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WO2009050365A3 - Procede de preparation de derives ( poly) aminoalkylaminoacetamide d ' epipodophyllotoxine, utiles pour leurs applications en therapeutique comme agent anticancereux - Google Patents

Procede de preparation de derives ( poly) aminoalkylaminoacetamide d ' epipodophyllotoxine, utiles pour leurs applications en therapeutique comme agent anticancereux Download PDF

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Publication number
WO2009050365A3
WO2009050365A3 PCT/FR2008/051700 FR2008051700W WO2009050365A3 WO 2009050365 A3 WO2009050365 A3 WO 2009050365A3 FR 2008051700 W FR2008051700 W FR 2008051700W WO 2009050365 A3 WO2009050365 A3 WO 2009050365A3
Authority
WO
WIPO (PCT)
Prior art keywords
epipodophyllotoxin
poly
preparing
therapeutics
anticancer agent
Prior art date
Application number
PCT/FR2008/051700
Other languages
English (en)
Other versions
WO2009050365A2 (fr
Inventor
Yves Guminski
Martial Grousseaud
Thierry Imbert
Original Assignee
Pierre Fabre Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament filed Critical Pierre Fabre Medicament
Priority to US12/733,864 priority Critical patent/US8664409B2/en
Priority to EP08839817A priority patent/EP2203456A2/fr
Priority to JP2010526342A priority patent/JP5346026B2/ja
Publication of WO2009050365A2 publication Critical patent/WO2009050365A2/fr
Publication of WO2009050365A3 publication Critical patent/WO2009050365A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention a pour objet un nouveau procédé de préparation des dérivés (poly)aminoalkylaminoacétamide d'épipodophyllotoxine et de leurs sels caractérisé en ce qu'il comprend une étape de couplage peptidique de la 4 amino 4' déméthylépipodophyllotoxine avec un réactif aminé comportant des groupements protecteurs.
PCT/FR2008/051700 2007-09-25 2008-09-23 Nouveau procede de preparation de derives (poly)aminoalkylaminoacetamide d'epipodophyllotoxine, utiles pour leurs applications en therapeutique comme agent anticancereux. WO2009050365A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/733,864 US8664409B2 (en) 2007-09-25 2008-09-23 Process for the preparation of (poly) aminoalkylaminoacetamide derivatives of epipodophyllotoxin useful for their applications in therapeutics as anticancer agent
EP08839817A EP2203456A2 (fr) 2007-09-25 2008-09-23 Procede de preparation de derives (poly)aminoalkylaminoacetamide d'epipodophyllotoxine, utiles pour leurs applications en therapeutique comme agent anticancereux
JP2010526342A JP5346026B2 (ja) 2007-09-25 2008-09-23 抗ガン剤として治療への応用に有効な、エピポドフィロトキシンの（ポリ）アミノアルキルアミノアセトアミド誘導体の調製方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0706693A FR2921369B1 (fr) 2007-09-25 2007-09-25 Nouveau procede de preparation de derives (poly) aminoalkylaminoacetamide d'epipodophyllotoxine,utiles pour leurs applications en therapeutique comme agent anticancereux.
FR0706693 2007-09-25

Publications (2)

Publication Number Publication Date
WO2009050365A2 WO2009050365A2 (fr) 2009-04-23
WO2009050365A3 true WO2009050365A3 (fr) 2009-10-29

Family

ID=39399036

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/051700 WO2009050365A2 (fr) 2007-09-25 2008-09-23 Nouveau procede de preparation de derives (poly)aminoalkylaminoacetamide d'epipodophyllotoxine, utiles pour leurs applications en therapeutique comme agent anticancereux.

Country Status (5)

Country Link
US (1) US8664409B2 (fr)
EP (1) EP2203456A2 (fr)
JP (1) JP5346026B2 (fr)
FR (1) FR2921369B1 (fr)
WO (1) WO2009050365A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2935143B1 (fr) 2008-08-19 2010-12-03 Pf Medicament Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998034910A1 (fr) * 1997-02-10 1998-08-13 Transgene S.A. Composes glycerolipidiques utiles pour le transfert d'une substance active dans une cellule cible
WO2004073375A2 (fr) * 2003-02-18 2004-09-02 Ranbaxy Laboratories Limited Derives de podophyllotoxine utiles comme agents antitumoraux
WO2005100363A1 (fr) * 2004-04-16 2005-10-27 Pierre Fabre Medicament Derives de polyaminoacetamide d'epipodophyllotoxine, leurs methodes de preparation et leurs utilisation sous forme d'agents therapeutiques anticancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9907269A (pt) * 1998-01-30 2001-04-03 Aventis Pharma Sa Agente de transferência de ácidos nucleicos, composição, utilização de um agente de transferência, e, processos de transferência de ácidos nucleicos nas células, de preparação de uma composição e de tratamento de doenças.
US6566393B1 (en) * 2002-06-21 2003-05-20 The University Of North Carolina At Chapel Hill Etoposide analogs and methods of use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998034910A1 (fr) * 1997-02-10 1998-08-13 Transgene S.A. Composes glycerolipidiques utiles pour le transfert d'une substance active dans une cellule cible
WO2004073375A2 (fr) * 2003-02-18 2004-09-02 Ranbaxy Laboratories Limited Derives de podophyllotoxine utiles comme agents antitumoraux
WO2005100363A1 (fr) * 2004-04-16 2005-10-27 Pierre Fabre Medicament Derives de polyaminoacetamide d'epipodophyllotoxine, leurs methodes de preparation et leurs utilisation sous forme d'agents therapeutiques anticancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BYK G ET AL: "One Pot Synthesis of Unsymmetrically Functionalized Polyamines by a Solid Phase Strategy Starting from their Symmetrical Polyamine-Counterparts", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, vol. 38, no. 18, 5 May 1997 (1997-05-05), pages 3219 - 3222, XP004059812, ISSN: 0040-4039 *
CHRISTOPHE JACOPIN ET AL.: "Glycosidation of alkylamino-alkan-1-ol. A simple and convenient synthesis of glycosylated cationic lipids", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, 2002, GBOXFORD, pages 1447 - 1450, XP002481454 *
KAMAL A ET AL: "Synthesis of 4-beta-Amido and 4-beta-Sulphonamido Analogues of Podophyllotoxin as Potential Antitumor Agents", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 11, no. 23, 17 November 2003 (2003-11-17), pages 5135 - 5142, XP002281030, ISSN: 0968-0896 *

Also Published As

Publication number Publication date
JP2010540506A (ja) 2010-12-24
US8664409B2 (en) 2014-03-04
JP5346026B2 (ja) 2013-11-20
FR2921369B1 (fr) 2014-07-11
WO2009050365A2 (fr) 2009-04-23
EP2203456A2 (fr) 2010-07-07
US20120022273A1 (en) 2012-01-26
FR2921369A1 (fr) 2009-03-27

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