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WO2009012039A3 - Crystalline polymorphs - Google Patents

Crystalline polymorphs Download PDF

Info

Publication number
WO2009012039A3
WO2009012039A3 PCT/US2008/068558 US2008068558W WO2009012039A3 WO 2009012039 A3 WO2009012039 A3 WO 2009012039A3 US 2008068558 W US2008068558 W US 2008068558W WO 2009012039 A3 WO2009012039 A3 WO 2009012039A3
Authority
WO
WIPO (PCT)
Prior art keywords
crystalline polymorphs
present
compositions
provides
ethoxycarbonylprop
Prior art date
Application number
PCT/US2008/068558
Other languages
French (fr)
Other versions
WO2009012039A2 (en
Inventor
Joseph J Kopcho
Scott J Hecker
Patricia Frech
Mike Deason
Qun Dang
Karen Gushurst
Donglai Yang
Original Assignee
Metabasis Therapeutics Inc
Joseph J Kopcho
Scott J Hecker
Patricia Frech
Mike Deason
Qun Dang
Karen Gushurst
Donglai Yang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabasis Therapeutics Inc, Joseph J Kopcho, Scott J Hecker, Patricia Frech, Mike Deason, Qun Dang, Karen Gushurst, Donglai Yang filed Critical Metabasis Therapeutics Inc
Publication of WO2009012039A2 publication Critical patent/WO2009012039A2/en
Publication of WO2009012039A3 publication Critical patent/WO2009012039A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides for crystalline forms of 2-amino-5-(2,2- dimethylpropionyl)-4-{[5-(N,N'-(2-ethoxycarbonylprop-2-yl)phosphonamido] furan-2-yl}thiazole and compositions thereof including pharmaceutical compositions. The present invention further provides for methods of using and processes for making the same.
PCT/US2008/068558 2007-07-13 2008-06-27 Crystalline polymorphs WO2009012039A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94968107P 2007-07-13 2007-07-13
US60/949,681 2007-07-13

Publications (2)

Publication Number Publication Date
WO2009012039A2 WO2009012039A2 (en) 2009-01-22
WO2009012039A3 true WO2009012039A3 (en) 2009-03-19

Family

ID=40260294

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/068558 WO2009012039A2 (en) 2007-07-13 2008-06-27 Crystalline polymorphs

Country Status (1)

Country Link
WO (1) WO2009012039A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (en) 2010-03-03 2011-09-09 Sanofi Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP3352762A4 (en) * 2015-09-22 2019-06-05 Viking Therapeutics, Inc. THERAPIES COMBINED WITH GLUCOSE PRODUCTION INHIBITORS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756360B1 (en) * 1998-12-24 2004-06-29 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
WO2006023515A2 (en) * 2004-08-18 2006-03-02 Metabasis Therapeutics, Inc. Novel thiazole inhibitors of fructose 1,6-bisphosphatase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756360B1 (en) * 1998-12-24 2004-06-29 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
WO2006023515A2 (en) * 2004-08-18 2006-03-02 Metabasis Therapeutics, Inc. Novel thiazole inhibitors of fructose 1,6-bisphosphatase

Also Published As

Publication number Publication date
WO2009012039A2 (en) 2009-01-22

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