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WO2009020137A1 - アミノピラゾールアミド誘導体 - Google Patents

アミノピラゾールアミド誘導体 Download PDF

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Publication number
WO2009020137A1
WO2009020137A1 PCT/JP2008/064085 JP2008064085W WO2009020137A1 WO 2009020137 A1 WO2009020137 A1 WO 2009020137A1 JP 2008064085 W JP2008064085 W JP 2008064085W WO 2009020137 A1 WO2009020137 A1 WO 2009020137A1
Authority
WO
WIPO (PCT)
Prior art keywords
hydrogen atom
aminopyrazole
amide derivative
formula
optionally substituted
Prior art date
Application number
PCT/JP2008/064085
Other languages
English (en)
French (fr)
Inventor
Yoshihiro Horiuchi
Noriko Nunami
Hiroto Tatamidani
Eiko Ohata
Original Assignee
Dainippon Sumitomo Pharma Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Sumitomo Pharma Co., Ltd. filed Critical Dainippon Sumitomo Pharma Co., Ltd.
Priority to BRPI0815112-1A priority Critical patent/BRPI0815112A2/pt
Priority to CN200880110520A priority patent/CN101827820A/zh
Priority to CA2695437A priority patent/CA2695437A1/en
Priority to JP2009526467A priority patent/JPWO2009020137A1/ja
Priority to EP08826977A priority patent/EP2189449A4/en
Priority to US12/672,236 priority patent/US20110071289A1/en
Priority to MX2010001566A priority patent/MX2010001566A/es
Priority to AU2008284746A priority patent/AU2008284746A1/en
Publication of WO2009020137A1 publication Critical patent/WO2009020137A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

　糖尿病などの疾患の予防または/および治療薬として有用な、下記式（１）で表される化合物またはその薬学上許容される塩を提供する。 （式中、ＲAおよびＲBは、それぞれ独立して、置換されてもよいアルキル基等を表す。ＲCは置換されてもよいアルキル基等を表す。ＲDは水素原子等を表す。ＲEは水素原子等を表す。 　ＲFは、下記式（Ｇ１）： から選ばれ、１つの水素原子が結合手となった基等を表す。）
PCT/JP2008/064085 2007-08-06 2008-08-06 アミノピラゾールアミド誘導体 WO2009020137A1 (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
BRPI0815112-1A BRPI0815112A2 (pt) 2007-08-06 2008-08-06 Derivado de aminopirazol amida
CN200880110520A CN101827820A (zh) 2007-08-06 2008-08-06 氨基吡唑酰胺衍生物
CA2695437A CA2695437A1 (en) 2007-08-06 2008-08-06 Aminopyrazole amide derivative
JP2009526467A JPWO2009020137A1 (ja) 2007-08-06 2008-08-06 アミノピラゾールアミド誘導体
EP08826977A EP2189449A4 (en) 2007-08-06 2008-08-06 AMINOPYRAZOLE AMIDE DERIVATIVE
US12/672,236 US20110071289A1 (en) 2007-08-06 2008-08-06 Aminopyrazole amide derivative
MX2010001566A MX2010001566A (es) 2007-08-06 2008-08-06 Derivado de aminopirazolamida.
AU2008284746A AU2008284746A1 (en) 2007-08-06 2008-08-06 Aminopyrazole amide derivative

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-204739 2007-08-06
JP2007204739 2007-08-06
JP2008074895 2008-03-24
JP2008-074895 2008-03-24

Publications (1)

Publication Number Publication Date
WO2009020137A1 true WO2009020137A1 (ja) 2009-02-12

Family

ID=40341369

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/064085 WO2009020137A1 (ja) 2007-08-06 2008-08-06 アミノピラゾールアミド誘導体

Country Status (11)

Country Link
US (1) US20110071289A1 (ja)
EP (1) EP2189449A4 (ja)
JP (1) JPWO2009020137A1 (ja)
KR (1) KR20100044829A (ja)
CN (1) CN101827820A (ja)
AU (1) AU2008284746A1 (ja)
BR (1) BRPI0815112A2 (ja)
CA (1) CA2695437A1 (ja)
MX (1) MX2010001566A (ja)
RU (1) RU2010108325A (ja)
WO (1) WO2009020137A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013157511A1 (ja) * 2012-04-16 2013-10-24 大日本住友製薬株式会社 アリールアミノピラゾール誘導体
WO2015068773A1 (ja) * 2013-11-08 2015-05-14 石原産業株式会社 含窒素飽和複素環化合物
JP2016512243A (ja) * 2013-03-15 2016-04-25 ヴァーセオン コーポレイション トロンビン阻害剤としてのハロゲノピラゾール
JP2016520115A (ja) * 2013-05-28 2016-07-11 レデックス ファーマ ピーエルシーＲｅｄｘ Ｐｈａｒｍａ Ｐｌｃ ヘッジホッグシグナル伝達経路阻害剤としての複素環化合物

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ603156A (en) 2010-03-30 2014-10-31 Verseon Corp Multisubstituted aromatic compounds as inhibitors of thrombin
CN102633659B (zh) * 2012-02-23 2013-12-04 浙江普洛康裕制药有限公司 一种反式4-氨基-1-羟基金刚烷盐酸盐的合成方法
RU2019101889A (ru) 2013-03-15 2019-03-28 Версеон Корпорейшн Полизамещенные ароматические соединения в качестве ингибиторов сериновых протеаз
AU2015317522A1 (en) 2014-09-17 2017-03-23 Verseon Corporation Pyrazolyl-substituted pyridone compounds as serine protease inhibitors
CA2977993A1 (en) 2015-02-27 2016-09-01 Verseon Corporation Substituted pyrazole compounds as serine protease inhibitors
CN111548317A (zh) * 2020-04-28 2020-08-18 苏州纪元康生物科技有限公司 一种依法韦伦合成方法及制备其中间体方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089470A2 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S New amide derivatives and pharmaceutical use thereof
WO2005016877A2 (en) 2003-08-07 2005-02-24 Merck & Co., Inc. Pyrazole carboxamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1
WO2005095350A1 (en) * 2004-03-23 2005-10-13 Amgen Inc. Pyrazole compounds and uses related thereto
WO2006024627A2 (en) * 2004-08-30 2006-03-09 Janssen Pharmaceutica N.V. N-2 adamantanyl-2-phenoxy-acetamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8084467B2 (en) * 1999-10-18 2011-12-27 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US7393842B2 (en) * 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
JP2004502642A (ja) * 2000-02-11 2004-01-29 ブリストル−マイヤーズ　スクイブ　カンパニー カンナビノイドレセプターモジュレーター、それらの製造方法、および呼吸系および非呼吸系疾患の処置のためのカンナビノイドレセプターモジュレーターの使用
US7880001B2 (en) * 2004-04-29 2011-02-01 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089470A2 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S New amide derivatives and pharmaceutical use thereof
WO2005016877A2 (en) 2003-08-07 2005-02-24 Merck & Co., Inc. Pyrazole carboxamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1
WO2005095350A1 (en) * 2004-03-23 2005-10-13 Amgen Inc. Pyrazole compounds and uses related thereto
WO2006024627A2 (en) * 2004-08-30 2006-03-09 Janssen Pharmaceutica N.V. N-2 adamantanyl-2-phenoxy-acetamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
"Greene's Protective Groups in Organic Synthesis", 1981, JOHN WILEY & SONS INC.
"The Experimental Chemistry", vol. 22, MARUZEN
C. D. JONES; M. KASELJ ET AL., J. ORG. CHEM., vol. 63, 1998, pages 2758 - 2760
R.C. LAROCK, COMPREHENSIVE ORGANIC TRANSFORMATIONS, 1989
See also references of EP2189449A4 *
THE JOURNAL OF ORGANIC CHEMISTRY, vol. 48, 1983, pages 1099

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013157511A1 (ja) * 2012-04-16 2013-10-24 大日本住友製薬株式会社 アリールアミノピラゾール誘導体
JP2016512243A (ja) * 2013-03-15 2016-04-25 ヴァーセオン コーポレイション トロンビン阻害剤としてのハロゲノピラゾール
JP2016520115A (ja) * 2013-05-28 2016-07-11 レデックス ファーマ ピーエルシーＲｅｄｘ Ｐｈａｒｍａ Ｐｌｃ ヘッジホッグシグナル伝達経路阻害剤としての複素環化合物
WO2015068773A1 (ja) * 2013-11-08 2015-05-14 石原産業株式会社 含窒素飽和複素環化合物

Also Published As

Publication number Publication date
AU2008284746A1 (en) 2009-02-12
CN101827820A (zh) 2010-09-08
JPWO2009020137A1 (ja) 2010-11-04
EP2189449A4 (en) 2011-10-19
RU2010108325A (ru) 2011-09-20
KR20100044829A (ko) 2010-04-30
US20110071289A1 (en) 2011-03-24
CA2695437A1 (en) 2009-02-12
MX2010001566A (es) 2010-03-15
BRPI0815112A2 (pt) 2015-08-25
EP2189449A1 (en) 2010-05-26

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