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WO2008134289A3 - High relaxivity coordinatively unsaturated lanthanide complexes - Google Patents

High relaxivity coordinatively unsaturated lanthanide complexes Download PDF

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Publication number
WO2008134289A3
WO2008134289A3 PCT/US2008/061078 US2008061078W WO2008134289A3 WO 2008134289 A3 WO2008134289 A3 WO 2008134289A3 US 2008061078 W US2008061078 W US 2008061078W WO 2008134289 A3 WO2008134289 A3 WO 2008134289A3
Authority
WO
WIPO (PCT)
Prior art keywords
lanthanide complexes
coordinatively unsaturated
high relaxivity
unsaturated lanthanide
relaxivity
Prior art date
Application number
PCT/US2008/061078
Other languages
French (fr)
Other versions
WO2008134289A2 (en
Inventor
Dennis A Moore
Original Assignee
Mallinckrodt Inc
Dennis A Moore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc, Dennis A Moore filed Critical Mallinckrodt Inc
Publication of WO2008134289A2 publication Critical patent/WO2008134289A2/en
Publication of WO2008134289A3 publication Critical patent/WO2008134289A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention is directed to tetraazamacrocyclic compounds and lanthanide complexes thereof useful as MRI contrast agents having enhanced relaxivity.
PCT/US2008/061078 2007-04-26 2008-04-22 High relaxivity coordinatively unsaturated lanthanide complexes WO2008134289A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91405407P 2007-04-26 2007-04-26
US60/914,054 2007-04-26

Publications (2)

Publication Number Publication Date
WO2008134289A2 WO2008134289A2 (en) 2008-11-06
WO2008134289A3 true WO2008134289A3 (en) 2008-12-11

Family

ID=39760993

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/061078 WO2008134289A2 (en) 2007-04-26 2008-04-22 High relaxivity coordinatively unsaturated lanthanide complexes

Country Status (1)

Country Link
WO (1) WO2008134289A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012151539A2 (en) * 2011-05-05 2012-11-08 New York University Lanthanoid complex capsule and particle contrast agents, methods of making and using thereof
WO2015142583A1 (en) * 2014-03-17 2015-09-24 The Board Of Regents Of The University Of Texas System New gadolinium-based contrast agents for sensitive detection of zn2+ with mri
AU2018261888B2 (en) 2017-05-05 2022-06-30 Centre For Probe Development And Commercialization Pharmacokinetic enhancements of bifunctional chelates and uses thereof
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
WO2018204872A2 (en) 2017-05-05 2018-11-08 Fusion Pharmaceuticals Inc. Igf-1r monoclonal antibodies and uses thereof
CN114573609B (en) * 2022-03-07 2024-02-06 桂林理工大学 A single-molecule magnet based on an asymmetric dinuclear dysprosium complex and its preparation method

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5053503A (en) * 1989-02-17 1991-10-01 Centocor Chelating agents
CA2055093A1 (en) * 1990-11-08 1992-05-09 Johannes Platzek Mono-n-substituted 1,4,7,10-tetraazacyclododecane derivatives, process for their production and pharmaceutical agents containing these derivatives
WO1995024221A1 (en) * 1986-08-18 1995-09-14 The Dow Chemical Company Bioactive and/or targeted dendrimer conjugates
WO1995028392A1 (en) * 1994-04-14 1995-10-26 Nycomed Salutar Inc. Chelant compounds
WO1996011023A1 (en) * 1994-10-10 1996-04-18 Nycomed Salutar Inc. Liposomal agents
WO1996028433A1 (en) * 1995-03-10 1996-09-19 Nycomed Imaging A.S Polyazacycloalkane compounds
WO2005062828A2 (en) * 2003-12-23 2005-07-14 Bracco Imaging S.P.A. New compounds useful as metal chelators
WO2008073828A2 (en) * 2006-12-08 2008-06-19 Northwestern University Compositions and methods for magnetic resonance imaging contrast agents
WO2008098056A2 (en) * 2007-02-06 2008-08-14 Epix Pharmaceuticals, Inc. High relaxivity chelates

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995024221A1 (en) * 1986-08-18 1995-09-14 The Dow Chemical Company Bioactive and/or targeted dendrimer conjugates
US5053503A (en) * 1989-02-17 1991-10-01 Centocor Chelating agents
CA2055093A1 (en) * 1990-11-08 1992-05-09 Johannes Platzek Mono-n-substituted 1,4,7,10-tetraazacyclododecane derivatives, process for their production and pharmaceutical agents containing these derivatives
WO1995028392A1 (en) * 1994-04-14 1995-10-26 Nycomed Salutar Inc. Chelant compounds
WO1996011023A1 (en) * 1994-10-10 1996-04-18 Nycomed Salutar Inc. Liposomal agents
WO1996028433A1 (en) * 1995-03-10 1996-09-19 Nycomed Imaging A.S Polyazacycloalkane compounds
WO2005062828A2 (en) * 2003-12-23 2005-07-14 Bracco Imaging S.P.A. New compounds useful as metal chelators
WO2008073828A2 (en) * 2006-12-08 2008-06-19 Northwestern University Compositions and methods for magnetic resonance imaging contrast agents
WO2008098056A2 (en) * 2007-02-06 2008-08-14 Epix Pharmaceuticals, Inc. High relaxivity chelates

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DESSOLIN J ET AL: "Tri-N-Boc-tetraazamacrocycle-nucleoside conjugates: synthesis and anti-HI activities", NUCLEOSIDES & NUCLEOTIDES, vol. 17, no. 5, 13 April 1998 (1998-04-13), pages 957 - 968, XP002094374, ISSN: 0732-8311 *
KARFELD L S ET AL: "Use of a genetically engineered protein for the design of a multivalent MRI contrast agent", BIOCONJUGATE CHEMISTRY, vol. 18, no. 6, November 2007 (2007-11-01), pages 1697 - 1700, XP009106214, ISSN: 1043-1802 *
ZECH S G ET AL: "Probing the water coordination of protein-targeted MRI contrast agents by pulsed ENDOR spectroscopy", CHEMPHYSCHEM - A EUROPEAN JOURNAL OF CHEMICAL PHYSICS & PHYSICALCHEMISTRY, vol. 6, no. 12, December 2005 (2005-12-01), pages 2570 - 2577, XP009105424, ISSN: 1439-4235 *

Also Published As

Publication number Publication date
WO2008134289A2 (en) 2008-11-06

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