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WO2009053889A3 - Manipulation of particles by dielectrophoresis - Google Patents

Manipulation of particles by dielectrophoresis Download PDF

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Publication number
WO2009053889A3
WO2009053889A3 PCT/IB2008/054305 IB2008054305W WO2009053889A3 WO 2009053889 A3 WO2009053889 A3 WO 2009053889A3 IB 2008054305 W IB2008054305 W IB 2008054305W WO 2009053889 A3 WO2009053889 A3 WO 2009053889A3
Authority
WO
WIPO (PCT)
Prior art keywords
electrodes
particles
region
driving
manipulation
Prior art date
Application number
PCT/IB2008/054305
Other languages
French (fr)
Other versions
WO2009053889A2 (en
Inventor
Paul L. Collins
Original Assignee
Koninklijke Philips Electronics N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics N.V. filed Critical Koninklijke Philips Electronics N.V.
Publication of WO2009053889A2 publication Critical patent/WO2009053889A2/en
Publication of WO2009053889A3 publication Critical patent/WO2009053889A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02—Separators
    • B03C5/022—Non-uniform field separators
    • B03C5/028—Non-uniform field separators using travelling electric fields, i.e. travelling wave dielectrophoresis [TWD]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Electrostatic Separation (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

The present invention provides a dielectrophoretic device for manipulation of at least a first and a second type of particles (1, 2) present in a sample fluid. The device comprises at least one array (3) of electrodes (4), the array (3) comprising at least a plurality of electrodes (4) in a first region (5) and a plurality of electrodes (4) in a second region (6), driving means (32) for driving the electrodes (4) of the first and second region (5, 6) of the array (3) to generate a travelling wave dielectrophoretic force to be exerted on the at least first and second types of particles (1, 2), and a controller (30) for controlling the driving means (32), the controller (30) being adapted for first driving the electrodes (4) of the first and second region (5, 6) with a same driving signal and subsequently changing the driving signal to electrodes (4) of at least one of the first and second region (5, 6) so as to separate at least some particles (1) of the first type from the particles (2) of the second type. The present invention also provides a method for forming such a dielectrophoretic device, a method for manipulation of at least a first and a second type of particles (1, 2) present in a sample fluid and a controller (30) for controlled driving of electrodes (4) of such a dielectrophoretic device.
PCT/IB2008/054305 2007-10-22 2008-10-20 Manipulation of particles by dielectrophoresis WO2009053889A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07119025A EP2052783A1 (en) 2007-10-22 2007-10-22 Manipulation of particles by dielectrophoresis
EP07119025.0 2007-10-22

Publications (2)

Publication Number Publication Date
WO2009053889A2 WO2009053889A2 (en) 2009-04-30
WO2009053889A3 true WO2009053889A3 (en) 2009-10-15

Family

ID=39217890

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/054305 WO2009053889A2 (en) 2007-10-22 2008-10-20 Manipulation of particles by dielectrophoresis

Country Status (2)

Country Link
EP (1) EP2052783A1 (en)
WO (1) WO2009053889A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5653859A (en) * 1993-01-21 1997-08-05 Parton; Adrian Methods of analysis/separation
WO1997034689A1 (en) * 1996-03-18 1997-09-25 University College Of North Wales Apparatus with electrode arrays for carrying out chemical, physical or physico-chemical reactions
WO2001005512A1 (en) * 1999-07-20 2001-01-25 University Of Wales, Bangor Dielectrophoretic apparatus & method
US6185084B1 (en) * 1997-10-06 2001-02-06 California Institute Of Technology Electrostatic particle transportation
US6596143B1 (en) * 2000-09-27 2003-07-22 Aviva Biosciences Corporation Apparatus for switching and manipulating particles and method of use thereof
US20050123992A1 (en) * 2003-12-03 2005-06-09 Palo Alto Research Center Incorporated Concentration and focusing of bio-agents and micron-sized particles using traveling wave grids

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750015A (en) * 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
US6294063B1 (en) * 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
CA2471925A1 (en) * 2002-01-04 2003-07-24 Peter R.C. Gascoyne Wall-less channels for fluidic routing and confinement
US20050148064A1 (en) * 2003-12-29 2005-07-07 Intel Corporation Microfluid molecular-flow fractionator and bioreactor with integrated active/passive diffusion barrier
US20060177815A1 (en) * 2004-11-29 2006-08-10 The Regents Of The University Of California Dielectrophoretic particle sorter

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5653859A (en) * 1993-01-21 1997-08-05 Parton; Adrian Methods of analysis/separation
WO1997034689A1 (en) * 1996-03-18 1997-09-25 University College Of North Wales Apparatus with electrode arrays for carrying out chemical, physical or physico-chemical reactions
US6185084B1 (en) * 1997-10-06 2001-02-06 California Institute Of Technology Electrostatic particle transportation
WO2001005512A1 (en) * 1999-07-20 2001-01-25 University Of Wales, Bangor Dielectrophoretic apparatus & method
US6596143B1 (en) * 2000-09-27 2003-07-22 Aviva Biosciences Corporation Apparatus for switching and manipulating particles and method of use thereof
US20050123992A1 (en) * 2003-12-03 2005-06-09 Palo Alto Research Center Incorporated Concentration and focusing of bio-agents and micron-sized particles using traveling wave grids

Also Published As

Publication number Publication date
WO2009053889A2 (en) 2009-04-30
EP2052783A1 (en) 2009-04-29

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