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WO2009070564A3 - Compositions and methods for prevention of infection in transcutaneous osseointegrated implants - Google Patents

Compositions and methods for prevention of infection in transcutaneous osseointegrated implants Download PDF

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Publication number
WO2009070564A3
WO2009070564A3 PCT/US2008/084640 US2008084640W WO2009070564A3 WO 2009070564 A3 WO2009070564 A3 WO 2009070564A3 US 2008084640 W US2008084640 W US 2008084640W WO 2009070564 A3 WO2009070564 A3 WO 2009070564A3
Authority
WO
WIPO (PCT)
Prior art keywords
infection
preventing
transcutaneous
relates
wound
Prior art date
Application number
PCT/US2008/084640
Other languages
French (fr)
Other versions
WO2009070564A2 (en
Inventor
Roy D. Bloebaum
Cathy Petti
Juliana Szakacs
Teri G.R. Chou
Original Assignee
Macrochem Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrochem Corporation filed Critical Macrochem Corporation
Publication of WO2009070564A2 publication Critical patent/WO2009070564A2/en
Publication of WO2009070564A3 publication Critical patent/WO2009070564A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

This invention relates to a method of preventing wound infection by administering a therapeutic formulation comprising a peptide to a wound site. More specifically, the invention relates to the use of amphiphilic peptides in preventing and treating infections. The invention also relates to preventing wound infectionin a host by administering a biologically active amphiphilic peptide or biologically active protein to a host having a wound wherein the peptide or protein is administered in an amount effective to prevent wound infection. Even more specifically the invention relates to the use of cationic amphiphilic peptides in preventing and treating infections associated with transcutaneous osseointegreated implants.
PCT/US2008/084640 2007-11-27 2008-11-25 Compositions and methods for prevention of infection in transcutaneous osseointegrated implants WO2009070564A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99043007P 2007-11-27 2007-11-27
US60/990,430 2007-11-27

Publications (2)

Publication Number Publication Date
WO2009070564A2 WO2009070564A2 (en) 2009-06-04
WO2009070564A3 true WO2009070564A3 (en) 2009-08-27

Family

ID=40679204

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/084640 WO2009070564A2 (en) 2007-11-27 2008-11-25 Compositions and methods for prevention of infection in transcutaneous osseointegrated implants

Country Status (1)

Country Link
WO (1) WO2009070564A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104602762B (en) * 2012-06-12 2017-04-05 帝普休姆制药有限公司 Stable pexiganan formula

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012174373A1 (en) * 2011-06-16 2012-12-20 Dipexium Pharmaceuticals Methods of treating and inhibiting pathogens with resistance-mechanisms
NL2021630B1 (en) * 2018-09-14 2020-05-06 Stichting Katholieke Univ Polyurethane sheet
WO2020043834A1 (en) * 2018-08-30 2020-03-05 Stichting Katholieke Universiteit Polyurethane sheet

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5045531A (en) * 1989-12-18 1991-09-03 Magainin Sciences Inc. Wound treatment employing biologically active ion channel forming peptides and proteins
US5792831A (en) * 1990-02-08 1998-08-11 Magainin Pharmaceuticals Inc. Analogues of magainin peptides containing D-amino acids

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5045531A (en) * 1989-12-18 1991-09-03 Magainin Sciences Inc. Wound treatment employing biologically active ion channel forming peptides and proteins
US5792831A (en) * 1990-02-08 1998-08-11 Magainin Pharmaceuticals Inc. Analogues of magainin peptides containing D-amino acids

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GOPINATH, D. ET AL.: "Pexiganan-incorporated collagen matrices for infected wound-healing processes in rat.", J. BIOMED. MATER. RES. PTA, vol. 73, no. 3, 2005, pages 2666 - 2672 *
ROTEM, S. ET AL.: "Physicochemical properties that enhance discriminative antibacterial activity of short dermaseptin derivatives", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 50, no. 8, 2006, pages 1161 - 1168 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104602762B (en) * 2012-06-12 2017-04-05 帝普休姆制药有限公司 Stable pexiganan formula

Also Published As

Publication number Publication date
WO2009070564A2 (en) 2009-06-04

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