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WO2008134261A3 - Procédé de détermination de la structure d'une protéine, identification d'un gène, analyse mutationnelle et conception d'une protéine - Google Patents

Procédé de détermination de la structure d'une protéine, identification d'un gène, analyse mutationnelle et conception d'une protéine Download PDF

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Publication number
WO2008134261A3
WO2008134261A3 PCT/US2008/060786 US2008060786W WO2008134261A3 WO 2008134261 A3 WO2008134261 A3 WO 2008134261A3 US 2008060786 W US2008060786 W US 2008060786W WO 2008134261 A3 WO2008134261 A3 WO 2008134261A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
structure determination
mutational analysis
gene identification
design
Prior art date
Application number
PCT/US2008/060786
Other languages
English (en)
Other versions
WO2008134261A2 (fr
Inventor
Charles Michael Fortmann
Yeona Kang
David H. Coleman
Original Assignee
The Research Foundation Of State University Of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2007/067639 external-priority patent/WO2007140061A2/fr
Application filed by The Research Foundation Of State University Of New York filed Critical The Research Foundation Of State University Of New York
Priority to US12/301,963 priority Critical patent/US20100304983A1/en
Publication of WO2008134261A2 publication Critical patent/WO2008134261A2/fr
Publication of WO2008134261A3 publication Critical patent/WO2008134261A3/fr

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/20—Protein or domain folding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/30—Detection of binding sites or motifs
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/50—Mutagenesis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Landscapes

  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Theoretical Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne un procédé et un système de calcul efficaces permettant de prédire les régions de repliement et les structures secondaires et tertiaires associées, d'une protéine. L'invention concerne, en outre, des procédés et des systèmes de tri des séquences d'acides aminés sur la base des structures prédites, ainsi que des procédés et des systèmes permettant de déterminer la présence ou l'absence de gènes dans des séquences d'acides nucléiques ou encore de mutations structurelles dans des séquences d'acides aminés. L'invention concerne encore un procédé et un système de conception d'une protéine.
PCT/US2008/060786 2007-04-27 2008-04-18 Procédé de détermination de la structure d'une protéine, identification d'un gène, analyse mutationnelle et conception d'une protéine WO2008134261A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/301,963 US20100304983A1 (en) 2007-04-27 2008-04-18 Method for protein structure determination, gene identification, mutational analysis, and protein design

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
USPCT/US2007/0067639 2007-04-27
PCT/US2007/067639 WO2007140061A2 (fr) 2006-05-23 2007-04-27 Méthode de détermination et de prédiction du pliage automone de protéines

Publications (2)

Publication Number Publication Date
WO2008134261A2 WO2008134261A2 (fr) 2008-11-06
WO2008134261A3 true WO2008134261A3 (fr) 2009-12-30

Family

ID=39930731

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/060786 WO2008134261A2 (fr) 2007-04-27 2008-04-18 Procédé de détermination de la structure d'une protéine, identification d'un gène, analyse mutationnelle et conception d'une protéine

Country Status (1)

Country Link
WO (1) WO2008134261A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011100395A1 (fr) * 2010-02-11 2011-08-18 The Research Foundation Of State University Of New York Procédés de calcul pour la détermination de structures d'une protéine
CN112480204A (zh) * 2020-04-13 2021-03-12 南京大学 一种采用Aerolysin纳米孔道的蛋白质/多肽测序方法
CN114649052B (zh) * 2022-03-22 2024-10-25 山东省计算中心（国家超级计算济南中心） 基于超算互联网的rna结构预测方法及系统
CN116486906B (zh) * 2023-04-17 2024-03-19 深圳新锐基因科技有限公司 基于氨基酸残基突变提高蛋白质分子稳定性的方法及装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030130797A1 (en) * 1999-01-27 2003-07-10 Jeffrey Skolnick Protein modeling tools
US20050130224A1 (en) * 2002-05-31 2005-06-16 Celestar Lexico- Sciences, Inc. Interaction predicting device

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030130797A1 (en) * 1999-01-27 2003-07-10 Jeffrey Skolnick Protein modeling tools
US20050130224A1 (en) * 2002-05-31 2005-06-16 Celestar Lexico- Sciences, Inc. Interaction predicting device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
AVBELJ ET AL.: "Prediction of the Three-Dimensional Structure of Proteins Using the Electrostatic Screening Model and Hierarchic Condensation.", PROTEINS: STRUCTURE, FUNCTION, AND GENETICS, vol. 31, 1998, pages 74 - 96 *

Also Published As

Publication number Publication date
WO2008134261A2 (fr) 2008-11-06

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