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WO2008136279A1 - ヘテロ環置換ピリジン誘導体の塩またはその結晶 - Google Patents

ヘテロ環置換ピリジン誘導体の塩またはその結晶 Download PDF

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Publication number
WO2008136279A1
WO2008136279A1 PCT/JP2008/057569 JP2008057569W WO2008136279A1 WO 2008136279 A1 WO2008136279 A1 WO 2008136279A1 JP 2008057569 W JP2008057569 W JP 2008057569W WO 2008136279 A1 WO2008136279 A1 WO 2008136279A1
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WO
WIPO (PCT)
Prior art keywords
crystal
salt
heterocycle
pyridine derivative
substituted pyridine
Prior art date
Application number
PCT/JP2008/057569
Other languages
English (en)
French (fr)
Inventor
Jun Niijima
Kazutaka Nakamoto
Masayuki Matsukura
Keigo Tanaka
Eiichi Yamamoto
Takuma Minamisono
Original Assignee
Eisai R & D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R & D Management Co., Ltd. filed Critical Eisai R & D Management Co., Ltd.
Priority to EP08740624A priority Critical patent/EP2143723A4/en
Priority to JP2009512922A priority patent/JPWO2008136279A1/ja
Priority to CN2008800070238A priority patent/CN101622251B/zh
Priority to CA002685194A priority patent/CA2685194A1/en
Priority to AU2008246798A priority patent/AU2008246798A1/en
Publication of WO2008136279A1 publication Critical patent/WO2008136279A1/ja
Priority to IL200216A priority patent/IL200216A0/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

　本発明の目的は、へテロ環置換ピリジン誘導体の塩またはその結晶を提供することである。本発明によれば、３－（３－（４－（ピリジン－２－イルオキシメチル）－ベンジル）－イソキサゾール－５－イル）－ピリジン－２－イルアミンの酸付加塩またはその結晶が提供される。
PCT/JP2008/057569 2007-04-27 2008-04-18 ヘテロ環置換ピリジン誘導体の塩またはその結晶 WO2008136279A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP08740624A EP2143723A4 (en) 2007-04-27 2008-04-18 SALT OF A PYRIDINE DERIVATIVE SUBSTITUTED BY HETEROCYCLE OR CRYSTALS OF THE SAME
JP2009512922A JPWO2008136279A1 (ja) 2007-04-27 2008-04-18 ヘテロ環置換ピリジン誘導体の塩またはその結晶
CN2008800070238A CN101622251B (zh) 2007-04-27 2008-04-18 杂环取代吡啶衍生物的盐或其结晶
CA002685194A CA2685194A1 (en) 2007-04-27 2008-04-18 Heterocycle-substituted pyridine derivatives salt or crystal thereof
AU2008246798A AU2008246798A1 (en) 2007-04-27 2008-04-18 Salt of heterocycle-substituted pyridine derivative or crystal thereof
IL200216A IL200216A0 (en) 2007-04-27 2009-08-03 Heterocycle-substituted pyridine derivative's salt or crystal thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US91457207P 2007-04-27 2007-04-27
JP2007-118411 2007-04-27
JP2007118411 2007-04-27
US60/914,572 2007-04-27

Publications (1)

Publication Number Publication Date
WO2008136279A1 true WO2008136279A1 (ja) 2008-11-13

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/057569 WO2008136279A1 (ja) 2007-04-27 2008-04-18 ヘテロ環置換ピリジン誘導体の塩またはその結晶

Country Status (9)

Country Link
US (1) US8058444B2 (ja)
EP (1) EP2143723A4 (ja)
JP (1) JPWO2008136279A1 (ja)
KR (1) KR20100015897A (ja)
CN (2) CN102702185A (ja)
AU (1) AU2008246798A1 (ja)
CA (1) CA2685194A1 (ja)
IL (1) IL200216A0 (ja)
WO (1) WO2008136279A1 (ja)

Cited By (9)

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WO2009081970A1 (ja) 2007-12-26 2009-07-02 Eisai R & D Management Co., Ltd. ヘテロ環置換ピリジン誘導体の製造方法
WO2009084621A1 (ja) 2007-12-27 2009-07-09 Eisai R & D Management Co., Ltd. ヘテロ環およびホスホノキシメチル基が置換したピリジン誘導体ならびにそれらを含有する抗真菌剤
WO2010047120A1 (ja) 2008-10-24 2010-04-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ環及びγ－グルタミルアミノ基が置換したピリジン誘導体並びにそれらを含有する抗真菌剤
WO2011051198A2 (de) 2009-10-30 2011-05-05 Bayer Cropscience Ag Pyridin-derivate als pflanzenschutzmittel
EP2345328A1 (en) * 2008-09-19 2011-07-20 Sumitomo Chemical Company, Limited Composition for agricultural use
JP2013532131A (ja) * 2010-05-19 2013-08-15 サンド・アクチエンゲゼルシヤフト ポサコナゾール中間体の製造
US9199919B2 (en) 2010-05-19 2015-12-01 Sandoz Ag Process for the preparation of chiral hydrazides
US9206146B2 (en) 2010-05-19 2015-12-08 Sandoz Ag Purification of posaconazole and of posaconazole intermediates
US9493428B2 (en) 2011-06-16 2016-11-15 Sandoz Ag Process for the preparation of a chiral compound

Families Citing this family (9)

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JP4795022B2 (ja) * 2003-09-30 2011-10-19 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ環化合物を含有する新規な抗真菌剤
TWI385169B (zh) * 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
EP2065377B1 (en) 2006-09-21 2011-11-23 Eisai R&D Management Co., Ltd. Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
TW200841879A (en) * 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
US8522915B2 (en) * 2007-12-19 2013-09-03 Westerngeco L.L.C. Method and system for selecting parameters of a seismic source array
JP2012176900A (ja) * 2009-06-24 2012-09-13 Eisai R & D Management Co Ltd （（ホスホノオキシ）メチル）ピリジニウム環を有するピリジン誘導体およびそれらを含有する抗真菌剤
KR102795392B1 (ko) 2017-12-07 2025-04-11 바실리아 파마슈티카 인터내셔널 아게, 올슈빌 헤테로사이클 치환된 피리딘 유도체 항진균제
CA3104653A1 (en) 2018-06-25 2020-01-02 Amplyx Pharmaceuticals, Inc. Pyridine derivatives substituted by heterocyclic ring and amino group
CN110776505A (zh) * 2018-07-29 2020-02-11 朱允涛 一种氘代的异恶唑类化合物的制备方法和用途

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WO2009081970A1 (ja) 2007-12-26 2009-07-02 Eisai R & D Management Co., Ltd. ヘテロ環置換ピリジン誘導体の製造方法
US8410277B2 (en) 2007-12-26 2013-04-02 Eisai R&D Managment Co., Ltd. Method for manufacturing heterocycle substituted pyridine derivatives
WO2009084621A1 (ja) 2007-12-27 2009-07-09 Eisai R & D Management Co., Ltd. ヘテロ環およびホスホノキシメチル基が置換したピリジン誘導体ならびにそれらを含有する抗真菌剤
EP2345328A1 (en) * 2008-09-19 2011-07-20 Sumitomo Chemical Company, Limited Composition for agricultural use
EP2345328A4 (en) * 2008-09-19 2014-06-25 Sumitomo Chemical Co COMPOSITION FOR USE IN AGRICULTURE
WO2010047120A1 (ja) 2008-10-24 2010-04-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ環及びγ－グルタミルアミノ基が置換したピリジン誘導体並びにそれらを含有する抗真菌剤
WO2011051198A2 (de) 2009-10-30 2011-05-05 Bayer Cropscience Ag Pyridin-derivate als pflanzenschutzmittel
JP2013532131A (ja) * 2010-05-19 2013-08-15 サンド・アクチエンゲゼルシヤフト ポサコナゾール中間体の製造
US9073904B2 (en) 2010-05-19 2015-07-07 Sandoz Ag Preparation of posaconazole intermediates
US9199919B2 (en) 2010-05-19 2015-12-01 Sandoz Ag Process for the preparation of chiral hydrazides
US9206146B2 (en) 2010-05-19 2015-12-08 Sandoz Ag Purification of posaconazole and of posaconazole intermediates
US9493428B2 (en) 2011-06-16 2016-11-15 Sandoz Ag Process for the preparation of a chiral compound

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CA2685194A1 (en) 2008-11-13
KR20100015897A (ko) 2010-02-12
AU2008246798A1 (en) 2008-11-13
IL200216A0 (en) 2010-04-29
EP2143723A4 (en) 2011-05-18
CN101622251B (zh) 2012-07-04
US8058444B2 (en) 2011-11-15
CN102702185A (zh) 2012-10-03
US20080275244A1 (en) 2008-11-06
CN101622251A (zh) 2010-01-06
EP2143723A1 (en) 2010-01-13

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