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WO2009076732A1 - Cathéter pour la perfusion locale de médicaments - Google Patents

Cathéter pour la perfusion locale de médicaments Download PDF

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Publication number
WO2009076732A1
WO2009076732A1 PCT/BR2008/000054 BR2008000054W WO2009076732A1 WO 2009076732 A1 WO2009076732 A1 WO 2009076732A1 BR 2008000054 W BR2008000054 W BR 2008000054W WO 2009076732 A1 WO2009076732 A1 WO 2009076732A1
Authority
WO
WIPO (PCT)
Prior art keywords
balloon
infusion
catheter
distal
proximal
Prior art date
Application number
PCT/BR2008/000054
Other languages
English (en)
Inventor
Alexandre Do Canto Zago
Elton Luiz Ferlin
Luiz Fernando Rodrigues Junior
Original Assignee
Brz Bio Tecnologia Ltda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brz Bio Tecnologia Ltda filed Critical Brz Bio Tecnologia Ltda
Priority to EP08714501A priority Critical patent/EP2224990A4/fr
Publication of WO2009076732A1 publication Critical patent/WO2009076732A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1002—Balloon catheters characterised by balloon shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12027—Type of occlusion
    • A61B17/1204—Type of occlusion temporary occlusion
    • A61B17/12045—Type of occlusion temporary occlusion double occlusion, e.g. during anastomosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12136—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1011—Multiple balloon catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/12127—Double occlusion, e.g. for creating blood-free anastomosis site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/1052—Balloon catheters with special features or adapted for special applications for temporarily occluding a vessel for isolating a sector

Definitions

  • the present invention relates to a catheter for local drug infusion. More specifically, it comprises a catheter with the proximal and distal sealing portions that form a chamber to potentialize the infusion of medication into an arterial wall.
  • a balloon catheter is a catheter with an inflatable balloon at one end which is placed on the lesion level inside the coronary artery, said balloon being inflated so as to compress the atherosclerotic plaque against the vessel wall increasing its luminal area and improving the passage of blood to the heart muscle.
  • the primary objective of the balloon dilation of arterial occlusive lesions is obviously to increase the diameter of the arterial lumen enough to restore the adequate tissue perfusion.
  • Balloon catheters differ in the material of the balloon, the presence of a friction-reducing coating on the balloon, the balloon inflation mechanism, the length of the catheter tip which extends beyond the balloon, and the length of the balloon body.
  • the diameter of the inflated balloon must be about 10 to 20% larger than the normal lumen of the vessel to be dilated.
  • Balloon catheters were first manufactured using polyvinyl chloride (PVC), but they were very yielding, which resulted in lesser pressure when inflated, and had a tendency to dilate beyond the desired diameter. At present, the balloon catheters are less yielding and are manufactured from polyethylene and its subproducts, polyester and interlaced Dacron fibers.
  • the technical literature feature balloon catheters that perform local drug infusion. However, these conventional balloon catheters do not seal the proximal and distal portions of the balloon so as to concentrate the released medication in a coronary artery wall. Additionally, the contact of the balloon with the blood vessel wall augments the resistance to the passage of medication from the inside of the balloon to the vessel wall, thus increasing even more the leakage of the drug into the proximal and distal portions of the balloon. The leakage of medication proximal of the balloon may promote the formation of clots, and the distal leakage - the infusion of doses higher than necessary with its possible adverse effects.
  • this invention refers to a local drug infusion catheter that comprises a three-lumen catheter having an occluding balloon disposed in the proximal portion, an infusion balloon disposed in the distal portion, and openings on the catheter surface disposed between the occlusion balloon and the infusion balloon for distal infusion of saline solution.
  • a local drug infusion catheter comprises a one-lumen catheter fitted with an infusion balloon that has an elongated body, and, whose ends are provided with symmetric protrusions which come into contact with the coronary artery wall, and a medial portion with a depression, creating a chamber between the surface of the medial portion of the infusion balloon and the artery wall, said chamber being sealed in the distal and proximal portions by the protrusions disposed on the ends of the infusion balloon.
  • a local drug infusion catheter comprises a three-lumen catheter with one occlusion balloon in the proximal portion and one occlusion balloon in the distal portion, there being openings disposed on the catheter surface between the proximal and the distal occlusion balloon.
  • a local drug infusion catheter that has the proximal and distal sealing and forms a chamber between the balloon and the coronary artery wall is a characteristic feature of this invention, said chamber being filled with medication when the balloon is inflated in order to concentrate and potentialize the release of medication into the coronary artery.
  • a local drug infusion catheter that occupies less area, when in contact with the artery surface, thus minimizing the damage to the arterial wall endothelium caused by the inflation of the infusion balloon is a characteristic feature of this invention.
  • a catheter that has a compliant occlusion balloon inflated at low pressure, which causes negligible endothelial damage, is a characteristic feature of this invention.
  • a local drug infusion catheter that significantly reduces the possibility of generating clots and the dispersion of medication in the circulation, after obstructing the arterial lumen, and, consequently, interrupting temporarily the blood flow, allowing the arterial segment distal to the occlusion balloon to be washed with saline solution, and releasing medication only on the sides is a characteristic feature of this invention.
  • Fig.1 is a view of the catheter.
  • Fig.2 is a view of the catheter positioned inside the artery showing the release of medication.
  • Fig. 3 is a detailed view of the infusion balloon and the release of fluid medication into the artery wall.
  • Fig. 4 is a view of the catheter described in the second embodiment, placed inside the artery showing the release of medication.
  • Fig.5 is a detailed view of the infusion balloon and of the release of fluid medication into the artery wall.
  • Fig.6 is a view of the catheter of the third embodiment.
  • Fig.7 is a view of the catheter of the third embodiment positioned inside the artery showing the formation of the chamber and the release of medication.
  • the local drug infusion catheter comprises a three-lumen catheter (10).
  • the first lumen (11) serves to inflate the proximal occlusion balloon (20) and to stop the blood flow from passing to the arterial segment to be treated.
  • the second lumen (12) allows the segment into which the medication will be infused to be washed with saline solution (removal of blood) by infusing saline solution through the openings (15) into the portion between the occlusion balloon (20) and the infusion balloon (30).
  • the washing of the artery (100) avoids trapping blood in the compartment created by the infusion catheter and the interaction of the medication with static blood, which makes possible the formation of blood clots and the reduction in the penetration of medication into the vessel wall.
  • the third lumen (13) makes possible the infusion of medication into the coronary artery wall (100) by inflating the infusion balloon (30), and the consequent formation of a medication-filled chamber between the infusion balloon (30) and the coronary artery wall (100), said medication that penetrates the arterial wall by a difference in the concentration.
  • the infusion balloon (30) has openings (31 ) in the medial portion and prevents medication from leaking into the portions proximal of or distal to the infusion balloon, thus avoiding a waste and unnecessary administration of medication with its possible adverse effects.
  • the local drug infusion catheter comprises a three-lumen (11 , 12, and13) catheter (10) that has an occlusion balloon (20) in the proximal portion, which, when inflated, seals the passage of blood to the arterial segment distal to the occlusion balloon (20); and an infusion balloon (30) in the distal portion for local administration of medication through the openings (31 ) disposed on the surface of the infusion balloon (30), said infusion balloon (30) that has a geometric shape and forms a chamber (50) between the infusion balloon (30) and the wall of the coronary artery (100) to be filled with medication when said infusion balloon (30) is inflated; and the openings (15) on the surface of the catheter (10) disposed between the occlusion balloon (20) and the infusion balloon (30) for the purpose of allowing the distal infusion of saline solution in order to wash the artery (100) and avoid clots in the arterial lumen.
  • a three-lumen (11 , 12, and13) catheter (10) that has an
  • the infusion balloon (30) has an elongated shape and its ends are provided with symmetric protrusions (32) that come into contact with the wall of the coronary artery (100), and the medial portion with a depression (33) that avoids the contact of the surface of the infusion balloon (30) with the artery wall (100) creating a chamber (50) between the surface of the infusion balloon medial portion (33) and the artery wall (100), said chamber (50) being sealed in the distal and proximal portions by the protrusions (32) disposed on the ends of the infusion balloon (30).
  • the chamber (50) is filled with medication that penetrates the artery wall (100) by a difference in the concentration allowing the infusion of the fluid medication.
  • the surface of the medial portion (33) of the infusion balloon (50) is provided with permeability that allows the fluid medication to flow towards the chamber (50) formed between the surface of the medial portion (33) of the infusion balloon (30) and the wall of the coronary artery (100).
  • the occlusion balloon (20) and the infusion balloon (30) are preferably of polymeric material such as, but not limited to, polyester, polyamide, polyurethane, polytetrafluorethylene and polyolephines or copolymers.
  • the local drug infusion catheter is introduced and positioned at the site chosen by a surgeon.
  • the occlusion balloon (20) is then inflated to seal the passage of blood distal to the occlusion balloon (20).
  • saline solution is injected into the arterial segment distal to the occlusion balloon (20) through the openings (15) disposed on the catheter (10) between the occlusion balloon (20) and the infusion balloon (30).
  • the infusion balloon (30) previously positioned at the site to be treated is inflated, its medial portion being lowered (33), positioned in the arterial segment into which medication is locally infused, and the protrusions (32) sealing the proximal and distal portions, forming a chamber (50) where the fluid medication is dissipated, and, later on, penetrates inside the arterial wall (100) by a difference in the concentration and pressure.
  • the local drug infusion catheter comprises a one-lumen (13) catheter (10) fitted with an infusion balloon (30) that has an elongated shape, and, whose ends are provided with symmetric protrusions that come into contact with the wall of the coronary artery (100), and the medial portion with a depression (33) that prevents the surface of the infusion balloon (30) from being in contact with the artery wall (100), thus creating a chamber (50) between the surface of the infusion balloon medial portion (33) and the artery wall (100), said chamber (50) being sealed in the distal and proximal portions by the protrusions (32) disposed on the ends of the infusion balloon (30).
  • the infusion balloon (30) has openings (31 ) in the medial portion and prevents medication from leaking into the portions proximal of and distal to the infusion balloon, avoiding a waste and unnecessary administration of medication with its possible adverse effects.
  • the chamber (50) is filled with medication that penetrates the artery wall (100) by a difference in the concentration allowing the infusion of the fluid medication.
  • the surface of the medial portion (33) of the infusion balloon (30) is provided with permeability that allows the fluid medication to flow towards the chamber (50) formed between the surface of the medial portion (33) of the infusion balloon (30) and the wall of the coronary artery (100).
  • the infusion balloon (30) is preferably of polymeric material such as, but not limited to, polyester, polyamide, polyurethane, polytetrafluorethylene, and polyolephines or copolymers.
  • the local drug infusion catheter is introduced and positioned at the site chosen by a surgeon.
  • the saline solution is then injected into the artery to be treated by means of the guide catheter.
  • the infusion balloon (30) previously positioned at the site to be treated is inflated, its medial portion (33) being lowered, positioned in the arterial segment into which the medication is locally infused, and the protrusions (32) sealing the proximal and distal portions, thus forming a chamber (50) where the fluid medication is dissipated, and, later on, penetrates inside the arterial wall (100) by a difference in the concentration and pressure.
  • the local drug infusion catheter is a three- lumen catheter (10).
  • the first lumen (16) serves to inflate the proximal occlusion balloon (60) and stop the blood flow from passing to the arterial segment to be treated.
  • the second lumen (17) allows saline solution and medication to be infused through the openings (19) disposed on the portion between the proximal occlusion balloon (60) and the distal occlusion balloon (70).
  • the third lumen (18) serves to inflate the distal occlusion balloon
  • the local drug infusion catheter comprises a catheter fitted with three lumens (16, 17, and 18) that has a proximal occlusion balloon (60), a distal occlusion balloon (70), and openings (19) disposed on the surface of the catheter (10) between the proximal (60) and the distal occlusion balloon (70) for the release of fluid medication.
  • a chamber (50) is formed in the interspace between the proximal (60) and the distal occlusion balloon (70), when they are inflated, and the coronary artery wall (100), said chamber (50) being filled with fluid medication that penetrates the artery wall (100) by a difference in the concentration, allowing the infusion of fluid medication.
  • the proximal occlusion balloon (60) and the distal occlusion balloon (70) are preferably of polymeric material such as, but not limited to, polyester, polyamide, polyurethane, polytetrafluorethylene, and polyolephines or copolymers.
  • the local drug release catheter is introduced and positioned at the site chosen by a surgeon.
  • the proximal occlusion balloon (60) is then inflated to seal the passage of blood.
  • the saline solution is injected through the openings disposed on the surface of the catheter between the proximal occlusion balloon (60) and the distal occlusion balloon (70) to remove blood from the arterial segment to be treated; next, the pure fluid medication is infused to fill the space between the proximal (60) and the distal occlusion balloon (70) avoiding its dilution with the previously infused saline solution. Later on, in a short period of time, in order to avoid the prolonged and excessive infusion of fluid medication, the distal occlusion balloon (70) is inflated, forming a chamber (50) between the two occlusion balloons (60 and 70) filled with pure fluid medication.
  • the infusion of fluid medication through the openings disposed on the catheter surface between the proximal (60) and the distal occlusion balloon (70) must be continued for a period of time in order to make the medication penetrate inside the arterial wall (100) by a difference in the concentration and pressure.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention porte sur un cathéter pour la perfusion locale de médicaments qui comprend, dans un premier mode de réalisation, un cathéter (10) à trois lumières (11, 12 et 13) comportant un ballonnet d'occlusion (20) dans sa partie proximale et un ballonnet de perfusion (30) dans sa partie distale, des ouvertures (15) étant ménagées dans la surface du cathéter (10) entre le ballonnet d'occlusion (20) et le ballonnet de perfusion (30) afin de permettre la perfusion distale d'une solution saline, le ballonnet de perfusion (30) créant une chambre (50) entre la surface de sa partie médiale (33) et la paroi de l'artère (100). Dans un deuxième mode de réalisation, le cathéter de perfusion locale de médicament comprend un cathéter (10) à une lumière (13) équipé d'un ballonnet de perfusion (30) qui crée une chambre (50) entre la surface de sa partie médiale (33) et la paroi de l'artère (100), ladite chambre (50) étant hermétiquement fermée en sa partie distale et en sa partie proximale par des protubérances (32) disposées aux extrémités du ballonnet de perfusion (30). Dans un troisième mode de réalisation, un cathéter (10) à trois lumières (16, 17 et 18) comporte un ballonnet d'occlusion (60) dans sa partie proximale et un ballonnet d'occlusion (70) dans sa partie distale, des ouvertures (19) étant ménagées dans la surface du cathéter (10), entre le ballonnet d'occlusion proximal (60) et le ballonnet d'occlusion distal (70).
PCT/BR2008/000054 2007-12-17 2008-02-25 Cathéter pour la perfusion locale de médicaments WO2009076732A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08714501A EP2224990A4 (fr) 2007-12-17 2008-02-25 Cathéter pour la perfusion locale de médicaments

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRPI0704785-1 2007-12-17
BRPI0704785-1A BRPI0704785A2 (pt) 2007-12-17 2007-12-17 Cateter para infusão local de fármacos

Publications (1)

Publication Number Publication Date
WO2009076732A1 true WO2009076732A1 (fr) 2009-06-25

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR2008/000054 WO2009076732A1 (fr) 2007-12-17 2008-02-25 Cathéter pour la perfusion locale de médicaments

Country Status (3)

Country Link
EP (1) EP2224990A4 (fr)
BR (1) BRPI0704785A2 (fr)
WO (1) WO2009076732A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016070032A1 (fr) 2014-10-30 2016-05-06 Neurotronic, Inc. Ablation chimique et méthodes destinées à traiter diverses maladies
US9629985B2 (en) 2013-04-05 2017-04-25 Sanford Health Drug delivery balloon apparatus and methods for use
AU2015210390B2 (en) * 2010-03-06 2018-03-15 Nfusion Vascular Systems, Llc Recovery catheter assembly
CN110681034A (zh) * 2019-11-06 2020-01-14 上海慧达医疗器械有限公司 循环式药物灌注导管
US10537375B2 (en) 2015-04-24 2020-01-21 Neurotronic, Inc. Chemical ablation and method of treatment for various diseases
US11382689B2 (en) 2012-11-02 2022-07-12 Neurotronic, Inc. Chemical ablation formulations and methods of treatments for various diseases
US12208224B2 (en) 2012-11-02 2025-01-28 Neurotronic, Inc. Chemical ablation and method of treatment for various diseases

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116808415B (zh) * 2023-08-28 2023-11-07 四川省医学科学院·四川省人民医院 一种腔道供药装置

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983003356A1 (fr) * 1982-04-02 1983-10-13 Harvey Wolinsky Procedes et appareil pour eliminer des etranglements d'arteres
WO1996004952A1 (fr) 1994-08-08 1996-02-22 Schneider (Usa) Inc. Catheters de perfusion de medicaments et de perfusion de medicaments par dilatation a remplacement rapide
WO1997017099A1 (fr) 1995-11-06 1997-05-15 C.R. Bard, Inc. Catheter a ballonnet pour l'application de medicaments
WO2001070325A2 (fr) 2000-03-21 2001-09-27 Advanced Cardiovascular Systems, Inc. Systeme de protection contre l'embolie
US20030045860A1 (en) * 2001-09-04 2003-03-06 Jomed Gmbh Methods for minimally invasive, localized delivery of sclerotherapeutic agents
EP1669099A1 (fr) 2004-12-09 2006-06-14 Acrostak Corp. Ensemble de cathéter pour le traitement de vaisseaux sanguins avec médicaments
EP1790350A1 (fr) * 2005-11-24 2007-05-30 Interstitial Therapeutics Utilisation d'une composition contenant de la kératinocyte pour le traitement de la restenose
WO2007117915A1 (fr) * 2006-04-07 2007-10-18 Medtronic Vascular, Inc. Système de photopolymérisation à cathéter en boucle fermée et méthode pour traiter un trouble vasculaire

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983003356A1 (fr) * 1982-04-02 1983-10-13 Harvey Wolinsky Procedes et appareil pour eliminer des etranglements d'arteres
WO1996004952A1 (fr) 1994-08-08 1996-02-22 Schneider (Usa) Inc. Catheters de perfusion de medicaments et de perfusion de medicaments par dilatation a remplacement rapide
WO1997017099A1 (fr) 1995-11-06 1997-05-15 C.R. Bard, Inc. Catheter a ballonnet pour l'application de medicaments
WO2001070325A2 (fr) 2000-03-21 2001-09-27 Advanced Cardiovascular Systems, Inc. Systeme de protection contre l'embolie
US20030045860A1 (en) * 2001-09-04 2003-03-06 Jomed Gmbh Methods for minimally invasive, localized delivery of sclerotherapeutic agents
EP1669099A1 (fr) 2004-12-09 2006-06-14 Acrostak Corp. Ensemble de cathéter pour le traitement de vaisseaux sanguins avec médicaments
EP1790350A1 (fr) * 2005-11-24 2007-05-30 Interstitial Therapeutics Utilisation d'une composition contenant de la kératinocyte pour le traitement de la restenose
WO2007117915A1 (fr) * 2006-04-07 2007-10-18 Medtronic Vascular, Inc. Système de photopolymérisation à cathéter en boucle fermée et méthode pour traiter un trouble vasculaire

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Balloon catheter for delivering therapeutic agents", RESEARCH DISCLOSURE, vol. 429, no. 2, 1 January 2000 (2000-01-01)
See also references of EP2224990A4 *

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015210390B2 (en) * 2010-03-06 2018-03-15 Nfusion Vascular Systems, Llc Recovery catheter assembly
US10092732B2 (en) 2010-03-06 2018-10-09 Nfusion Vascular Systems, Llc Recovery catheter assembly
US11684417B2 (en) 2012-11-02 2023-06-27 Neurotronic, Inc. Chemical ablation formulations and methods of treatments for various diseases
US12208224B2 (en) 2012-11-02 2025-01-28 Neurotronic, Inc. Chemical ablation and method of treatment for various diseases
US12193731B2 (en) 2012-11-02 2025-01-14 Neurotronic, Inc. Chemical ablation formulations and methods of treatments for various diseases
US11517725B2 (en) 2012-11-02 2022-12-06 Neurotronic, Inc. Chemical ablation and method of treatment for various diseases
US11382689B2 (en) 2012-11-02 2022-07-12 Neurotronic, Inc. Chemical ablation formulations and methods of treatments for various diseases
US10905862B2 (en) 2013-04-05 2021-02-02 Sanford Health Drug delivery balloon apparatus and methods for use
US9629985B2 (en) 2013-04-05 2017-04-25 Sanford Health Drug delivery balloon apparatus and methods for use
US10258775B2 (en) 2013-04-05 2019-04-16 Sanford Health Drug delivery balloon apparatus and methods for use
US12076512B2 (en) 2013-04-05 2024-09-03 Sanford Health Fluid delivery balloon apparatus and methods for use
US10286191B2 (en) 2014-10-30 2019-05-14 Neurotronic, Inc. Chemical ablation and method of treatment for various diseases
US10758713B2 (en) 2014-10-30 2020-09-01 Neurotronic, Inc. Chemical ablation and method of treatment for various diseases
US11648378B2 (en) 2014-10-30 2023-05-16 Neurotronic, Inc. Chemical ablation and method of treatment for various diseases
WO2016070032A1 (fr) 2014-10-30 2016-05-06 Neurotronic, Inc. Ablation chimique et méthodes destinées à traiter diverses maladies
US12005207B2 (en) 2014-10-30 2024-06-11 Neurotronic, Inc. Chemical ablation and method of treatment for various diseases
CN107106820A (zh) * 2014-10-30 2017-08-29 纽敦力公司 治疗多种疾病的化学消融和方法
EP3212274A4 (fr) * 2014-10-30 2018-06-27 Neurotronic, Inc. Ablation chimique et méthodes destinées à traiter diverses maladies
US10537375B2 (en) 2015-04-24 2020-01-21 Neurotronic, Inc. Chemical ablation and method of treatment for various diseases
CN110681034A (zh) * 2019-11-06 2020-01-14 上海慧达医疗器械有限公司 循环式药物灌注导管

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Publication number Publication date
EP2224990A4 (fr) 2012-03-28
EP2224990A1 (fr) 2010-09-08
BRPI0704785A2 (pt) 2018-04-10

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