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WO2009033489A3 - Selective pacl inhibitors for use in the treatment of migraine and headaches - Google Patents

Selective pacl inhibitors for use in the treatment of migraine and headaches Download PDF

Info

Publication number
WO2009033489A3
WO2009033489A3 PCT/DK2008/050223 DK2008050223W WO2009033489A3 WO 2009033489 A3 WO2009033489 A3 WO 2009033489A3 DK 2008050223 W DK2008050223 W DK 2008050223W WO 2009033489 A3 WO2009033489 A3 WO 2009033489A3
Authority
WO
WIPO (PCT)
Prior art keywords
migraine
inhibitors
treatment
selective
pacl
Prior art date
Application number
PCT/DK2008/050223
Other languages
French (fr)
Other versions
WO2009033489A2 (en
Inventor
Jes Olesen
Steffen Birk
Original Assignee
Glostrup Hospital
Jes Olesen
Steffen Birk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glostrup Hospital, Jes Olesen, Steffen Birk filed Critical Glostrup Hospital
Publication of WO2009033489A2 publication Critical patent/WO2009033489A2/en
Publication of WO2009033489A3 publication Critical patent/WO2009033489A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to the use of selective PAC1 inhibitors in the manufacture of a medicament for the treatment of migraine or headache.
PCT/DK2008/050223 2007-09-11 2008-09-11 Selective pacl inhibitors for use in the treatment of migraine and headaches WO2009033489A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DKPA200701313 2007-09-11
DKPA200701313 2007-09-11
DKPA200800469 2008-03-31
DKPA200800469 2008-03-31
US5714808P 2008-05-29 2008-05-29
US60/057,148 2008-05-29
DKPA200801180 2008-08-28
DKPA200801180 2008-08-28

Publications (2)

Publication Number Publication Date
WO2009033489A2 WO2009033489A2 (en) 2009-03-19
WO2009033489A3 true WO2009033489A3 (en) 2009-05-07

Family

ID=40263329

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2008/050223 WO2009033489A2 (en) 2007-09-11 2008-09-11 Selective pacl inhibitors for use in the treatment of migraine and headaches

Country Status (1)

Country Link
WO (1) WO2009033489A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014144632A2 (en) 2013-03-15 2014-09-18 Amgen Inc. Human pac1 antibodies
US9700549B2 (en) 2013-10-03 2017-07-11 David Wise Compositions and methods for treating pelvic pain and other conditions
JP6956631B2 (en) 2014-09-15 2021-11-02 アムジェン インコーポレイテッド Bispecific anti-CGRP receptor / PAC1 receptor antigen-binding protein and its use
JP6924148B2 (en) 2015-04-16 2021-08-25 ハー・ルンドベック・アクチエゼルスカベット Anti-PACAP antibodies and their use
US10822408B2 (en) 2015-12-15 2020-11-03 Amgen Inc. PACAP antibodies and uses thereof
SG11201808630WA (en) 2016-04-15 2018-10-30 Alder Biopharmaceuticals Inc Humanized anti-pacap antibodies and uses thereof
AR111842A1 (en) 2017-06-02 2019-08-21 Amgen Inc PAC1 PEPTIDE ANTAGONISTS
UY38050A (en) 2018-01-12 2019-07-31 Amgen Inc PAC1 ANTIBODIES AND THEIR USES CROSSED REFERENCE TO RELATED APPLICATIONS

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997040388A1 (en) * 1996-04-25 1997-10-30 Shiseido Company, Ltd. Peptides having specific affinity to pacap type 1 receptors
WO2002033103A2 (en) * 2000-10-16 2002-04-25 Deutsches Krebsforschungszentrum Non-human mammal with modified pacap type i receptor
US20020182729A1 (en) * 2001-01-11 2002-12-05 Dicicco-Bloom Emanuel Pituitary adenylate cyclase-activating polypeptide (PACAP) is an anti-mitogenic signal for selected neuronal precursors in vivo
US20050129687A1 (en) * 2003-11-03 2005-06-16 University Of Vermont And State Agricultural College Use of inhibitors of PACAP receptor activity for treatment of overactive bladder and pelvic floor pain syndrome
US20070054843A1 (en) * 2005-08-26 2007-03-08 Yeomans David C Methods for treatment of headaches by administration of oxytocin
CN101125881A (en) * 2007-07-20 2008-02-20 暨南大学 Recombinant PAC1 receptor antagonist D(25-44)RMMAX and its expression method and application

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997040388A1 (en) * 1996-04-25 1997-10-30 Shiseido Company, Ltd. Peptides having specific affinity to pacap type 1 receptors
WO2002033103A2 (en) * 2000-10-16 2002-04-25 Deutsches Krebsforschungszentrum Non-human mammal with modified pacap type i receptor
US20020182729A1 (en) * 2001-01-11 2002-12-05 Dicicco-Bloom Emanuel Pituitary adenylate cyclase-activating polypeptide (PACAP) is an anti-mitogenic signal for selected neuronal precursors in vivo
US20050129687A1 (en) * 2003-11-03 2005-06-16 University Of Vermont And State Agricultural College Use of inhibitors of PACAP receptor activity for treatment of overactive bladder and pelvic floor pain syndrome
US20070054843A1 (en) * 2005-08-26 2007-03-08 Yeomans David C Methods for treatment of headaches by administration of oxytocin
CN101125881A (en) * 2007-07-20 2008-02-20 暨南大学 Recombinant PAC1 receptor antagonist D(25-44)RMMAX and its expression method and application

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BEEBE ET AL: "Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 18, no. 6, 18 January 2008 (2008-01-18), pages 2162 - 2166, XP022526351, ISSN: 0960-894X *
BIRK ET AL: "The effect of intravenous PACAP38 on cerebral hemodynamics in healthy volunteers", REGULATORY PEPTIDES, ELSEVIER SCIENCE BV, NL, vol. 140, no. 3, 28 March 2007 (2007-03-28), pages 185 - 191, XP005928170, ISSN: 0167-0115 *
JONGSMA H ET AL: "MARKEDLY REDUCED CHRONIC NOCICEPTIVE RESPONSE IN MICE LACKING THE PAC1 RECEPTOR", NEUROREPORT, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 12, no. 10, 20 July 2001 (2001-07-20), pages 2215 - 2219, XP001071197, ISSN: 0959-4965 *
MORO OSAMU ET AL: "Functional characterization of structural alterations in the sequence of the vasodilatory peptide maxadilan yields a pituitary adenylate cyclase-activating peptide type 1 receptor-specific antagonist", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 33, 13 August 1999 (1999-08-13), pages 23103 - 23110, XP002514471, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2009033489A2 (en) 2009-03-19

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