WO2009005798A3 - Antifungal formulation and method of preparation - Google Patents
Antifungal formulation and method of preparation Download PDFInfo
- Publication number
- WO2009005798A3 WO2009005798A3 PCT/US2008/008179 US2008008179W WO2009005798A3 WO 2009005798 A3 WO2009005798 A3 WO 2009005798A3 US 2008008179 W US2008008179 W US 2008008179W WO 2009005798 A3 WO2009005798 A3 WO 2009005798A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- peptide
- amino acid
- acid sequence
- preparation
- fungal
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Biochemistry (AREA)
- Physiology (AREA)
- Birds (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A pharmaceutical preparation for treating a microbial infection such as a fungal or bacterial infection in an individual comprises a peptide or a pharmaceutically acceptable salt thereof, wherein said peptide has an amino acid sequence of at least 8 amino acids selected from the group of amino acid sequences consisting of the amino acid sequence of peptide P-1 13 as set forth in SEQ ID NO: 18 and various modifications thereof, wherein the buffer molarity of the pharmaceutical preparation is suitable to achieve greater than 99% killing of C. albicans in vitro. A pharmaceutical preparation for treating a microbial infection such as a fungal or bacterial infection in an individual comprises a peptide or a pharmaceutically acceptable salt thereof, wherein said peptide has an amino acid sequence of at least 8 amino acids selected from the group of amino acid sequences consisting of the amino acid sequence of peptide P-113 as set forth in SEQ ID NO: 18 and various modifications thereof, wherein the pharmaceutical preparation has a buffer molarity of about 25 mM or less. A method for treating a microbial infection such as a fungal or bacterial infection in an individual comprises administering to the individual a therapeutically effective amount of a preparation comprising a peptide or a pharmaceutically acceptable salt thereof, wherein said peptide has an amino acid sequence of at least 8 amino acids selected from the group of amino acid sequences consisting of the amino acid sequence of peptide P-113 as set forth in SEQ ID NO: 18 and various modifications thereof, wherein the buffer molarity of the preparation is suitable to achieve greater than 99% killing of C. albicans in vitro. A method for treating a microbial infection such as a fungal or bacterial infection in an individual comprises administering to the individual a therapeutically effective amount of a preparation comprising a peptide or a pharmaceutically acceptable salt thereof, wherein said peptide has an ami
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95821607P | 2007-07-03 | 2007-07-03 | |
US60/958,216 | 2007-07-03 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2009005798A2 WO2009005798A2 (en) | 2009-01-08 |
WO2009005798A8 WO2009005798A8 (en) | 2009-03-12 |
WO2009005798A3 true WO2009005798A3 (en) | 2009-08-13 |
Family
ID=40134809
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/008179 WO2009005798A2 (en) | 2007-07-03 | 2008-07-01 | Antifungal formulation and method of preparation |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009005798A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130310326A1 (en) * | 2012-05-18 | 2013-11-21 | Rapid Pathogen Screening, Inc. | Histatin for Corneal Wound Healing and Ocular Surface Disease |
US20170022256A1 (en) * | 2015-07-23 | 2017-01-26 | General Biologicals Corporation | Anti-fungal and anti-bacterial peptide and therapeutic method using same |
US12195755B2 (en) | 2019-05-20 | 2025-01-14 | Brown University | Placental lipid bilayer for cell-free molecular interaction studies |
US11273124B2 (en) | 2019-05-23 | 2022-03-15 | Brown University | Antifungal nanoparticles for targeted treatment of fungal infections |
CN113975263B (en) * | 2021-10-20 | 2023-06-09 | 河南希百康健康产业有限公司 | Composition for inhibiting fungi and preparation method and application thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996040768A2 (en) * | 1995-06-07 | 1996-12-19 | Periodontix, Inc. | Anti-fungal and anti-bacterial histatin-based peptides |
-
2008
- 2008-07-01 WO PCT/US2008/008179 patent/WO2009005798A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5631228A (en) * | 1991-11-01 | 1997-05-20 | Periodontix, Inc. | Anti-fungal and anti-bacterial histatin-based peptides |
WO1996040768A2 (en) * | 1995-06-07 | 1996-12-19 | Periodontix, Inc. | Anti-fungal and anti-bacterial histatin-based peptides |
Non-Patent Citations (6)
Title |
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HELMERHORST E J ET AL: "A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 449, no. 2-3, 23 April 1999 (1999-04-23), pages 105 - 110, XP004259541, ISSN: 0014-5793 * |
MICKELS N ET AL: "Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis.", JOURNAL OF CLINICAL PERIODONTOLOGY MAY 2001, vol. 28, no. 5, May 2001 (2001-05-01), pages 404 - 410, XP002532737, ISSN: 0303-6979 * |
NISHIKAWA MASANOBU ET AL: "Antimicrobial activity of a chelatable poly(arginyl-histidine) produced by the ergot fungus Verticillium kibiense.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY JAN 2004, vol. 48, no. 1, January 2004 (2004-01-01), pages 229 - 235, XP002532735, ISSN: 0066-4804 * |
PERDOK J F ET AL: "Physicochemical properties of commercially available mouthrinses", JOURNAL OF DENTISTRY, ELSEVIER, vol. 18, no. 3, 1 June 1990 (1990-06-01), pages 147 - 150, XP023107911, ISSN: 0300-5712, [retrieved on 19900601] * |
ROTHSTEIN D M ET AL: "Anticandida activity is retained in P-113, a 12-amino-acid fragment of histatin 5.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY MAY 2001, vol. 45, no. 5, May 2001 (2001-05-01), pages 1367 - 1373, XP002532736, ISSN: 0066-4804 * |
XU T ET AL: "Anticandidal activity of major human salivary histatins.", INFECTION AND IMMUNITY AUG 1991, vol. 59, no. 8, August 1991 (1991-08-01), pages 2549 - 2554, XP002532734, ISSN: 0019-9567 * |
Also Published As
Publication number | Publication date |
---|---|
WO2009005798A2 (en) | 2009-01-08 |
WO2009005798A8 (en) | 2009-03-12 |
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