+

WO2008139844A1 - グルクロン酸発酵によるグルクロン酸の製造方法 - Google Patents

グルクロン酸発酵によるグルクロン酸の製造方法 Download PDF

Info

Publication number
WO2008139844A1
WO2008139844A1 PCT/JP2008/057706 JP2008057706W WO2008139844A1 WO 2008139844 A1 WO2008139844 A1 WO 2008139844A1 JP 2008057706 W JP2008057706 W JP 2008057706W WO 2008139844 A1 WO2008139844 A1 WO 2008139844A1
Authority
WO
WIPO (PCT)
Prior art keywords
glucuronic acid
glucose
producing
glucuronolactone
hydroxymethyl group
Prior art date
Application number
PCT/JP2008/057706
Other languages
English (en)
French (fr)
Inventor
Tetsuya Ito
Yuki Ario
Eriko Kishino
Koki Fujita
Original Assignee
Ensuiko Sugar Refining Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ensuiko Sugar Refining Co., Ltd. filed Critical Ensuiko Sugar Refining Co., Ltd.
Priority to KR1020097022126A priority Critical patent/KR101430537B1/ko
Priority to CN2008800151470A priority patent/CN101679936B/zh
Priority to JP2009514060A priority patent/JP5118132B2/ja
Priority to AU2008249370A priority patent/AU2008249370B2/en
Priority to US12/598,456 priority patent/US8530186B2/en
Priority to AT08751896T priority patent/ATE528388T1/de
Priority to EP08751896A priority patent/EP2143785B1/en
Publication of WO2008139844A1 publication Critical patent/WO2008139844A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

  　本発明は、グルコースのヒドロキシメチル基を特異的に酸化する能力に優れた微生物及びこの微生物を用いてグルコースの直接酸化によりグルクロン酸及び／又はグルクロノラクトンを製造する方法を提供することを課題とするものであり、本発明は、グルコースから直接グルクロン酸を生成する微生物であって、グルコースのヒドロキシメチル基を特異的に酸化する能力を有し、１６ＳｒＲＮＡに対応するＤＮＡの塩基配列が、配列表の配列番号１に記載の塩基配列を有する変異菌株、及び当該変異菌株を用い、グルコースのヒドロキシメチル基を特異的に酸化してグルクロン酸及び／又はグルクロノラクトンを製造する方法であり、本発明により、Ｄ－グルクロン酸及び／又はＤ－グルクロノラクトンを、高収率、廉価、容易、且つ安全に製造し、提供することが可能である。
PCT/JP2008/057706 2007-05-08 2008-04-21 グルクロン酸発酵によるグルクロン酸の製造方法 WO2008139844A1 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
KR1020097022126A KR101430537B1 (ko) 2007-05-08 2008-04-21 글루쿠론산 발효에 의한 글루쿠론산의 제조 방법
CN2008800151470A CN101679936B (zh) 2007-05-08 2008-04-21 通过葡糖醛酸发酵来制造葡糖醛酸的方法
JP2009514060A JP5118132B2 (ja) 2007-05-08 2008-04-21 グルクロン酸発酵によるグルクロン酸の製造方法
AU2008249370A AU2008249370B2 (en) 2007-05-08 2008-04-21 Method for producing glucuronic acid by glucuronic acid fermentation
US12/598,456 US8530186B2 (en) 2007-05-08 2008-04-21 Method for producing glucuronic acid by glucuronic acid fermentation
AT08751896T ATE528388T1 (de) 2007-05-08 2008-04-21 Verfahren zur herstellung von glucuronsäure mittels fermentation von glucuronsäure
EP08751896A EP2143785B1 (en) 2007-05-08 2008-04-21 Method for producing glucuronic acid by glucuronic acid fermentation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007123975 2007-05-08
JP2007-123975 2007-05-08

Publications (1)

Publication Number Publication Date
WO2008139844A1 true WO2008139844A1 (ja) 2008-11-20

Family

ID=40002062

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/057706 WO2008139844A1 (ja) 2007-05-08 2008-04-21 グルクロン酸発酵によるグルクロン酸の製造方法

Country Status (8)

Country Link
US (1) US8530186B2 (ja)
EP (1) EP2143785B1 (ja)
JP (1) JP5118132B2 (ja)
KR (1) KR101430537B1 (ja)
CN (1) CN101679936B (ja)
AT (1) ATE528388T1 (ja)
AU (1) AU2008249370B2 (ja)
WO (1) WO2008139844A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013183610A1 (ja) 2012-06-04 2013-12-12 塩水港精糖株式会社 Ｄ－グルカル酸生産菌およびｄ－グルカル酸の製造方法
WO2024179615A1 (zh) * 2023-02-28 2024-09-06 诸城市浩天药业有限公司 一种葡萄糖醛酸的制备方法及葡醛内酯的制备工艺

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102367244B (zh) * 2011-10-31 2013-07-10 暨南大学 一种葡萄糖酸内酯的制备方法
JP6163557B2 (ja) * 2012-09-21 2017-07-12 シンセティック ジェノミクス インコーポレーテッド 化学物質およびその誘導体を生成するための組成物および方法
US9528133B2 (en) 2012-09-21 2016-12-27 Synthetic Genomics, Inc. Compositions and methods for producing chemicals and derivatives thereof
CN106414753A (zh) * 2014-03-21 2017-02-15 合成基因组股份有限公司 用于生产化学品及其衍生物的组合物和方法
CN115607487B (zh) * 2022-09-16 2023-09-26 佛山天韵化妆品科技有限公司 一种亮肤抗衰制剂及其应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0335882B2 (ja) 1984-02-17 1991-05-29 Fuji Robin Kk
JPH0568542A (ja) 1991-09-12 1993-03-23 Takeda Chem Ind Ltd アルコール脱水素酵素およびその製造法
JPH067157A (ja) 1985-10-22 1994-01-18 Takeda Chem Ind Ltd シュードグルコノバクター属酸化菌
JPH0776594A (ja) * 1992-11-27 1995-03-20 Takeda Chem Ind Ltd 糖カルボン酸の製造法及び新規糖カルボン酸
JPH10251263A (ja) 1997-03-10 1998-09-22 Chugoku Kayaku Kk Ｄ−グルクロノラクトンの製造方法
JPH11147043A (ja) 1997-09-08 1999-06-02 Chugai Pharmaceut Co Ltd 有機化合物の１級水酸基の選択的酸化方法およびその方法に使用する触媒吸着樹脂
JP2003159079A (ja) 2001-11-29 2003-06-03 Fujisawa Pharmaceut Co Ltd アルコール／アルデヒドデヒドロゲナーゼ、その製造方法およびその用途
JP2006314223A (ja) 2005-05-11 2006-11-24 Yokohama Kokusai Bio Kenkyusho:Kk グルクロン酸及び／又はグルクロノラクトンの製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4543331A (en) * 1982-03-05 1985-09-24 Shionogi & Co., Ltd. Fermentative or enzymatic production of 2-keto-L-gulonic acid
DK617386A (da) * 1985-12-26 1987-06-27 Takeda Chemical Industries Ltd Fremgangsmaade til fremstilling af 2-keto-d-glucarsyre
TW293036B (ja) * 1992-11-27 1996-12-11 Takeda Pharm Industry Co Ltd
TW515844B (en) * 1997-01-31 2003-01-01 Fujisawa Pharmaceutical Co A fermentation method for producing 2-keto-L-gulonic acid

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0335882B2 (ja) 1984-02-17 1991-05-29 Fuji Robin Kk
JPH067157A (ja) 1985-10-22 1994-01-18 Takeda Chem Ind Ltd シュードグルコノバクター属酸化菌
JPH0568542A (ja) 1991-09-12 1993-03-23 Takeda Chem Ind Ltd アルコール脱水素酵素およびその製造法
JPH0776594A (ja) * 1992-11-27 1995-03-20 Takeda Chem Ind Ltd 糖カルボン酸の製造法及び新規糖カルボン酸
JPH10251263A (ja) 1997-03-10 1998-09-22 Chugoku Kayaku Kk Ｄ−グルクロノラクトンの製造方法
JPH11147043A (ja) 1997-09-08 1999-06-02 Chugai Pharmaceut Co Ltd 有機化合物の１級水酸基の選択的酸化方法およびその方法に使用する触媒吸着樹脂
JP2003159079A (ja) 2001-11-29 2003-06-03 Fujisawa Pharmaceut Co Ltd アルコール／アルデヒドデヒドロゲナーゼ、その製造方法およびその用途
JP2006314223A (ja) 2005-05-11 2006-11-24 Yokohama Kokusai Bio Kenkyusho:Kk グルクロン酸及び／又はグルクロノラクトンの製造方法

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013183610A1 (ja) 2012-06-04 2013-12-12 塩水港精糖株式会社 Ｄ－グルカル酸生産菌およびｄ－グルカル酸の製造方法
US20150152448A1 (en) * 2012-06-04 2015-06-04 Ensuiko Sugar Refining Co., Ltd. D-Glucaric Acid Producing Bacterium, and Method for Manufacturing D-Glucaric Acid
JPWO2013183610A1 (ja) * 2012-06-04 2016-02-01 塩水港精糖株式会社 Ｄ−グルカル酸生産菌およびｄ−グルカル酸の製造方法
US10975396B2 (en) 2012-06-04 2021-04-13 Ensuiko Sugar Refining Co., Ltd. D-glucaric acid producing bacterium, and method for manufacturing D-glucaric acid
US12241112B2 (en) 2012-06-04 2025-03-04 Ensuiko Sugar Refining Co., Ltd. D-glucaric acid producing bacterium, and method for manufacturing D-glucaric acid
WO2024179615A1 (zh) * 2023-02-28 2024-09-06 诸城市浩天药业有限公司 一种葡萄糖醛酸的制备方法及葡醛内酯的制备工艺

Also Published As

Publication number Publication date
KR20100019419A (ko) 2010-02-18
JP5118132B2 (ja) 2013-01-16
EP2143785B1 (en) 2011-10-12
CN101679936A (zh) 2010-03-24
KR101430537B1 (ko) 2014-08-18
EP2143785A1 (en) 2010-01-13
US20100075381A1 (en) 2010-03-25
US8530186B2 (en) 2013-09-10
CN101679936B (zh) 2013-04-03
AU2008249370B2 (en) 2013-09-05
ATE528388T1 (de) 2011-10-15
JPWO2008139844A1 (ja) 2010-07-29
AU2008249370A1 (en) 2008-11-20
EP2143785A4 (en) 2010-06-02

Similar Documents

Publication Publication Date Title
WO2008139844A1 (ja) グルクロン酸発酵によるグルクロン酸の製造方法
Chon et al. Abundance of denitrifying genes coding for nitrate (narG), nitrite (nirS), and nitrous oxide (nosZ) reductases in estuarine versus wastewater effluent-fed constructed wetlands
PE20060952A1 (es) Microorganismos productores de acido l-glutamico y metodo para la produccion de acido l-glutamico
Fowler et al. Identification of toluene degraders in a methanogenic enrichment culture
WO2009118176A8 (de) Neue 12alpha-hydroxysteroiddehydrogenasen, deren herstellung und verwendung
WO2006031424A3 (en) Mutant e. coli strain with increased succinic acid production
WO2003008614A3 (en) Process for the preparation of l-amino acids using strains of the enterobacteriaceae family which contain an enhanced suca or sucb gene
MX2010009984A (es) Selección de organismos capaces de fermentar sustratos mixtos.
WO2010114245A3 (ko) 5'-이노신산 생산성이 향상된 코리네박테리움 속 미생물 및 이를 이용한 핵산의 생산방법
WO2008093847A1 (ja) キシリトールデヒドロゲナーゼをコードするｄｎａ
UA103335C2 (ru) Способ изготовления добавки для ферментативного расщепления микотоксинов, добавка и ее применение
EP2333054A4 (en) NEW, THERMOCOCCUS SPP ISOLATED HYDROGENASE, THESE CODING GENES, AND METHOD FOR PRODUCING HYDROGEN THROUGH MICROORGANISMS WITH THE GENE
CY1110827T1 (el) Μια μεθοδος παραγωγης ηλεκτρικου οξεος απο ακατεργαστα υδρολυματα
WO2002036797A3 (en) Process for the fermentative preparation of l-amino acids using strains of the enterobacteriaceae family
WO2007099230A3 (fr) Systeme d ' expression chez la levure pour la production de molecules aromatiques
WO2007054972A3 (en) Method of producing sucrose-6-acetate by whole-cell biocatalysis
EP2479273A3 (en) Primer and probe for detection of mycobacterium avium and method for detection of mycobacterium avium using the same
WO2003000913A3 (de) Verfahren zur fermentativen herstellung von pyruvat
WO2003038106A3 (en) A process for the production of l-amino acids using strains of the enterobacteriaceae family which contain an enhanced fadr or iclr gene
EP1431400A3 (en) Method of detecting acid-fast bacteria using ribosomal RNA as target
EP1726655A4 (en) BETA-fructofuranosidase MUTANT
Iwai et al. Screening of fluorinated materials degrading microbes
EP2141236A8 (en) Process for production of lipstatin and microorganisms therefore
WO2008111608A1 (ja) 新規水素発生菌
WO2010092304A3 (fr) Procedes de production d'acide succinique

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880015147.0

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08751896

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 20097022126

Country of ref document: KR

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 2009514060

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 12598456

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2008249370

Country of ref document: AU

Ref document number: 2008751896

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2008249370

Country of ref document: AU

Date of ref document: 20080421

Kind code of ref document: A

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载