSN: 1542-3565 *
RUIZ-ORTEGA M ET AL: "PROINFLAMMATORY ACTIONS OF ANGIOTENSINS", CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, RAPID SCIENCE, LONDON, GB, vol. 10, no. 3, 1 May 2001 (2001-05-01), pages 321 - 329, XP009083081, ISSN: 1062-4821 *
SOTERIADOU K P ET AL: "THE SER-ARG-TYR-ASP REGION OF THE MAJOR SURFACE GLYCOPROTEIN OF LEISHMANIA MIMICS THE ARG-GLY-ASP-SER CELL ATTACHMENT REGION OF FIBRONECTIN", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 20, 1992, pages 13980 - 13985, XP002542303, ISSN: 0021-9258 *
THEUER JUERGEN ET AL: "Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats", BMC CARDIOVASCULAR DISORDERS, BIOMED CENTRAL, LONDON, GB, vol. 2, no. 1, 18 January 2002 (2002-01-18), pages 3, XP021015221, ISSN: 1471-2261 *
THORAX, vol. 53, no. 6, June 1998 (1998-06-01), pages 459 - 462, ISSN: 0040-6376 *
TUBERCULOSIS AND RESPIRATORY DISEASES 200311 KR, vol. 55, no. 5, November 2003 (2003-11-01), pages 478 - 487, ISSN: 0378-0066 *
UHAL BRUCE D ET AL: "Angiotensin-TGF-beta 1 crosstalk in human idiopathic pulmonary fibrosis: Autocrine mechanisms in myofibroblasts and macrophages", CURRENT PHARMACEUTICAL DESIGN, vol. 13, no. 12, April 2007 (2007-04-01), pages 1247 - 1256, XP009121584, ISSN: 1381-6128 *
XIAO FAN ET AL: "Polymorphisms in the promoter region of the angiotensinogen gene are associated with liver cirrhosis in patients with chronic hepatitis B", JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 21, no. 9, September 2006 (2006-09-01), pages 1488 - 1491, XP002541997, ISSN: 0815-9319 *

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