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WO2009093169A1 - Dispositif d'administration topique d'oxyde nitrique sur une surface cutanée - Google Patents

Dispositif d'administration topique d'oxyde nitrique sur une surface cutanée Download PDF

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Publication number
WO2009093169A1
WO2009093169A1 PCT/IB2009/050193 IB2009050193W WO2009093169A1 WO 2009093169 A1 WO2009093169 A1 WO 2009093169A1 IB 2009050193 W IB2009050193 W IB 2009050193W WO 2009093169 A1 WO2009093169 A1 WO 2009093169A1
Authority
WO
WIPO (PCT)
Prior art keywords
piezoelectric transformer
nitric oxide
output section
skin surface
skin
Prior art date
Application number
PCT/IB2009/050193
Other languages
English (en)
Inventor
Daiyu Hayashi
Matthias Born
Albert A. Comberg
Original Assignee
Koninklijke Philips Electronics N.V.
Philips Intellectual Property & Standards Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics N.V., Philips Intellectual Property & Standards Gmbh filed Critical Koninklijke Philips Electronics N.V.
Publication of WO2009093169A1 publication Critical patent/WO2009093169A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/30—Gas therapy for therapeutic treatment of the skin

Definitions

  • the invention relates to a device for the topical delivery of nitric oxide to a skin surface.
  • Skin disorders such as tissue wounds, inflammatory or autoimmune skin diseases, are a rapidly increasing problem, presumably resulting as a consequence of environmental impacts on the human body.
  • 3 % of the global population suffers from neurodermatitis which is a chronic persistent allergic disease with 10 % of all children being affected.
  • Another 3 % of the world population suffers from psoriasis. These numbers add up to about 400 million people, with an annual increase of 5 to 10 %.
  • nitric oxide has a positive influence on skin disorders.
  • nitric oxide is produced from oxygen molecules and ⁇ -amino acids by the biosynthesis of enzymes.
  • Nitric oxide is also synthesized in human skin. It is known that nitric oxide plays a central role in protecting the human body against invading pathogens and tumor cells, and in healing inflammatory cells and tissues.
  • nitric oxide directly to the affected parts of skin cells and tissues from an external source.
  • the mediating activities due to externally provided nitric oxide are identical or very similar to that of the nitric oxide synthesized in the human body, as long as an appropriate amount of nitric oxide is dosed. No chemical substances other than those existing in the human body are involved. Consequently, side effects as described hereinbefore are not expected to occur. Since both the lifetime of nitric oxide in the atmosphere and that of nitric oxide dissolved in a bodily fluid are at most in the order of a millisecond, the activity of nitric oxide is well controlled by its dose amount and duration.
  • a device for forming a nitric oxide containing gas flow to treat a biological object is known from US20050218007A1.
  • the nitric oxide containing gas flow is formed from a source gas comprising oxygen and nitrogen in a housing comprising two electrodes insulated from each other, a stationary arc discharge being generated and maintained between the electrodes.
  • the known device comprises a relatively large discharge device, a gas cylinder and a power supply.
  • the known device may be adequately applied for the treatment of a skin disorder in a professional environment with sufficient equipment and infrastructure, such as a hospital, but for many patients who suffer daily from a painful chronic skin disease it is a burden to visit such a place on a regular basis.
  • a device comprising a power supply and a piezoelectric transformer having a resonance frequency, the piezoelectric transformer comprising an input section and an output section, wherein the power supply is arranged to apply an alternating input voltage having an alternation frequency to the input section of the piezoelectric transformer in order to create an alternating output voltage at the output section, the alternation frequency being substantially equal to the resonance frequency.
  • a high alternating output voltage is created at the output section of the piezoelectric transformer, enabling the generation of an electrical discharge in the ambient atmosphere.
  • the electrical discharge produces nitrogen atoms and oxygen atoms due to the dissociation of nitrogen molecules and oxygen molecules present in the ambient air, respectively.
  • the nitrogen and oxygen atoms recombine to form nitric oxide that subsequently diffuses towards the skin surface.
  • Piezoelectric transformers are known in the art as such, see for example J. Yang, Analysis of Piezoelectric Devices, World Scientific (2006). It is also known to use a piezoelectric transformer to generate an electrical discharge in an ambient atmosphere. For example, K.
  • the piezoelectric transformer is positioned within a housing having an opening enabling a communication between the piezoelectric transformer and the skin surface via the ambient atmosphere, such that the shortest distance between the output section of the piezoelectric transformer and the opening of the housing is at least 1 micrometer per volt of the alternating output voltage. For example, when the output voltage at the output section of the piezoelectric transformer is 1 kV, the shortest distance between the output section and the opening of the housing is at least 1 millimeter.
  • This embodiment is arranged to prevent the direct flow of an electrical current from the output side of the piezoelectric transformer to the skin surface. In many cases, such an electrical current may cause pain and destruction or irreparable damage of skin cells.
  • the device further comprises a grounded electrode adjacent to the output section of the piezoelectric transformer. This embodiment is arranged to prevent the direct flow of an electrical current from the output side of the piezoelectric transformer to the skin surface.
  • the device further comprises an air displacement device. This embodiment enables the diffusion process of nitric oxide to be controlled.
  • the device further comprises a unit for providing a gas flow in the vicinity of the piezoelectric transformer and the skin surface.
  • This embodiment enables a gas mixture that is desired for a particular electrical discharge to be supplied.
  • Fig. 1 is a schematic cross section of the device according to the invention. It should be noted that this figure is diagrammatic and not drawn to scale. For the sake of clarity and convenience, relative dimensions and proportions of parts of this figure have been shown exaggerated or reduced in size.
  • FIG. 1 A cross section of a device 1 according to the invention is shown in Fig. 1.
  • the device 1 comprises a housing 11, a power supply 12, and a piezoelectric transformer 13.
  • the housing 11 comprises an opening 111 enabling a communication between the piezoelectric transformer 13 and a skin surface 2 via the ambient atmosphere.
  • the piezoelectric transformer 13 has an input section 131 and an output section 132, the input section 131 being provided on two opposite sides with a first electrode 121 and a second electrode 122, respectively.
  • the power supply 12 is a standard AC power supply capable of supplying, across the first electrode 121 and the second electrode 122 of the input section 131 of the piezoelectric transformer 13, an alternating input voltage 123 having a magnitude in a range of approximately 10 V to 100 V, with an alternation frequency in a range of approximately 1 kHz to 500 kHz, and with an output power in a range of approximately 10 W to 100 W.
  • the power supply 12 may either be present inside or outside the housing 11.
  • the first electrode 121 and the second electrode 122 are both copper electrodes, but the skilled person will understand that other suitable metallic electrodes exist.
  • the piezoelectric transformer 13 comprises a rectangular piece of single-layer piezoelectric material, such as barium titanate (BaTiO 2 ), lead titanate (PbTiOs), lead zirconate (PbZrOs), or lead titanate zirconate (PbZr x Tii_ x ⁇ 3, wherein 0 ⁇ x ⁇ l).
  • the piezoelectric transformer 13 has a length of 3.3 cm, a width of 2.3 cm, and a thickness of 0.8 mm.
  • the piezoelectric transformer 13 has a resonance frequency of approximately 84 kHz in the longitudinal direction.
  • the output section 132 of the piezoelectric transformer 13 is preferably positioned in the vicinity of the skin to be treated.
  • the distance between the output section 132 of the piezoelectric transformer 13 and the skin surface is more than 30 cm, the amount of nitric oxide that is created at the output section 132 and that is subsequently able to reach the skin surface is negligible.
  • the piezoelectric transformer 13 is positioned within the housing 11 such that the shortest distance d between the output section 132 of the piezoelectric transformer 13 and the opening 111 of the housing 11 is at least 1 micrometer per volt of the alternating output voltage that is created at the output side 132 of the piezoelectric transformer 13.
  • the shortest distance d between the output section 132 and the opening of the housing 111 is at least 1 millimeter.
  • a further safety measure is present in the device 1 , in the form of a grounded electrode 124 adjacent to the output section 132 of the piezoelectric transformer 13.
  • the device 1 comprises a ventilator 14.
  • air displacement devices such as a pump or a heating element that is arranged to displace air by means of a thermal chimney effect caused by local differences in air density.
  • the device 1 also comprises a unit 15 for providing a gas flow 16 in the vicinity of the output section 132 of the piezoelectric transformer 13, which is useful in case a certain gas mixture is desired for the electrical discharges.
  • the device according to the invention may comprise a plurality of piezoelectric transformers 13, that can for instance be assembled as a matrix, which can be addressed by an external control circuit.
  • the device 1 can be used in a liquid or on a liquid surface.
  • the part with the piezoelectric transformer 13 may be directly placed on the wet skin surface for the treatment.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Electrotherapy Devices (AREA)
  • Plasma Technology (AREA)

Abstract

L'invention concerne un dispositif (1) d'administration topique d'oxyde nitrique sur une surface cutanée, comprenant un transformateur piézoélectrique (13) qui sert de moyen de production d'oxyde nitrique. Le dispositif selon l'invention convient à une utilisation par un patient à domicile.
PCT/IB2009/050193 2008-01-22 2009-01-20 Dispositif d'administration topique d'oxyde nitrique sur une surface cutanée WO2009093169A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08150484.7 2008-01-22
EP08150484 2008-01-22

Publications (1)

Publication Number Publication Date
WO2009093169A1 true WO2009093169A1 (fr) 2009-07-30

Family

ID=40469831

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/050193 WO2009093169A1 (fr) 2008-01-22 2009-01-20 Dispositif d'administration topique d'oxyde nitrique sur une surface cutanée

Country Status (1)

Country Link
WO (1) WO2009093169A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017500110A (ja) * 2013-12-12 2017-01-05 レリオン プラズマ ゲーエムベーハー 創傷用治療器具

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993017741A1 (fr) * 1992-03-11 1993-09-16 The General Hospital Corporation Production d'un melange comprenant de l'oxyde nitrique et de l'air pour applications medicales
WO1996013164A1 (fr) * 1994-10-28 1996-05-09 University Of Akron, The Accelerateurs de cicatrisation a base de polymeres
US6013097A (en) * 1994-11-21 2000-01-11 Augautine Medical, Inc. Wound treatment device for attachment to skin
US6103275A (en) * 1998-06-10 2000-08-15 Nitric Oxide Solutions Systems and methods for topical treatment with nitric oxide
US20020082566A1 (en) * 2000-12-26 2002-06-27 Sensormedics Corporation Device and method for treatment of surface infections with nitric oxide
US20050218007A1 (en) * 2001-02-09 2005-10-06 Pekshev Aleksandr V Method and device for forming an no-containing gas flow for affecting a biological object
US20070190184A1 (en) * 2006-02-16 2007-08-16 Ino Therapeutics Llc Method and apparatus for generating nitric oxide for medical use
WO2007092284A2 (fr) * 2006-02-03 2007-08-16 Cure Therapeuctics, Inc. Timbre transdermique contenant un donneur de no a faible dose

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993017741A1 (fr) * 1992-03-11 1993-09-16 The General Hospital Corporation Production d'un melange comprenant de l'oxyde nitrique et de l'air pour applications medicales
WO1996013164A1 (fr) * 1994-10-28 1996-05-09 University Of Akron, The Accelerateurs de cicatrisation a base de polymeres
US6013097A (en) * 1994-11-21 2000-01-11 Augautine Medical, Inc. Wound treatment device for attachment to skin
US6103275A (en) * 1998-06-10 2000-08-15 Nitric Oxide Solutions Systems and methods for topical treatment with nitric oxide
US20020082566A1 (en) * 2000-12-26 2002-06-27 Sensormedics Corporation Device and method for treatment of surface infections with nitric oxide
US20050218007A1 (en) * 2001-02-09 2005-10-06 Pekshev Aleksandr V Method and device for forming an no-containing gas flow for affecting a biological object
WO2007092284A2 (fr) * 2006-02-03 2007-08-16 Cure Therapeuctics, Inc. Timbre transdermique contenant un donneur de no a faible dose
US20070190184A1 (en) * 2006-02-16 2007-08-16 Ino Therapeutics Llc Method and apparatus for generating nitric oxide for medical use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017500110A (ja) * 2013-12-12 2017-01-05 レリオン プラズマ ゲーエムベーハー 創傷用治療器具

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