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WO2009074749A3 - Dérives de nicotinamide. leur préparation et leur application en thérapeutique - Google Patents

Dérives de nicotinamide. leur préparation et leur application en thérapeutique Download PDF

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Publication number
WO2009074749A3
WO2009074749A3 PCT/FR2008/001338 FR2008001338W WO2009074749A3 WO 2009074749 A3 WO2009074749 A3 WO 2009074749A3 FR 2008001338 W FR2008001338 W FR 2008001338W WO 2009074749 A3 WO2009074749 A3 WO 2009074749A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
preparation
hydrogen atom
therapeutic use
nicotinamide derivatives
Prior art date
Application number
PCT/FR2008/001338
Other languages
English (en)
Other versions
WO2009074749A2 (fr
Inventor
Jerome Arigon
Claude Bernhart
Monsif Bouaboula
Pierre Casellas
Romain Combet
Samir Jegham
Sandrine Hllalret
Pierre Fraisse
Original Assignee
Sanofi Aventis
Jerome Arigon
Claude Bernhart
Monsif Bouaboula
Pierre Casellas
Romain Combet
Samir Jegham
Sandrine Hllalret
Pierre Fraisse
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis, Jerome Arigon, Claude Bernhart, Monsif Bouaboula, Pierre Casellas, Romain Combet, Samir Jegham, Sandrine Hllalret, Pierre Fraisse filed Critical Sanofi Aventis
Priority to MX2010003445A priority Critical patent/MX2010003445A/es
Priority to CA2700559A priority patent/CA2700559A1/fr
Priority to EP08859496A priority patent/EP2205566A2/fr
Priority to CN200880109332A priority patent/CN101808996A/zh
Priority to BRPI0817973-5A priority patent/BRPI0817973A2/pt
Priority to AU2008334457A priority patent/AU2008334457A1/en
Priority to JP2010526335A priority patent/JP2010540504A/ja
Publication of WO2009074749A2 publication Critical patent/WO2009074749A2/fr
Publication of WO2009074749A3 publication Critical patent/WO2009074749A3/fr
Priority to IL204663A priority patent/IL204663A0/en
Priority to US12/732,749 priority patent/US20100222319A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention est relative à un composé de formule (I) : dans laquelle : • A représente un groupe -NR1R'1 OU (C1-C6)aIcoxy; • Z et Z' représentent respectivement N et CH; N et CF; N et N; CH et CH; CH et N; • L représente un groupe -CH=CH- ou -CH2CH2- ou -(CH2)n-Y-; • R1 et R'1 sont tels que : (i) R1 représente : - un atome d'hydrogène; - un groupe aryle éventuellement substitué par un ou plusieurs atome(s) d'halogène; - un groupe hétéroaryle; - un groupe (C3-C6)cycloalkyle; - un groupe (C1-C6)alkyle et R'1 représente un atome d'hydrogène ou un groupe (C1-C6)alkyle; ou (ii) R1 et R'1 forment ensemble avec l'atome d'azote auquel ils sont reliés un groupe hétérocycloalkyle; • R2 représente un groupe -Q-R4; • Q représente un atome d'oxygène ou le groupe -NH-. • R4 représente : - un atome d'hydrogène; - un groupe hétéroaryle; - un groupe (C3-C6)cycloalkyle; - un groupe (C1-C6)alkyle, éventuellement substitué • R3 représente au moins un substituant du noyau pyridine.
PCT/FR2008/001338 2007-09-28 2008-09-26 Dérives de nicotinamide. leur préparation et leur application en thérapeutique WO2009074749A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
MX2010003445A MX2010003445A (es) 2007-09-28 2008-09-26 Derivados de nicotinamida, su preparacion y su uso terapeutico.
CA2700559A CA2700559A1 (fr) 2007-09-28 2008-09-26 Derives de nicotinamide, leur preparation et leur application en therapeutique
EP08859496A EP2205566A2 (fr) 2007-09-28 2008-09-26 Dérives de nicotinamide. leur préparation et leur application en thérapeutique
CN200880109332A CN101808996A (zh) 2007-09-28 2008-09-26 烟酰胺衍生物、它们的制备和它们的在治疗学中的应用
BRPI0817973-5A BRPI0817973A2 (pt) 2007-09-28 2008-09-26 derivados de nicotinamida, o respectivo preparo e a respectiva aplicação em terapêutica
AU2008334457A AU2008334457A1 (en) 2007-09-28 2008-09-26 Nicotinamide derivatives, preparation thereof and therapeutic use thereof
JP2010526335A JP2010540504A (ja) 2007-09-28 2008-09-26 ニコチンアミド誘導体、これらの調製およびこれらの治療目的使用
IL204663A IL204663A0 (en) 2007-09-28 2010-03-22 Nicotinamide derivatives, preparastion thereof and therapeutic use thereof
US12/732,749 US20100222319A1 (en) 2007-09-28 2010-03-26 Nicotinamide derivatives, preparation thereof and therapeutic use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0706799 2007-09-28
FR0706799A FR2921657A1 (fr) 2007-09-28 2007-09-28 Derives de nicotinamide, leur preparation et leur application en therapeutique

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/732,749 Continuation US20100222319A1 (en) 2007-09-28 2010-03-26 Nicotinamide derivatives, preparation thereof and therapeutic use thereof

Publications (2)

Publication Number Publication Date
WO2009074749A2 WO2009074749A2 (fr) 2009-06-18
WO2009074749A3 true WO2009074749A3 (fr) 2009-08-20

Family

ID=39356668

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/001338 WO2009074749A2 (fr) 2007-09-28 2008-09-26 Dérives de nicotinamide. leur préparation et leur application en thérapeutique

Country Status (19)

Country Link
US (1) US20100222319A1 (fr)
EP (1) EP2205566A2 (fr)
JP (1) JP2010540504A (fr)
KR (1) KR20100065165A (fr)
CN (1) CN101808996A (fr)
AR (1) AR066171A1 (fr)
AU (1) AU2008334457A1 (fr)
BR (1) BRPI0817973A2 (fr)
CA (1) CA2700559A1 (fr)
CL (1) CL2008002893A1 (fr)
FR (1) FR2921657A1 (fr)
IL (1) IL204663A0 (fr)
MX (1) MX2010003445A (fr)
PA (1) PA8797301A1 (fr)
PE (1) PE20091033A1 (fr)
RU (1) RU2010116765A (fr)
TW (1) TW200918056A (fr)
UY (1) UY31367A1 (fr)
WO (1) WO2009074749A2 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2501594T3 (es) 2005-11-08 2014-10-02 Vertex Pharmaceuticals Incorporated Composición farmacéutica que contiene un modulador heterocíclico de transportadores de casete de unión a ATP
EP2789606B1 (fr) 2007-05-09 2017-11-15 Vertex Pharmaceuticals Incorporated Modulateurs de CFTR
JP2011506330A (ja) 2007-12-07 2011-03-03 バーテックス ファーマシューティカルズ インコーポレイテッド ３−（６−（１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソル−５−イル）シクロプロパンカルボキサミド）−３−メチルピリジン−２−イル）安息香酸の固体状形態
SI2639224T1 (sl) * 2007-12-07 2016-12-30 Vertex Pharmaceuticals Incorporated Postopek za pripravo cikloalkilkarboksiamido-piridinskih benzojskih kislin
NZ620944A (en) 2008-02-28 2015-02-27 Vertex Pharma Heteroaryl derivatives as cftr modulators
FR2943675A1 (fr) * 2009-03-24 2010-10-01 Sanofi Aventis Composes anticancereux, leur preparation et leur application en therapeutique
FR2943669B1 (fr) * 2009-03-24 2011-05-06 Sanofi Aventis Derives de nicotinamide,leur preparation et leur application en therapeutique
FR2943670B1 (fr) * 2009-03-24 2011-05-06 Sanofi Aventis Derives anticancereux,leur preparation et leur application en therapeutique
EP2440204B1 (fr) 2009-06-12 2013-12-18 Bristol-Myers Squibb Company Composés de nicotinamide utiles en tant que modulateurs de kinases
US8912184B1 (en) 2010-03-01 2014-12-16 Alzheimer's Institute Of America, Inc. Therapeutic and diagnostic methods
AU2011223790A1 (en) * 2010-03-01 2012-08-30 Myrexis, Inc. Compounds and therapeutic uses thereof
US8552034B2 (en) 2010-04-07 2013-10-08 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid and administration thereof
US8827372B2 (en) 2010-07-07 2014-09-09 Frontis Corp. Blowing system
FR2965263A1 (fr) * 2010-09-24 2012-03-30 Sanofi Aventis Derives de thienopyridine nicotinamide, leur preparation et leur application en therapeutique
PL2573073T3 (pl) * 2011-09-26 2015-04-30 Sanofi Sa Pochodne pirazolochinolinonu, ich wytwarzanie i ich zastosowanie terapeutyczne
US9169246B2 (en) 2011-09-26 2015-10-27 Sanofi Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof
CN103012397B (zh) * 2011-09-26 2017-03-01 赛诺菲 吡唑并喹啉酮衍生物、其制备方法及其治疗用途
WO2015073231A1 (fr) 2013-11-12 2015-05-21 Vertex Pharmaceuticals Incorporated Procédé de préparation de compositions pharmaceutiques pour le traitement de maladies à médiation assurée par le cftr
CN103804270B (zh) * 2014-01-23 2016-06-22 中国药科大学 5-(4-甲脒基苄氧基)色氨酸衍生物、其制法及应用
ES2882656T3 (es) 2014-11-18 2021-12-02 Vertex Pharma Proceso para realizar pruebas de alto rendimiento de cromatografía líquida de alta resolución
CN107522641B (zh) * 2016-06-22 2020-05-05 复旦大学 联芳基脲类衍生物或其盐及其制备方法和用途
US10647665B2 (en) 2016-06-22 2020-05-12 Fudan University Biaryl urea derivative or salt thereof and preparation process and use for the same
EP3787612A4 (fr) * 2018-05-04 2021-11-17 Remedy Plan, Inc. Traitements du cancer ciblant des cellules souches cancéreuses
CN110396065A (zh) * 2019-06-25 2019-11-01 南京普锐达医药科技有限公司 一种2,4-二氯-5-嘧啶甲酰氯的合成方法
PH12022551081A1 (en) * 2019-11-06 2024-06-19 Remedy Plan Inc Cancer treatments targeting cancer stem cells

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Publication number Priority date Publication date Assignee Title
WO2000035864A1 (fr) * 1998-12-16 2000-06-22 Bayer Aktiengesellschaft Nouveaux composes de biphenyle et d'analogues de biphenyle utilises en tant qu'antagonistes d'integrines
WO2002048099A1 (fr) * 2000-12-16 2002-06-20 Merck Patent Gmbh Derives d'amides d'acides carboxyliques et leur utilisation dans le traitement de troubles thrombo-emboliques et de tumeurs
WO2005051366A2 (fr) * 2003-11-28 2005-06-09 Novartis Ag Derives de diaryluree utilises en traitement de maladies dependant de proteines kinases

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DE4301110A1 (de) * 1993-01-18 1994-07-21 Bayer Ag Verfahren zur Herstellung von 2-Amino-5-aminomethyl-pyridin
US20040067985A1 (en) * 2002-10-04 2004-04-08 Fortuna Haviv Method of inhibiting angiogenesis
US20060216288A1 (en) * 2005-03-22 2006-09-28 Amgen Inc Combinations for the treatment of cancer

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2000035864A1 (fr) * 1998-12-16 2000-06-22 Bayer Aktiengesellschaft Nouveaux composes de biphenyle et d'analogues de biphenyle utilises en tant qu'antagonistes d'integrines
WO2002048099A1 (fr) * 2000-12-16 2002-06-20 Merck Patent Gmbh Derives d'amides d'acides carboxyliques et leur utilisation dans le traitement de troubles thrombo-emboliques et de tumeurs
WO2005051366A2 (fr) * 2003-11-28 2005-06-09 Novartis Ag Derives de diaryluree utilises en traitement de maladies dependant de proteines kinases

Also Published As

Publication number Publication date
IL204663A0 (en) 2010-11-30
WO2009074749A2 (fr) 2009-06-18
AR066171A1 (es) 2009-07-29
AU2008334457A1 (en) 2009-06-18
EP2205566A2 (fr) 2010-07-14
FR2921657A1 (fr) 2009-04-03
KR20100065165A (ko) 2010-06-15
BRPI0817973A2 (pt) 2019-04-09
PE20091033A1 (es) 2009-08-17
PA8797301A1 (es) 2009-05-15
CL2008002893A1 (es) 2009-10-16
CA2700559A1 (fr) 2009-06-18
US20100222319A1 (en) 2010-09-02
MX2010003445A (es) 2010-04-27
RU2010116765A (ru) 2011-11-27
TW200918056A (en) 2009-05-01
CN101808996A (zh) 2010-08-18
JP2010540504A (ja) 2010-12-24
UY31367A1 (es) 2009-04-30

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