WO2009027785A3 - 1, 3-oxazole derivatives as cetp inhibitors - Google Patents
1, 3-oxazole derivatives as cetp inhibitors Download PDFInfo
- Publication number
- WO2009027785A3 WO2009027785A3 PCT/IB2008/002164 IB2008002164W WO2009027785A3 WO 2009027785 A3 WO2009027785 A3 WO 2009027785A3 IB 2008002164 W IB2008002164 W IB 2008002164W WO 2009027785 A3 WO2009027785 A3 WO 2009027785A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cholesterol
- formula
- levels
- compounds
- ldl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Pharmaceutical compounds according to Formula I and derivatives, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans. Formula (I) or a pharmaceutically acceptable salt of said compound; wherein Formula (II) M and J are each independently CH2 or a bond wherein at least one of M and J are CH2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96896807P | 2007-08-30 | 2007-08-30 | |
| US60/968,968 | 2007-08-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2009027785A2 WO2009027785A2 (en) | 2009-03-05 |
| WO2009027785A3 true WO2009027785A3 (en) | 2009-09-17 |
Family
ID=40344842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IB2008/002164 WO2009027785A2 (en) | 2007-08-30 | 2008-08-18 | 1, 3-oxazole derivatives as cetp inhibitors |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR068064A1 (en) |
| TW (1) | TW200918509A (en) |
| WO (1) | WO2009027785A2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012030165A2 (en) | 2010-08-31 | 2012-03-08 | 서울대학교산학협력단 | Use of the fetal reprogramming of a ppar δ agonist |
| CA2841117A1 (en) | 2011-07-08 | 2013-01-17 | Novartis Ag | 1,2-disubstituted-4-benzylamino-piperidinyl derivatives as cetp inhibitors useful for the treatment of atherosclerosis in high triglyceride subjects |
| WO2014111953A1 (en) * | 2013-01-17 | 2014-07-24 | Glenmark Pharmaceuticals Limited; Glenmark Generics Limited | Process for preparation of anacetrapib and intermediates thereof |
| ES2705577T3 (en) | 2013-12-05 | 2019-03-26 | Bayer Cropscience Ag | Derivatives of N-cyclopropyl-N - {[2- (1-cyclopropyl substituted) phenyl] methylene} - (thio) carboxamide |
| CN110157711B (en) * | 2019-02-01 | 2023-10-24 | 大连大学 | Method for cloning full-length segment of coding region of human srebp1 gene |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995008532A1 (en) * | 1993-09-21 | 1995-03-30 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| WO2007079186A2 (en) * | 2005-12-30 | 2007-07-12 | Merck & Co., Inc. | 1, 3-oxazolidin-2-one derivatives useful as cetp inhibitors |
| WO2007081571A2 (en) * | 2005-12-30 | 2007-07-19 | Merck & Co., Inc. | Cetp inhibitors |
-
2008
- 2008-08-18 WO PCT/IB2008/002164 patent/WO2009027785A2/en active Application Filing
- 2008-08-28 AR ARP080103743A patent/AR068064A1/en not_active Application Discontinuation
- 2008-08-29 TW TW097133211A patent/TW200918509A/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995008532A1 (en) * | 1993-09-21 | 1995-03-30 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| WO2007079186A2 (en) * | 2005-12-30 | 2007-07-12 | Merck & Co., Inc. | 1, 3-oxazolidin-2-one derivatives useful as cetp inhibitors |
| WO2007081571A2 (en) * | 2005-12-30 | 2007-07-19 | Merck & Co., Inc. | Cetp inhibitors |
Non-Patent Citations (2)
| Title |
|---|
| RUGGERI, R.B.: "Cholesteryl ester transfer protein: pharmacological inhibition for the modulation of plasma cholesterol levels and promising target for the prevention of atherosclerosis.", CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 5, 2005, pages 257 - 264, XP002515715 * |
| SIKORSKI, J.A,.: "Oral cholesteryl ester transfer protein (CETP) inhibitors:a potential new approach for treating coronary artery disease.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, 2006, pages 1 - 22, XP002515716 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AR068064A1 (en) | 2009-11-04 |
| TW200918509A (en) | 2009-05-01 |
| WO2009027785A2 (en) | 2009-03-05 |
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