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WO2009005647A3 - Composés et procédé de préparation d'intermédiaires chiraux pour la synthèse de la proxétine - Google Patents

Composés et procédé de préparation d'intermédiaires chiraux pour la synthèse de la proxétine Download PDF

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Publication number
WO2009005647A3
WO2009005647A3 PCT/US2008/007870 US2008007870W WO2009005647A3 WO 2009005647 A3 WO2009005647 A3 WO 2009005647A3 US 2008007870 W US2008007870 W US 2008007870W WO 2009005647 A3 WO2009005647 A3 WO 2009005647A3
Authority
WO
WIPO (PCT)
Prior art keywords
paroxetine
compounds
synthesis
chiral intermediates
prepare chiral
Prior art date
Application number
PCT/US2008/007870
Other languages
English (en)
Other versions
WO2009005647A2 (fr
Inventor
Robert William Scott
Sean Timothy Neville
Lishan Zhao
Ningqing Ran
Original Assignee
Bioverdant Inc
Robert William Scott
Sean Timothy Neville
Lishan Zhao
Ningqing Ran
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioverdant Inc, Robert William Scott, Sean Timothy Neville, Lishan Zhao, Ningqing Ran filed Critical Bioverdant Inc
Publication of WO2009005647A2 publication Critical patent/WO2009005647A2/fr
Publication of WO2009005647A3 publication Critical patent/WO2009005647A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des composés et des procédés qui produisent des intermédiaires et des précurseurs de la paroxétine et composés associés. L'invention concerne également des procédés de préparation de la paroxétine.
PCT/US2008/007870 2007-06-27 2008-06-24 Composés et procédé de préparation d'intermédiaires chiraux pour la synthèse de la proxétine WO2009005647A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93746607P 2007-06-27 2007-06-27
US60/937,466 2007-06-27

Publications (2)

Publication Number Publication Date
WO2009005647A2 WO2009005647A2 (fr) 2009-01-08
WO2009005647A3 true WO2009005647A3 (fr) 2009-04-09

Family

ID=40076855

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/007870 WO2009005647A2 (fr) 2007-06-27 2008-06-24 Composés et procédé de préparation d'intermédiaires chiraux pour la synthèse de la proxétine

Country Status (1)

Country Link
WO (1) WO2009005647A2 (fr)

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* Cited by examiner, † Cited by third party
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CA3177159A1 (fr) 2010-06-22 2011-12-29 Sun Pharmaceutical Industries (Australia) Pty Ltd Acides nucleiques et polypeptides de methyltransferase
EP2596012B1 (fr) 2010-07-22 2017-12-06 Sun Pharmaceutical Industries (Australia) Pty Limited Cytochrome p450 végétal
GB201204407D0 (en) 2012-03-13 2012-04-25 Glaxosmithkline Australia Pty Ltd Nucleic acid molecule
CN104262255A (zh) * 2014-09-22 2015-01-07 四川大学 一种不对称催化合成γ-硝基吡唑酰胺化合物的方法
CN104892491B (zh) * 2015-05-06 2017-05-17 浙江海森药业有限公司 一种合成帕罗西汀手性中间体的方法
CN105400758A (zh) * 2015-11-26 2016-03-16 青岛康原药业有限公司 一种氯化钠-氨水、丙酮协同纯化胰激肽酶原的方法及提高胰激肽酶原稳定性的药物组合物
US20210315240A1 (en) 2018-08-31 2021-10-14 Mars, Incorporated Anthocyanin-based colorant compositions and methods of use thereof
AU2020357887A1 (en) * 2019-10-01 2022-04-07 Mars, Incorporated Enzymatic treatment of anthocyanins
CN114214375B (zh) * 2021-12-27 2024-03-19 江苏威凯尔医药科技有限公司 (r)-3-(4-卤代-1h-吡唑-1-基)-3-环戊基丙酸酯的制备方法
AU2023272468A1 (en) 2022-05-14 2024-11-14 Novonesis Plant Biosolutions A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993022284A1 (fr) * 1992-05-06 1993-11-11 Smithkline Beecham Plc Procede d'hydrolyse stereospecifique de derives de piperidinedione

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993022284A1 (fr) * 1992-05-06 1993-11-11 Smithkline Beecham Plc Procede d'hydrolyse stereospecifique de derives de piperidinedione

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
D. A. GREENHALGH ET AL.: "A Novel Chiral Base Mediated Glutarimide Desymmetrisation: Application to the Asymmetric Synthesis of (-)-Paroxetine", SYNLETT, no. 12, 2 December 2002 (2002-12-02), GEORG THIEME VERLAG, STUTTGART; DE, pages 2074 - 2076, XP002513234, ISSN: 0936-5214 *

Also Published As

Publication number Publication date
WO2009005647A2 (fr) 2009-01-08

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