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WO2009005798A3 - Antifungal formulation and method of preparation - Google Patents

Antifungal formulation and method of preparation Download PDF

Info

Publication number
WO2009005798A3
WO2009005798A3 PCT/US2008/008179 US2008008179W WO2009005798A3 WO 2009005798 A3 WO2009005798 A3 WO 2009005798A3 US 2008008179 W US2008008179 W US 2008008179W WO 2009005798 A3 WO2009005798 A3 WO 2009005798A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
amino acid
acid sequence
preparation
fungal
Prior art date
Application number
PCT/US2008/008179
Other languages
French (fr)
Other versions
WO2009005798A2 (en
WO2009005798A8 (en
Inventor
David J Cheng
Frank G Oppenheim
Eva J Helmerhorst
Original Assignee
Pacgen Biopharmaceuticals Corp
Univ Boston
David J Cheng
Frank G Oppenheim
Eva J Helmerhorst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacgen Biopharmaceuticals Corp, Univ Boston, David J Cheng, Frank G Oppenheim, Eva J Helmerhorst filed Critical Pacgen Biopharmaceuticals Corp
Publication of WO2009005798A2 publication Critical patent/WO2009005798A2/en
Publication of WO2009005798A8 publication Critical patent/WO2009005798A8/en
Publication of WO2009005798A3 publication Critical patent/WO2009005798A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Biochemistry (AREA)
  • Physiology (AREA)
  • Birds (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A pharmaceutical preparation for treating a microbial infection such as a fungal or bacterial infection in an individual comprises a peptide or a pharmaceutically acceptable salt thereof, wherein said peptide has an amino acid sequence of at least 8 amino acids selected from the group of amino acid sequences consisting of the amino acid sequence of peptide P-1 13 as set forth in SEQ ID NO: 18 and various modifications thereof, wherein the buffer molarity of the pharmaceutical preparation is suitable to achieve greater than 99% killing of C. albicans in vitro. A pharmaceutical preparation for treating a microbial infection such as a fungal or bacterial infection in an individual comprises a peptide or a pharmaceutically acceptable salt thereof, wherein said peptide has an amino acid sequence of at least 8 amino acids selected from the group of amino acid sequences consisting of the amino acid sequence of peptide P-113 as set forth in SEQ ID NO: 18 and various modifications thereof, wherein the pharmaceutical preparation has a buffer molarity of about 25 mM or less. A method for treating a microbial infection such as a fungal or bacterial infection in an individual comprises administering to the individual a therapeutically effective amount of a preparation comprising a peptide or a pharmaceutically acceptable salt thereof, wherein said peptide has an amino acid sequence of at least 8 amino acids selected from the group of amino acid sequences consisting of the amino acid sequence of peptide P-113 as set forth in SEQ ID NO: 18 and various modifications thereof, wherein the buffer molarity of the preparation is suitable to achieve greater than 99% killing of C. albicans in vitro. A method for treating a microbial infection such as a fungal or bacterial infection in an individual comprises administering to the individual a therapeutically effective amount of a preparation comprising a peptide or a pharmaceutically acceptable salt thereof, wherein said peptide has an ami
PCT/US2008/008179 2007-07-03 2008-07-01 Antifungal formulation and method of preparation WO2009005798A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95821607P 2007-07-03 2007-07-03
US60/958,216 2007-07-03

Publications (3)

Publication Number Publication Date
WO2009005798A2 WO2009005798A2 (en) 2009-01-08
WO2009005798A8 WO2009005798A8 (en) 2009-03-12
WO2009005798A3 true WO2009005798A3 (en) 2009-08-13

Family

ID=40134809

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/008179 WO2009005798A2 (en) 2007-07-03 2008-07-01 Antifungal formulation and method of preparation

Country Status (1)

Country Link
WO (1) WO2009005798A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130310326A1 (en) * 2012-05-18 2013-11-21 Rapid Pathogen Screening, Inc. Histatin for Corneal Wound Healing and Ocular Surface Disease
US20170022256A1 (en) * 2015-07-23 2017-01-26 General Biologicals Corporation Anti-fungal and anti-bacterial peptide and therapeutic method using same
US12195755B2 (en) 2019-05-20 2025-01-14 Brown University Placental lipid bilayer for cell-free molecular interaction studies
US11273124B2 (en) 2019-05-23 2022-03-15 Brown University Antifungal nanoparticles for targeted treatment of fungal infections
CN113975263B (en) * 2021-10-20 2023-06-09 河南希百康健康产业有限公司 Composition for inhibiting fungi and preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040768A2 (en) * 1995-06-07 1996-12-19 Periodontix, Inc. Anti-fungal and anti-bacterial histatin-based peptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631228A (en) * 1991-11-01 1997-05-20 Periodontix, Inc. Anti-fungal and anti-bacterial histatin-based peptides
WO1996040768A2 (en) * 1995-06-07 1996-12-19 Periodontix, Inc. Anti-fungal and anti-bacterial histatin-based peptides

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
HELMERHORST E J ET AL: "A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 449, no. 2-3, 23 April 1999 (1999-04-23), pages 105 - 110, XP004259541, ISSN: 0014-5793 *
MICKELS N ET AL: "Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis.", JOURNAL OF CLINICAL PERIODONTOLOGY MAY 2001, vol. 28, no. 5, May 2001 (2001-05-01), pages 404 - 410, XP002532737, ISSN: 0303-6979 *
NISHIKAWA MASANOBU ET AL: "Antimicrobial activity of a chelatable poly(arginyl-histidine) produced by the ergot fungus Verticillium kibiense.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY JAN 2004, vol. 48, no. 1, January 2004 (2004-01-01), pages 229 - 235, XP002532735, ISSN: 0066-4804 *
PERDOK J F ET AL: "Physicochemical properties of commercially available mouthrinses", JOURNAL OF DENTISTRY, ELSEVIER, vol. 18, no. 3, 1 June 1990 (1990-06-01), pages 147 - 150, XP023107911, ISSN: 0300-5712, [retrieved on 19900601] *
ROTHSTEIN D M ET AL: "Anticandida activity is retained in P-113, a 12-amino-acid fragment of histatin 5.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY MAY 2001, vol. 45, no. 5, May 2001 (2001-05-01), pages 1367 - 1373, XP002532736, ISSN: 0066-4804 *
XU T ET AL: "Anticandidal activity of major human salivary histatins.", INFECTION AND IMMUNITY AUG 1991, vol. 59, no. 8, August 1991 (1991-08-01), pages 2549 - 2554, XP002532734, ISSN: 0019-9567 *

Also Published As

Publication number Publication date
WO2009005798A2 (en) 2009-01-08
WO2009005798A8 (en) 2009-03-12

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