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WO2009028253A1 - ペプチドの製造法 - Google Patents

ペプチドの製造法 Download PDF

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Publication number
WO2009028253A1
WO2009028253A1 PCT/JP2008/061207 JP2008061207W WO2009028253A1 WO 2009028253 A1 WO2009028253 A1 WO 2009028253A1 JP 2008061207 W JP2008061207 W JP 2008061207W WO 2009028253 A1 WO2009028253 A1 WO 2009028253A1
Authority
WO
WIPO (PCT)
Prior art keywords
protein
peptide
synthesis activity
production method
peptide synthesis
Prior art date
Application number
PCT/JP2008/061207
Other languages
English (en)
French (fr)
Inventor
Kuniki Kino
Toshinobu Arai
Masahiro Kokubo
Makoto Yagasaki
Original Assignee
Kyowa Hakko Bio Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Bio Co., Ltd. filed Critical Kyowa Hakko Bio Co., Ltd.
Priority to US12/675,420 priority Critical patent/US20100248307A1/en
Priority to JP2009530014A priority patent/JPWO2009028253A1/ja
Publication of WO2009028253A1 publication Critical patent/WO2009028253A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

　本発明によれば、ペプチド合成活性を有する蛋白質、該蛋白質をコードするDNA、該DNAを含有する組換え体DNA、該組換え体DNAで形質転換された形質転換体、該形質転換体等を用いたペプチド合成活性を有する蛋白質の製造法、ペプチド合成活性を有する蛋白質を用いたペプチドの製造法、およびペプチド合成活性を有する蛋白質を生産する形質転換体または微生物の培養物等を酵素源に用いたペプチドの製造法が提供される。
PCT/JP2008/061207 2007-08-31 2008-06-19 ペプチドの製造法 WO2009028253A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/675,420 US20100248307A1 (en) 2007-08-31 2008-06-19 Peptide production method
JP2009530014A JPWO2009028253A1 (ja) 2007-08-31 2008-06-19 ペプチドの製造法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-225766 2007-08-31
JP2007225766 2007-08-31

Publications (1)

Publication Number Publication Date
WO2009028253A1 true WO2009028253A1 (ja) 2009-03-05

Family

ID=40386982

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/061207 WO2009028253A1 (ja) 2007-08-31 2008-06-19 ペプチドの製造法

Country Status (3)

Country Link
US (1) US20100248307A1 (ja)
JP (1) JPWO2009028253A1 (ja)
WO (1) WO2009028253A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113789280A (zh) * 2021-09-18 2021-12-14 北京科技大学 一种降解尿酸的纺锤形赖氨酸芽孢杆菌制剂及其制备方法与应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114015590B (zh) * 2021-08-09 2024-01-12 江苏大学 超声辅助适应性进化选育的贝莱斯芽孢杆菌及其应用
WO2024226391A1 (en) * 2023-04-24 2024-10-31 The Trustees Of The University Of Pennsylvania Synthetic variants of antimicrobial peptides

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011652A1 (ja) * 2002-07-26 2004-02-05 Ajinomoto Co., Inc. トリペプチド以上のペプチドの製造方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK28283A (da) * 1982-01-26 1983-07-27 Kazutomo Imahori Fremgangsmaade til syntetisering af peptider eller peptidderivater
IT1264712B1 (it) * 1993-07-13 1996-10-04 Eniricerche Spa Metodo di sintesi biologica di peptidi
IT1277466B1 (it) * 1995-08-09 1997-11-10 Eniricerche Spa Peptide sintetasi ingegnerizzate e loro impiego per la produzione via non-ribosomale di peptidi
WO2004058960A1 (ja) * 2002-12-26 2004-07-15 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
JPWO2005103260A1 (ja) * 2004-04-21 2007-08-16 協和醗酵工業株式会社 ジペプチドの製造法
US7514243B2 (en) * 2004-06-25 2009-04-07 Kyowa Hakko Kogyo Co., Ltd. Process for producing dipeptides
US9081199B2 (en) * 2005-03-18 2015-07-14 Kyowa Hakko Bio Co., Ltd. Process for the production of dipeptides by a dipeptide-synthesizing enzyme
JP5256039B2 (ja) * 2006-09-25 2013-08-07 協和発酵バイオ株式会社 ジペプチドの製造法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011652A1 (ja) * 2002-07-26 2004-02-05 Ajinomoto Co., Inc. トリペプチド以上のペプチドの製造方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DUITMAN E.H. ET AL.: "The mycosubtilin synthetase of bacillus subtilis ATCC6633: multifunctional hybrid between a peptide synthetase, an amino transferase, and a fatty acid synthase", PROC NATL ACAD SCI USA, vol. 96, no. 23, 1999, pages 13294 - 13299, XP002145095, DOI: doi:10.1073/pnas.96.23.13294 *
JUN NOGUCHI ET AL.: "Bacillus licheniformis yurai shinki L-amino acid ligase o mochiita L-amino acid dipeptide no gosei", DAI 59 KAI THE SOCIETY FOR BIOTECHNOLOGY, 2 August 2007 (2007-08-02), JAPAN,TAIKAI KOEN YOSHISHU, pages 83(2C11-1) *
REY M.W, ET AL.: "Complete genome sequence of the industrial bacterium bacillus licheniformis and comparisons with closely related bacillus species", GENOME BIOL., vol. 5, no. 10, 2004, pages R77, XP002580906 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113789280A (zh) * 2021-09-18 2021-12-14 北京科技大学 一种降解尿酸的纺锤形赖氨酸芽孢杆菌制剂及其制备方法与应用
CN113789280B (zh) * 2021-09-18 2023-02-17 北京科技大学 一种降解尿酸的纺锤形赖氨酸芽孢杆菌制剂及其制备方法与应用

Also Published As

Publication number Publication date
JPWO2009028253A1 (ja) 2010-11-25
US20100248307A1 (en) 2010-09-30

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