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WO2008131364A3 - Méthode de diagnostic de la maladie d'alzheimer et marqueurs associés - Google Patents

Méthode de diagnostic de la maladie d'alzheimer et marqueurs associés Download PDF

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Publication number
WO2008131364A3
WO2008131364A3 PCT/US2008/061068 US2008061068W WO2008131364A3 WO 2008131364 A3 WO2008131364 A3 WO 2008131364A3 US 2008061068 W US2008061068 W US 2008061068W WO 2008131364 A3 WO2008131364 A3 WO 2008131364A3
Authority
WO
WIPO (PCT)
Prior art keywords
load
methods
disease
gab2
gene
Prior art date
Application number
PCT/US2008/061068
Other languages
English (en)
Other versions
WO2008131364A2 (fr
Inventor
Dietrich A Stephan
Eric M Reiman
Jennifer Webster
Christopher B Heward
Original Assignee
Translational Genomics Res Inst
Kronos Science Lab
Dietrich A Stephan
Eric M Reiman
Jennifer Webster
Christopher B Heward
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Translational Genomics Res Inst, Kronos Science Lab, Dietrich A Stephan, Eric M Reiman, Jennifer Webster, Christopher B Heward filed Critical Translational Genomics Res Inst
Publication of WO2008131364A2 publication Critical patent/WO2008131364A2/fr
Publication of WO2008131364A3 publication Critical patent/WO2008131364A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des marqueurs génétiques et des méthodes de diagnostic et de criblage de maladie d'Alzheimer apparue tardivement (LOAD). L'invention concerne également une analyse d'association sur le génome entier de polymorphismes de nucléotide simple (SNP), dont un certain nombre sont situés dans le gène de la protéine de liaison 2 associée à GRB2 (GAB2), ainsi que d'autres marqueurs associés à d'autres gènes. L'invention permet d'identifier deux nouveaux haplotypes dans le gène GAB2, c'est-à-dire, un haplotype d'atténuation de risque de LOAD et un haplotype de limitation de risque de LOAD. Ces haplotypes permettent de modifier le risque de LOAD de manière différente en association avec des allèles APOE. L'invention concerne en outre des méthodes thérapeutiques et des agents pour limiter la détérioration de cellules associées à LOAD.
PCT/US2008/061068 2007-04-20 2008-04-21 Méthode de diagnostic de la maladie d'alzheimer et marqueurs associés WO2008131364A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US92563807P 2007-04-20 2007-04-20
US60/925,638 2007-04-20
US93358207P 2007-06-06 2007-06-06
US60/933,582 2007-06-06

Publications (2)

Publication Number Publication Date
WO2008131364A2 WO2008131364A2 (fr) 2008-10-30
WO2008131364A3 true WO2008131364A3 (fr) 2009-02-12

Family

ID=39876185

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/061068 WO2008131364A2 (fr) 2007-04-20 2008-04-21 Méthode de diagnostic de la maladie d'alzheimer et marqueurs associés

Country Status (1)

Country Link
WO (1) WO2008131364A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040067512A1 (en) * 2001-11-09 2004-04-08 Neurogenetics, Inc. Single nucleotide polymorphisms and mutations on Alpha-2-Macroglobulin
US20040116682A1 (en) * 1998-03-06 2004-06-17 Nordine Cheikh Nucleic acid molecules and other molecules associated with the carbon assimilation pathway
US20050170399A1 (en) * 1996-05-23 2005-08-04 Stefan Somlo Polycystic kidney disease PKD2 gene and uses thereof
US20070054278A1 (en) * 2003-11-18 2007-03-08 Applera Corporation Polymorphisms in nucleic acid molecules encoding human enzyme proteins, methods of detection and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050170399A1 (en) * 1996-05-23 2005-08-04 Stefan Somlo Polycystic kidney disease PKD2 gene and uses thereof
US20040116682A1 (en) * 1998-03-06 2004-06-17 Nordine Cheikh Nucleic acid molecules and other molecules associated with the carbon assimilation pathway
US20040067512A1 (en) * 2001-11-09 2004-04-08 Neurogenetics, Inc. Single nucleotide polymorphisms and mutations on Alpha-2-Macroglobulin
US20070054278A1 (en) * 2003-11-18 2007-03-08 Applera Corporation Polymorphisms in nucleic acid molecules encoding human enzyme proteins, methods of detection and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MAO ET AL.: "A novel role for Gab2 in bFGF-mediated cell survival during retinoic acid-induced neuronal differentiation", JOURNAL OF CELL BIOLOGY, vol. 170, 2005, pages 305 - 316 *
MISRA ET AL.: "Binding of receptor-recognized forms of alpha 2-macroglobulin to the alpha 2-macroglobulin signaling receptor activates phosphatidylinositol 3-kinase", JOURNAL BIOLOGICAL CHEMISTRY, vol. 273, 1998, pages 13399 - 13402 *

Also Published As

Publication number Publication date
WO2008131364A2 (fr) 2008-10-30

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