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WO2008139754A1 - 2,6-di-tert-butylphenol derivative and melanogenesis inhibitor comprising 2,6-di-tert-butylphenol derivative as the active ingredient - Google Patents

2,6-di-tert-butylphenol derivative and melanogenesis inhibitor comprising 2,6-di-tert-butylphenol derivative as the active ingredient Download PDF

Info

Publication number
WO2008139754A1
WO2008139754A1 PCT/JP2008/051618 JP2008051618W WO2008139754A1 WO 2008139754 A1 WO2008139754 A1 WO 2008139754A1 JP 2008051618 W JP2008051618 W JP 2008051618W WO 2008139754 A1 WO2008139754 A1 WO 2008139754A1
Authority
WO
WIPO (PCT)
Prior art keywords
tert
active ingredient
butylphenol derivative
melanogenesis inhibitor
general formula
Prior art date
Application number
PCT/JP2008/051618
Other languages
French (fr)
Japanese (ja)
Inventor
Kouji Yokoyama
Takayuki Katagiri
Makoto Kimura
Yuko Saitoh
Original Assignee
Pola Chemical Industries Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pola Chemical Industries Inc. filed Critical Pola Chemical Industries Inc.
Priority to JP2009514026A priority Critical patent/JPWO2008139754A1/en
Publication of WO2008139754A1 publication Critical patent/WO2008139754A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

It is intended to provide a novel melanogenesis inhibitor which has a novel mother nucleus and can be added to a skin external preparation. More specifically, a melanogenesis inhibitor which contains a compound represented by the following general formula (A) or a pharmacologically acceptable salt thereof as the active ingredient. General formula (A) In the above general formula, Ra1 and Ra2 each independently represents a hydrogen atom or an alkyl group, and Ra3 represents an aromatic group.
PCT/JP2008/051618 2007-05-10 2008-02-01 2,6-di-tert-butylphenol derivative and melanogenesis inhibitor comprising 2,6-di-tert-butylphenol derivative as the active ingredient WO2008139754A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009514026A JPWO2008139754A1 (en) 2007-05-10 2008-02-01 Melanin production inhibitor comprising 2,6-di-tert-butylphenol derivative and 2,6-di-tert-butylphenol derivative as active ingredients

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-125486 2007-05-10
JP2007125486 2007-05-10

Publications (1)

Publication Number Publication Date
WO2008139754A1 true WO2008139754A1 (en) 2008-11-20

Family

ID=40001977

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/051618 WO2008139754A1 (en) 2007-05-10 2008-02-01 2,6-di-tert-butylphenol derivative and melanogenesis inhibitor comprising 2,6-di-tert-butylphenol derivative as the active ingredient

Country Status (3)

Country Link
JP (1) JPWO2008139754A1 (en)
TW (1) TW200902075A (en)
WO (1) WO2008139754A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105669406A (en) * 2016-01-04 2016-06-15 双键化工（上海）有限公司 Method for preparation of 2-hydroxy-2,2-diphenyl-1-(p-methylphenyl)ethanone

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3592931A (en) * 1967-06-16 1971-07-13 Ciba Ltd Preparations for combating harmful microorganisms
JPS62129212A (en) * 1985-11-29 1987-06-11 Pola Chem Ind Inc Cosmetic
JPS62249939A (en) * 1986-04-04 1987-10-30 ロレアル Aromatic compound, manufacture and use for human and animal drug and cosmetics
JPS63502281A (en) * 1986-01-17 1988-09-01 ライカ−　ラボラトリ−ス　インコ−ポレ−テツド Anti-inflammatory composition for topical use
JPH06206805A (en) * 1992-02-17 1994-07-26 Hisamitsu Pharmaceut Co Inc Tyrosinase inhibitor and external preparation for skin using the same
JPH09136811A (en) * 1995-11-15 1997-05-27 Shiseido Co Ltd Preparation for lightening skin color
JPH10101543A (en) * 1996-10-02 1998-04-21 Kansai Kouso Kk Tyrosinase-activity inhibitor, and cosmetic
WO2007094200A1 (en) * 2006-02-14 2007-08-23 Pola Chemical Industries Inc. Skin-whitening cosmetic

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3592931A (en) * 1967-06-16 1971-07-13 Ciba Ltd Preparations for combating harmful microorganisms
JPS62129212A (en) * 1985-11-29 1987-06-11 Pola Chem Ind Inc Cosmetic
JPS63502281A (en) * 1986-01-17 1988-09-01 ライカ−　ラボラトリ−ス　インコ−ポレ−テツド Anti-inflammatory composition for topical use
JPS62249939A (en) * 1986-04-04 1987-10-30 ロレアル Aromatic compound, manufacture and use for human and animal drug and cosmetics
JPH06206805A (en) * 1992-02-17 1994-07-26 Hisamitsu Pharmaceut Co Inc Tyrosinase inhibitor and external preparation for skin using the same
JPH09136811A (en) * 1995-11-15 1997-05-27 Shiseido Co Ltd Preparation for lightening skin color
JPH10101543A (en) * 1996-10-02 1998-04-21 Kansai Kouso Kk Tyrosinase-activity inhibitor, and cosmetic
WO2007094200A1 (en) * 2006-02-14 2007-08-23 Pola Chemical Industries Inc. Skin-whitening cosmetic

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GEORGE N.Z. ET AL.: "New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, no. 16, 2006, pages 5616 - 5624, XP005534887 *
PAVLICKOVA L. ET AL.: "Quinone methides and fuchsones. Part XIV. Preparation and reactions of 5,7-di-tert-butyl-1,2-diphenylspiro[2,5]octa-1,4,7-trien-6-one: a revision of the literature", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 44, no. 6, 1979, pages 1810 - 1818 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105669406A (en) * 2016-01-04 2016-06-15 双键化工（上海）有限公司 Method for preparation of 2-hydroxy-2,2-diphenyl-1-(p-methylphenyl)ethanone
CN105669406B (en) * 2016-01-04 2018-08-03 大丰鑫源达化工有限公司 The method for preparing 2- hydroxyl -2,2- diphenyl -1- (p-methylphenyl) ethyl ketone

Also Published As

Publication number Publication date
JPWO2008139754A1 (en) 2010-07-29
TW200902075A (en) 2009-01-16

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