WO2009093169A1 - Dispositif d'administration topique d'oxyde nitrique sur une surface cutanée - Google Patents
Dispositif d'administration topique d'oxyde nitrique sur une surface cutanée Download PDFInfo
- Publication number
- WO2009093169A1 WO2009093169A1 PCT/IB2009/050193 IB2009050193W WO2009093169A1 WO 2009093169 A1 WO2009093169 A1 WO 2009093169A1 IB 2009050193 W IB2009050193 W IB 2009050193W WO 2009093169 A1 WO2009093169 A1 WO 2009093169A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- piezoelectric transformer
- nitric oxide
- output section
- skin surface
- skin
- Prior art date
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title claims abstract description 56
- 230000000699 topical effect Effects 0.000 title claims abstract description 8
- 238000006073 displacement reaction Methods 0.000 claims description 3
- 210000003491 skin Anatomy 0.000 description 20
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 239000007789 gas Substances 0.000 description 8
- 208000017520 skin disease Diseases 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 239000003570 air Substances 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 125000004430 oxygen atom Chemical group O* 0.000 description 3
- 210000004927 skin cell Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 2
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 2
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 229960004544 cortisone Drugs 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000010494 dissociation reaction Methods 0.000 description 2
- 230000005593 dissociations Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 229910015806 BaTiO2 Inorganic materials 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000012766 Growth delay Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 201000009053 Neurodermatitis Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 206010040925 Skin striae Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 150000001371 alpha-amino acids Chemical class 0.000 description 1
- 235000008206 alpha-amino acids Nutrition 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 208000037896 autoimmune cutaneous disease Diseases 0.000 description 1
- JRPBQTZRNDNNOP-UHFFFAOYSA-N barium titanate Chemical compound [Ba+2].[Ba+2].[O-][Ti]([O-])([O-])[O-] JRPBQTZRNDNNOP-UHFFFAOYSA-N 0.000 description 1
- 229910002113 barium titanate Inorganic materials 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- NKZSPGSOXYXWQA-UHFFFAOYSA-N dioxido(oxo)titanium;lead(2+) Chemical compound [Pb+2].[O-][Ti]([O-])=O NKZSPGSOXYXWQA-UHFFFAOYSA-N 0.000 description 1
- 238000010891 electric arc Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- HFGPZNIAWCZYJU-UHFFFAOYSA-N lead zirconate titanate Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Ti+4].[Zr+4].[Pb+2] HFGPZNIAWCZYJU-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/30—Gas therapy for therapeutic treatment of the skin
Definitions
- the invention relates to a device for the topical delivery of nitric oxide to a skin surface.
- Skin disorders such as tissue wounds, inflammatory or autoimmune skin diseases, are a rapidly increasing problem, presumably resulting as a consequence of environmental impacts on the human body.
- 3 % of the global population suffers from neurodermatitis which is a chronic persistent allergic disease with 10 % of all children being affected.
- Another 3 % of the world population suffers from psoriasis. These numbers add up to about 400 million people, with an annual increase of 5 to 10 %.
- nitric oxide has a positive influence on skin disorders.
- nitric oxide is produced from oxygen molecules and ⁇ -amino acids by the biosynthesis of enzymes.
- Nitric oxide is also synthesized in human skin. It is known that nitric oxide plays a central role in protecting the human body against invading pathogens and tumor cells, and in healing inflammatory cells and tissues.
- nitric oxide directly to the affected parts of skin cells and tissues from an external source.
- the mediating activities due to externally provided nitric oxide are identical or very similar to that of the nitric oxide synthesized in the human body, as long as an appropriate amount of nitric oxide is dosed. No chemical substances other than those existing in the human body are involved. Consequently, side effects as described hereinbefore are not expected to occur. Since both the lifetime of nitric oxide in the atmosphere and that of nitric oxide dissolved in a bodily fluid are at most in the order of a millisecond, the activity of nitric oxide is well controlled by its dose amount and duration.
- a device for forming a nitric oxide containing gas flow to treat a biological object is known from US20050218007A1.
- the nitric oxide containing gas flow is formed from a source gas comprising oxygen and nitrogen in a housing comprising two electrodes insulated from each other, a stationary arc discharge being generated and maintained between the electrodes.
- the known device comprises a relatively large discharge device, a gas cylinder and a power supply.
- the known device may be adequately applied for the treatment of a skin disorder in a professional environment with sufficient equipment and infrastructure, such as a hospital, but for many patients who suffer daily from a painful chronic skin disease it is a burden to visit such a place on a regular basis.
- a device comprising a power supply and a piezoelectric transformer having a resonance frequency, the piezoelectric transformer comprising an input section and an output section, wherein the power supply is arranged to apply an alternating input voltage having an alternation frequency to the input section of the piezoelectric transformer in order to create an alternating output voltage at the output section, the alternation frequency being substantially equal to the resonance frequency.
- a high alternating output voltage is created at the output section of the piezoelectric transformer, enabling the generation of an electrical discharge in the ambient atmosphere.
- the electrical discharge produces nitrogen atoms and oxygen atoms due to the dissociation of nitrogen molecules and oxygen molecules present in the ambient air, respectively.
- the nitrogen and oxygen atoms recombine to form nitric oxide that subsequently diffuses towards the skin surface.
- Piezoelectric transformers are known in the art as such, see for example J. Yang, Analysis of Piezoelectric Devices, World Scientific (2006). It is also known to use a piezoelectric transformer to generate an electrical discharge in an ambient atmosphere. For example, K.
- the piezoelectric transformer is positioned within a housing having an opening enabling a communication between the piezoelectric transformer and the skin surface via the ambient atmosphere, such that the shortest distance between the output section of the piezoelectric transformer and the opening of the housing is at least 1 micrometer per volt of the alternating output voltage. For example, when the output voltage at the output section of the piezoelectric transformer is 1 kV, the shortest distance between the output section and the opening of the housing is at least 1 millimeter.
- This embodiment is arranged to prevent the direct flow of an electrical current from the output side of the piezoelectric transformer to the skin surface. In many cases, such an electrical current may cause pain and destruction or irreparable damage of skin cells.
- the device further comprises a grounded electrode adjacent to the output section of the piezoelectric transformer. This embodiment is arranged to prevent the direct flow of an electrical current from the output side of the piezoelectric transformer to the skin surface.
- the device further comprises an air displacement device. This embodiment enables the diffusion process of nitric oxide to be controlled.
- the device further comprises a unit for providing a gas flow in the vicinity of the piezoelectric transformer and the skin surface.
- This embodiment enables a gas mixture that is desired for a particular electrical discharge to be supplied.
- Fig. 1 is a schematic cross section of the device according to the invention. It should be noted that this figure is diagrammatic and not drawn to scale. For the sake of clarity and convenience, relative dimensions and proportions of parts of this figure have been shown exaggerated or reduced in size.
- FIG. 1 A cross section of a device 1 according to the invention is shown in Fig. 1.
- the device 1 comprises a housing 11, a power supply 12, and a piezoelectric transformer 13.
- the housing 11 comprises an opening 111 enabling a communication between the piezoelectric transformer 13 and a skin surface 2 via the ambient atmosphere.
- the piezoelectric transformer 13 has an input section 131 and an output section 132, the input section 131 being provided on two opposite sides with a first electrode 121 and a second electrode 122, respectively.
- the power supply 12 is a standard AC power supply capable of supplying, across the first electrode 121 and the second electrode 122 of the input section 131 of the piezoelectric transformer 13, an alternating input voltage 123 having a magnitude in a range of approximately 10 V to 100 V, with an alternation frequency in a range of approximately 1 kHz to 500 kHz, and with an output power in a range of approximately 10 W to 100 W.
- the power supply 12 may either be present inside or outside the housing 11.
- the first electrode 121 and the second electrode 122 are both copper electrodes, but the skilled person will understand that other suitable metallic electrodes exist.
- the piezoelectric transformer 13 comprises a rectangular piece of single-layer piezoelectric material, such as barium titanate (BaTiO 2 ), lead titanate (PbTiOs), lead zirconate (PbZrOs), or lead titanate zirconate (PbZr x Tii_ x ⁇ 3, wherein 0 ⁇ x ⁇ l).
- the piezoelectric transformer 13 has a length of 3.3 cm, a width of 2.3 cm, and a thickness of 0.8 mm.
- the piezoelectric transformer 13 has a resonance frequency of approximately 84 kHz in the longitudinal direction.
- the output section 132 of the piezoelectric transformer 13 is preferably positioned in the vicinity of the skin to be treated.
- the distance between the output section 132 of the piezoelectric transformer 13 and the skin surface is more than 30 cm, the amount of nitric oxide that is created at the output section 132 and that is subsequently able to reach the skin surface is negligible.
- the piezoelectric transformer 13 is positioned within the housing 11 such that the shortest distance d between the output section 132 of the piezoelectric transformer 13 and the opening 111 of the housing 11 is at least 1 micrometer per volt of the alternating output voltage that is created at the output side 132 of the piezoelectric transformer 13.
- the shortest distance d between the output section 132 and the opening of the housing 111 is at least 1 millimeter.
- a further safety measure is present in the device 1 , in the form of a grounded electrode 124 adjacent to the output section 132 of the piezoelectric transformer 13.
- the device 1 comprises a ventilator 14.
- air displacement devices such as a pump or a heating element that is arranged to displace air by means of a thermal chimney effect caused by local differences in air density.
- the device 1 also comprises a unit 15 for providing a gas flow 16 in the vicinity of the output section 132 of the piezoelectric transformer 13, which is useful in case a certain gas mixture is desired for the electrical discharges.
- the device according to the invention may comprise a plurality of piezoelectric transformers 13, that can for instance be assembled as a matrix, which can be addressed by an external control circuit.
- the device 1 can be used in a liquid or on a liquid surface.
- the part with the piezoelectric transformer 13 may be directly placed on the wet skin surface for the treatment.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plasma Technology (AREA)
- Electrotherapy Devices (AREA)
Abstract
L'invention concerne un dispositif (1) d'administration topique d'oxyde nitrique sur une surface cutanée, comprenant un transformateur piézoélectrique (13) qui sert de moyen de production d'oxyde nitrique. Le dispositif selon l'invention convient à une utilisation par un patient à domicile.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08150484 | 2008-01-22 | ||
EP08150484.7 | 2008-01-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009093169A1 true WO2009093169A1 (fr) | 2009-07-30 |
Family
ID=40469831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2009/050193 WO2009093169A1 (fr) | 2008-01-22 | 2009-01-20 | Dispositif d'administration topique d'oxyde nitrique sur une surface cutanée |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009093169A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017500110A (ja) * | 2013-12-12 | 2017-01-05 | レリオン プラズマ ゲーエムベーハー | 創傷用治療器具 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993017741A1 (fr) * | 1992-03-11 | 1993-09-16 | The General Hospital Corporation | Production d'un melange comprenant de l'oxyde nitrique et de l'air pour applications medicales |
WO1996013164A1 (fr) * | 1994-10-28 | 1996-05-09 | University Of Akron, The | Accelerateurs de cicatrisation a base de polymeres |
US6013097A (en) * | 1994-11-21 | 2000-01-11 | Augautine Medical, Inc. | Wound treatment device for attachment to skin |
US6103275A (en) * | 1998-06-10 | 2000-08-15 | Nitric Oxide Solutions | Systems and methods for topical treatment with nitric oxide |
US20020082566A1 (en) * | 2000-12-26 | 2002-06-27 | Sensormedics Corporation | Device and method for treatment of surface infections with nitric oxide |
US20050218007A1 (en) * | 2001-02-09 | 2005-10-06 | Pekshev Aleksandr V | Method and device for forming an no-containing gas flow for affecting a biological object |
US20070190184A1 (en) * | 2006-02-16 | 2007-08-16 | Ino Therapeutics Llc | Method and apparatus for generating nitric oxide for medical use |
WO2007092284A2 (fr) * | 2006-02-03 | 2007-08-16 | Cure Therapeuctics, Inc. | Timbre transdermique contenant un donneur de no a faible dose |
-
2009
- 2009-01-20 WO PCT/IB2009/050193 patent/WO2009093169A1/fr active Application Filing
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993017741A1 (fr) * | 1992-03-11 | 1993-09-16 | The General Hospital Corporation | Production d'un melange comprenant de l'oxyde nitrique et de l'air pour applications medicales |
WO1996013164A1 (fr) * | 1994-10-28 | 1996-05-09 | University Of Akron, The | Accelerateurs de cicatrisation a base de polymeres |
US6013097A (en) * | 1994-11-21 | 2000-01-11 | Augautine Medical, Inc. | Wound treatment device for attachment to skin |
US6103275A (en) * | 1998-06-10 | 2000-08-15 | Nitric Oxide Solutions | Systems and methods for topical treatment with nitric oxide |
US20020082566A1 (en) * | 2000-12-26 | 2002-06-27 | Sensormedics Corporation | Device and method for treatment of surface infections with nitric oxide |
US20050218007A1 (en) * | 2001-02-09 | 2005-10-06 | Pekshev Aleksandr V | Method and device for forming an no-containing gas flow for affecting a biological object |
WO2007092284A2 (fr) * | 2006-02-03 | 2007-08-16 | Cure Therapeuctics, Inc. | Timbre transdermique contenant un donneur de no a faible dose |
US20070190184A1 (en) * | 2006-02-16 | 2007-08-16 | Ino Therapeutics Llc | Method and apparatus for generating nitric oxide for medical use |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017500110A (ja) * | 2013-12-12 | 2017-01-05 | レリオン プラズマ ゲーエムベーハー | 創傷用治療器具 |
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