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WO2009081716A1 - Grain sphérique, son procédé de fabrication et procédé pour produire d'une préparation à libération entretenue - Google Patents

Grain sphérique, son procédé de fabrication et procédé pour produire d'une préparation à libération entretenue Download PDF

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Publication number
WO2009081716A1
WO2009081716A1 PCT/JP2008/072169 JP2008072169W WO2009081716A1 WO 2009081716 A1 WO2009081716 A1 WO 2009081716A1 JP 2008072169 W JP2008072169 W JP 2008072169W WO 2009081716 A1 WO2009081716 A1 WO 2009081716A1
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WIPO (PCT)
Prior art keywords
central core
spherical
coating layer
producing
particle
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PCT/JP2008/072169
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English (en)
Japanese (ja)
Inventor
Ikuo Tanai
Terumi Takahashi
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Freund Corporation
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Filing date
Publication date
Application filed by Freund Corporation filed Critical Freund Corporation
Publication of WO2009081716A1 publication Critical patent/WO2009081716A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P30/00—Shaping or working of foodstuffs characterised by the process or apparatus
    • A23P30/10—Moulding

Definitions

  • the present invention relates to a spherical particle, a method for producing the same, and a method for producing a controlled release preparation.
  • Controlled release is one of the techniques for keeping the physiologically active substance concentration-time pattern at the site of action of the physiologically active substance (drug) optimal.
  • a controlled release formulation for realizing controlled release (Controlled Release formulation)
  • the surface of a spherical particle for example, “Nonparel (registered trademark)” manufactured by Freund Sangyo Co., Ltd.
  • the surface of a spherical particle is coated (layer) After filming, there is a film coated with a film substrate according to the purpose.
  • This spherical particle for layering is required to be closer to the true sphere in order to accurately control the release rate of the physiologically active substance.
  • the spherical particles for layering are manufactured by the following method, for example.
  • particles serving as a central core (hereinafter referred to as central core particles) are rolled in various granulators, and a powder that is a main component of spherical particles is supplied thereto.
  • it is granulated by spraying a liquid for wetting the central core particles and powder.
  • the granulated particles are then dried to form spherical particles for layering.
  • a granulated sugar crystal is charged as a central core particle in an operating centrifugal rolling device.
  • fine particles or fine powder of sucrose is sprayed on the crystal while spraying an aqueous solution of sucrose as a binder.
  • fine particles or fine powder of sucrose is coated on granulated sugar crystals and granulated into a spherical shape (see paragraph [0004] of Patent Document 1). JP 2004-67670 A
  • the present invention has been made in view of the above circumstances, and an object thereof is a spherical particle having a small particle diameter and high sphericity while using central core particles made of crystal grains, and a method for producing the same. Furthermore, it aims at the manufacturing method of the controlled release formulation which uses this spherical particle.
  • the spherical grain of the present invention is characterized in that a coating layer is fixed on the surface of the central core particle obtained by cutting the corner of the crystal grain.
  • the method for producing a spherical grain of the present invention comprises a first step of cutting the corners of the crystal grains to form central core particles, and a second step of fixing a coating layer on the surface of the central core particles.
  • the second step is a step of supplying a powdery coating layer forming component and spraying a liquid while rolling or flowing the central core particle to fix the coating layer on the surface of the central core particle.
  • the second step is a step of spraying a liquid on the surface of the core core particles while rolling or flowing, and fixing the coating layer forming component dissolved or dispersed in the liquid to the core particles. preferable.
  • the crystal grains comprise crystals of any of physiologically active substances that can be taken orally, pharmaceuticals, or food additives.
  • the crystal grains are preferably made of sugar crystals.
  • the crystal grains are preferably made of pharmaceutical crystals.
  • the crystal grains are preferably made of organic acid crystals.
  • the production method of the controlled-release preparation of the present invention is preferably a method in which a spherical particle obtained by the production method is layered with a component containing a physiologically active substance, and further film coating is performed.
  • the method for producing spherical particles of the present invention it is possible to obtain spherical particles having a small particle diameter and high sphericity while using central core particles made of crystal grains. Further, the spherical particles of the present invention have a small particle diameter and a high sphericity. Therefore, when the spherical particles of the present invention are used when producing a controlled release preparation, a controlled release preparation having preferable release controllability can be obtained.
  • the spherical grain of this embodiment is characterized in that a coating layer is fixed to the surface of the central core particle obtained by cutting the corner of the crystal grain.
  • crystal grains used for the central core particles it is preferable to use crystals such as orally ingestible physiologically active substances, pharmaceuticals or food additives.
  • crystals such as orally ingestible physiologically active substances, pharmaceuticals or food additives.
  • the central core particles according to the present embodiment those obtained by cutting off the corners of these crystal grains are used.
  • sugars such as glucose, fructose, sucrose, and lactose
  • sugar alcohols such as mannitol, xylitol, and erythritol
  • organic acids such as citric acid, tartaric acid, ascorbic acid, and sodium salts, calcium salts, and potassium salts thereof
  • Salts Inorganic substances typified by inorganic salts such as salt; pharmaceuticals and health foods typified by ethenamide, aspirin, ephedrine and the like.
  • sucrose, lactose, citric acid, and tartaric acid are preferably used.
  • the spherical particle coating layer of the present embodiment is fixed to the surface of the central core particle.
  • the term “fixed” refers to a state in which the coating layer is fixed to the surface of the central core particle using a liquid or the like so that a part of the coating layer is not taken off and scattered. Therefore, it is different from the one in which only the powder is adhered to the central core particle without using a liquid or the like.
  • the spherical particles of the present embodiment are used as the central core of a controlled release preparation or the like, it is difficult for the coating layer to scatter or be lost.
  • the coating layer forming component it is preferable to use pharmaceutical / food additives such as sugar, sugar alcohol, starches, organic acids, physiologically active substances that can be taken orally, film coating agents used for pharmaceuticals / food, and the like.
  • film coating agent include cellulose derivatives such as methylcellulose (MC), ethylcellulose (EC), hydroxylpropylcellulose (HPC), hydroxypropylmethylcellulose (HPMC), and carboxymethylethylcellulose (CMEC); non-xanthan gum, locust bean gum and the like Cellulose polysaccharides; synthetic polymers such as polyethylene oxide, acrylic acid polymer, polyvinyl alcohol, and polyvinylpyrrolidone.
  • the sphericity (minor axis / major axis) of the spherical particles of the present embodiment is preferably 0.85 or more.
  • components containing a physiologically active substance can be more uniformly layered. Therefore, the release rate of the physiologically active substance in the controlled release preparation using the spherical particles can be controlled more accurately.
  • the spherical grain manufacturing method of the present embodiment includes a first step of cutting the corners of the crystal grains to form central core particles, and a second step of fixing a coating layer on the surface of the central core particles. It is characterized by.
  • the shape of the crystal grains used for forming the central core particles is not particularly limited, but a shape close to a cubic is preferable for spheroidization.
  • the size of the crystal grains is preferably 50 ⁇ m or more and 1000 ⁇ m or less, more preferably 75 ⁇ m or more and 500 ⁇ m, as measured by a sieving method (hereinafter referred to as the particle size). More preferably, it is as follows. When the particle diameter of the crystal grains is larger than 1000 ⁇ m, it is difficult to use as a component of the preparation. If the crystal grain size is less than 50 ⁇ m, aggregation may occur in the second step of forming the coating layer.
  • An apparatus having a stirring blade, a rotor, an agitator and the like can be used to cut the corners of the crystal grains.
  • this apparatus include a stirring granulator (for example, a tabletop stirring granulator manufactured by Kawata Co., Ltd., SUPER MIXER, PICCOLO, etc.) and a combined fluidized bed granulation coating apparatus (for example, Freund Sangyo Co., Ltd.). Spiraflow made of). Conditions such as the number of rotations and movement time during operation of the apparatus are adjusted to such an extent that the corners of the crystal grains can be cut while observing the crystal grains.
  • the second step of fixing the coating layer on the surface of the central core particle obtained in the first step include the following first and second modes.
  • the first aspect is a step of fixing the coating layer on the surface of the central core particle by supplying a powdery coating layer forming component and spraying a liquid while rolling or flowing the central core particle.
  • the second aspect is a step of fixing the coating layer forming component dissolved or dispersed in the liquid to the central core particles while spraying the liquid on the surface of the central core particles while rolling or flowing.
  • a centrifugal rolling coating apparatus 10 of FIG. 1 includes a centrifugal rolling chamber 11 that granulates while rolling central core particles and the like.
  • the centrifugal rolling chamber 11 includes a cylindrical fixed wall 12 disposed so that the axis is in the vertical direction, and a circular rotating tray 13.
  • the rotating tray 13 is disposed inside the fixed wall 12 and rotates in the horizontal direction around the central axis 14 while leaving a predetermined clearance from the inner wall of the fixed wall 12.
  • the centrifugal rolling coating apparatus 10 granulates a spherical shape by rolling central core particles and powders of components forming a coating layer on a rotating dish 13.
  • the rotating dish 13 has a shape in which the peripheral edge is gradually inclined upward, and the powder can be uniformly rolled thereon. Further, a thermometer such as a thermocouple (not shown) is installed in the centrifugal rolling chamber 11 so that the particle temperature can be measured.
  • a thermometer such as a thermocouple (not shown) is installed in the centrifugal rolling chamber 11 so that the particle temperature can be measured.
  • the centrifugal rolling chamber 11 is provided with a powder supply tube (powder supply device) 15 from which the powder of the component forming the coating layer can be sprayed. Further, the centrifugal rolling chamber 11 is provided with a spraying device 16 so that a liquid containing a component that acts as a binder can be sprayed into the centrifugal rolling chamber 11 as necessary. Further, in this example, an air chamber 17 is formed below the rotating dish 13. By sending compressed air from the compressed air supply pipe 18 into the air chamber 17, high-pressure air (hereinafter referred to as slit air) from the clearance portion between the inner wall of the fixed wall 12 and the rotating dish 13 into the centrifugal rolling chamber 11. .) Is introduced. The mixing air circulation of the powder is further enhanced by the slit air.
  • Reference numeral 19 in the drawing denotes an exhaust port.
  • the apparatus having the same basic configuration as the centrifugal rolling coating apparatus shown in FIG. 1 include “CF granulator” and “Granurex” manufactured by Freund Corporation.
  • the fluidized bed granulation coating apparatus examples include “Flow Coater” manufactured by Freund Sangyo Co., Ltd.
  • the composite fluidized granulation coating apparatus can also be used for the first step as described above. Therefore, when a composite fluidized granulation coating apparatus is used, the first step and the second step can be continuously performed with one apparatus by appropriately setting conditions.
  • a powdery coating layer forming component is introduced from the powder supply pipe 15 while rolling the central core particles on the rotating dish 13. If the diameter of the rotating dish 13 is about 360 mm, the rotating dish 13 is rotated at, for example, 100 rpm or more and 200 rpm or less.
  • the liquid is sprayed from the spraying device 16 while introducing slit air into the centrifugal rolling chamber 11. In this way, the powdery coating layer forming component is granulated while being wetted.
  • the powdery coating layer forming component is preferably introduced in an amount of 10 to 300 parts by mass, more preferably 10 to 120 parts by mass, with respect to 100 parts by mass of the central core particle. As described above, in this embodiment, it is possible to spheroidize with a smaller amount of the coating layer forming component as compared with the case where powder layering is performed without cutting the corners of the crystal grains. Therefore, in this embodiment, not only the process time can be shortened but also the yield can be expected.
  • the particle diameter of the powdery coating layer forming component is not particularly limited, but is preferably a powder whose particle diameter is 1/10 or less of the diameter of the central core particle.
  • the powdery coating layer-forming component among the coating layer-forming components, it is particularly preferable to use powders such as sugars, sugar alcohols, starches, pharmaceutical and food additives such as organic acids, or physiologically active substances that can be taken orally. preferable.
  • binders include sugars, sugar alcohols, organic acids, cellulose derivatives such as hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose acetate succinate, starches, polyvinylpyrrolidone, poly (meth) acrylic acid and esters thereof , Polyvinyl alcohol and derivatives thereof, and polyoxyethylene hydrogenated castor oil. These components may be used alone or in combination of two or more.
  • a liquid is sprayed on the surface of the central core particles while rolling or flowing, and the coating layer forming component dissolved or dispersed in the liquid is fixed to the central core particles.
  • This embodiment can also be implemented using a centrifugal roll coating apparatus 10 as shown in FIG.
  • the central core particles are rolled on the rotating dish 13.
  • liquid is sprayed from the spraying device 16 while introducing slit air into the centrifugal rolling chamber 11. And it granulates with the coating layer formation component melt
  • the coating layer forming component that forms the coating layer may be dissolved or dispersed in a liquid to be sprayed in advance before spraying. Moreover, the coating layer forming component which forms a coating layer may be dissolved by the sprayed liquid after spraying. That is, as the liquid sprayed to form the coating layer of the present embodiment, the following three modes are exemplified.
  • An organic solvent such as alcohol, and a mixed liquid of water and an organic solvent liquid C.
  • the coating layer forming component it is preferable to use a component having a binder effect among the coating layer forming components.
  • the thing without a binder effect or a thing with a weak binder effect can be used by using together with a coating layer formation component with a high binder effect.
  • the concentration of the coating layer forming component in the solution is set near the solubility upper limit of the coating layer forming component.
  • the concentration of the dispersoid may be appropriately set in consideration of viscosity, sprayability, and the like. Further, the dispersoid may be dispersed in (Liquid A).
  • the liquid to be sprayed is a solution or dispersion containing the coating layer forming component in advance
  • spherical particles are produced using the centrifugal rolling coating apparatus 10 by the following method.
  • the central core particles are rolled on the rotating dish 13.
  • the liquid containing the coating layer forming component is sprayed onto the central core particles rolling from the spraying device 16, and the coating layer is formed on the surface of the central core particles.
  • the spherical particles of this embodiment are obtained by the above method.
  • the liquid is a solution (liquid A)
  • the abrasion resistance is improved, which is more preferable.
  • liquid to be sprayed is (liquid C)
  • (liquid C) is preferably allowed to act as a solvent for dissolving the fine powder (solute) of crystal grains generated in the first step after spraying.
  • the centrifugal rolling coating apparatus 10 using the centrifugal rolling coating apparatus 10, first, the central core particles and the fine powder thereof are rolled on the rotating dish 13. Next, while introducing slit air into the centrifugal rolling chamber 11, (fine liquid C) is sprayed onto the fine powder from the spray device 16 as a solvent.
  • the spray amount of (Liquid C) is an amount capable of dissolving the fine powder as the solute, and is appropriately adjusted according to the components.
  • the spherical particles of the present embodiment obtained through the first step and the second step may be taken out of the centrifugal tumbling coating apparatus and then transferred to an apparatus such as a fluidized bed apparatus and dried. it can.
  • the corners of the crystal grains serving as the central core particles are cut in advance, and then the coating layer is formed. Therefore, spherical particles having a sufficiently high sphericity can be obtained without forming a thick coating layer. Furthermore, the particle diameter of the spherical particles can be reduced. Further, when a liquid is used in forming the coating layer, voids are not easily generated in the coating layer, so that spherical particles having higher hardness than those obtained by powder layering can be obtained. Such spherical particles of the present embodiment can be used for medicines and the like because the control of release control is accurate when used in controlled release preparations and the like.
  • the production method of the controlled-release preparation of this embodiment is preferably a method in which a spherical particle obtained by the production method is layered with a component containing a physiologically active substance, and then film coating is further performed.
  • the spherical particles are formed of a component containing a physiologically active substance (drug), they can be used as drug particles or the like as they are.
  • Spherical particle layering and film coating with a component containing a physiologically active substance, etc. is performed by centrifugal rolling granulation coating apparatus (for example, “CF Granulator”, “Granurex” manufactured by Freund Sangyo Co., Ltd.), flow, etc.
  • a layer granulation coating apparatus for example, “Flow coater” manufactured by Freund Sangyo Co., Ltd.
  • a composite granulation coating apparatus for example, “Spiraflow” manufactured by Freund Sangyo Co., Ltd.
  • physiologically active substances include hypnotics / sedatives, antipyretic analgesics, antipsychotic agents, autonomic agents, antiparkinson agents, antihistamines, cardiotonic agents, diuretics, antihypertensive agents, vasoconstrictors, Arteriosclerotic agents, antitussive expectorants, vitamins, nourishing tonics, antibiotics, gastrointestinal drugs and the like.
  • a film base suitable for the purpose such as release control or masking of a physiologically active substance, may be appropriately used.
  • Example 1 Tartaric acid crystals (L-Tartaric acid S, manufactured by Fuso Chemical Industry Co., Ltd.) were put into a table type stirring granulator (manufactured by Kawata Co., Ltd., SUPER MIXER PICCOLO), stirred at 2500 rpm for 60 minutes, and the corners of the crystal were shaved. It was. Thereafter, the corner-cut crystals were sieved to obtain central core particles having a particle diameter of 180 ⁇ m or more and 250 ⁇ m or less.
  • a table type stirring granulator manufactured by Kawata Co., Ltd., SUPER MIXER PICCOLO
  • CF-360EX centrifugal rolling type coating granulator CF granulator
  • an aqueous tartaric acid solution having a concentration of 50% by mass was added to the central core particles. It sprayed until the mass of the solid content of tartaric acid with respect to the mass of 100 became 100 mass%.
  • spherical particles of tartaric acid having a sphericity of 0.90, a particle diameter of 212 ⁇ m or more and 355 ⁇ m or less were obtained in a yield of about 92%.
  • the solid content means a component excluding moisture (the amount of dry matter obtained by subtracting moisture from the total amount).
  • Example 2 A tartaric acid crystal having a particle diameter of 180 ⁇ m or more and 250 ⁇ m or less obtained by the same operation as in Example 1 was used as the central core particle.
  • Centrifugal fluid coating granulator CF granulator was charged with 500 g of central core particles, and 500 g of L-tartaric acid S pulverized product was charged into the central core particles while spraying an aqueous tartaric acid solution having a concentration of 50% by mass onto the central core particles. .
  • the core particles were powder layered.
  • the spray amount of the tartaric acid aqueous solution was 180 g.
  • spherical particles of tartaric acid having a sphericity of 0.90, a particle diameter of 212 ⁇ m or more and 355 ⁇ m or less were obtained in a yield of about 85%.
  • the minor axis / major axis ratio is the ratio of the minor axis to the major axis of a spherical particle, and is a measure of sphericity.
  • the ratio between the short axis and the long axis is determined by randomly placing spherical particles on the sample stage, taking a photograph, and measuring the length of the long axis (major axis) of the 50 spherical particles and the length of the short axis perpendicular to the midpoint of the long axis.
  • the length (minor axis) is measured, the ratio of the minor axis to the major axis is determined for each, and the average value of 50 is shown.
  • a yield is the value calculated
  • the coating layer forming component is powdery or liquid. Both sphericities are excellent at 0.90.
  • Comparative Example 1 and Comparative Example 2 using crystal grains that do not cut corners as the central core particles the sphericity is less than 0.85 regardless of whether the coating layer forming component is powdery or liquid. The desired sphericity was not obtained.
  • Example 3 Crystals of granulated sugar having a particle size of 300 ⁇ m or more and 425 ⁇ m or less (manufactured by Shimizu Minato Sugar Co., Ltd.) were put into a table type stirring granulator, stirred at 2000 rpm for 30 minutes, and the corners of the crystal were cut to obtain core particles. . Next, 500 g of the obtained core particles are put into a centrifugal tumbling type coating granulator CF granulator, and 10 mass in an aqueous solution having a concentration of 40 mass% in which white sugar (manufactured by Shimizu Minato Sugar Co., Ltd.) is dissolved. A liquid in which% corn starch was suspended was sprayed to form a coating layer.
  • spherical particles having a sphericity of 0.95, a friability of 0.4%, a granule hardness of 152 g, and a particle diameter of 355 ⁇ m or more and 500 ⁇ m or less were obtained with a yield of about 72%.
  • spherical particles having a sphericity of 0.92, a friability of 0.7%, a granule hardness of 100 g, and a particle diameter of 425 ⁇ m or more and 600 ⁇ m or less were obtained with a yield of about 80%.
  • spherical particles having a sphericity of 0.83, a friability of 0.47%, a granule hardness of 260 g, and a particle diameter of 425 ⁇ m or more and 600 ⁇ m or less were obtained with a yield of about 80%.
  • Granule hardness After the obtained spherical particles are selected to be 425 ⁇ m or more and 500 ⁇ m or less, the granule hardness is measured using GRANO (Okada Seiko Co., Ltd.) under the conditions of measuring load 1 kg, measuring speed 100 ⁇ m / sec, tip diameter 3 mm ⁇ . did. The granule hardness is an average value of 20 grains.
  • C Granule hardness is 100 g or more.
  • D Granule hardness is less than 100 g.
  • the spherical particles obtained in Examples 3 and 4 are granulated using central core particles with the corners of the crystal grains cut, the sphericity is excellent. Further, the spherical particles obtained in Examples 3 and 4 were excellent in both friability and granule hardness because a liquid was used as the coating layer forming component. On the other hand, in Comparative Example 3 obtained by using crystal grains that do not cut the corners as the central core particles, spherical particles with high sphericity were obtained, but both the surface and the interior had voids, and desirable friability and The granule hardness could not be obtained.
  • the present invention relates to a spherical particle and a method for producing the same. According to the method for producing spherical particles of the present invention, spherical particles having a small particle diameter and high sphericity can be obtained. Furthermore, according to the spherical particle of the present invention, a controlled release preparation having preferable release controllability can be obtained.
  • Such a controlled-release preparation of the present invention is a hypnotic / sedative, antipyretic analgesic / anti-inflammatory agent, neuropsychiatric agent, autonomic nerve agent, anti-parkinsonian agent, antihistamine, cardiotonic agent, diuretic agent, antihypertensive agent, vasoconstrictor, It can be used in arteriosclerotic agents, antitussive expectorants, vitamins, nourishing tonics, antibiotics, gastrointestinal drugs and the like.

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Abstract

L'invention porte sur un procédé de fabrication d'un grain sphérique caractérisé par le fait qu'il comporte la première étape consistant à arrondir des bords d'un grain cristallin pour former un grain central et la seconde étape consistant à fixer une couche d'enrobage sur la surface du grain central tel que décrit ci-dessus. Selon ce procédé de fabrication, un grain sphérique ayant une petite dimension de grain et une sphéricité élevée peut être obtenu. De plus, l'utilisation de ces grains sphériques permet de produire une préparation à libération entretenue présentant une libération efficacement régulée.
PCT/JP2008/072169 2007-12-25 2008-12-05 Grain sphérique, son procédé de fabrication et procédé pour produire d'une préparation à libération entretenue WO2009081716A1 (fr)

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JP2007-331675 2007-12-25
JP2007331675A JP2009155215A (ja) 2007-12-25 2007-12-25 球形粒及びその製造方法並びに放出制御製剤の製造方法

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WO2012066656A1 (fr) * 2010-11-17 2012-05-24 日本たばこ産業株式会社 Granulés à adsorbant supporté et leur procédé de fabrication, filtre à cigarette et cigarette

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03227916A (ja) * 1990-02-02 1991-10-08 Ss Pharmaceut Co Ltd 発泡性製剤組成物
JP2000128774A (ja) * 1998-10-26 2000-05-09 Tanabe Seiyaku Co Ltd 薬物を含有する球形微粒子の製法
WO2002036168A1 (fr) * 2000-11-06 2002-05-10 Asahi Kasei Kabushiki Kaisha Particules cellulosiques destinees a des preparations pharmaceutiques
JP2005532279A (ja) * 2002-03-28 2005-10-27 ラブ・ファルマ・オサケユキテュア 担体粒子を処理するための方法およびその使用
JP2006306766A (ja) * 2005-04-27 2006-11-09 Nikken Chem Co Ltd テオフィリン徐放性微粒子製剤及びその製造方法
JP2007259887A (ja) * 2006-03-27 2007-10-11 Freunt Ind Co Ltd 粒子の製造方法および遠心転動造粒装置

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03227916A (ja) * 1990-02-02 1991-10-08 Ss Pharmaceut Co Ltd 発泡性製剤組成物
JP2000128774A (ja) * 1998-10-26 2000-05-09 Tanabe Seiyaku Co Ltd 薬物を含有する球形微粒子の製法
WO2002036168A1 (fr) * 2000-11-06 2002-05-10 Asahi Kasei Kabushiki Kaisha Particules cellulosiques destinees a des preparations pharmaceutiques
JP2005532279A (ja) * 2002-03-28 2005-10-27 ラブ・ファルマ・オサケユキテュア 担体粒子を処理するための方法およびその使用
JP2006306766A (ja) * 2005-04-27 2006-11-09 Nikken Chem Co Ltd テオフィリン徐放性微粒子製剤及びその製造方法
JP2007259887A (ja) * 2006-03-27 2007-10-11 Freunt Ind Co Ltd 粒子の製造方法および遠心転動造粒装置

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