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WO2009001192A3 - Nouveaux composés et leur utilisation - Google Patents

Nouveaux composés et leur utilisation Download PDF

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Publication number
WO2009001192A3
WO2009001192A3 PCT/IB2008/001620 IB2008001620W WO2009001192A3 WO 2009001192 A3 WO2009001192 A3 WO 2009001192A3 IB 2008001620 W IB2008001620 W IB 2008001620W WO 2009001192 A3 WO2009001192 A3 WO 2009001192A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel compounds
prsp
mrsa
vre
present
Prior art date
Application number
PCT/IB2008/001620
Other languages
English (en)
Other versions
WO2009001192A2 (fr
Inventor
Simi Pushpan
Uma Ramachandran
Mrinalkanti Kundu
Veenaa Anantharaman
Santhosh Subramanian
Radhakrishnan Viswanathan
Ravikumar Tadiparthi
Maneesh Paul-Sathyaseela
Shakti Singh Solanki
Kesavan Koppolu
Sathishkumar Devarajan
Martin Gnanamuthu
Thanga Mariappan
Narayanan Surendran
Sriram Rajagopal
Original Assignee
Orchid Research Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Research Laboratories Limited filed Critical Orchid Research Laboratories Limited
Priority to CA002692255A priority Critical patent/CA2692255A1/fr
Priority to EP08762934A priority patent/EP2170874A4/fr
Priority to US12/665,945 priority patent/US20100234390A1/en
Publication of WO2009001192A2 publication Critical patent/WO2009001192A2/fr
Publication of WO2009001192A3 publication Critical patent/WO2009001192A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne de nouveaux composés représentés par la formule générale (i), leurs dérivés, analogues, formes tautomères, stéréoisomères, polymorphes, hydrates, solvates, sels pharmaceutiquement acceptables ainsi que leurs compositions, métabolites et promédicaments. Les nouveaux composés se révèlent utiles en tant qu'agents antibactériens pour le traitement de pathologies telles qu'une pneumonie nosocomiale, une pneumonie acquise dans la collectivité, des infections causées par des entérocoques résistants à la vancomycine (ERV) et des bactéries telles que Staphylococcus aureus résistant à la méthicilline (SARM), Heamophilus influenzae (HI) et Streptococcus pneumoniae résistant à la pénicilline (SPRP). Les composés de la présente invention se révèlent efficaces contre un certain nombre de pathogènes humains ou animaux, notamment ERV, SPRP, HI et SARM.
PCT/IB2008/001620 2007-06-22 2008-06-20 Nouveaux composés et leur utilisation WO2009001192A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002692255A CA2692255A1 (fr) 2007-06-22 2008-06-20 Nouveaux composes et leur utilisation
EP08762934A EP2170874A4 (fr) 2007-06-22 2008-06-20 Nouveaux composés et leur utilisation
US12/665,945 US20100234390A1 (en) 2007-06-22 2008-06-20 Novel compound and their use

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1294CH2007 2007-06-22
IN1294/CHE/2007 2007-06-22
IN560CH2008 2008-03-05
IN560/CHE/2008 2008-03-05

Publications (2)

Publication Number Publication Date
WO2009001192A2 WO2009001192A2 (fr) 2008-12-31
WO2009001192A3 true WO2009001192A3 (fr) 2010-05-27

Family

ID=40186093

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/001620 WO2009001192A2 (fr) 2007-06-22 2008-06-20 Nouveaux composés et leur utilisation

Country Status (3)

Country Link
EP (1) EP2170874A4 (fr)
CA (1) CA2692255A1 (fr)
WO (1) WO2009001192A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8841306B2 (en) 2008-11-20 2014-09-23 Panacea Biotec Ltd. Antimicrobials
WO2013054275A1 (fr) * 2011-10-11 2013-04-18 Council Of Scientific & Industrial Research Sila-analogues de dérivés d'oxazolidinone et synthèse de ceux-ci
US10995097B2 (en) 2016-03-11 2021-05-04 The Board Of Trustees Of The University Of Illinois Small molecules active against gram-negative bacteria
WO2018237140A1 (fr) 2017-06-23 2018-12-27 The Board Of Trustees Of The University Of Illinois Inhibiteurs de la topoisomérase ayant une activité antibactérienne et une activité anti-cancéreuse
CN115466253B (zh) * 2021-06-16 2024-08-20 沈阳药科大学 含二硫代氨基甲酸酯结构的噁唑烷酮类化合物及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032599A1 (fr) * 1998-11-27 2000-06-08 Pharmacia & Upjohn Company Agents antibacteriens oxazolidinone a fonction thiocarbonyle
US6255304B1 (en) * 1997-05-30 2001-07-03 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
WO2001058885A1 (fr) * 2000-02-10 2001-08-16 Pharmacia & Upjohn Company Thioamides d'oxazolidinone a substituants amides de piperazine
EP1130016A1 (fr) * 1998-11-11 2001-09-05 Hokuriku Seiyaku Co., Ltd. Derives d'acide thiocarbamique
WO2003082864A2 (fr) * 2002-04-01 2003-10-09 Cadila Healthcare Limited Nouveaux composes anti-infectieux, processus de preparation de ces composes et compositions pharmaceutiques les contenant
WO2005113520A1 (fr) * 2004-05-20 2005-12-01 Pharmacia & Upjohn Company Llc 2,3,5-trifluorphenyl oxazolidinones substitues a utiliser en tant qu'agents antibacteriens

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK156499A3 (en) * 1997-05-30 2000-06-12 Upjohn Co Oxazolidinone antibacterial agents having a thiocarbonyl functionality
PE20010851A1 (es) * 1999-12-14 2001-08-17 Upjohn Co Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina
US6642238B2 (en) * 2000-02-10 2003-11-04 Pharmacia And Upjohn Company Oxazolidinone thioamides with piperazine amide substituents
AR042086A1 (es) * 2002-11-21 2005-06-08 Upjohn Co N-aril-2- oxazolidinon -5- carboxamidas y sus derivados, usados como agentes antibacterianos
US20050203102A1 (en) * 2004-03-09 2005-09-15 Orchid Chemicals & Pharmaceuticals Ltd. antibacterial agents

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255304B1 (en) * 1997-05-30 2001-07-03 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
EP1130016A1 (fr) * 1998-11-11 2001-09-05 Hokuriku Seiyaku Co., Ltd. Derives d'acide thiocarbamique
WO2000032599A1 (fr) * 1998-11-27 2000-06-08 Pharmacia & Upjohn Company Agents antibacteriens oxazolidinone a fonction thiocarbonyle
WO2001058885A1 (fr) * 2000-02-10 2001-08-16 Pharmacia & Upjohn Company Thioamides d'oxazolidinone a substituants amides de piperazine
WO2003082864A2 (fr) * 2002-04-01 2003-10-09 Cadila Healthcare Limited Nouveaux composes anti-infectieux, processus de preparation de ces composes et compositions pharmaceutiques les contenant
WO2005113520A1 (fr) * 2004-05-20 2005-12-01 Pharmacia & Upjohn Company Llc 2,3,5-trifluorphenyl oxazolidinones substitues a utiliser en tant qu'agents antibacteriens

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2170874A4 *

Also Published As

Publication number Publication date
WO2009001192A2 (fr) 2008-12-31
EP2170874A4 (fr) 2011-08-31
EP2170874A2 (fr) 2010-04-07
CA2692255A1 (fr) 2008-12-31

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